Wei Wang^1*, Yudi Zhang^1*, Wenli Yang^2*, Yueyuan Han^1*, Zheng Ge, MD, PhD³ and Hongyan Tong, PhD^4*

¹Department of Hematology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
²Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
³Zhongda Hospital Southeast University, Nanjing, China
⁴The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

Marco Gabriele Raddi, MD^1*, Angela Consagra^1*, Luca Rigodanza, MD^1*, Cristina Amato, SN^1*, Alessandro Sanna, MD^2*, Giorgio Mattiuz, PhD^3*, Sven De Pourcq^3*, Elena Tofacchi^3*, Maria Diez-Campelo, MD, PhD^4*, Juan Carlos Caballero Berrocal, MD^5*, Sophie Park, MD, PhD⁶, Mathieu Meunier, MD, PhD^6*, Celia Orlando^6*, Michaela Fontenay, MD, PhD^7*, Olivier Kosmider, PharmD, PhD^7*, Nicolas Chapuis, MD, PhD^7*, Uwe Platzbecker, MD⁸, Katharina Zoldan, MD^8*, Anne Sophie Kubasch, MD^8* and Valeria Santini, MD¹

¹MDS Unit, DMSC, AOU Careggi, University of Florence, Firenze, Italy
²Hematology, AOU Careggi, Florence, Italy
³MDS Unit, DMSC, University of Florence, Firenze, Italy
⁴Hospital Universitario de Salamanca, Salamanca, Spain
⁵Hospital Clínico de Valladolid, Valladolid, Spain
⁶Clinique Universitaire d’hématologie, Université de Grenoble-Alpes, CHU de Grenoble, Grenoble, France
⁷Laboratory of Hematology, Université Paris Cité and Assistance Publique-Hôpitaux de Paris. Centre, Hôpital Cochin, Paris, France
⁸Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Medical Center Leipzig, Leipzig, Germany

Esther Natalie Oliva, MD¹, Uwe Platzbecker, MD², Matteo Giovanni Della Porta, MD^3*, Guillermo Garcia-Manero, MD⁴, Valeria Santini, MD⁵, Pierre Fenaux, MD, PhD⁶, Jake Shortt⁷, Rami S. Komrokji, MD⁸, Christopher Pelligra^9*, Shien Guo, PhD^10*, Jennifer Lord-Bessen^11*, Hong Xiao^11*, Aylin Yucel^11*, Dimana Miteva^12*, Shelonitda Rose^13*, Sandra Kreitz^12*, Mikkael A. Sekeres, MD¹⁴ and Amer M. Zeidan, MBBS, MHS¹⁵

¹Hematology Division, Myelodysplastic Syndromes Section, U.O.C. Hematology Unit, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio di Calabria, Italy
²Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
³Cancer Center IRCCS Humanitas Research Hospital, Milan, Italy
⁴University of Texas MD Anderson Cancer Center, Houston, TX
⁵MDS Unit, DMSC, AOU Careggi, University of Florence, Firenze, Italy
⁶Department of Hematology, Université de Paris, Saint-Louis Hospital, Paris, France
⁷Monash University and Monash Health, Melbourne, VIC, Australia
⁸Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁹Clinical Outcomes Analytics, Evidera, Medellín, Colombia
¹⁰Clinical Outcomes Analytics, Evidera, Waltham, MA
¹¹Bristol Myers Squibb, Lawrence, NJ
¹²Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
¹³Bristol Myers Squibb, Princeton, NJ
¹⁴Sylvester Cancer Center, University of Miami, Miami, FL
¹⁵Section of Hematology, Department of Internal Medicine, Yale University School of Medicine - Yale Cancer Center, New Haven, CT

David Fandrei, MSc^1,2*, Tony Huynh, MD^2*, Marie Sebert, MD, PhD^2*, Lorea Aguinaga, MD^2*, Valeria Bisio, PhD^1*, Marion Espéli, PhD^1*, Karl Balabanian, PhD^1*, Hélène Moins-Teisserenc, MD, PhD^1*, Antoine Toubert, MD, PhD^1*, Nicolas Dulphy, PhD^1*, Pierre Fenaux, MD, PhD^2,3, Lionel Ades, MD, PhD^2,3 and Lin-Pierre Zhao, MD^1,2*

¹Institut de Recherche Saint-Louis, INSERM UMR 1160, Paris, France
²Hématologie Seniors, Université Paris Cité, APHP, Hôpital Saint-Louis, Paris, France
³Institut de Recherche Saint-Louis, INSERM UMR 944, Paris, France

