-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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Ticketed Session denotes that this is a ticketed session.

604.O2.6 604. Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms: New Targets and Drugs

Symposia: Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Acute Myeloid Malignancies, AML, Combination therapy, Apoptosis, Fundamental Science, Translational Research, MPN, Drug development, Bispecific Antibody Therapy, Genomics, Chronic Myeloid Malignancies, Diseases, Immune mechanism, Treatment Considerations, Biological therapies, Immunology, Non-Biological therapies, Metabolism, Myeloid Malignancies, Biological Processes, Molecular biology, Technology and Procedures, Pathogenesis
Monday, December 9, 2024: 2:45 PM-4:15 PM
Seaport Ballroom ABCD (Manchester Grand Hyatt San Diego)
Moderators:
Yana Pikman, MD, Dana-Farber Cancer Institute and Boston Children's Hospital and Paolo Gallipoli, MD/PhD, ARRAY(0xf1bc4c0)
Disclosures:
Gallipoli: Astellas: Honoraria; GSK: Other: Spouse works for GSK.
2:45 PM

Kalay Bertulfo, MS, MA, MPhil1, Hannah Miller1*, Ryan Najac1*, Juan Carlos Castelan2*, Cindy Ma1*, Koen Debackere, MD, PhD1*, Wenbin Xiao, MD, PhD3, Raajit Rampal, MD, PhD4, Ross L Levine, MD4, Chao Lu, PhD5*, Adolfo A. Ferrando, MD, PhD6* and Teresa Palomero, PhD1,7

1Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY
2Columbia University Irving Medical Center, New York, NY
3Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY
4Memorial Sloan Kettering Cancer Center, New York, NY
5Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY
6Regeneron Pharmaceuticals Inc., Tarrytown, NY
7Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY

3:00 PM

Ashley Varkey, DO1,2, Manpreet Bariana2*, Elena Cassella2*, Shaina Anuncio2*, Mark Batistick2*, Sonia Sequeira, PhD3*, Mahiuddin Ahmed, PhD4* and Johannes Zakrzewski, MD1,2,5

1Department of Pediatrics, Hackensack University Medical Center, Hackensack
2Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ
3Vitruviae LLC, Nutley, NJ
4Vitruviae LLC, Verona, NJ
5Department of Oncology, Georgetown University, Washington DC

3:15 PM

Nicole L Michmerhuizen, PhD1, Emily Heikamp, MD, PhD2, Masayuki Umeda, MD, PhD3, Ilaria Iacobucci, PhD4, Bright Arthur1*, Danika Di Giacomo, PhD1*, Ryan Hiltenbrand1*, Sandi Radko-Juettner, PhD1*, Pablo Portola1*, Aurelie Claquin1*, Bappaditya Chandra, PhD5*, David W Baggett5*, Hongling Huang, PhD6*, Peipei Zhou, PhD6*, Lingyun Long, PhD7*, Hao Shi6*, Yu Sun6*, Evangelia K Papachristou, PhD8*, Chandra Sekhar Reddy Chilamakuri8*, Francisca N. de L. Vitorino9*, Joanna M Gongora9*, Clive S D'Santos, PhD10*, Benjamin A Garcia, PhD11*, Richard W Kriwacki, PhD5*, Hongbo Chi, PhD12*, Alex Kentsis, MD, PhD13, Scott A Armstrong, MD, PhD14, Jeffery M Klco, MD, PhD1 and Charles G. Mullighan, MBBS, MSc, MD1

1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
2Dana Farber Cancer institute, Boston, MA
3Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN
4St. Jude Children's Research Hospital, Memphis, TN
5Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN
6Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN
7Department of Immunology, St Jude Children's Research Hospital, Memphis, TN
8Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom
9Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, MO
10Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, GBR
11Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO
12Department of Immunology, St. Jude Children’S Research Hospital, Memphis, TN
13Tow Center for Developmental Oncology, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
14Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA

3:30 PM

Samantha Levin-Furtney, MSc*, Michael Thomas*, Alycen M. Harney*, Mengge Shan*, Alexander Ivliev*, Adam Stefek*, Michael Cameron*, Sudeep Prajapati*, Michael Seiler*, Dominic Reynolds*, Silvia Buonamici and Charles Kung*

Remix Tx, Watertown, MA

3:45 PM

Nithya Balasundaram, PhD1, Hernan Tirado Andreas, MSc2*, Fleur Leguay, BSc2* and Nick Van Gastel, PhD2*

1Laboratory of Cellular Metabolism and Microenvironment, De Duve Institute, UC Louvain, Brussels, Brussels, Belgium
2Laboratory of Cellular Metabolism and Microenvironment, De Duve Institute, UC Louvain, Brussels, Belgium

4:00 PM

Nour Naji, MD1*, Taha Ahmedna1,2*, Theodora Chatzilygeroudi, MD1*, Tushar Nichakawade2*, Sean Lee2*, Brandy Perkins1*, Chen Lossos, MD3*, Bogdan Paun, MD1*, Evangeline Watson2*, Rena R. Xian, MD3, Styliani Karanika4*, Rick Jones1*, Suman Paul, MBBS, PhD1,2 and Theodoros Karantanos, MD, PhD5

1Division of Hematologic Malignancies, Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD
2Ludwig Center and Lustgarten Laboratory, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore
3Division of Hematopathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD
4Division of Infectious Diseases, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD
5Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD

*signifies non-member of ASH