66th ASH Annual Meeting: 506. Bone Marrow Microenvironment: The Bone Marrow Microenvironment in Disease

Symposia: Bone Marrow Microenvironment Oral and Poster Abstracts
Oral

Research, Fundamental Science, Acquired Marrow Failure Syndromes, Adult, MDS, Bone Marrow Failure Syndromes, Translational Research, CHIP, Hematopoiesis, Chronic Myeloid Malignancies, Diseases, Immunology, Biological Processes, Emerging technologies, Myeloid Malignancies, Technology and Procedures, Study Population, Human, Pathogenesis, Omics technologies

Room 11 (San Diego Convention Center)

Moderators:

Sandra Pinho, PhD, University of Illinois at Chicago and Anastasia N. Tikhonova, PhD,

Disclosures:

No relevant conflicts of interest to declare.

2:45 PM

817

Single-Cell Spatial Transcriptomics Identifies Lymphoid Aggregates with Location-Specific Alterations of Adaptive Immune Cells in Human MDS Bone Marrow

Robert Stanley, MD, PhD¹, Beatrice Zhang²^*, Kimon V Argyropoulos, MD PhD³^*, Brianna Gipson²^*, Kenyon Weis⁴^*, Alexander M. Lewis⁴^*, Zoe Katsamakis⁵^*, Karen Zhao¹^*, Catherine Snopkowski⁶^*, Matthew Zatzman, PhD⁷^*, Ning Fan¹^*, Ronan Chaligne, PhD⁸^*, Umesh Bhanot, MD⁹^*, Mikhail Roshal, MD, PhD³^*, Ahmet Dogan, MD, PhD², Benjamin D. Greenbaum, PhD⁷^*, Eytan M. Stein, MD¹⁰, Marcel R.M. van den Brink, MD, PhD¹¹, Omar Abdel-Wahab, MD¹² and Susan Dewolf, MD¹³^*

¹Memorial Sloan Kettering Cancer Center, New York
²Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Pediatrics, Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Single-cell Analytics Innovation Lab, MSKCC, New York
⁷Computational Oncology, Memorial Sloan Kettering Cancer Center, New York
⁸Single-cell Analytics Innovation Lab, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, NEW YORK, NY
⁹Pathology Department, Memorial Sloan Kettering Cancer Center, New York
¹⁰Department of Medicine; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY
¹¹Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
¹²Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹³Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY

3:00 PM

818

Targeting EBF1-ITGB8 Axis in MPN Bone Marrow Niche

Lyudmila Tsurkan, PhD¹^*, Melodie Doute, PhD²^*, Te Ling, PhD¹, Nicholas Morchel²^*, Amha Atakilit³^*, John D. Crispino, PhD⁴, Dean Sheppard⁵^* and Marta Derecka, PhD¹

¹St. Jude Children's Research Hospital, Memphis, TN
²St. Jude Children's Research Hospital, Memphis
³UCSF, San Francisco
⁴Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁵UCSF, San Francisco, CA

3:15 PM

819

Cytokine Secretion from Megakaryocytes Is Governed By Small GTPASES through Autophagy

Isabelle C Becker, PhD, MSc^1,2, Maria Barrachina, PhD², Joshua Lykins³^*, Virginia Camacho, PhD^1,2, Harvey G. Roweth, PhD^2,4, Kellie R Machlus, PhD^1,2, Sidney W. Whiteheart, PhD³ and Joseph E. Italiano, PhD^1,2

¹Vascular Biology Program, Boston Children's Hospital, Boston, MA
²Harvard Medical School, Boston, MA
³Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY
⁴Division of Hematology, Department of Medicine; Brigham and Women’s Hospital, Boston, MA

3:30 PM

820

Transcription Factor Programming of Human iPSC-Derived Sinusoidal Vascular Endothelial Cells Enhances Co-Cultured Hematopoietic Stem and Progenitor Cell Transplantation

Tianxiao Han¹^*, Rajesh D. Gunage, PhD¹^*, Ran Jing²^*, Olivia Stockard²^*, Alexandra F. Corbin¹^*, Luca Hensch³^*, Yang Tang²^*, Kenny Chen¹^*, Song Yang, PhD¹^*, Yi Zhou, PhD¹^*, George Q. Daley, MD, PhD², Thorsten M. Schlaeger, PhD²^* and Leonard I. Zon, MD¹

¹Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital; Howard Hughes Medical Institute; Harvard Medical School; Harvard Stem Cell Institute; Harvard University, Boston, MA
²Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA
³Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School; Harvard University, Boston, MA

3:45 PM

821

Bone Marrow Microenvironment Dictates the Progression of Clonal Hematopoiesis through Stromal-Macrophage Cell-Cell Interactions

Kehan Ren, PhD^1,2, Ermin Li, Ph.D.¹^*, Xu Han, PhD¹^*, Pan Wang, Ph.D.^1,3^*, Inci Aydemir, MD¹^*, Kara Tao⁴^*, Madina Sukhanova, PhD⁵^* and Peng Ji, MD, PhD^1,2

¹Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL
²Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
³Northwestern University, Chicago
⁴Northwestern University, Chicago, IL
⁵Department of Pathology, Northwestern University, Chicago, IL

4:00 PM

822

Spatial Transcriptomics Identifies Aberrant Communication between Dendritic Cells and Leukemia Stem Cells As a Therapeutically Targetable Axis in Juvenile Myelomonocytic Leukemia

Eleni Louka, MD MRCPCH PhD FRCPath^1,2,3^*, Kristian Gurashi, PhD¹^*, Sean Wen¹^*, Mariolina Salio¹^*, Christina Simoglou Karali, PhD, MRes, BSc¹^*, Roman Doll, MSc, BSc¹^*, Sally-Ann Clark, PhD, BSc¹^*, Anastasia Kosmidou, MD¹^*, Rosalin Cooper⁴^*, Daniel Royston, DPhil, FRCPath, MBBChir⁴, Deena Iskander, MD, PhD⁵^*, Nawshad Hayder, MSc, BSc¹^*, Renuka Teague⁶^*, Cristina Tormo Garcia¹^*, Maria Greco¹^*, Paola Vargas Gutierrez¹^*, Joshua Bull⁷^*, Anupama Rao²^*, Irene Roberts, MD^1,8 and Adam J Mead, PhD, MRCP, FRCPath^1,3

¹Medical Research Council (MRC) Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
²Department of Haematology, Great Ormond Street Hospital, London, United Kingdom
³Department of Haematology, Oxford University Hospitals, Oxford, United Kingdom
⁴Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom
⁵Center for Haematology, Imperial College London, London, United Kingdom
⁶Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom
⁷Mathematical Institute, University of Oxford, Oxford, United Kingdom
⁸Department of Paediatrics, University of Oxford, Oxford, United Kingdom

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^*signifies non-member of ASH

506.O2.6 506. Bone Marrow Microenvironment: The Bone Marrow Microenvironment in Disease