Harinder Gill, MD, MBBS, FRCP, FRCPath¹, Hsin An Hou, MD^2*, Paul Lee^1*, Rita Yim, PhD^1*, Xavier Cheng-Hong Tsai², Melissa Ooi, PhD, FRCPath, MBBChir, MRCP^3*, Tsz-Shing Hui^4*, Radha Raghupathy, MD¹, Lynn Chin^1*, Lester Au^1*, Vivian Li^1*, Garret Man Kit Leung^1*, Edmond Ma^5*, Asif Javed, PhD^6*, Ho-Wan Ip, MBBS, FRCPA^7*, Wee-Joo Chng, MBBS, PhD, FRCPath, FRCP⁸, Wen-Chien Chou, MD, PhD⁹, Hwei-Fang Tien, MD, PhD⁹ and Yok-Lam Kwong, MD^10*

¹Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
²Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
³National University Cancer Institute, Singapore, Singapore
⁴Clinical Trial Centre, The University of Hong Kong, Hong Kong, Hong Kong
⁵Department of Pathology, The Hong Kong Sanatorium and Hospital, Hong Kong, Hong Kong
⁶School of Biomedical Sciences, The University of Hong Kong, Hong, Hong Kong
⁷Department of Pathology, The University of Hong Kong, Hong Kong, Hong Kong
⁸Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore
⁹Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
¹⁰Department of Medicine, The University of Hong Kong, Hong Kong, China

Alvin Shi, Ph.D^1*, Abdullah Mahmood Ali, PhD², Gordon Cann, Ph.D^1*, Rita Shaknovich, MD, PhD¹, Oliver Venn, Ph.D^1*, Azra Raza, MD³ and Qinwen Liu, Ph.D^1*

¹GRAIL, LLC, Menlo Park, CA
²Edward P. Evans Myelodysplastic Syndromes Center, Columbia University Irving Medical Center, New York, NY
³Edward P. Evans Myelodysplastic Syndrome Center and Department of Medicine, Columbia University Medical Center, New York, NY

Jing Wang, MD^1*, Siqi Li, MS^2*, Hao Jiang^3*, Ying-Jun Chang^4*, Xiao-su Zhao^5*, Jinsong JIA, MD, PhD^3*, Xiaolu Zhu, MD^5*, Lizhong Gong^1*, Xiaohong Liu^6*, Wen-Jing Yu^7* and Xiaojun Huang^8*

¹Peking University People’s Hospital,Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China
²Peking University People’s Hospital, Beijing, AL, CHN
³Peking University People’s Hospital, Beijing, CHN
⁴Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
⁵Peking University People’s Hospital, Beijing, China
⁶Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
⁷Peking University People's Hospital, Beijing, CHN
⁸Peking University People's Hospital，Institute of Hematology, Beijing, Wisconsin, CHN

Guillermo Montalban-Bravo, MD¹, David Swanson, PhD^2*, Rashmi Kanagal-Shamanna, MD³, Juan Jose Rodriguez-Sevilla, MD^4*, Danielle E. Hammond, MD¹, Kelly S. Chien, MD¹, Koji Sasaki, MD⁴, Elias Jabbour⁵, Courtney D. DiNardo, MD, MSc¹, Koichi Takahashi, MD, PhD¹, Nicholas J. Short, MD¹, Ghayas C. Issa⁶, Naveen Pemmaraju, MD¹, Tapan M. Kadia, MD¹, Farhad Ravandi, MD, MBBS¹, Naval Daver, MD¹, Gautam Borthakur, MD¹, Sanam Loghavi, MD⁷, Sherry Pierce, BSN, BA^1*, Carlos E. Bueso-Ramos⁷, Hagop M. Kantarjian, MD⁴ and Guillermo Garcia-Manero, MD⁶

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
³Hematopathology, MD Anderson Cancer Center, Houston, TX
⁴Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵University of Texas M.D. Anderson Cancer Ctr., Houston, TX
⁶The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Elizabeth A. Griffiths, MD¹, Pragya Srivastava, PhD^2*, Eduardo Cortes Gomez^3*, Junko Matsuzaki, PhD^4,5*, Kunle Odunsi, MD, PhD^4,5*, Laura W Dillon, PhD^6*, Devdeep Mukherjee, PhD^6*, Christopher S. Hourigan, DM, DPhil⁶, Jacqueline Peng^7*, Shovik Bandyopadhyay⁸, Kai Tan, PhD⁹, Krista Belko, PhD^10*, Amanda C. Przespolewski, DO², Eunice S. Wang, MD², Prashant Singh, PhD^11*, Jianmin Wang, PhD^3* and Michael J. Nemeth, PhD^12*

¹Leukemia Service, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
²Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
³Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁴Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁵Department of Obstetrics and Gynecology, University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL
⁶Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD
⁷Cellular and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁸Cellular and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, EUREKA, MO
⁹Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
¹⁰Clinical Research Services, Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹¹Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹²Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY

