Roberta Santos Azevedo, MD^1,2*, Francesca Morelli, MD^3,4*, Kiyomi Mashima, MD, PhD^1,5, Rayan Fardoun^1*, Svitlana Tyekucheva, PhD^6,7*, Stacey M Fernandes, BS^1*, Samantha J. Shupe, BS^1*, Marissa Terra^1*, Anisha Patel^1*, Joseph Yu^1* and Jennifer R. Brown, MD, PhD^1,5

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Hospital Nove de Julho, São Paulo, Brazil
³Department of Medical Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Hematology, University of Florence, Florence, Italy
⁵Department of Medicine, Harvard Medical School, Boston, MA
⁶Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁷Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA

Nitin Jain, MD¹, Philip Thompson, MBBS¹, Akhil Jain, MD^1*, Jan A. Burger, MD, PhD ², Alessandra Ferrajoli, MD¹, Jayastu Senapati, MD, MBBS, DM¹, Koichi Takahashi, MD, PhD¹, Mahesh Swaminathan, MD¹, Zeev Estrov, MD¹, Gautam Borthakur, MD¹, Prithviraj Bose, MD¹, Tapan M. Kadia, MD¹, Naveen Pemmaraju, MD¹, Koji Sasaki, MD¹, Divyam Bansal^1*, Marina Y. Konopleva¹, Elias Jabbour¹, Naveen Garg, MD^3*, Xuemei Wang, MS^4*, Rashmi Kanagal-Shamanna, MD⁵, Keyur P. Patel, MBBS, PhD⁶, Wei Wang^6*, Sa A. Wang⁶, Jeffrey L. Jorgensen, MD⁶, Wanda Lopez, RN^1*, Ana Ayala, RN^1*, William Plunkett, PhD⁷, Varsha Gandhi, PhD⁷, Hagop M. Kantarjian, MD¹, Susan M. O'Brien⁸, Michael J. Keating, MBBS¹ and William G. Wierda, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, MD Anderson Cancer Center, Houston, TX
³Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA

Anne-Sophie Michallet, MD, PhD^1*, Anne Quinquenel, MD, PhD^2*, Remi Letestu^3*, Tavernier Magali^4*, Stéphane Morisset^5*, Therese Aurran^6*, Kamel Laribi^7*, Florence Cymbalista, MD, PhD^8*, Vincent Levy, MD, PhD^9*, Laurence Simon^10*, Damien Roos Weil, MD, PhD^11*, Veronique Leblond, MD^12*, Marie Sarah Dilhuydy, MD^13*, Cecile Tomowiak^14*, Caroline Dartigeas^15*, Romain Guieze, MD, PhD^16*, Olivier Tournilhac^17*, Emmanuelle Ferrant, MD^18*, Sophie De Guibert^19*, Pierre Feugier^20*, Fatiha Merabet^21*, Stéphane Lepretre^22*, Philippe Carassou^23*, Julie Gay^24*, Benedicte Hivert^25*, Luc Matthieu Fornecker, MD, PhD^26*, Jehan Dupuis^27*, Lysiane Molina, MD^28*, Bruno Villemagne^29*, Guillaume Cartron, MD, Ph-D^30*, Bernard Drenou, MD^31*, Béatrice Mahé^32*, Omar Benbrahim^33*, Xavier Cahu^34*, Christelle Portois^35*, Loic Ysebaert, MD, PhD^36*, Florence Nguyen Khac^37*, Valerie Rouillé^38* and Alain Jacques Delmer, MD^39*

