66th ASH Annual Meeting: 711. Cell Collection and Manufacturing of HSPCs, CAR-T Cells, and Other Cellular Therapy Products: Innovations in Mobilization, Collection, and Manufacturing for Cellular Therapies

Symposia: Cell Collection and Manufacturing of HSPCs, CAR-T Cells, and Other Cellular Therapy Products Oral and Poster Abstracts
Oral

Maternal Health, Research, Clinical trials, Sickle Cell Disease, Adult, Autoimmune disorders, Fundamental Science, Translational Research, Lymphomas, Autoimmune hemolytic anemia, Clinical Practice (Health Services and Quality), Clinical Research, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Plasma Cell Disorders, B Cell lymphoma, Hemoglobinopathies, Hematopoiesis, Diseases, Immune Disorders, Cell expansion, Gene Therapy, Clinical procedures, Biological therapies, Treatment Considerations, Immunotherapy, Young adult , Lymphoid Malignancies, Emerging technologies, Biological Processes, Technology and Procedures, Gene editing, Study Population, Human, Animal model, Transplantation (Allogeneic and Autologous)

Room 25 (San Diego Convention Center)

Moderators:

Yvette C Tanhehco, MD, PhD, Columbia University and Patrick J. Hanley, PhD, Children's National Medical Center

Disclosures:

No relevant conflicts of interest to declare.

The theme of this oral session is mobilization and manufacturing of gene therapy, T cell adoptive immunotherapy, and CAR-T cell products. The purpose of this session is to educate attendees on novel methods of mobilization and manufacturing of cellular therapy products.

12:00 PM

145

Motixafortide (CXCR4 Inhibition) Alone and in Combination with Natalizumab (VLA-4 Inhibition) As a Novel Regimen to Mobilize Hematopoietic Stem Cells for Gene Therapies in Sickle Cell Disease: A First-in-Human, Proof-of-Principle Safety and Feasibility Study

Zachary D. Crees, MD¹, Michael P. Rettig, PhD¹, Reyka G. Jayasinghe, PhD²^*, Stephanie Christ, MS³^*, Feng Gao⁴^*, Hailey Sappington³^*, Sana Saif Ur Rehman, MD⁵, Suzanne R. Thibodeaux, MD, PhD⁶^*, Ella Sorani, PhD⁷^*, Allison A. King, MD, PhD, MPH⁸ and John F. DiPersio, MD, PhD⁹

¹Division of Oncology, Washington University School of Medicine, Saint Louis, MO
²Department of Internal Medicine, Division of Oncology, School of Medicine, Washington University, Saint Louis, MO
³Washington University, School of Medicine, St. Louis, MO
⁴Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, Saint Louis, MO
⁵Washington University, Saint Louis, MO
⁶Washington University School of Medicine, Saint Louis, MO
⁷BiolineRx, Modi'in, Israel
⁸School of Medicine, Washington University, Clayton, MO
⁹Washington University School of Medicine, St. Louis, MO

12:15 PM

146

SAGES1: Clinical Translation of CRISPR Genome Editing Strategy to Induce Fetal Hemoglobin to Treat Sickle Cell Disease

Rachel M Levine, PhD¹^*, Erin A Dempsey, BA¹^*, Nikitha Nimmagadda, MS¹^*, Yoonjeong Jang, DVM, PhD¹, Kalin Mayberry²^*, Jingjing Zhang³^*, David Cullins¹^*, Catherine Willis⁴^*, Alicia Powers⁴^*, Young-In Kim-Hoehammer⁵^*, Jie Lin⁵^*, Fei Zhang⁵^*, Neha Das Gupta, PhD⁴^*, Will Lewis⁵^*, Varun Katta²^*, Yichao Li, PhD¹^*, Timothy Lockey, PhD⁶^*, Yong Cheng, PhD¹, Patti Lehigh⁵^*, Frank Fazio⁴^*, Alexis Kristine Leonard, MD¹, Akshay Sharma, MBBS⁷, Sheng Zhou, PhD⁸, Shengdar Q Tsai, PhD², Mitchell J Weiss, MD, PhD² and Jonathan S Yen, PhD²

¹Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
²Department of Hematology, St. Jude Childrens Research Hospital, Memphis, TN
³St. Jude Children Res. Hospital, Memphis, TN
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵St. Jude Children's Research Hospital, Memphis
⁶Department of Therapeutics Production and Quality, St. Jude Children's Research Hospital, Memphis, TN
⁷Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN
⁸Experimental Cellular Therapeutics Laboratory, St. Jude Children's Research Hospital, Memphis, TN

12:30 PM

147

Treg Selection from G-CSF Stimulated Donors Improves Outcomes of Immune-Suppression Free HLA-Haploidentical Hematopoietic Cell Transplantation with T Cell Adoptive Immunotherapy