Valeria Santini, MD^1*, Amer M. Zeidan, MBBS, MHS², Pierre Fenaux, MD, PhD³, Yazan F. Madanat, MD⁴, Tymara Berry, MD^5*, Faye M. Feller, MD⁵, Libo Sun, PhD^5*, Qi Xia, PhD^5*, Ying Wan, MD, PhD^5*, Fei Huang, PhD⁵, Michael R. Savona, MD^6* and Uwe Platzbecker, MD⁷

¹MDS UNIT, DMSC, Azienda Ospedaliero-Universitaria Careggi & University of Florence, Florence, Italy
²Yale School of Medicine and Yale Cancer Center, Yale University, New Haven, CT
³Hôpital Saint-Louis, Université Paris 7, Paris, France
⁴Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
⁵Geron Corporation, Parsippany, NJ
⁶Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
⁷Cellular Therapy and Hemostaseology, Leipzig University Hospital, Leipzig, Germany

Thibault Comont^1*, Olivier Kosmider, MD, PhD^2*, Mael Heiblig^3*, Benjamin Terrier, MD, PhD^4*, Didier Bouscary^5*, Guillaume Le Guenno^6*, Roderau Outh^7*, Maxime Samson^8*, Achille Aouba^9*, Estibaliz Lazarro^10*, Odile Rauzy^1*, Lucie Rigolot^11*, Pierre Peterlin^12*, Alexandre Maria^13*, Edouard Flammarion^14*, Alice Garnier, MD^15*, Benoit De Renzis^16*, Shanti Natarajan^17*, Benjamin Carpentier^18*, Marielle Roux-Sauvat^19*, Jose Torregrosa^20*, Fabienne Closs-Prophette^21*, Julien Rossignol^22*, Nicolas Schleinitz^23*, Celine Dieval^24*, Jonahan Broner^25*, Marie-Pierre Gourin, MD^26*, Gaetan Sauvetre^27*, Benoit Faucher^28*, Julien Vinit^29*, Sylvie Grosleron^30*, Alexis Mathian^31*, Louis Terriou, MD PhD^32*, Cyrille Coustal^33*, Philippe Guilpain^34*, Paola Marianetti-Guingel^35*, Holy Bezanahary^36*, Norbert Vey, MD³⁷, Bilal Mohty^38*, Thomas Moulinet^39*, Vincent Grobost^6*, Sophie Dimicoli^40*, Benoit Suzon^41*, Antoinette Perlat^42*, Pierre Hirsh^43*, Lise Larcher^44*, Lin Pierre Zhao, MD^45*, Sophie Georgin-Lavialle^46*, Arsene Mekinian^47*, Pierre Fenaux, MD, PhD⁴⁸, Vincent Jachiet^47*, French VEXAS study group^49*, Minhemon French Network of immune disorders associated with hemopathies^49* and GFM Groupe Francophone des Myélodysplasies^49*

¹Toulouse University Hospital, Toulouse, France
²Cochin Hospital, Paris, FRA
³Hematology Department, Centre Hospitalier Lyon Sud, Pierre-Bénite, France
⁴Department of Internal Medicine, National Referral Center for Rare and Systemic Autoimmune Diseases, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
⁵APHP Cochin Hospital, Paris, FRA
⁶Clermont-Ferrand University Hospital, Clermont-Ferrand, FRA
⁷Perpignan Hospital, Perpigan, France
⁸CHU Dijon, Dijon, FRA
⁹CHU CAEN, CAEN, FRA
¹⁰Bordeaux University Hospital, Bordeaux, France
¹¹CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
¹²Hematology Department, Hôpital Hotel Dieu, NANTES CEDEX 1, France
¹³Montpellier University Hospital, Montpellier, FRA
¹⁴AP HP, Paris, FRA
¹⁵Hematology clinic, Nantes University Hospital, Nantes, France
¹⁶Clermont Ferrand Hospital, Clermont-Ferrand, France
¹⁷C.H.U. Strasbourg Hopital Civil, Strasbourg, FRA
¹⁸Saint Vincent de Paul Hospital, Lille, FRA
¹⁹PIERRE OUDOT BOURGOIN JALLIEU HOSPITAL, BOURGOIN JALLIEU, France
²⁰Poitiers University Hospital, Poitiers, FRA
²¹Le Mans Hospital, Le Mans, France
²²Hématologie, NECKER ENFANTS MALADES Hospital APHP, Paris, FRA
²³Marseille University Hospital AP-HM, Marseille, FRA
²⁴Rochefort Hospital, ROCHEFORT CEDEX, FRA
²⁵Nîmes University Hospital, Nîmes, FRA
²⁶CHU Limoges, Limoges, FRA
²⁷Rouen University Hospital, Rouen, FRA
²⁸Marseille University Hospital, Marseille, France
²⁹CHWM, Chalon sur Saône, France
³⁰Agen Hospital, Agen, France
³¹Pitié-Salpêtrière Hospital, AP-HP, Paris, France
³²Lille University Hospital, Lille, FRA
³³Montpellier Univeristy Hospital, Montpellier, France
³⁴Montpellier University Hospital, Montpellier, France
³⁵Reims University Hospital, Reims, France
³⁶Limoges University hospital, Limoges, FRA
³⁷Department of Hematology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM, Marseille, France
³⁸Geneva University Hospital, Geneve, CHE
³⁹Inserm 1098, Nancy, FRA
⁴⁰Bordeaux University Hospital, Pessac, FRA
⁴¹Fort de France University Hospital, Fort de France, France
⁴²CHU Rennes, Rennes, FRA
⁴³Saint antoine hospital APHP, Paris, France
⁴⁴Hopital Saint-Louis and University De Paris, Paris, FRA
⁴⁵Saint Louis hospital APHP, Paris, France
⁴⁶INSERM and AP-HP, Paris, FRA
⁴⁷Saint Antoine Hospital AP-HP, Paris, France
⁴⁸Hôpital Saint-Louis, Hematology Department, AP-HP, Paris, France
⁴⁹APHP, Paris, France