¹Centre Leon Berard, Lyon, France
²Hematology department, Robert Debré University Hospital, Reims, France
³APHP, Avicennes Hospital, Bobigny, FM, FRA
⁴APHP, la pitié salpetriere, Paris, FRANCE, FRA
⁵Hospices Civils De Lyon, Chazey-sur-Ain, FRA
⁶Institut Paoli-Calmettes, Marseille, FRA
⁷Hematology Department, Le Mans Hospital, Le Mans, France
⁸Hopital Avicenne, Bobigny, FRA
⁹Hôpital Avicenne, AP-HP, BOBIGNY, France
¹⁰hospital Corbeil essonnes, Corbeil-Essonnes, FRA
¹¹Clinical Hematology, APHP, La Pitié Salpétriere, Sorbonne Universite, Paris, FRA
¹²APHP, La pitié salpétriere, Paris, FRA
¹³CHU Bordeaux, PESSAC, FRA
¹⁴Centre Hospitalier Universitaire de Poitiers, Poitiers, France
¹⁵CHU Bretonneau, Tours, FRA
¹⁶CHU Estaing, Clermont Ferrand, FRA
¹⁷CHU clermont ferrand, Clermont ferrand, France
¹⁸CHU Lyon Sud, Pierre Benite, FRA
¹⁹Centre Hospitalier Pontchaillou, Rennes, FRA
²⁰Henri Poincaré University, Vandoeuvre Les Nancy, FRA
²¹andre mignot hospital, LE CHESNAY, FRA
²²centre henri becquerel, Rouen, FRA
²³chu metz thionville, Ars Laquenexy, FRA
²⁴Hospital St Antoine, Paris, FRA
²⁵GHICL, Lille, FRA
²⁶Institut de cancérologie Strasbourg Europe, Strasbourg, France
²⁷APHP, Creteil, Creteil, FRA
²⁸CHU grenoble, grenoble, France
²⁹CH la roche sur yon, La Roche Sur Yon, FRA
³⁰Dept. Biological Hematology, Montpellier University Hospital Center, Montpellier, FRA
³¹HôPital Emile Muller, Mulhouse Cedex 1, FRA
³²CHU nantes, Nantes, FRA
³³HOPITAL LA SOURCE, La Source, FRA
³⁴hospital cesson sevigne, cesson sevigne, France
³⁵CHU SAINT ETIENNE, Saint Etienne, FRA
³⁶Hematology Department, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
³⁷Hôpital Pitié-Salpêtrière, Service d'Hématologie, Paris Cedex 13, France
³⁸CHU montpellier, montpellier, France
³⁹Hôpital Robert Debré CHU de Reims, Reims Cedex, -, FRA

Lindsey E. Roeker, MD¹, Jennifer A. Woyach, MD², Chan Y. Cheah, MBBS, FRACP, FRCPA, DMSc³, Catherine C Coombs, MD^4*, Nirav N. Shah, MD⁵, William G. Wierda, MD, PhD⁶, Manish Patel, MD^7*, Donald E. Tsai, MD, PhD^8*, Binoj Nair, PhD^8*, Chunxiao Wang, Ph.D.^9*, Xiang Zhao^8*, Narasimha Marella, Ph.D.^8*, Caleb Ho, M.D.⁸, Samuel McNeely, PhD^9* and Jennifer R. Brown, MD, PhD¹⁰

¹Memorial Sloan Kettering Cancer Center, New York, NY
²The Ohio State University Comprehensive Cancer Center, Columbus, OH
³Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
⁴University of California Irvine Health, Orange, CA
⁵Medical College of Wisconsin, Milwaukee, WI
⁶MD Anderson Cancer Center, Houston, TX
⁷Florida Cancer Specialists, Sarah Cannon Research Institute, Sarasota, FL
⁸Loxo@Lilly, Indianapolis, IN
⁹Eli Lilly and Company, Indianapolis, IN
¹⁰Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA

Mariia Mikhaleva, MD^1,2*, Svitlana Tyekucheva, PhD^3,4*, Kiyomi Mashima, MD, PhD^1,5, Stacey M Fernandes, BS^1*, Matthew S. Davids, MD, MMSc^1,5 and Jennifer R. Brown, MD, PhD^1,5

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Russian Research Institute of Hematology and Transfusiology, Saint-Petersburg, Russia
³Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA
⁵Department of Medicine, Harvard Medical School, Boston, MA

Paul J. Hampel, MD¹, Kari G. Rabe, MS^2*, Yucai Wang, MD, PhD³, Steven R Hwang, MD, BS³, Saad S. Kenderian, MD³, Eli Muchtar, MD², Jose F. Leis, MD, PhD⁴, Amber Koehler, PA-C^5*, Mazie Tsang, MD⁶, Ricardo Parrondo, MD⁷, Rachel Bubik, PharmD^2*, Susan Marie Schwager^2*, Curtis A. Hanson, MD^8*, Esteban Braggio, PhD⁹, Susan L. Slager, PhD³, Min Shi, MD, PhD^2*, Daniel L. Van Dyke, PhD², Timothy G. Call, MD³, Neil E. Kay, MD^3,10, Wei Ding, MD, PhD³ and Sameer A. Parikh, MD¹

¹Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
²Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Division of Hematology and Oncology, Mayo Clinic Arizona, Scottsdale, AZ
⁵Division of Hematology, Department of Medicine, Mayo Clinic, Rochester
⁶Mayo Clinic, Phoenix, AZ
⁷Division of Hematology-Oncology, Mayo Clinic, Jacksonville, FL
⁸Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, Rochester, MN
⁹Department of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
¹⁰Department of Immunology, Mayo Clinic, Rochester, MN

