Peilin Ma^1*, Vinidhra Sridharan^2*, Krista Wollerman^1*, Debjani Dutta^3*, Ram Kumar Singh^3*, Sambuddo Mukherjee, Ph.D.^3*, Chad C. Bjorklund^4*, Patrick R Hagner, PhD^5*, Michael Amatangelo, PhD^5* and Anita K. Gandhi, PhD⁵

¹Formerly Bristol Myers Squibb, Princeton, NJ
²Bristol Myers Squibb, Basking Ridge, NJ
³Biocon Bristol Myers Squibb Research Center, Bangalore, India
⁴Bristol Myers Squibb, Princeton, NJ
⁵Bristol Myers Squibb, Summit, NJ

Jeremy Kinder, PhD^1*, Chanel Athena Estrada^1*, Brian Granger, BS^1*, Allison O'Rourke, PhD^1*, Ouwen Liang, BS^1*, Aaron Lampano, BS^1*, Garrett Zipp, BS^1*, Vandana Chaturvedi, PhD^1*, Xiaomeng Hu, PhD^1*, Chi Young^2*, Neal van Hoeven, PhD^1*, Sonja Schrepfer^3* and Terry J. Fry, MD¹

¹Sana Biotechnology, Seattle, WA
²Sana Biotechnology, South San Francisco, CA
³Sana Biotechnology, San Mateo, CA

Sinto Sebastian Chirackal, PhD^1*, Taro Hitosugi², Gregory Ahmann³, Esteban Braggio, PhD⁴, Marta Chesi, PhD⁵, P. Leif Bergsagel, MD⁶ and Rafael Fonseca, MD⁷

¹Haematology and Oncology, Mayo Clinic Arizona, Scottsdale, AZ
²Department of Oncology, Mayo Clinic, Rochester, MN
³Department of Hematology/Oncology, Mayo Clinic Arizona, Scottsdale, AZ
⁴Department of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁵Mayo Clinic Arizona, Scottsdale, AZ
⁶Mayo Clinic Arizona, Phoenix, AZ
⁷Division of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ

Anna Maria Corsale^1*, Marta Di Simone, PhD^2*, Mojtaba Shekarkar Azgomi, PhD^3*, Maria Speciale^2*, Emilia Gigliotta^4*, Francesca Garofano^5*, Cristina Aquilina^2*, Candida Vullo^6*, Nadia Caccamo^3*, Francesco Dieli, MD^7*, Serena Meraviglia^3*, Sergio Siragusa, MD⁸ and Cirino Botta, MD, PhD^3*

¹University of Palermo, CASTELDACCIA, Italy
²University of Palermo, Palermo, Italy
³University of Palermo, Palermo, ITA
⁴Department of Health Promotion, Mother and Child Care,Internal Medicine and Medical Specialties, Palermo, Italy
⁵University of Palermo, Palermo, AL, Italy
⁶Department of Health Promotion, Mother and Child Care,Internal Medicine and Medical Specialties, palermo, Italy
⁷University of Palermo, Palermo, PA, ITA
⁸Policlinico Universitario di Palermo, Palermo, ITA

Phaik Ju Teoh^1,2,3,4,5*, Ricardo De Matos Simoes, PhD^1,2,4,6*, Tae-Hoon Chung^7*, Torsten Steinbrunn, MD, PhD^8,9,10*, Lisa B Leypoldt, MD^1,2,4,11*, Olga Dashevsky, PhD^1,2,4,6*, Francisca Vazquez, Ph.D.^12*, Wee-Joo Chng, MBBS, PhD, FRCPath, FRCP^{13,14,15,16,17} and Constantine S Mitsiades, MD^1,2,4,6

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Medicine, Harvard Medical School, Boston, MA
³Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⁴Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA
⁵Cancer Science Institute of Singapore, Singapore, Singapore
⁶Ludwig Center, Harvard Medical School, Boston, MA
⁷National University of Singapore, Singapore, SGP
⁸Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Boston, MA
⁹Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
¹⁰Department of Internal Medicine II, University Hospital Würzburg, Wurzburg, Germany
¹¹Department of Hematology, Oncology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
¹²Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge
¹³National University Hospital National University Cancer Institute, Singapore, Singapore
¹⁴Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
¹⁵National University Hospital, Singapore, SGP
¹⁶Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore
¹⁷Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Rena Feinman, PhD¹, Ariel Aptekmann, PhD^1*, Iriana Colorado, MSc^1*, Samuel Roy, BSc^1*, Katelyn Quino, BSc^1*, Noreen Ahmed, MD^2*, Adolfo Aleman, MD, CCRP^3*, Rashmi Unawane, MBBS^4*, Joshua Zenreich, BSc^4*, Alana Barofsky, BSc^1*, Kashish Bhatt, MSc^1*, Michele L. Donato, MD⁵, Noa Biran, MD³ and David S. Siegel, MD, PhD^1,6

¹Center for Discovery & Innovation, Hackensack Meridian Health, Nutley, NJ
²Department of Internal Medicine, Hackensack Meridian Health, Hackensack, NJ
³Multiple Myeloma Division, John Theurer Cancer Center, Hackensack Meridian Health, Hackensack, NJ
⁴John Theurer Cancer Center, Hackensack, NJ
⁵Stem Cell Transplantation and Cellular Therapy Program, John Theurer Cancer Center, Hackensack Meridian Health, Hackensack, NJ
⁶Multiple Myeloma Division, Hackensack Univ. Med. Ctr., Hackensack, NJ