Uwe Platzbecker, MD¹, Rami S. Komrokji, MD², Amer M. Zeidan, MBBS, MHS³, Pierre Fenaux, MD, PhD⁴, Mikkael A. Sekeres, MD⁵, Michael R. Savona, MD^6*, Yazan F. Madanat, MD⁷, Anna Jonášová, MD, PhD^8*, Thomas Illmer, MD^9*, Laurie Sherman, BSN¹⁰, Tymara Berry, MD^10*, Jennifer Riggs, MPH^10*, Qi Xia, PhD^10*, Shyamala Navada, MD^10*, Ying Wan, MD, PhD^10*, Fei Huang, PhD¹⁰, Faye M. Feller, MD¹⁰ and Valeria Santini, MD^11*

¹Cellular Therapy and Hemostaseology, Leipzig University Hospital, Leipzig, Germany
²Moffitt Cancer Center, Tampa, FL
³Yale School of Medicine and Yale Cancer Center, Yale University, New Haven, CT
⁴Hôpital Saint-Louis, Université Paris 7, Paris, France
⁵Sylvester Cancer Center, University of Miami, Miami, FL
⁶Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
⁷Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
⁸General Hospital, Prague, Czech Republic
⁹Hematology Private Practice, Dresden, Germany
¹⁰Geron Corporation, Parsippany, NJ
¹¹MDS UNIT, DMSC, Azienda Ospedaliero-Universitaria Careggi & University of Florence, Florence, Italy

Guillermo Garcia-Manero, MD¹, Roger M. Lyons, MD², Savita Nandal, MD³, Mushtaq Ashraf, MD^3*, Ramarao Thellaboina^3*, Julie Ruckel-Kumar^3*, Hans D. Menssen, MD, PhD⁴ and Amer M. Zeidan, MBBS, MHS⁵

¹University of Texas MD Anderson Cancer Center, Houston, TX
²Texas Oncology/US Oncology Research, San Antonio, TX
³Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁴Novartis Pharma AG, Basel, Switzerland
⁵Section of Hematology, Department of Internal Medicine, Yale University School of Medicine - Yale Cancer Center, New Haven, CT

Tariq Kewan, MBBChir¹, Jan Philipp Bewersdorf, MD², Ondrej Blaha, PhD^3*, Maximilian Stahl, MD⁴, Najla H Al Ali, MS^5*, Amy E. DeZern, MD, MHS⁶, Mikkael A. Sekeres, MD⁷, Hetty E. Carraway, MD, MBA⁸, Pinkal Desai, MD, MPH⁹, Elizabeth A. Griffiths, MD¹⁰, Eytan M. Stein¹¹, Andrew M. Brunner, MD¹², Maria L Amaya, MD, PhD¹³, Joshua F. Zeidner, MD¹⁴, Michael R. Savona, MD¹⁵, Jessica M. Stempel, MD¹⁶, Namrata Sonia Chandhok, MD¹⁷, Constantine Logothetis, MD¹⁸, Hunter Cochran, MD¹⁹, Abhay Singh, MD, MPH²⁰, Gail J. Roboz, MD²¹, Benjamin Rolles, MD²², Eunice S. Wang, MD²³, Amyah C. Harris^24*, Rory M. Shallis, MD²⁵, Zhuoer Xie, MD, MS⁵, Eric Padron, MD⁵, David A Sallman, MD²⁶, Jaroslaw P. Maciejewski, M.D., Ph.D., FACP²⁷, Matteo Giovanni Della Porta, MD^28*, Rami S. Komrokji, MD⁵ and Amer M. Zeidan, MBBS, MHS¹⁶