Kerry A Rogers, MD¹, Qiuhong Zhao, MS^1*, Seema A Bhat, MD¹, John C. Byrd, MD², Cara Grantier, CNP^3*, Michael R. Grever, MD¹, Corinne Hoffman, MS, NP^3*, Adam S Kittai, MD¹, Gerard Lozanski, MD^4*, Margaret S. Lucas, PA-C^1*, Lindsey Rike^3*, Shanmugapriya Thangavadivel, PhD^1*, William E. Carson III, MD, PhD^5* and Jennifer A. Woyach, MD¹

¹Division of Hematology, The Ohio State University, Columbus, OH
²Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
³Comprehensive Cancer Center, The Ohio State University, Columbus, OH
⁴Department of Pathology, The Ohio State University, Columbus, OH
⁵Department of Surgery, The Ohio State University, Columbus

Loic Ysebaert, MD, PhD^1*, Emmanuelle Ferrant, MD^2*, Marie Sarah Dilhuydy, MD^3*, Anne-Sophie Michallet, MD, PhD^4*, Luca Inchiappa^5*, Romain Guieze, MD, PhD^6*, Emmanuelle Tchernonog^7*, Ana Cavillon^8*, Marie Christine Bene^9* and Luc-Matthieu Fornecker, MD, PhD^10*

¹Hematology Department, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
²Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d’Hématologie Clinique, Pierre-Bénite, France
³CHU Bordeaux, PESSAC, FRA
⁴Centre Leon Berard, Lyon, France
⁵Hematology Department, Institut Paoli-Calmettes, MARSEILLE CEDEX 09, France
⁶CHU Estaing, Clermont Ferrand, FRA
⁷Hematology Department, CHU Montpellier, Montpellier Cedex 5, France
⁸Statistics Department, Institut Universitaire du Cancer de Toulouse-Oncopôle, Toulouse, France
⁹Hopital Hotel Dieu & Hme, Nantes, France
¹⁰Hematology Department, Institut De Cancérologie Strasbourg Europe, Strasbourg, France

Andrew H. Lipsky, MD¹, Brian T. Hill, MD², Allison Winter, MD³, Spencer Henick Bachow, MD⁴, Aaron D. Viny, MD, MS¹, Todd L. Rosenblat, MD, MS^1*, Joseph Jurcic, MD¹ and Nicole Lamanna, MD⁵

¹Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY
²Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Center, Cleveland, OH
³Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁴Eugene M. & Christine E. Lynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL
⁵Herbert Irving Comprehensive Cancer Center, New York-Presbyterian/Columbia University Medical Center, New York, NY

Andrea Visentin, MD, PhD^1*, Enrico Gaffo, PhD^2*, Moritz Furstenau, MD^3*, Jennifer A. Woyach, MD⁴, Panagiotis Baliakas, MD^5*, Kerry A Rogers, MD⁶, Cecelia Miller, PhD^4*, Claudia Haferlach, MD⁷, Karla Plevova^8*, David Graham Oscier, MD, PhD⁹, Zadie Davis^10*, Florence Nguyen Khac^11*, Eleonora Roncaglia, MS^12*, Gian Matteo Rigolin, MD^13*, Anastasia Athanasiadou, MD^14*, Fanny Baran-Marszak, MD, PhD^15*, Alberto Valiente^16*, Maria Jose Terol, MD^17*, Pau Abrisqueta, MD, PhD¹⁸, Blanca Espinet, PhD^19*, Anna Puiggros, PhD^19*, Annalisa Martines^20*, Laura Bonaldi^20*, Francesca Romana Mauro^21*, Lydia Scarfo, MD²², Thomas Chatzikonstantinou^23*, Eugen Tausch, MD^24*, Karl Anton Kreuzer^3*, Arnon P. Kater, MD, PhD²⁵, Francesc Bosch, MD, PhD²⁶, Michael Doubek, MD^8*, Panayiotis Panayiotidis, MD²⁷, Olga Kalashnikova, MD^28*, Federica Frezzato, PhD^29*, Monica Facco, MS^29*, Valeria Ruocco, MD^29*, Alessia Buratin, PhD^12*, Silvia Orsi^12*, Alessandro Cellini, MD^29*, Francesco Angotzi^29*, Chiara Adele Cavarretta, MD^29*, Ivan Zatta, MD^29*, Andrea Serafin, MD^29*, Robin Foa^30*, Barbara F. Eichhorst, MD³¹, Antonio Cuneo, MD^32*, Kostas Stamatopoulos^33*, Paolo Ghia, MD, PhD³⁴, Stefania Bortoluzzi, PhD^35* and Livio Trentin²⁹

