Tianxiao Han^1,2,3,4*, Rajesh D. Gunage^1,2,3,4*, Ran Jing^3,4,5*, Alexandra F. Corbin^1,2,3,4*, Kenny Zhi Ming Chen^1,2,3,4*, Yang Tang^6*, Olivia Stockard^1*, Song Yang^1,2,3,4*, Yi Zhou, PhD^1,2,3,4*, George Q. Daley, MD, PhD^4,5,6, Thorsten M. Schlaeger, PhD^1* and Leonard I. Zon, MD^2,3,4,7

¹Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA
²Howard Hughes Medical Institute, Boston, MA
³Harvard Medical School, Boston, MA
⁴Harvard University, Cambridge, MA
⁵Harvard Medical School/Boston Children's Hospital, Boston, MA
⁶Department of Hematology/Oncology, Harvard Medical School/Boston Children's Hospital, Boston, MA
⁷Harvard Stem Cell Institute, Cambridge, MA

Shovik Bandyopadhyay¹, Michael Duffy, PhD^2*, Kyung Jin Ahn^3*, Minxing Pang^4*, David Smith, PhD^5*, Gwendolyn Duncan^6*, Jonathan Sussman^7*, Jihan Zhang^7*, Jeffrey Huang^7*, Yulieh Lin, PhD^2*, Barbara Xiong^4*, Tamjid Imtiaz^7*, Chia Hui Chen^3*, Anusha Thadi^6*, Changya Chen, PhD³, Jason Xu, PhD⁸, Melissa Reichart^9*, Vinodh Pillai, MD^4*, Oraine Snaith, MD^4*, Derek Oldridge^3*, Siddharth Bhattacharyya, MD⁴, Ivan Maillard¹⁰, Martin Carroll, MD¹¹, Charles Nelson^9*, Ling Qin, PhD^2* and Kai Tan, PhD¹²

¹Cellular and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, EUREKA, MO
²McKay Orthopedic Research Laboratory, University of Pennsylvania, Philadelphia, PA
³Children's Hospital of Philadelphia, Philadelphia, PA
⁴University of Pennsylvania, Philadelphia, PA
⁵Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA
⁶Children's Hospital of Philadelphia, Philadelphia
⁷University of Pennsylvania, Philadelphia
⁸Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁹Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia
¹⁰Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA
¹¹Division of Hematology/Oncology, Department of Medicine, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA
¹²Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Aditi Dey^1*, Richard Burt, PhD, FRCPath, MRCP^2,3,4*, Emily Annie Cutler, MSc^1*, Hermione Elsie Allen, MSc^1*, Jenny Chatzigerou, MSc^1*, Rodothea Amerikanou, MBBChir^1*, Samantha Atkinson, BSc^3,4*, Ashish Dhir, PhD^5*, Kristina Kirschner, PhD^6* and Adele Kay Fielding, MBBS, PhD^7,8

¹University College London, London, United Kingdom
²University College London Hospital, London, United Kingdom
³The Francis Crick Institute, London, United Kingdom
⁴Imperial College London, London, United Kingdom
⁵University of Edinburgh, Edinburgh, United Kingdom
⁶Cancer Research UK Beatson Institute, Glasgow, United Kingdom
⁷UCL Cancer Institute, London, United Kingdom
⁸Centre for Blood Research, University of York, York, United Kingdom

Tim Robin Wagner^1*, Niklas Kehl^1*, Simon Steiger^1*, Michael Kilian, PhD^2*, Kane Foster, MSc^3*, Tamara Boschert^1*, Gabrielle M. Hernandez^4*, Jennifer Abelin, PhD^4*, Katharina Lindner^1*, Lilli Sophie Sester, MD^5*, Jan Frenking, MD^5*, Bruno Schönfelder^1*, Daria Galas-Filipowicz^3*, Evie Fitzsimons^3*, Edward W. Green, PhD^1*, Patrick Schmidt, PhD^6*, Sebastian Uhrig, PhD^1*, Lukas Bunse, MD^1*, Benny Chain, PhD^3*, Hartmut Goldschmidt⁵, Niels Weinhold, PhD^5*, Stefan Fröhling, MD^6*, Carsten Müller-Tidow, MD^5*, Steven A. Carr, PhD^4*, Kwee Yong³, Karsten Rippe^1*, Marc S. Raab^5*, Michael Platten, MD^1*, Stefan B Eichmüller^1* and Mirco Julian Friedrich, MD, PhD^4*

¹German Cancer Research Center (DKFZ), Heidelberg, Germany
²Brigham and Women's Hospital, Boston
³Cancer Institute, University College London, London, United Kingdom
⁴Broad Institute of MIT and Harvard, Cambridge, MA
⁵Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany
⁶National Center for Tumor Diseases, Heidelberg, Germany

Thilinie Bandara^*, Lijian Shao, MD, PhD^*, Na Yoon Paik^*, Jacob Neethling, Paulina Rodriguez^* and Kostandin V Pajcini, PhD

Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, IL

Laura Sudupe^1*, Emma Muiños-Lopez, PhD^2*, Isabel A Calvo, PhD^2*, Ana Rosa Lopez-Perez, PhD^3*, Amaia Vilas-Zornoza^4*, Sarai Sarvide^5*, Purificacion Ripalda-Cemborain^2*, Azari Bantan^1*, Jin Ye^1*, Vincenzo Lagani^1*, Paula Aguirre-Ruiz^2*, Patxi San-Martin^2*, Itziar Cenzano, PhD^4*, Marta Larrayoz, PhD^2*, Laura Alvarez-Gigli, MD^6*, Marta Abengozar-Muela, MD^6*, Borja Saez-Ochoa, PhD^2*, Phillip T Newton^7*, Jesper Tegner, PhD^1*, Bruno Paiva^2,8*, Jose A. A Martinez-Climent, MD^2,5, David Gomez-Cabrero^1,9* and Felipe Prosper, MD, PhD^4,8,10