¹Section of Hematology, Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, New Haven, CT
²Memorial Sloan Kettering Cancer Center, New York, NY
³Yale Cancer Center, Yale University, New Haven
⁴Dana Farber Institute, Boston, MA
⁵Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁶Sidney Kimmel CCC, Johns Hopkins University, Baltimore, MD
⁷Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
⁸Department of Hematology and Medical Oncology, Taussig Cancer institute, Leukemia Program, Cleveland Clinic, Cleveland, OH
⁹Weill Cornell Medicine, The New York Presbyterian Hospital, New York, NY
¹⁰Leukemia Service, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹¹Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Division of Hematology/Oncology, Dana-Farber Cancer Institute, Boston, MA
¹³Division of Hematology, University of Colorado, Aurora, CO
¹⁴University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC
¹⁵Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
¹⁶Section of Hematology, Department of Internal Medicine, Yale University School of Medicine - Yale Cancer Center, New Haven, CT
¹⁷University of Miami, Miami, FL
¹⁸Washington University, Saint Louis, MO
¹⁹Washington University in St. Louis, Saint Louis, MO
²⁰Taussig cancer center, Cleveland Clinic, Cleveland Clinic, Cleveland, OH
²¹Weill Cornell Medicine and The New York Presbyterian Hospital, New York, NY
²²Division of Hematology, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA
²³Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
²⁴Dana Farber Cancer Institute, Boston, MA
²⁵Section of Hematology, Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, Killingworth, CT
²⁶H. Lee Moffitt Cancer Center, Tampa, FL
²⁷Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²⁸Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy

Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^1,2,3, Anmol Baranwal, MBBS^4*, Syed Shah, MBBS^4*, Monika Kutyna, PhD^1,2*, Christopher N. Hahn, PhD^5,6*, Maymona Abdelmajid^4*, Danielle Rud^4*, Rakchha Chhetri, MBBS MHID Grad Cert. Biostat^2*, Kaaren K. Reichard, MD⁷, Dong Chen, MD, PhD⁷, Thomas Wiseman^2*, Anna Brown, PhD, BSc^6,8*, Hamish S Scott, PhD, BSc^6,8, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^1,2,3, David M. Ross, MBBS, PhD, FRACP, FRCPA^1,2*, Daniel Thomas, MD, PhD^1,2,3, Aref Al-Kali, MD⁴, Hassan Alkhateeb, MD^4*, James M. Foran, MD⁹, Cecilia Y. Arana Yi, MD¹⁰, Naseema Gangat, MBBS⁴, Mrinal M. Patnaik, MD, MBBS⁴, Ayalew Tefferi, MD⁴, Chung Hoow Kok, PhD, BSc^1,3, Rong He, MD⁷ and Mithun V Shah, MD, PhD⁴

¹Blood Cancer, Precision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia
²Haematology, Central Adelaide Local Health Network (CALHN), Adelaide, SA, Australia
³Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵University of South Australia, Adelaide, SA, Australia
⁶Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia
⁷Division of Hematopathology, Mayo Clinic, Rochester, MN
⁸Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia
⁹Hematology/Oncology, Mayo Clinic, Jacksonville, FL
¹⁰Hematology/Oncology, Mayo Clinic, Scottsdale, AZ

Sandra Huber, PhD^*, Constance Regina Baer, PhD, Stephan Hutter, PhD^*, Gregor Hoermann, MD, PhD, Christian Pohlkamp, MD^*, Wencke Walter, PhD^*, Manja Meggendorfer, PhD, Wolfgang Kern, MD, Torsten Haferlach, MD, PhD and Claudia Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

Sandra Novoa Jáuregui, MD^1*, Tzu Chen^2*, Sara Torres-Esquius, MSc^3*, Salvador Carrillo-Tornel^4*, Marta Santiago, MD^5*, Teresa Bernal Del Castillo, MD, PhD^6*, Francisca Maria Hernandez, MD^7*, Alessandro Liquori, PhD^5,8*, Ivan Martin Castillo^9*, Mar Tormo, M.D.¹⁰, Barbara Tazon, PhD^11*, Adoracion Blanco^12*, Laura Palomo, PhD^13*, Jose Cervera, MD, PhD^14*, Francesc Bosch, MD, PhD^15,16, David Valcarcel, MD, PhD^1,17, Maria Diez-Campelo, MD, PhD^18*, Julia Montoro, PhD^19* and Andres Jerez, MD, PhD^20*