¹Hematology unit, Department of Medicine, University of Padova, Padova, Italy
²Computational Genomics Group, Department of Molecular Medicine, University of Padova, Padova, ITA
³Department I of Internal Medicine, University of Cologne, Cologne, Germany
⁴The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁵Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
⁶Division of Hematology, The Ohio State University, Columbus, OH
⁷MLL Munich Leukemia Laboratory, Inning am Ammersee, Germany
⁸Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University-University Hospital Brno, Brno, Czech Republic
⁹Division of Haematology, University Hospitals Dorset, Bournemouth, United Kingdom
¹⁰Molecular Pathology, University Hospitals Dorset, Royal Bournemouth Hospital, Bournemouth, United Kingdom
¹¹Hôpital Pitié-Salpêtrière, Service d'Hématologie, Paris, France
¹²Computational Genomics Group, Department of Molecular Medicine, University of Padua, Padova, Italy
¹³Hematology Section, St. Anna University Hospital, Ferrara, Italy
¹⁴Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
¹⁵Laboratoire d'hématologie, Hopital Avicenne, Assistance Publique-Hôpitaux de Paris, Paris, France
¹⁶Servicio de Genética. Hospital Universitario de Navarra, PAMPLONA, Spain
¹⁷Servicio de Hematología y Oncología Médica, Hospital Clinico Universitario de Valencia, Valencia, Spain
¹⁸Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
¹⁹Laboratori de Citogenètica, Servei de Patologia, Hospital del Mar, GRETNHE, IMIM, Barcelona, Spain
²⁰Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCSS, Padova, Italy
²¹Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
²²Strategic Research program on CLL, Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy
²³Institute of Applied Biosciences, Centre For Research and Technology Hellas,, Thessaloniki, Greece
²⁴Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany
²⁵Academic Medical Center, Amsterdam Zuidoost, NH, Netherlands
²⁶Department of Hematology, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Barcelona, Spain
²⁷First Department of Propedeutics,University of Athens, Athens, Greece
²⁸Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation, St. Petersburg, Russian Federation
²⁹Hematology Unit, Department of Medicine, University of Padova, Padova, Italy
³⁰Hematology, University Sapienza and Hospital Umberto I, Rome, Italy
³¹University of Cologne, Cologne, Germany
³²Division of Hematology, University of Ferrara, Ferrara, Ferrara, Italy
³³Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece
³⁴Universita' Vita-Salute San Raffaele C.F. 97187560152, Milano, MI, Italy
³⁵Computational Genomics Group, Department of Molecular Medicine, University of Padua,, Padova, Italy

Paul J. Hampel, MD¹, Kari G. Rabe, MS^2*, Yucai Wang, MD, PhD³, Saad S. Kenderian, MD³, Wei Ding, MD, PhD³, Eli Muchtar, MD¹, Jose F. Leis, MD, PhD⁴, Amber Koehler, PA-C^5*, Mazie Tsang, MD⁶, Ricardo Parrondo, MD⁷, Rachel Bubik, PharmD^1*, Susan Marie Schwager^1*, Curtis A. Hanson, MD^8*, Esteban Braggio, PhD⁹, Susan L. Slager, PhD¹⁰, Min Shi, MD, PhD^1*, Daniel L. Van Dyke, PhD¹, Timothy G. Call, MD³, Neil E. Kay, MD^3,11 and Sameer A. Parikh, MD¹²

¹Mayo Clinic, Rochester, MN
²Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Division of Hematology and Oncology, Mayo Clinic Arizona, Scottsdale, AZ
⁵Division of Hematology, Department of Medicine, Mayo Clinic, Rochester
⁶Mayo Clinic, Phoenix, AZ
⁷Mayo Clinic, Jacksonville, FL
⁸Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, Rochester, MN
⁹Department of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
¹⁰Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
¹¹Department of Immunology, Mayo Clinic, Rochester, MN
¹²Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN

Ahmad Alhuraiji¹, Ayman Alhejazi, MD^2*, Mohamed Samra^3*, Bhausaheb Bagal, MD, DM^4*, Miguel Arturo Pavlovsky, MD⁵, Macarena Roa^6*, Shang-Ju Wu^7*, Efreen H Montano Figueroa, MD^8*, Veena Selvaratnam, MBBS, FRCPath^9*, Chee-Yen Lin, MD^10*, Pushpalata K^11*, Akemi Ishikawa^12* and Francisco Gonzalez Hernandez^13*

¹Kuwait Cancer Centre, Shuwaikh, KWT
²College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
³National Cancer Institute, Cairo University, Cairo, EGY
⁴Department of Medical Oncology, Tata Memorial Centre, Mumbai, India
⁵FUNDALEU, Buenos Aires, Argentina
⁶Hospital Del Salvador, Santiago de Chile, Chile, Buenos Aires, ARG
⁷National Taiwan University Hospital, Taiwan, Taipei, TWN
⁸Hospital General de México, Ciudad de México, México, Ciudad de México, Mexico
⁹Ampang Hospital, Ampang, Malaysia
¹⁰National University Hospital (Singapore) Pte Ltd, Singapore, Singapore, Singapore
¹¹International Study Manager/International Evidence Generation Oncology, AstraZeneca Pharma India, India, India
¹²Pan-International CREEK Study Project Lead/Hematology Medical Manager, AstraZeneca Mexicoakemi, Mexico, Mexico
¹³International Medical Director, Hematology & Genitourinary Cancer, AstraZeneca, Switzlerland, Switzerland

John N. Allan, MD¹, Tao Ran, PhD^2*, Zhijie Ding, PhD^3*, Jinghua He, PhD, MPH^2*, Alex Bokun, PharmD^3*, Zaina P Qureshi, PhD, MS, MPH^3* and Susan M. O'Brien⁴

¹Weill Cornell Medicine, Long Island City, NY
²Janssen Scientific Affairs, LLC, Titusville, NJ
³Janssen Scientific Affairs, LLC, Horsham, PA
⁴Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA

Mazyar Shadman, MD, MPH¹, Ian W. Flinn, MD, PhD², Edwin C. Kingsley, MD^3*, Benjamin B. Freeman, MD⁴, Moshe Levy^5*, Charles M. Farber, MD, PhD^6*, James D'Olimpio, MD^7*, Jennifer L. Cultrera, MD⁸, Ben Zhang, MD^9*, Rocco J. Crescenzo, DO^10*, Adam Idoine, PhD^10*, Xiaoping Zhang, MD^10*, Kunthel By, PhD^10* and Jeff P. Sharman, MD¹¹

¹Fred Hutchinson Cancer Center, Seattle, WA
²Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN
³Comprehensive Cancer Centers of Nevada, Las Vegas, NV
⁴Summit Medical Group, Florham Park, NJ
⁵Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, TX
⁶Morristown Medical Center, Atlantic Hematology Oncology, Morristown, NJ
⁷North Shore University Hospital, Manhasset, NY
⁸Florida Cancer Specialists & Research Institute, Leesburg, FL
⁹Minnesota Oncology Clinic, Burnsville, MN
¹⁰BeiGene USA, Inc, San Mateo, CA
¹¹Willamette Valley Cancer Institute and Research Center/US Oncology Research, Eugene, OR

Jacob Soumerai¹, Thais Gift^2*, Zaid Yousif^2,3*, Raj Desai, PhD^4*, Lynn Huynh, DrPH, MBA, MPH^4*, Gregory Belsky^5*, Mei Sheng Duh, RPh, MPH, ScD⁴ and Marie Sanchirico^2*

¹Massachusetts General Hospital Cancer Center: Hematology Oncology, Boston, MA
²Takeda Pharmaceuticals USA, Inc., Lexington, MA
³University of California San Diego, La Jolla, CA
⁴Analysis Group, Inc., Boston, MA
⁵Mass General Brigham, Research Information Science & Computing, Somerville, MA

