Amelia K Haj, MD, PhD^1,2,3, David Paul^4*, Sharjeel A Chaudhry, MD^2,3,5,6,7*, Harish Eswaran, MD⁸, Sophia Dhrolia^4*, Sean J. Jurgens, MD, MSc^2,9*, Xin Wang, MBBS^2,3*, Lu-Chen Weng, PhD^2*, Justine Ryu, MD^2,10, Seung Hoan Choi, PhD^2*, Satoshi Koyama, MD^2*, Simone Sanna-Cherchi, MD^11*, Wolfgang Bergmeier, PhD¹², Nigel Mackman, PhD⁴, Patrick Ellinor, MD, PhD^2,3,9*, Steven Grover, PhD¹² and Pavan K Bendapudi, MD^2,3,13,14

¹Department of Pathology, Massachusetts General Hospital, Cambridge, MA
²The Broad Institute of MIT and Harvard, Cambridge, MA
³Harvard Medical School, Boston, MA
⁴University of North Carolina At Chapel Hill, Chapel Hill, NC
⁵Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA
⁶Division of Cardiology, The Johns Hopkins University, School of Medicine, Baltimore, MD
⁷Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, LAUREL, MD
⁸Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁹Massachusetts General Hospital, Boston, MA
¹⁰Section of Hematology, Yale University School of Medicine, New Haven, CT
¹¹Division of Nephrology, Columbia University Irving Medical School, New York, NY
¹²University of North Carolina at Chapel Hill, Chapel Hill, NC
¹³Division of Thrombosis and Hemostasis, Beth Israel Deaconess Medical Center, Boston, MA
¹⁴Division of Hematology, Department of Medicine, Massachusetts General Hospital, Cambridge, MA

Rodrigo P. Silva-Aguiar^1*, Ernest R. Chan, PhD^2*, Alessandro S. Pinheiro^3*, Alona Merkulova, MS^1*, Karina I. Carvalho, PhD^4*, Jeffrey R. Schelling, MD^5,6*, Meghan Kapp, MD^6,7*, Ana Acacia S. Pinheiro, PhD^8*, Celso Caruso-Neves, PhD^9* and Alvin H. Schmaier, MD^6,10

¹CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH
²Institute for Computational Biology, School of Medicine, Case Western Reserve University, Cleveland, OH
³Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH
⁴Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH
⁵Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH
⁶University Hospitals Cleveland Medical Center, Cleveland, OH
⁷Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH
⁸Federal University of Rio de Janeiro, Rio De Janeiro, BRA
⁹Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
¹⁰Department of Medicine, Case Western Reserve University, Cleveland, OH

Joshua Wischmeyer^1*, Christine Baird, MS^1*, Julian Grandvallet Contreras, BS^2*, Alexander Tran, MS^1*, Tsu Phang, PhD^3* and Marilyn Manco-Johnson, MD¹

¹Hemophilia & Thrombosis Center, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO
²Department of Pediatrics, Section of Hematology/Oncology/BMT, University of Colorado Anschutz Medical Campus, Aurora, CO
³Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO

Alessandro S. Pinheiro^1*, Douglas E Teixeira, MS^2*, Rodrigo P. Silva-Aguiar^3*, Alona Merkulova, MS^3*, Yelenna Skomorovska-Prokvolit, PhD^4*, Young Jun Shim^5*, Keith R. McCrae, MD^6,7, David Midem, MD^3*, Sidney Ogolla, PhD^8*, Ana Acacia S. Pinheiro, PhD^9*, James Kazura, MD^4* and Alvin H. Schmaier, MD^10,11

¹Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH
²Case Western Reserve University, Cleveland, OH
³CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH
⁴Case Western Reserve University, Cleveland
⁵Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
⁶Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH
⁷Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁸Kenya Medical Research Institute, Kissumu, Kenya
⁹Federal University of Rio de Janeiro, Rio De Janeiro, BRA
¹⁰Department of Medicine, Case Western Reserve University, Cleveland, OH
¹¹University Hospitals Cleveland Medical Center, Cleveland, OH

Nilesh Pandey, PhD¹, Harpreet Kaur, PhD^2*, Lakshmi Chandaluri^3*, Sumit Kumar Anand^3*, Tarek Magdy Mohamed, PhD^3*, Karen Stokes, PhD^4*, Kavitha Beedupalli, MBBS^5*, A Wayne Orr^3*, Oren Rom^3* and Nirav Dhanesha, PhD⁶

¹Department of Pathology and Translational Pathobiology, Louisiana State University, Shreveport, LA
²Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA
³Department of Pathology and Translational Pathobiology, Louisiana State University, Shreveport
⁴Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA
⁵Department of Hematology and Oncology and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA
⁶Department of Pathology, LSUHS-Shreveport, Shreveport, LA

Nikhil Ranjan, PhD¹, Michael Cole, MD, DPhil¹, Gloria F. Gerber, MD², Shruti Chaturvedi, MBBS³, Mark A. Crowther, MD, MSc, FRSC, FRCPC, LLM⁴, Evan M. Braunstein, MD, PhD⁵, Daniel Flores-Guerrero^6*, Alexis Reed, RN^1*, Michelle Petri, MD, MPH^7*, Keith R. McCrae, MD⁸ and Robert A. Brodsky, MD¹

¹Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
²Division of Hematology, Johns Hopkins University, Baltimore, MD
³Division of Hematology, Department of Medicine, Johns Hopkins Hospital, BALTIMORE, MD
⁴Department of Medicine, McMaster University, Hamilton, ON, Canada
⁵Incyte Corporation, Wilmington, DE
⁶Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
⁷Johns Hopkins, Johns Hopkins Hospital, MD
⁸Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH