Yi Li, MS^*, Munehisa Yabuki, PhD^* and W. Jason Cummings, PhD^*

Omeros Corporation, Seattle, WA

Orianne Wagner-Ballon, MD, PhD¹, Anna Raimbault, PharmD, PhD^2*, Camille Debord, PharmD^3*, Valérie Soenen, MD, PhD^4*, Anne-Catherine Lhoumeau, PharmD, PhD^5*, Jean-Philippe Vial, MD^6*, Veronique Harrivel, MD^7*, Juliette Vo Xuan, PharmD^8*, Marie Loosveld, MD, PhD^9*, Gerard Socié¹⁰, Regis Peffault De Latour^11*, Ekbel Amri^12*, Manuelle Rongy, PhD, MSc^12*, Bernard Drenou, MD^13*, Agathe Debliquis, PharmD^14* and Magali Le Garff-Tavernier^15*

¹Hematology and Immunology Department, Henri Mondor University Hospital, UPEC, Assistance Publique Hopitaux de Paris, Creteil, FRA
²Service d’Hématologie Biologique, APHP Hôpital Saint Louis, Paris, France
³Nantes University Hospital, Nantes, FRA
⁴Laboratoire d’Hématologie, CRHU Lille, Lille, France
⁵Department of Biopathology, Institut Paoli-Calmettes, Marseille, France
⁶CHU Bordeaux, PESSAC, France
⁷Hematology Laboratory, Centre hospitalier universitaire d'Amiens, Amiens, FRA
⁸Hematology and Immunology Department, Henri Mondor University Hospital, UPEC, Assistance Publique Hopitaux de Paris, Créteil, France
⁹Hematology Laboratory, Marseille, FRA
¹⁰Hopital St. Louis, Department of Hematology - BMT, Paris, France
¹¹BMT Unit, Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France
¹²Alexion Pharma France, Paris, France
¹³Service d'Hématologie, Groupe Hospitalier de la Région Mulhouse Sud Alsace, Mulhouse, France
¹⁴Laboratoire d’Hématologie, Groupe Hospitalier de la Région Mulhouse Sud Alsace, Mulhouse, France
¹⁵Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Pitie-Salpetriere Hospital, Paris, France

Antonio M Risitano, MD, PhD^1,2, Bing Han, MD, PhD^3*, Austin Kulasekararaj, MD, MBBS, FRCPath, MRCP^4,5,6, Yasutaka Ueda^7*, Phillip Scheinberg, MD⁸, Carlos de Castro^9*, Jaroslaw P. Maciejewski, M.D., Ph.D., FACP¹⁰, Josefin Snellman^11*, Ranjan Tiwari^12*, Marion Dahlke, MD, MSc^13* and Régis Peffault de Latour^14,15*

¹AORN Moscati, Avellino, Italy
²University of Naples Federico II, Naples, Italy
³Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
⁴King’s College Hospital NHS, London, United Kingdom
⁵National Institute for Health and Care Research and Wellcome King’s Research Facility, London, United Kingdom
⁶King’s College London, London, United Kingdom
⁷Osaka University Graduate School of Medicine, Suita, Japan
⁸Hospital A Beneficência Portuguesa, São Paulo, Brazil
⁹Duke University School of Medicine, Durham, NC
¹⁰Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
¹¹Novartis Pharma AG, Basel, Switzerland
¹²Novartis Healthcare Pvt. Ltd, Hyderabad, India
¹³Novartis, Basel, Switzerland
¹⁴French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Paris, France
¹⁵Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France

Hiroki Mizumaki, MD, PhD^1*, Shouguo Gao, PhD^1*, Zhijie Wu, MD PhD^1*, Emma M. Groarke, MD², Lemlem Alemu^1*, Diego Quinones Raffo^3*, Olga Rios^1*, Sachiko Kajigaya, PhD^1*, Bhavisha A. Patel, MD¹ and Neal S. Young, MD¹

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
³National Heart, Lung, and Blood Institute (NHLBI)/NIH, Bethesda, MD