Riccardo Bomben^1*, Antonella Zucchetto, PhD^2*, Roberta Laureana^3*, Annalisa Chiarenza, MD^4*, Jacopo Olivieri^5*, Erika Tissino, PhD^6*, Francesca Rossi^7*, Filippo Vit, PhD^8*, Tamara Bittolo^1*, Robel Papotti^9*, Federico Pozzo, MSc^9*, Annalisa Gaglio^9*, Massimo Degan^9*, Jerry Polesel^10*, Roberto Marasca, MD¹¹, Gianluigi Reda, MD^12*, Andrea Visentin, MD, PhD^13*, Riccardo Moia, MD^14*, Idanna Innocenti, PhD^15*, Candida Vitale, MD, PhD^16*, Roberta Murru, MD^17*, Marzia Varettoni^18*, Agostino Tafuri, MD¹⁹, Francesco Zaja, MD^20*, Massimiliano Postorino^21*, Enrica Antonia Martino, MD^22,23*, Adalgisa Condolucci^24*, Davide Rossi²⁵, Antonio Cuneo, MD^26*, Francesco Di Raimondo, MD²⁷, Paolo Sportoletti, MD^28*, Ilaria Del Giudice^29*, Robin Foa^30*, Francesca Romana Mauro^31*, Marta Coscia, MD, PhD^32*, Luca Laurenti, MD^33*, Gianluca Gaidano, MD, PhD^34,35, Livio Trentin³⁶, Maria Ilaria Del Principe, MD^37*, Massimo Gentile, MD^22* and Valter Gattei, MD³⁸

¹CRO Aviano National Cancer Institute,Clinical and Experimental Onco-Hematology Unit, Aviano, Italy
²Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
³Division of Haematology, University of Tor Vergata, Rome, Roma, ITA
⁴Division of Hematology, Policlinico, Department of Surgery and Medical Specialties, University of Catania, Catania, Catania, Italy
⁵Clinica Ematologica, Centro Trapianti e Terapie Cellulari "Carlo Melzi", Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy
⁶Clinical and Experimental Onco-Hematology Unit, Centro Di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⁷Clinical and Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano (PN), ITA
⁸Clinical and Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, ITA
⁹Clinical and Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
¹⁰Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
¹¹Hematology Unit, Department of Oncology and Hematology, Azienda-Ospedaliero Universitaria (AOU) of Modena, Policlinico, Modena, Modena, Italy
¹²Division of Ematology, Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico di Milano, Milano, Milano, Italy
¹³Hematology unit, Department of Medicine, University of Padova, Padova, Italy
¹⁴Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Novara, Italy
¹⁵Fondazione Universitaria Policlinico A Gemelli di Roma, Roma, Roma, Italy
¹⁶A.O.U. Città della Salute e della Scienza di Torino, Torino, Torino, Italy
¹⁷Hematology and Stem Cell Transplantation Unit, Ospedale A. Businco, ARNAS G. Brotzu, Cagliari, CAGLIARI, Italy
¹⁸Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹⁹Department of Clinical and Molecular Medicine and Hematology, Sant'Andrea - University Hospital - Sapienza, University of Rome, Rome, Italy
²⁰DSM, University of Trieste, Trieste, Italy
²¹Division of Haematology, University of Tor Vergata, Rome, Roma, Italy
²²Department of Onco-Hematology, Hematology Unit AO of Cosenza, Cosenza, Italy
²³Biothecnology Research Unit, AO of Cosenza, Cosenza, Italy
²⁴Oncology Institute of Southern Switzerland and Institute of Oncology Research, Bellinzona, Bellinzona, Switzerland
²⁵Clinic of Hematology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
²⁶Division of Hematology, University of Ferrara, Ferrara, Ferrara, Italy
²⁷Division of Hematology, Policlinico, Department of Surgery and Medical Specialties, University of Catania, Catania, ITA
²⁸Centro di Ricerca Emato-Oncologica (CREO), Dipartimento di Medicina e Chirurgia, University of Perugia, Perugia, Italy
²⁹Hematology, Department of Translational and Precision Medicine, ‘Sapienza’ University, Rome, Rome, Italy
³⁰Hematology, University Sapienza and Hospital Umberto I, Rome, Italy
³¹Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
³²A.O.U. Città della Salute e della Scienza di Torino, Torino, Torino, To, ITA
³³Division of Hematology, Fondazione Universitaria Policlinico A Gemelli di Roma, Rome, Italy
³⁴SCDU Ematologia, AOU Maggiore della Carità, Novara, ITA
³⁵Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Novara, ITA
³⁶Department of Medicine, Hematology and Clinical Immunology Branch, Padua University School of Medicine, Padua, Italy
³⁷Hematology, Department of Biomedicine and Prevention, University Tor Vergata, Roma, Italy
³⁸Centro Di Riferimento Oncologico, Aviano, Italy