¹Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology KAUST, Thuwal, Saudi Arabia
²Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain, Pamplona, Spain
³Translational Bioinformatics Unit, Navarrabiomed, Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain., Pamplona, Spain
⁴Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain
⁵Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain, Pamplona, Spain
⁶Department of Pathology, Clinica Universidad de Navarra (CUN), Pamplona, Spain
⁷Department of Women’s and Children’s Health, Karolinska Institutet, Sweden; Astrid Lindgren Children´s hospital, Stockholm, Sweden, Stockholm, Sweden
⁸Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain
⁹Translational Bioinformatics Unit, Navarrabiomed, Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
¹⁰Hematology and Cell Therapy Department, Clinica Universidad de Navarra, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain

Abhishek A Mangaonkar, MBBS¹, Terra L. Lasho, PhD¹, Justin Boysen^2*, Christy M Finke^3*, Jenna A. Fernandez, PhD^2*, Jose. C. Villasboas, MD^1*, Christopher Dean^3*, Alejandro Ferrer, PhD¹, Moritz Binder, MD¹, Liguo Wang, PhD^4*, Jeong-Heon Lee^5*, Kaaren K. Reichard, MD⁶ and Mrinal M. Patnaik, MD, MBBS²

¹Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN
³Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁴Quantitative Health Sciences, Mayo Clinic, Mayo Clinic, Rochester, MN
⁵Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁶Division of Hematopathology, Mayo Clinic, Rochester, MN

Richa Rai, PhD^1*, Jonathan Feld, MD², Iyinyeloluwa Okulate^3,4,5,6*, Stella Melana, PhD^7*, Richard Sheppard, MD^2*, Erin Demakos, RN², Shafinaz Hussein, MD^2*, Rachel Chen, PHD^3,8*, Rachel Lee, PHD^3,8*, Ronaldo de Real, PHD^3,8*, Geoffrey Kelly^3,8*, Brian Lee, PHD^3,8*, Travis Dawson, PHD^3,8*, Zhihong Chen, PhD^3,4,8*, Vladimir Roudko, PHD^3,4,8*, Seunghee kim-Schulze, PHD^3,4,5,8*, Lewis R R. Silverman, MD^2,9 and Amir Horowitz, PHD^3,5,10,11*

¹Department of Medicine, Icahn School of Medicine At Mount Sinai, New York, NY
²Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
³The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁴Department of Immunology & Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY
⁵Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
⁶Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁷Department of Medicine, Icahn School of Medicine At Sinai, NEW YORK, NY
⁸Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY
⁹Tisch Cancer Institute, Department of Medicine, New York, NY
¹⁰Tisch Cancer Institute, Icahn School of Medicine At Mount Sinai, New York, NY
¹¹Departments of Immunology & Immunotherapy, Icahn School of Medicine At Mount Sinai, New York, NY

Jennifer J Chia, MD, PhD^1,2, Apeksha Singh^2,3, Yu-Sheng Eason Lin, PhD^2*, Tiffany Tran, PhD^1*, Jennifer King, MD, PhD^4*, Dinesh S. Rao, MD, PhD¹ and Alexander Hoffmann, PhD^2*

¹Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
²Signaling Systems Laboratory, UCLA, Los Angeles, CA
³UCLA-Caltech Medical Scientist Training Program, Los Angeles, CA
⁴Department of Medicine, UCLA, Los Angeles, CA

Mauricio Nicolás Ferrao Blanco, PhD¹, Elizabeth Schweighart^1*, Lennart Kester^2*, Jayne Hehir-Kwa^1*, Mirjam E. Belderbos, MD, PhD¹, Monique L. den Boer, PhD^1,3, Olaf Heidenreich, PhD¹ and Josef Vormoor, MD PhD¹

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands
³Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Department of Pediatric Oncology/Hematology, Netherlands, Rotterdam, Netherlands

Alice Cani, PhD^1*, Carlotta Caterina Damanti, PhD^2,3*, Federica Lovisa, PhD^2,3*, Enrico Gaffo, PhD^4*, Giulia Borile, PhD^5*, Elisa Carraro, PhD^6*, Pina Fusco, PhD^3,7*, Elena Varotto, MD, PhD^8*, Stefania Bortoluzzi, PhD^9*, Alessandra Biffi, MD, PhD^2,6*, Barbara Buldini, MD, PhD^2,3, Carmelo Rizzari, MD^10*, Marta Pillon, MD, PhD^6*, Lara Mussolin, PhD^2,3* and Silvia Bresolin, PhD^2,3*

¹Department of Women's and Children's Health, Onco-hematology lab and clinic, University of Padova, Padova, Italy
²University of Padua, Maternal and Child Health Department, Padova, Italy
³Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy
⁴Computational Genomics Group, Department of Molecular Medicine, University of Padova, Padova, ITA
⁵Foundation Istituto Ricerca Pediatrica (IRP), Padova, Italy
⁶Padua University Hospital, Pediatric Hematology, Oncology and Stem Cell Transplant Division, Padova, Italy
⁷University of Padua, Department of Industrial Engineering (DII), Padova, Italy
⁸Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, University of Padova, Padova, Italy, University of Padua, Padova, Italy
⁹Computational Genomics Group, Department of Molecular Medicine, University of Padua,, Padova, Italy
¹⁰Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy