66th ASH Annual Meeting: 113. Sickle Cell Disease, Sickle Cell Trait, and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational: Attenuating Sickle Cell Disease Complications

Symposia: Sickle Cell Disease, Sickle Cell Trait, and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Sickle Cell Disease, Combination therapy, Translational Research, Sickle Cell Trait, Genetic Disorders, Hemoglobinopathies, Diseases, Treatment Considerations, Biological Processes, Multi-systemic interactions, Study Population, Pathogenesis, Animal model

Room 31 (San Diego Convention Center)

Moderators:

Oluwabukola Gbotosho, PhD, University of Cincinnati and Rafal Pawlinski, PhD, University of North Carolina

Disclosures:

Pawlinski: CSL: Consultancy, Research Funding; Glycan: Consultancy.

This session focuses on novel processes and mechanisms contributing to organ damage and pain in sickle cell disease.

4:30 PM

619

IFN-I Promotes T Cell-Independent Immunity and RBC Autoantibodies Via Modulation of B-1 Cell Subsets in Murine SCD

Shan Su, PhD¹, Weili Bao, MS¹^*, Yunfeng Liu, PhD¹, Patricia Shi, MD², Deepa Manwani, MD³, Irina Murakhovskaya, MD⁴, Sally Campbell Lee, MD⁵, Cheryl Lobo, PhD⁶, Avital Mendelson, PhD⁷, Xiuli An, MD, PhD⁸, Hui Zhong, PhD⁹, Woelsung Yi, PhD¹^* and Karina Yazdanbakhsh, PhD¹

¹Laboratory of Complement Biology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
²New York Blood Center, New York, NY
³Department of Pediatric Hematology-Oncology, Albert Einstein College of Medicine, Bronx, NY
⁴Division of Hematology, Department of Medicine, Montefiore Medical Center, Brooklyn, NY
⁵Department of Pathology, University of Illinois at Chicago, Chicago, IL
⁶Laboratory of Blood-Borne Parasites, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
⁷Laboratory of Stem Cell Biology and Engineering, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
⁸Laboratory of Membrane Biology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
⁹Laboratory of Immune Regulation, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY

4:45 PM

620

A Novel Mouse Model of Hemoglobin-SC Disease: Bridging the Knowledge Gap in Sickle Cell Disease

Tahereh Setayesh¹^*, Mengna Chi, PhD¹^*, Zachery Oestreicher, PhD²^*, Masahide Sakabe, PhD¹^*, Xin Mei, PhD¹^*, Katherine Vandenheuvel, MD³^*, Tim M. Townes, PhD⁴^*, Yueh-Chiang Hu, PhD⁵^* and Punam Malik, MD^3,6

¹Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH
²Center for Advanced Microscopy and Imaging, University of Miami, Oxford, Ohio, United States, Oxford, OH
³Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Univ. of AL at Birmingham, Birmingham, AL
⁵Transgenic Animal and Genome Editing Core, Cincinnati Children's Hospital, Cincinnati, OH
⁶Cincinnati Children's Hospital Medical Center, Cincinnati

5:00 PM

621

Rap-536, a Murine Luspatercept Analog Ameliorates Anemia and Vaso-Occlusion in Experimental Model of Sickle Cell Disease

Thiago Trovati Maciel, PhD¹^*, Haoua M Bazoum¹^*, Rachel Rignault-Bricard¹^*, Shikha Saini²^*, Isabelle Chevalme¹^*, Sara El Hoss¹^*, Robert Li, BS³^*, Slimane Allali^1,4^*, Rajasekhar N.V.S. Suragani, PhD⁵ and Olivier Hermine, MD, PhD^1,6

¹Institut Imagine - INSERM U1163, Paris, France
²Hematology Translational Medicine, Bristol Myers Squibb, Summit, NJ
³Cardiometabolic Division, Merck Research Laboratories, Boston, MA
⁴Sickle Cell Center, Pediatrics Department, Necker Hospital for Sick Children, APHP, Paris Cité University, Paris, FRA
⁵Hematology Translational Medicine, Bristol Myers Squibb, Cambridge, MA
⁶Hematology, Necker Hospital, Greater Paris University Hospitals (AP-HP), Paris, France

5:15 PM

622

Social Stress Impacts Multicellular Molecular Mechanisms in the Brain Affecting Nociception and Neuroimmune Activity in Sickle Cell Disease

Donovan A Argueta, PhD¹, Carolina Mireles, BS¹^*, Kendall O'Daniel, BS¹^*, Mya Arellano, BS¹^*, Stacy B Kiven, BS¹^*, Mingyu Du, BS²^*, Zhiqun Tan, PhD²^*, Kevin G Johnston, PhD²^*, Xiangmin Xu, PhD²^* and Kalpna Gupta, PhD¹

¹Hematology/Oncology Division, Department of Medicine, University of California, Irvine, Irvine, CA
²Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA

5:30 PM

623

Targeted Induction of Hepatocyte Nuclear Factor 4α Protects Acute Kidney Injury By Upregulating Hemopexin Biosynthesis during Acute Hemolytic Events in Sickle Mice

Paritosh Mondal, PhD¹^*, Shane C Lenhart, BS²^*, Danielle Crosby, BS²^*, Diane Lenhart, MS²^* and Samit Ghosh, PhD³

5:45 PM

624

Heme-Mediated Tau Phosphorylation Is Critical for Neuroaxonal Damage and Cognitive Impairment in Sickle Cell Disease

Nandinii Sekar, BS¹^*, Shane C Lenhart, BS²^*, Paritosh Mondal, PhD³^*, Lesley Foley, BS⁴^*, Samit Ghosh, PhD⁵, Enrico M Novelli, MD, MS⁶, T Kevin Hitchens, PhD MBA⁴^*, Xiaoming Hu, PhD⁷^* and Rimi Hazra¹^*

¹Pittsburgh Heart Lung and Blood Vascular Medicine Institute (VMI), Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
²Pittsburgh Heart Lung Blood Vascular Medicine Institute (VMI), Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
³Pittsburgh Heart Lung and Blood Vascular Medicine Institute (VMI), Division of Classical Hematology,Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁴Advanced Imaging Center, University of Pittsburgh, Pittsburgh, PA
⁵Pittsburgh Heart Lung Blood Vascular Medicine Institute (VMI), Division of Classical Hematology, Department of Medicine, Univ. of Pittsburgh-Of The Commonwealth System of Higher Edu, Pittsburgh, PA
⁶Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, and Division of Classical Hematology, University of Pittsburgh, Pittsburgh, PA
⁷Department of Neurology, University of Pittsburgh, Pittsburgh, PA

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

113.O2.6 113. Sickle Cell Disease, Sickle Cell Trait, and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational: Attenuating Sickle Cell Disease Complications – Lessons from Pre-clinical Models