Enrica Antonia Martino, MD^1*, Francesca Romana Mauro^2*, Gianluigi Reda, MD^3*, Luca Laurenti, MD^4*, Andrea Visentin, MD, PhD^5*, Annamaria Frustaci^6*, Ernesto Vigna, MD^7*, Sara Pepe, MD, PhD^8*, Gioacchino Catania, MD^9*, Giacomo Loseto, MD^10*, Roberta Murru, MD^11*, Annalisa Chiarenza, MD^12*, Paolo Sportoletti, MD^13*, Maria Ilaria Del Principe, MD^14*, Marta Coscia, MD, PhD^15*, Sara Galimberti^16*, Alessandra Tedeschi^17*, Davide Rossi^18,19, Livio Trentin²⁰, Fortunato Morabito^21*, Valter Gattei, MD²² and Massimo Gentile, MD^23*

¹UOC Ematologia Cosenza, Cosenza, Italy
²Department of Translational and Precision Medicine, Hematology unit, 'Sapienza' University, Roma, Italy
³Hematology Department, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan, Milan, Italy
⁴S. Ematologia, Dipartimento Scienze Radiologiche Radioterapiche ed Ematologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
⁵Hematology unit, Department of Medicine, University of Padova, Padova, Italy
⁶Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
⁷U.O. Di Ematologia, Ospedale L'Annunziata, Cosenza, ITA
⁸Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
⁹Hematology and Marrow Transplant,, A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria, Alessandria, ITA
¹⁰IRCCS Istituto Tumori “Giovanni Paolo II”, Hematology Unit, Bari, Italy
¹¹Hematology and Stem Cell Transplantation Unit, Ospedale Oncologico A. Businco, ARNAS "G. Brotzu", Cagliari, Italy
¹²Division of Hematology, Policlinico, Department of Surgery and Medical Specialties, University of Catania, Catania, Catania, Italy
¹³Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy
¹⁴Hematology, Department of Biomedicine and Prevention, University Tor Vergata, Roma, Italy
¹⁵A.O.U. Città della Salute e della Scienza di Torino, Torino, Torino, To, ITA
¹⁶Ematologia di Pisa, Pisa, ITA
¹⁷Niguarda Ca' Granda Hospital, Milano, ITA
¹⁸Clinic of Hematology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
¹⁹Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
²⁰Hematology Unit, Department of Medicine, University of Padova, Padova, Italy
²¹Biothecnology Research Unit, AO of Cosenza, Cosenza, ITA
²²Centro Di Riferimento Oncologico, Aviano, Italy
²³Haematology, Azienda Ospedaliera di Cosenza, Cosenza, Italy, Cosenza, Italy

Francesco Autore^1*, Andrea Visentin, MD, PhD^2*, Marina Deodato, MD^3*, Candida Vitale, MD, PhD^4*, Eugenio Galli^5*, Alberto Fresa, MD^1*, RITA Fazzi^6*, Alessandro Sanna, MD^7*, Jacopo Olivieri^8*, Ilaria Scortechini^9*, Maria Ilaria Del Principe, MD^10*, Paolo Sportoletti, MD^11*, Luana Schiattone^12*, Nilla Maschio^13*, Davide Facchinelli^14*, Marta Coscia, MD, PhD^15*, Alessandra Tedeschi^16*, Livio Trentin¹⁷, Idanna Innocenti, PhD^18*, Anna Candoni, Professor, MD^19*, Alessandro Busca^20*, Livio Pagano, MD^21* and Luca Laurenti, MD^22*

¹Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
²Hematology unit, Department of Medicine, University of Padova, Padova, Italy
³Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
⁴A.O.U. Città della Salute e della Scienza di Torino, Torino, Torino, Italy
⁵Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
⁶Azienda Ospedaliera Universitaria Pisana, PIsa, Italy
⁷Hematology, AOU Careggi, Florence, Italy
⁸Clinica Ematologica, Centro Trapianti e Terapie Cellulari "Carlo Melzi", Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy
⁹Azienda ospedaliero Universitaria delle Marche, Ancona, Italy
¹⁰Hematology, Department of Biomedicine and Prevention, University Tor Vergata, Roma, Italy
¹¹Centro di Ricerca Emato-Oncologica (CREO), Dipartimento di Medicina e Chirurgia, University of Perugia, Perugia, Italy
¹²UOSD Centro Diagnosi e Terapia dei Linfomi, Presidio Ospedaliero Santo Spirito, Pescara, Italy
¹³Onco Hematology, Department of Oncology, Veneto Institute of Oncology IOV, IRCCS, Padua, Italy
¹⁴Ospedale San Bortolo, Vicenza, Italy
¹⁵A.O.U. Città della Salute e della Scienza di Torino, Torino, Torino, To, ITA
¹⁶ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
¹⁷Hematology Unit, Department of Medicine, University of Padova, Padova, Italy
¹⁸Fondazione Universitaria Policlinico A Gemelli di Roma, Roma, Roma, Italy
¹⁹Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Modena, Italy
²⁰S.S.C.V.D Trapianto di Cellule Staminali, A.O.U Citta della Salute e della Scienza di Torino – Torino, Italy, Torino, Italy
²¹Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Rome, Italy
²²Division of Hematology, Fondazione Universitaria Policlinico A Gemelli di Roma, Rome, Italy