Antonio Pierini, MD, PhD¹^*, Loredana Ruggeri, MD, PhD²^*, Valerio Viglione, MD¹^*, Simonetta Saldi, MD³^*, Rebecca Sembenico, MD¹^*, Caridi Matteo, MD¹^*, Francesco Zorutti, MD¹^*, Anna Castaldo, MD¹^*, Alessandra Cipiciani, MD⁴^*, Tiziana Zei⁵^*, Roberta iacucci Ostini⁵^*, Antonella Mancusi, PhD¹^*, Enrico Karim Jardini²^*, Eni Hoxha¹^*, Adelmo Terenzi⁵^*, Valeria Cardinali, MD, PhD²^*, Roberta La Starza, MD⁶^*, Cristina Mecucci, MD, PhD⁶, Andrea Velardi, MD, PhD¹^*, Massimo Fabrizio Martelli, MD, PhD¹^*, Maria Paola Martelli, MD, PhD^1,2^*, Cynthia Aristei, MD³^* and Alessandra Carotti, MD²^*

¹Department of Medicine and Surgery, Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
²Department of Medicine and Surgery, Division of Hematology and Clinical Immunology, S. Maria della Misericordia Hospital, Perugia, Italy
³Department of Medicine and Surgery, Radiation Oncology Section, University of Perugia, Perugia, Italy
⁴Università politecnica delle Marche, Ancona, Italy
⁵S. Maria della Misericordia Hospital, Perugia, Italy
⁶Hematology, CREO, Centro Ricerche Emato-Oncologiche, University of Perugia, Perugia, Italy

12:45 PM

148

A Synthetic Receptor Enables Breakthrough Scale Manufacturing of iPSC-Derived CD19-CAR Cell Therapies for Hematologic and Autoimmune Diseases

Dillon Jarrell, PhD¹^*, David Vereide, PhD¹^*, Cassidy Arnold, BS¹^*, Max Murphey¹^*, Ashley Yingst, MS, MBA¹^*, Ryan Koning, BS¹^*, Nikole Perdue²^*, Artem Romanov¹^*, Celeste Busch¹^*, Igor Slukvin, MD³, Ryan Crisman, PhD¹^*, Ryan P. Larson, PhD²^*, Andrew M. Scharenberg, MD²^*, Branden Salinas¹^* and Samantha Ohara, PhD¹^*

¹Umoja Biopharma, Louisville, CO
²Umoja Biopharma, Seattle, WA
³Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI

1:00 PM

149

Prolonged Persistence and Functional Activity of Anti-BCMA CAR-T Durcabtagene Autoleucel (PHE885) Manufactured Using the T-Charge™ Platform

Shuntaro Ikegawa, MD, PhD¹^*, Adam S. Sperling, MD, PhD^1,2, Sarah Nikiforow, MD, PhD^1,2, Andrew Ghazi, PhD³^*, Anthony Christidis, PhD³^*, David Quinn, BA⁴^*, Dexiu Bu, MD, PhD⁴^*, Jennifer Mataraza, PhD⁴^*, David Pearson, PhD⁵^*, Allison Charles, BS⁴^*, Marc Credi, MA⁴^*, Nina Orwitz, PhD⁶^*, Madisyn Strange¹^*, Rakuyo Tamada, BA¹^*, Kevin M. Panaro, BS¹^*, Casey Gervais, MS¹^*, Michela Ansuinelli, MD^1,7^*, Yohei Arihara, MD, PhD⁸^*, Rao Prabhala, PhD^1,2^*, Carol G. Reynolds, PhD¹^*, Robert Gentleman, PhD³^*, Serena De Vita, MD, PhD⁴^*, Nikhil C. Munshi, MD^2,9 and Jerome Ritz, MD^1,2

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Harvard Medical School, Boston, MA
³Center for Computational Biomedicine, Harvard Medical School, Boston
⁴Novartis Biomedical Research, Cambridge, MA
⁵Novartis Biomedical Research, Basel, Switzerland
⁶Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁷Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
⁸The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan
⁹Dana-Farber Cancer Institute, The Jerome Lipper Multiple Myeloma Center, Boston, MA

1:15 PM

150

Efficient Generation of CAR-T By the First Coacervate-Based Gene Delivery System

Peipei Zhu¹^*, Xiaofei Gao, PhD²^*, Yang Yuan, Ph.D³^*, Manman Lu³^*, Qing Zhang³^*, Menghao Ding³^*, Lihong Jiang³^*, Yaohuang Huang¹^* and Hsiang-Ying Lee, PhD⁴

¹Westlake University, Hangzhou, China
²School of Life Sciences, Westlake University, Hangzhou, China
³Westlake Therapeutics, Hangzhou, China
⁴School of Life Sciences, Peking University, Beijing, China

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^*signifies non-member of ASH

711.O1.6 711. Cell Collection and Manufacturing of HSPCs, CAR-T Cells, and Other Cellular Therapy Products: Innovations in Mobilization, Collection, and Manufacturing for Cellular Therapies