Huihui Fan^1*, Jing Hu^2*, Wenrui Yang^1*, Xin Zhao¹, Li Zhang^1*, Kang Zhou^1*, Youzhen Xiong^1*, Liping Jing, MD^3* and Fengkui Zhang^4*

¹Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
²Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China,, Tianjin, China
³Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, AL, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Anemia Therapeutic Center, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Xin Zhao, md¹, Jianping Li^2*, Huihui Fan^2*, Liping Jing, MD^3*, Li Zhang^2*, Kang Zhou^2*, Wenrui Yang^2*, Yuan Li^2*, Yang Yang^2*, Lei Ye, MD^2*, Guangxin Peng^2*, Youzhen Xiong^2*, Jun Shi^4* and Fengkui Zhang^2*

¹Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
³Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, AL, China
⁴Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Pontus Lundberg^1*, Silvia de la Iglesia, MD, PhD^2*, Richard J Kelly, PhD^3*, Austin Kulasekararaj, MD, MBBS, FRCPath, MRCP^4,5,6, Jun-Ichi Nishimura, MD, PhD⁷, Antonio M Risitano, MD, PhD⁸, Alexander Röth, MD⁹, Simon Buatois^10*, Sammy Chebon^10*, Himika Patel, PharmD^11* and Anna Kiialainen^10*

¹F. Hoffmann-La Roche Ltd., Basel, Switzerland
²Hematology Department, University Hospital of Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain
³Department of Haematology, St James's University Hospital, Leeds, United Kingdom
⁴Department of Haematological Medicine, King's College Hospital, London, United Kingdom
⁵National Institute for Health Research and Wellcome King's Clinical Research Facility, London, United Kingdom
⁶King’s College London, London, United Kingdom
⁷Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
⁸Hematology and BMT Unit, AORN San Giuseppe Moscati, Avellino, Italy
⁹Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany
¹⁰F. Hoffmann-La Roche Ltd, Basel, Switzerland
¹¹Genentech, Inc., San Fransisco, CA

Michihiro Hashimoto, PhD^1,2*, Jue Li^3*, Paul R. Andreassen, PhD^3* and Gang Huang, PhD^1,2

¹Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX
²Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, TX
³Cincinnati Children's Hosp. Med. Ctr., Cincinnati, OH

Jens Panse, MD^1,2, Jaroslav Cermak³, Olena Kyselova, MD, PhD^4*, Akihiko Gotoh, MD, PhD⁵, Fahri Sahin^6*, Hubert Schrezenmeier, MD^7,8, Alice C. Chang^9*, Brittany Gentile, PhD^10*, Marianne Uguen^11* and Bing Han^12*

¹Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany
²Center of Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf (ABCD), Germany
³Institute of Hematology and Blood Transfusion, Prague, Czech Republic
⁴Institute of Hematology and Transfusiology, National Academy of Medical Science, Kiev, Ukraine, Kiev, Ukraine
⁵Department of Hematology, Tokyo Medical University, Tokyo, JPN
⁶Division of Hematology, Department of Internal Medicine,, Ege University, Izmir, Turkey
⁷University of Ulm, Ulm, Germany
⁸German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany
⁹Genentech Inc., South San Francisco, CA, SUNNYVALE, CA
¹⁰Genentech, Inc., South San Francisco, CA, San Francisco, CA
¹¹F. Hoffman-La Roche, Basel, Switzerland
¹²Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, CHN

Wenrui Yang^*, Xin Zhao, Youzhen Xiong^*, Huihui Fan^*, Jianping Li^*, Lei Ye, MD^*, Li Zhang^*, Liping Jing, MD^* and Fengkui Zhang^*

Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China

Austin Kulasekararaj, MD, MBBS, FRCPath, MRCP¹, Francesco Lanza, MD^2*, Alexandros Arvanitakis^3*, Saskia MC Langemeijer, MD, PhD^4*, Satheesh Chonat, MD⁵, Jia Cao^6*, Vincent Chow^6* and Haby Henary^6*