¹Department of Hematology, Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, Barcelona, Spain
²Hospital General Universitario Morales Meseguer, Murcia, Spain
³Vall d'Hebron Universitary Hospital, UCGH. Spain, Barcelona, Spain
⁴Hematology and Medical Oncology Department, University Hospital Morales Meseguer. CRH-IMIB, Murcia, Spain
⁵Hematology Research Group, Instituto de Investigación Sanitaria La Fe, Valencia, Spain
⁶Servicio de Hematología, Hospital Universitario Central de Asturias Instituto de Investigación del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias, (IUOPA), Oviedo, Spain
⁷Department of Hematology, Hospital Virgen de las Nieves, Granada, Spain
⁸Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
⁹Clinic Universitary Hospital, INCLIVA, Valencia, ESP
¹⁰Hospital Clínico Universitario de Valencia, Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain
¹¹Department of Hematology, Department of Hematology, University Hospital Vall d’Hebron, University Autònoma of Barcelona (UAB). Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
¹²Department of Hematology, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain
¹³Experimental Hematology Unit,Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
¹⁴.., Valencia, Spain
¹⁵Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
¹⁶Department of Hematology, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Barcelona, Spain
¹⁷Vall d´Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d’Hebrón, Barcelona, Spain
¹⁸University Hospital of Salamanca, Salamanca, Spain
¹⁹Department of Hematology, Vall D'Hebron Hospital Universitari, Experimental Hema, Barcelona, ESP
²⁰Hematology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain

Zhuoer Xie, MD, MS^1,2, Kristen McCullough, PharmD¹, Terra L. Lasho, PhD³, Jenna A. Fernandez, PhD^1*, Christy M Finke^4*, Michelle Renee Amundson^3*, Betsy LaPlant, MS^5*, Abhishek Mangaokar^6*, Naseema Gangat, MBBS¹, Kaaren K. Reichard, MD⁷, Michelle Ann Elliott, MD³, Thomas E. Witzig, MD³ and Mrinal M. Patnaik, MD, MBBS⁴

¹Division of Hematology, Mayo Clinic, Rochester, MN
²H. Lee Moffitt Cancer Institute, Tampa, FL
³Mayo Clinic, Rochester, MN
⁴Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁵Mayo Clinic, Rochester, Biomedical Statistics & Informatics, Mayo Clinic, Rochester, MN
⁶Mayo Clinic, Rochester
⁷Division of Hematopathology, Mayo Clinic, Rochester, MN

Hui Yang, MD, PhD^1*, Guillermo Garcia-Manero, MD², Kelly S. Chien, MD¹, Koji Sasaki, MD¹, Sherry Pierce, BSN, BA^1*, Guillermo Montalban-Bravo, MD¹ and Rashmi Kanagal-Shamanna, MD³

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX

Jan Philipp Bewersdorf, MD^1,2, Tariq Kewan, MBBChir³, Ondrej Blaha, PhD^4,5,6*, Maximilian Stahl, MD⁷, Najla H Al Ali, MS^8*, Amy E. DeZern, MD, MHS⁹, Mikkael A. Sekeres, MD¹⁰, Geoffrey L Uy, MD¹¹, Hetty E. Carraway, MD, MBA¹², Pinkal Desai, MD, MPH¹³, Elizabeth A. Griffiths, MD¹⁴, Eytan M. Stein¹⁵, Andrew M. Brunner, MD¹⁶, Christine M. McMahon¹⁷, Joshua F. Zeidner, MD¹⁸, Michael R. Savona, MD¹⁹, Jessica M. Stempel, MD²⁰, Namrata Sonia Chandhok, MD²¹, Rahul Ramaswamy^22*, Gail J. Roboz, MD²³, Benjamin Rolles, MD²⁴, Eunice S. Wang, MD¹⁴, Amyah C. Harris^25*, Maria L Amaya, MD, PhD²⁶, Hayley Hawkins^27*, Justin Grenet, MD, MPhil²⁸, Carmelo Gurnari, MD²⁹, Rory M. Shallis, MD³⁰, Zhuoer Xie, MD, MS³¹, Jaroslaw P. Maciejewski, M.D., Ph.D., FACP²⁹, David A Sallman, MD³², Matteo Giovanni Della Porta, MD^33*, Rami S. Komrokji, MD⁸ and Amer M. Zeidan, MBBS, MHS³⁴