Samuel Kosydar, MD^1*, Kari G. Rabe, MS^2*, Yucai Wang, MD, PhD³, Saad S. Kenderian, MD^1,3, Wei Ding, MD, PhD⁴, Eli Muchtar, MD⁵, Jose F. Leis, MD, PhD⁶, Amber Koehler, PA-C^7*, Mazie Tsang, MD⁸, Ricardo Parrondo, MD⁹, Talal Hilal, MD⁸, Rachel Bubik, PharmD^1*, Susan Marie Schwager^1*, Curtis A. Hanson, MD^10*, Esteban Braggio, PhD¹¹, Susan L. Slager, PhD², Min Shi, MD, PhD^1*, Daniel L. Van Dyke, PhD¹, Timothy G. Call, MD³, Neil E. Kay, MD^1,3, Sameer A. Parikh, MD¹² and Paul J Hampel, MD¹

¹Mayo Clinic, Rochester, MN
²Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Mayo Clinic-Rochester, Rochester, MN
⁵Mayo Clinic, Rochester, Minnesota, Rochester, MN
⁶Division of Hematology and Oncology, Mayo Clinic Arizona, Scottsdale, AZ
⁷Division of Hematology, Department of Medicine, Mayo Clinic, Rochester
⁸Mayo Clinic, Phoenix, AZ
⁹Division of Hematology-Oncology, Mayo Clinic, Jacksonville, FL
¹⁰Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, Rochester, MN
¹¹Department of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
¹²Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN

John N. Allan, MD¹, Daniel Helbig², Erin Mulvey², Sarah Nazir^2*, Sandra Stewart^2*, Melissa L. Lapinta^2*, Sarah C. Rutherford, MD², Jia Ruan, MD, PhD³, John P. Leonard⁴, Peter Martin, MD² and Richard R. Furman²

¹Weill Cornell Medicine, Long Island City, NY
²Weill Cornell Medicine, New York
³Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
⁴Weill Cornell Medicine, New York, NY

Boyu Hu, MD¹, Adam S Kittai, MD², Kenneth Boucher, PhD^1*, Tony Pomicter, MS^3* and Deborah M. Stephens, DO¹

¹Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
²Division of Hematology, The Ohio State University, Columbus, OH
³The University of Utah, Salt Lake City, UT

David Lavie^1*, Muhit Ozcan, MD², Arvind Chaudhry, MD, PhD^3*, Xuan Zhou^4*, Ima Paydar^4*, Mohammed Z.H. Farooqui, DO⁴ and Paolo Ghia, MD, PhD⁵

¹Hadassah Medical Center, Jerusalem, Israel
²Hematology Department, Ankara University School of Medicine, Ankara, Turkey
³Summit Cancer Centers, Spokane, WA
⁴Merck & Co., Inc., Rahway, NJ
⁵Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy

Nitin Jain, MD¹, James D'Olimpio, MD^2*, Andew gillis-Smith, MD^3*, Seung Tae Lee, MD⁴, Nirav N. Shah, MD⁵, Javier Pinilla-Ibarz, MD, PhD⁶, Catherine C. Coombs, MD⁷, Jacqueline C. Barrientos, MD⁸, Shuo Ma, MD, PhD⁹, Masaaki Sawa, PhD^10*, Kyoko Miyamoto^11*, Akinori Arimura, PhD^11*, Varsha Gandhi, PhD¹² and William G. Wierda, MD, PhD¹³

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Clinical Research Alliance, Westbury, NY
³Hematology/Oncology, University of Massachusetts, Worcester, MA
⁴Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD
⁵Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
⁶H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁷University of California, Irvine, Irvine, CA
⁸Mount Sinai Medical Center, Miami Beach, FL
⁹Department of Medicine, Division of Hematology/Oncology and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University Feinberg School of Medicine, Chicago, IL
¹⁰Carna Biosciences, Inc., Kobe, Japan
¹¹CarnaBio USA, Inc., South San Francisco, CA
¹²Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
¹³The University of Texas MD Anderson Cancer Center, Houston, TX