¹Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, ENG, United Kingdom
²Hematology Unit and Metropolitan Romagna Transplant Network, University of Bologna, Ravenna, Italy
³Skånes Universitetssjukhus Malmö, Malmö, Sweden
⁴Department of Hematology, Radboud university medical center, Nijmegen, Netherlands
⁵Emory University and Children's Healthcare of Atlanta, Atlanta, GA
⁶Amgen Inc., Thousand Oaks, CA

Ahmet Celal Toprak, B.S.^1*, Taha Bat, MD², Mutlu Mete, Ph.D.^3*, Carmelo Gurnari, MD⁴, Zoe Bass, B.S.A.^1*, Jaroslaw P. Maciejewski, M.D., Ph.D., FACP⁴, Hussein Awada^4*, Alper Olcal, M.D.^2* and Ibrahim F. Ibrahim, M.D.⁵

¹University of Texas Southwestern Medical Center, Dallas, TX
²Department of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX
³Department of Computer Science and Information Systems, Texas A&M University - Commerce, Commerce, TX
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁵Department of Hematology and Oncology, UT Southwestern Medical Center, Dallas, TX

Anthony DeLise^1*, Natasa Zamurovic^2*, Regine Hansen^3*, Thierry Flandre^4*, Robert Schmouder^5* and Chiara Buono^6*

¹Novartis Institutes of Biomedical Research, Preclinical Safety, East Hanover, NJ
²Novartis Institutes For Biomedical Research, Basel, Switzerland
³Novartis Pharma AG, Preclinical Safety, Basel, Switzerland
⁴Novartis Institutes for Biomedical Research, Basel, Switzerland
⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁶Novartis Institutes for Biomedical Research, Cambridge, MA

Mark Orland, MD¹, Yasuo Kubota, MD, PhD^2*, Danai Dima, MD¹, Carlos Bravo-Perez, MD, PhD^1*, Luca Guarnera, MD^1*, Carmelo Gurnari, MD^1*, Jaroslaw P. Maciejewski, M.D., Ph.D., FACP¹ and Valeria Visconte, PhD¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Beachwood, OH

Robert Schmouder^1*, Guido Junge, MD, PhD^2*, Prasanna Kumar Nidamarthy^3* and Kenneth Kulmatycki^4*

¹Novartis Pharmaceuticals Corporation, East Hanover, NJ
²Novartis Institutes of Biomedical Research, Basel, Switzerland
³Novartis Healthcare Pvt. Ltd., Hyderabad, India
⁴Novartis Institutes of Biomedical Research, Cambridge, MA

Alexandra Pike, MBBS, FRCPath, MRCP^1*, Stephen John Richards, PhD, FRCPath^2*, Claire E McKinley, BSc^2*, Louise M Arnold, BSc (hons)^3*, Abraham Mullasseril Varghese, MBBS, MRCP^4*, Talha Munir, MBBS, MRCP, FRCPath, PhD^3*, Petra Muus, MD⁵, Peter Hillmen, MB ChB, PhD⁶, Morag Griffin, FRCPath, MRCP^5*, Richard J Kelly, PhD^5* and Darren Newton, PhD^7*

¹Leeds Institute of Medical Research, University of Leeds, Wakefield, ENG, United Kingdom
²Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom
³Department of Haematology, St. James's University Hospital, Leeds, United Kingdom
⁴Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
⁵Department of Haematology, St James's University Hospital, Leeds, United Kingdom
⁶Leeds Institute of Medical Research, St. James's University Hospital, Leeds, United Kingdom
⁷Leeds Institute of Medical Research, University of Leeds, Leeds, ENG, United Kingdom

Sung-Eun Lee, MD^1*, Gi-June Min^2*, Sung-Soo Park, MD^3*, Silvia Park^4*, Jae-Ho Yoon, MD², Byoung-Sik Cho^3*, Ki-Seong Eom^2*, Yoo-Jin Kim², Seok Lee², Chang-Ki Min^2*, Heeje Kim, MD, PhD³, Seok-Goo Cho^2* and Jong-Wook Lee, MD⁵

¹Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Houston, TX
²Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
³Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁴Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, AL, South Korea
⁵Department of Hematology, Seoul St. Mary's Hospital Catholic University of Korea, Seoul, South Korea