¹Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Medicine, Section of Hematology, Yale University, New Haven, CT
³Department of Internal Medicine, Section of Hematology, Yale University, New Haven, CT
⁴School of Public Health, Department of Biostatistics, Yale University, New Haven
⁵School of Public Health, Yale Center for Analytical Sciences, Yale University, New Haven
⁶Yale Cancer Center, Yale University, New Haven
⁷Dana Farber Institute, Boston, MA
⁸Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁹Johns Hopkins University, Baltimore, MD
¹⁰Sylvester Cancer Center, University of Miami, Miami, FL
¹¹Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹²Department of Hematology and Medical Oncology, Taussig Cancer institute, Leukemia Program, Cleveland Clinic, Cleveland, OH
¹³Weill Cornell Medicine, New York, NY
¹⁴Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹⁵Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁶Division of Hematology/Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁷University of Colorado School of Medicine, Aurora, CO
¹⁸University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC
¹⁹Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
²⁰Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT
²¹Division of Hematology, University of Miami Miller School of Medicine/ Sylvester Comprehensive Cancer Center, Miami, FL
²²Washington University, Saint Louis
²³New York Presbyterian Hospital, New York
²⁴Brigham and Women's Hospital/Harvard Medical School, Boston, MA
²⁵Dana Farber Cancer Institute, Boston
²⁶Division of Hematology, University of Colorado, Aurora, CO
²⁷Vanderbilt University Medical Center, Nashville
²⁸Weill Cornell, New York
²⁹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³⁰Section of Hematology, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT
³¹H. Lee Moffitt Cancer Institute, Tampa, FL
³²H. Lee Moffitt Cancer Center, Tampa, FL
³³Cancer Center IRCCS Humanitas Research Hospital, Milan, Italy
³⁴Department of Internal Medicine, Yale Cancer Center and Smilow Cancer Hospital, New Haven, CT

Lingxu Jiang^1*, Xin Huang^1*, Xinping Zhou^2*, Li Ye^1*, Lu Wang^1*, Chen Mei^1*, Liya Ma^3*, Gaixiang Xu^1*, Chao Hu^1*, Ziyang Zhou^1*, Xiaozhen Liu^1*, Yueyuan Han^1*, Zheng Ge, MD, PhD⁴ and Hongyan Tong, PhD^5*

¹Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
³Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China;, Hangzhou, China
⁴Zhongda Hospital Southeast University, Nanjing, China
⁵The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

Clifford M Csizmar, MD, PhD¹, Mark Gurney, MB, BCh, BAO^1*, Rashmi Kanagal-Shamanna, MD², Kelly S. Chien, MD³, Danielle E. Hammond, MD³, Terra L. Lasho, PhD¹, Christy M Finke^1*, Christopher Dean^1*, Abhishek A Mangaonkar, MBBS⁴, Naseema Gangat, MBBS⁵, Ayalew Tefferi, MD⁵, Hassan Alkhateeb, MD^5*, Guillermo Garcia-Manero, MD³, Guillermo Montalban-Bravo, MD³ and Mrinal M. Patnaik, MD, MBBS¹

¹Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Mayo Clinic, Rochester, MN
⁵Division of Hematology, Mayo Clinic, Rochester, MN

Kelly S. Chien, MD¹, Samuel Urrutia, MD², Ziyi Li, PhD^3*, Rashmi Kanagal-Shamanna, MD⁴, Ahmed Abdelhakeem, MD^1*, Tareq Abuasab, MD^1*, Emmanuel Almanza, MD^1*, Georgina Gener-Ricos^5*, Alex Bataller, MD, PhD^1*, Alexandre Bazinet, MD^1*, Guillermo Montalban-Bravo, MD¹, Nicholas J. Short, MD¹, Elias Jabbour⁶, Tapan M. Kadia, MD¹, Farhad Ravandi, MD, MBBS¹, Gautam Borthakur, MD¹, Danielle E. Hammond, MD¹, Mahesh Swaminathan, MD¹, Koji Sasaki, MD¹, Xiao Qin Dong^1*, Sherry Pierce, BSN, BA^1*, Hagop M. Kantarjian, MD¹ and Guillermo Garcia-Manero, MD⁷

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Hematopathology, MD Anderson Cancer Center, Houston, TX
⁵Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶University of Texas M.D. Anderson Cancer Ctr., Houston, TX
⁷University of Texas MD Anderson Cancer Center, Houston, TX

Dandan Song^* and Zheng Ge, MD, PhD

Department of Hematology, Zhongda Hospital, School of Medicine, Southeast University, Institute of Hematology Southeast University, Nanjing, China

Talha Badar, MD¹, Terra L. Lasho, PhD², Yael Kusne, MD, PhD^3*, Ludovica Marando^2*, Abhishek A Mangaonkar, MBBS², Christy M Finke^4*, James M. Foran, MD⁵, Aref Al-Kali, MD⁶, Hassan Alkhateeb, MD^6*, Naseema Gangat, MBBS⁶, Rong He, MD⁷, David Viswanatha, MD², Mark R. Litzow, MD⁶, Timothy Chlon, PhD⁸, Alejandro Ferrer, PhD² and Mrinal M. Patnaik, MD, MBBS⁴

¹Division of Hematology-Oncology, Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL
²Mayo Clinic, Rochester, MN
³Mayo Clinic, Pheonix, AZ
⁴Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁵Hematology/Oncology, Mayo Clinic, Jacksonville, FL
⁶Division of Hematology, Mayo Clinic, Rochester, MN
⁷Division of Hematopathology, Mayo Clinic, Rochester, MN
⁸Cincinnati Children's Hospital, Cincinnati, OH

Guillermo Garcia-Manero, MD¹, James McCloskey, MD², Elizabeth A. Griffiths, MD³, Amer M. Zeidan, MBBS, MHS⁴, Karen W.L. Yee, MD⁵, Aref Al-Kali, MD⁶, H. Joachim Deeg, MD⁷, Prapti A. Patel, MD⁸, Mitchell Sabloff, MSc, MD, FRCPC⁹, Mary-Margaret Keating, MD¹⁰, Nancy Zhu, MD^11*, Nashat Y. Gabrail, MD^12*, Salman Fazal, MD¹³, Joseph J. Maly^14*, Olatoyosi Odenike¹⁵, Hagop M. Kantarjian, MD¹, Amy E. DeZern, MD, MHS¹⁶, Casey L. O'Connell, MD¹⁷, Gail J. Roboz, MD¹⁸, Lambert Busque, MD¹⁹, Rena Buckstein, MD, FRCPC²⁰, Harsh Amin, MD^21*, Jasleen K. Randhawa, MD²², Brian Leber, MD²³, Shannon Lee^24*, Winny Chan, PhD^24*, Sonia Souza, PhD^24*, Yuri Sano, MD, PhD²⁴, Harold N. Keer, MD, PhD²⁴ and Michael R. Savona, MD²⁵

¹University of Texas MD Anderson Cancer Center, Houston, TX
²John Thuerer Cancer Center, Hackensack Medical Center, Hackensack, NJ
³Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁴Yale University and Yale Cancer Center, New Haven, CT
⁵Princess Margaret Cancer Centre, Toronto, Canada
⁶Mayo Clinic, Rochester, MN
⁷Fred Hutchinson Cancer Research Center, Seattle, WA
⁸University of Texas Southwestern Medical Center, Dallas, TX
⁹Ottawa Hospital Research Institute, University of Ottawa, Ottawa, NS, Canada
¹⁰Queen Elizabeth II (QEII) Health Sciences Centre, Halifax, NS, CAN
¹¹University of Alberta, Edmonton, AB, Canada
¹²Gabrail Cancer Center, Canton, OH
¹³West Penn Hospital, Allegheny Health Network, Pittsburgh, PA
¹⁴Norton Cancer Institute, Louisville, KY
¹⁵The University of Chicago Medicine and Comprehensive Cancer Center, Chicago, IL
¹⁶The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
¹⁷USC Keck School of Medicine, University of Southern California, Los Angeles, CA
¹⁸Weill Cornell Medicine, The New York Presbyterian Hospital, New York, NY
¹⁹Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada
²⁰Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
²¹Boca Raton Clinical Research, Boca Raton, FL
²²Houston Methodist Research Institute, Houston, TX
²³Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada
²⁴Astex Pharmaceuticals, Inc., Pleasanton, CA
²⁵Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN

David A Sallman, MD¹, Anthony M Hunter, MD², Zhuoer Xie, MD, MS³, Amy McLemore^4*, Andrew T. Kuykendall, MD³, Lisa Ann Nardelli, BS^4*, Onyee Chan, MD^3*, Eric Padron, MD³, Jeffrey Lancet, MD³ and Rami S. Komrokji, MD³

¹H. Lee Moffitt Cancer Center, Tampa, FL
²Emory University Internal Medicine Residency, Atlanta, GA
³Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁴Malignant Hematology Department, Moffitt Cancer Center, Tampa, FL

Lih En Hong, MBBS, FRACP^1*, Chung Hoow Kok, PhD, BSc^2,3, Monika Kutyna, PhD^3,4*, Joule J Li, MBBS, FRACP^5*, Rakchha Chhetri, MBBS MHID Grad Cert. Biostat^4*, David M. Ross, MBBS, PhD, FRACP, FRCPA^4,6*, Susan Branford, PhD^7,8, Hamish S Scott, PhD, BSc^7,8, Anna Brown, PhD, BSc^7,8*, Christopher N. Hahn, PhD^7,9*, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^2,3,4, Mrinal M. Patnaik, MD, MBBS¹⁰, Mithun V Shah, MD, PhD¹⁰, Susanna Proudman^1*, Mihir Wechalekar^11* and Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^2,3,4

¹Rheumatology Department, Royal Adelaide Hospital, Adelaide, SA, Australia
²Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
³Blood Cancer, Precision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia
⁴Haematology, Central Adelaide Local Health Network (CALHN), Adelaide, SA, Australia
⁵Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
⁶Department of Haematology, Flinders Medical Centre and University, Adelaide, SA, Australia
⁷Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia
⁸Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia
⁹University of South Australia, Adelaide, SA, Australia
¹⁰Division of Hematology, Mayo Clinic, Rochester, MN
¹¹Flinders University, Bedford Park, AUS