-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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331.O1.6 331. Thrombotic Microangiopathies/Thrombocytopenias: Clinical and Epidemiological: A Brave New World: Novel Tools, Targets and Treatments in TTP

Symposia: Thrombotic Microangiopathies/Thrombocytopenias: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Bleeding and Clotting, Adult, Autoimmune disorders, Epidemiology, Clinical Research, Platelet disorders, Genetic Disorders, Genomics, Bioinformatics, Health outcomes research, Health disparities research, Pediatric, Diversity, Equity, and Inclusion (DEI), Diseases, Thrombocytopenias, Immune Disorders, Real-world evidence, Thrombotic disorders, Treatment Considerations, Biological therapies, Registries, Survivorship, Monoclonal Antibody Therapy, Biological Processes, Technology and Procedures, Study Population, Human, Imaging, Omics technologies
Saturday, December 7, 2024: 12:00 PM-1:30 PM
Room 30 (San Diego Convention Center)
Moderators:
Konstantine Halkidis, MD, PhD, University of Kansas Medical Center and Kylee L Martens, MD, Oregon Health & Science University
Disclosures:
No relevant conflicts of interest to declare.

This oral abstract session will cover new developments in thrombotic thrombocytopenic purpura (TTP) including novel treatment approaches for congenital and immune TTP and critical issues that emerge during TTP survivorship.
12:00 PM

Julia Weisinger1*, Jehane Fadlallah2*, Christelle Barbet3*, Francois Provot4*, Pascale Poullin5*, Antoine Neel6*, Manon Marie7*, Virginie Rieu8*, Tarik Kanouni9*, Olivier Moranne10*, Elie Azoulay11*, Bérangère Joly12*, Agnès Veyradier12* and Paul Coppo, MD1*

1Centre de Référence des Microangiopathies Thrombotiques, Service d'hématologie, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris and Sorbonne Université, Paris, France
2Service d'Immunopathologie Clinique, Saint Louis hospital, AP-HP, Paris, France
3Service de Néphrologie-Immunologie Clinique, CHRU de Tours, Tours, France
4Service de Néphrologie, Hôpital Albert Calmette, Lille, France
5Service d'Hémaphérèse, Hôpital de La Conception, CHU de Marseille, Marseille, France
6Service de Médecine Interne, CHU de Nantes, Nantes, France
7Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France
8Service de Médecine Interne, CHU de Clermont-Ferrand, Clermont-Ferrand, France
9Hopital Saint-Eloi, CHU de Montpellier, Montpellier, France
10CHU De Nimes, Nimes, France
11Médecine Intensive Réanimation, Hôpital Saint Louis, AP-HP, Paris, France
12Service d'Hématologie biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris Nord, Université Paris Cité, Paris, France

12:15 PM

Senthil Sukumar, MD, MSc1, Jenna Brown, B.A.2*, Marshall Mazepa, MD3, Spero Cataland, MD4 and Shruti Chaturvedi, MBBS5

1Section of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX
2Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
3Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN
4Division of Hematology, The Ohio State University, Columbus, OH
5Division of Hematology, Department of Medicine, Johns Hopkins University, BALTIMORE, MD

12:30 PM

Marie Scully, MD1, Claire Berger, MD, PhD2*, Nathalie Biebuyck3*, Santiago Bonanad Boix, MD4*, Claire Dossier5*, Wolf-Achim Hassenpflug, MD6*, Karim Kentouche7*, Beverly Schaefer, MD8, Silvia Maria Trisolini9*, Runhui Wu, MD10, Juan Xiao11*, Feng Xue, MD12*, Björn Mellgård13, Munjal Patel13*, Parth Patwari, MD, PhD13*, Linda T. Wang13*, Shan Xiao13* and Pinghai Zhang13*

1Department of Haematology, University College London Hospital, Haematology Theme-NIHR UCLH/UCL BRC, London, United Kingdom
2University Hospital, Department of Paediatric Oncology, University Jean Monnet Saint-Étienne, Mines Saint-Etienne, Inserm, Sainbiose U1059, 42023 Saint-Etienne, France
3Department of Pediatric Nephrology, Hôpital Universitaire Necker-Enfants Malades, Assistance-Publique Hôpitaux de Paris, Paris, France
4Hemostasis and Thrombosis Unit, Department of Hematology, Hospital Universitari i Politècnic La Fe, Valencia, Spain
5Department of Pediatric Nephrology, Robert-Debré Hospital, Assistance Publique – Hôpitaux de Paris (AP-HP) and University of Paris, Paris, France
6Department of Pediatric Hematology and Oncology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
7Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universitätsklinikum Jena, Jena, Germany
8University at Buffalo, Roswell Park Oishei Children's Cancer and Blood Disorders Program, Buffalo, NY
9Haematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
10Hematology Department, National Center for Children's Health, Beijing Children's Hospital, Beijing, China
11Department of Pediatrics, Peking Union Medical College Hospital, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing, China
12Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, China
13Takeda Development Center Americas, Inc., Cambridge, MA

12:45 PM

Adrienne Kaufman1, Marshall Mazepa, MD2 and Michael D Evans, MS3*

1Division of Hematology, Oncology and Transplantion, Unviersity of Minnesota, Scottsdale, AZ
2Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN
3University of Minnesota, Minneapolis, MN

1:00 PM

Amelia K Haj, MD, PhD1,2,3, Sean J. Jurgens, MD, MSc2,4,5*, Xin Wang, MBBS2,3*, Justine Ryu, MD2,6, Seung Hoan Choi, PhD2*, Patrick Ellinor, MD, PhD2,3,4* and Pavan K Bendapudi, MD2,3,7,8

1Department of Pathology, Massachusetts General Hospital, Cambridge, MA
2The Broad Institute of MIT and Harvard, Cambridge, MA
3Harvard Medical School, Boston, MA
4Massachusetts General Hospital, Boston, MA
5Department of Experimental Cardiology, University of Amsterdam, Amsterdam, Netherlands
6Section of Hematology, Yale University School of Medicine, New Haven, CT
7Division of Thrombosis and Hemostasis, Beth Israel Deaconess Medical Center, Boston, MA
8Division of Hematology, Department of Medicine, Massachusetts General Hospital, Cambridge, MA

1:15 PM

Shruti Chaturvedi, MBBS1, Jenna Brown, B.A.2*, Jia Yu3, Gloria F. Gerber, MD4 and Doris Lin5*

1Division of Hematology, Department of Medicine, Johns Hopkins University, BALTIMORE, MD
2Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
3University of Pittsburgh School of Medicine, Pittsburgh, PA
4Division of Hematology, Johns Hopkins University, Baltimore, MD
5Johns Hopkins University, Baltimore, MD

*signifies non-member of ASH