65th ASH Annual Meeting & Exposition: 102. Iron Homeostasis and Biology: Poster III

Symposia: Iron Homeostasis and Biology Oral and Poster Abstracts
Poster

Halls G-H (San Diego Convention Center)

Combination Therapy with Luspatercept and the Ferroportin Inhibitor Vamifeport Is Superior to Either Drug Alone in Improving Anemia and Reducing Myeloid Skewing in MDS

Ada Antypiuk¹^*, Steven Vance¹^*, Franz Dürrenberger²^*, Vania Manolova, PhD²^* and Francesca Vinchi, PhD¹

¹Iron Research Laboratory, New York Blood Center, New York, NY
²CSL Vifor, St. Gallen, Switzerland

3837

Novel Anti-TMPRSS6 Monoclonal Antibody Provides a Potential Therapeutic Approach for the Treatment of Polycythemia Vera

Buxin Chen, PhD¹^*, Jean Wang²^*, Lei Huang, PhD¹^*, Matthew Bujold¹^* and Xin Du, PhD¹

¹Mabwell Therapeutics, La Jolla, CA
²Mabwell Therapeutics, La Jolla

3838

Incidence of Fractures after Intravenous Iron: A Retrospective Analysis Comparing Ferric Carboxymaltose and Ferric Derisomaltose

Heinz Zoller, MD^1,2^*, Lorenz Michael Pammer, MD^1,2^*, Benedikt Schaefer, MD, PhD^1,2^*, Martina Saretto¹^*, Sonja Wagner, MSc^1,2^*, Elke Pertler, MSc^1,2^* and Herbert Tilg, MD¹^*

¹Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Innsbruck, Austria
²Christian Doppler Laboratory for iron and phosphate biology, Innsbruck, Austria

3839

Selective Inhibition of Repulsive Guidance Molecule C/Hemojuvelin (RGMc/HJV) with SRK-256 to Mobilize Iron in Functional Iron Deficiency

Leslie K. Cortes, Ph.D.^*, Samantha B. Nicholls, Ph.D.^*, Frederick C. Streich Jr., Ph.D.^*, Chris Boston, M.S.^*, Ajai Pal, Ph.D.^*, Bimal Regmi^*, Shaun M. Cote, Ph.D.^*, Kaleigh Canonico^* and Mo Qatanani, Ph.D.^*

Scholar Rock, Cambridge, MA

3840

Moderate Iron Deficiency Does Not Potentiate Renal or Cardiac Calcification and Subsequent Tissue Injury in Mouse Models of CKD

Brian Czaya, PhD¹^*, Moya Zhang, B.S.¹^*, Joseph Olivera, PhD¹^*, Amber Lundin¹^*, Veena Sangkhae, PhD¹, Grace Jung¹^*, Tomas Ganz, MD, PhD², Mark Hanudel, MD, MS¹^* and Elizabeta Nemeth, PhD¹

¹Center for iron disorders, David Geffen School of Medicine At UCLA, Los Angeles, CA
²Center for Iron Disorders, David Geffen School of Medicine at UCLA, Los Angeles, CA

3841

Single Ascending Doses of REGN7999, a Monoclonal Antibody Inhibitor of TMPRSS6, Increase Serum Hepcidin and Cause Deep, Sustained Reductions in Serum Iron in Healthy Human Volunteers

Sylvie Rottey¹^*, Nikhil Singh²^*, Emily Labriola-Tompkins²^*, Heinrich E Lob, PhD², Kusha Mohammadi²^*, Hazem Hassan²^*, Lorna Farrelly²^*, Swati Duggal²^*, Harvey Chin²^*, Sarah Hatsell²^*, Michael E. Burczynski²^*, Olivier Harari, MD²^*, Lorah Perlee, PhD²^* and Griet Van Lancker¹^*

¹Drug Research Unit Ghent, Ghent University Hospital, Ghent, Belgium
²Regeneron Pharmaceuticals, Inc., Tarrytown, NY

3842

Ferritin Reference Ranges in an Adult Population of Working-Age Adults without Anemia

Caixai Bi¹^*, Robert T Means Jr., MD^2,3, Edward Wong, MD, MA⁴, Lance A Bare¹^* and Michael J McPhaul, MD⁵^*

¹Quest Diagnostics, Secaucus, NJ
²Departments of Internal Medicine, Pathology, and Medical Education, East Tennessee State University, Johnson City, TN
³Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN
⁴Quest Diagnostics, Chantilly, VA
⁵Quest Diagnostics, San Juan Capistrano, CA

3843

Absence of MHC Class I Expression on Target Cells Exacerbates Iron Dependent CD4+ T Cell Mediated Killing

Emma Lauder¹^*, Dongchang Zhao, PhD²^*, Lu Li²^*, Yaping Sun, MD, PhD, MS²^*, Katherine Oravecz-Wilson, MS, BS¹^*, Laure Maneix, PhD²^*, Ana Santibanez²^* and Pavan Reddy, MD³

¹University of Michigan, Ann Arbor, MI
²Baylor College of Medicine, Houston, TX
³Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston

3844

Hepcidin and Erythroferrone Levels across Human Pregnancy, and the Effect of IV Iron Infusion – a Revamp Substudy

Katherine Fielding, FRACP FRCPA MBBS¹, Martin Mwangi, PhD²^*, Ernest Moya²^*, Ricardo Ataide, PhD³^*, Glory Mzembe²^*, Louise Randall, PhD³^*, Sabine Braat^3,4^*, Rebecca Harding, PhD³^*, Kamija S. Phiri, PhD⁵^* and Sant-Rayn Pasricha, MD, PhD^6,7,8

¹The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
²Training Research Unit of Excellence (TRUE), Blantyre, Malawi
³The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
⁴Methods and Implementation Support for Clinical and Health Research Hub, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Australia
⁵Training and Research Unit of Excellence (TRUE), Blantyre, Malawi
⁶Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, Fitzroy North, VIC, Australia
⁷Diagnostic Haematology, Royal Melbourne Hospital, Parkville, VIC, Australia
⁸Clinical Haematology, Royal Melbourne Hospital & Peter MacCallum Cancer Centre, Parkville, Australia

3845

Hemoglobin Scavenging Proteins Reduce Free Hemoglobin during Venovenous Extracorporeal Circulation and Reduce Markers of Organ Damage and Inflammation

Krianthan Govender¹^*, Derek Lamb, BSc²^*, Cynthia Walser¹^*, Paul Buehler, PharmD, PhD²^*, Andre Francis Palmer, PhD³^*, Robert Owens, MD⁴^* and Pedro Cabrales, PhD¹^*

¹Functional Cardiovascular Engineering Laboratory, University of California, San Diego, La Jolla, CA
²Center for Blood Oxygen Transport and Hemostasis, University of Maryland, Baltimore, MD
³Andre Palmer Laboratory for Artificial Blood Research, The Ohio State University, Columbus, OH
⁴Division of Pulmonary, Critical Care, and Sleep Medicine, University of California, San Diego, La Jolla, CA

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