Chad C. Bjorklund^1*, Junfei Zhao, Ph.D^2*, Gaurav Jain, Ph.D.^3*, Natasha Shtraizent, Ph.D.^2*, Maria Ortiz, Ph.D.^4*, Sambuddo Mukherjee, Ph.D.^5*, Patrick R Hagner, PhD^2* and Anita K. Gandhi, PhD²

¹Bristol Myers Squibb, Princeton, NJ
²Bristol Myers Squibb, Summit, NJ
³Biocon Bristol Myers Squibb Research & Development Center, Bangalore, IND
⁴CITRE, Bristol Myers Squibb, Seville, Spain
⁵Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India

Milad Moloudizargari^1,2*, Ada Alice Dona^1,2*, Miso Park^3*, Theophilus Tandoh^1,2*, Mariam Murtadha, PhD^1,4*, Enrico Caserta^1,2*, Alexander Pozhitkov^1,2*, Yinghui Zhu^1,2,5*, Ottavio Napolitano^1,2*, James Sanchez^2*, Lokesh Nigam^1,2*, Amanda Duplan^1,2*, Arnab Chowdhury^2*, Lucy Y. Ghoda, PhD^6*, Jonathan Keats^2,7*, Scott R. Goldsmith², Michael Rosenzweig², Amrita Krishnan, MD⁸, John C. Williams^3* and Flavia Pichiorri^1,2

¹Department of Hematologic Malignancies Translational Science, City of Hope, Monrovia, CA
²Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA
³Department of Cancer Biology and Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, CA
⁴Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Los Angeles, CA
⁵Research Center for Translational Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
⁶Department of Hematologic Malignancies Translational Science, City of Hope, Duarte, CA
⁷Translational Genomics Research Institute, Phoenix, CA
⁸Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Irvine, CA

Oumaima Jaouadi, PhD^1*, Nathan Becker, MS^1*, Enze Liu, PhD^1*, Meng Jingwei, PhD^2* and Brian A. Walker, PhD¹

¹Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN
²High-Throughput Technologies, Chemical Genomics Core Facility, Indiana University School of Medicine, Indianapolis, IN

Shirong Liu, MD, PhD^1*, John M Hatcher, PhD^1*, Amanda Kofides^1*, Alexa G Canning, BA^1*, Jinhua Wang, PhD^2*, Xia Liu, MD^1*, Nickolas Tsakmaklis, BA^1*, Maria Luisa Guerrera, MD¹, Christopher J Patterson^1*, Zachary R Hunter, PhD¹, Shayna R Sarosiek¹, Jorge J. Castillo, MD¹, Sara J. Buhrlage, PhD^2* and Steven P. Treon, MD, PhD, FRCP¹

¹Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, MA
²Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA

Veronica Canarte, BS¹, Tyler Moser-Katz^2*, Catherine Gavile^1*, Benjamin G. Barwick³, Kelvin P. Lee, MD⁴ and Lawrence H. Boise⁵

¹Emory University, Atlanta, GA
²Emory University, Atlanta
³Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University, Atlanta, GA
⁴Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN
⁵Winship Cancer Institute of Emory University, Atlanta

Shirong Liu, MD, PhD^*, Amanda Kofides^*, Xia Liu, MD^*, Alexa G Canning, BA^*, Nickolas Tsakmaklis, BA^*, Maria Luisa Guerrera, MD, Christopher J Patterson^*, Zachary R Hunter, PhD, Kris Richardson, PhD^*, Catherine A. Flynn, NP^*, Kirsten Meid, MPH^*, Megan Little^*, Katherine Stockman^*, Timothy P. White^*, Shayna R Sarosiek, Jorge J. Castillo, MD and Steven P. Treon, MD, PhD, FRCP

Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, MA

Praneeth Reddy Sudalagunta, PhD^1*, Rafael Renatino-Canevarolo, PhD^2*, Mark B Meads, PhD^3*, David Noyes^3*, Alexandra Achille^3*, Maria Silva^1*, Xiaohong Zhao, MD, PhD^3*, Raghunandan Reddy Alugubelli^3*, Daniel Lastorino^4*, Oliver Hampton, PhD, MSc^5*, Ciara Louise L. Freeman, MD, PhD, MSc⁶, Stephen Wu, PhD^7*, Andrea Ellero, PhD^7*, Lauren C. Peres, PhD, MPH^8*, Doris K. Hansen, MD^8*, Tomer Mark, MD^7*, Christopher J. Walker, PhD^7*, Pietro Taverna, PhD⁷, Rachid Baz, MD⁸, Kenneth Shain, MD, PhD^8* and Ariosto Siqueira Silva, PhD^8*

¹Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center, Tampa, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁴NTRO Clinic Research Operations, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁵Science and Innovation Division, Aster Insights, Tampa, FL
⁶Moffitt Cancer Center, Tampa, FL
⁷Karyopharm Therapeutics Inc., Newton, MA
⁸H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Li Qin, PhD^1*, Luz Yurany Moreno Rueda, PhD, MSc^2*, Iqbal Mahmud, PhD^3*, Isere Kuiatse, PhD^2*, Wei Tan, PhD^2*, Hans Lee, MD², Krina K. Patel, MD, MSc², David E. Symer, MD, PhD², Elisabet E. Manasanch, MD² and Robert Z. Orlowski, MD, PhD^2,4

¹Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Bellaire, TX
²Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX

Maria Luisa Guerrera, MD¹, Zachary R Hunter, PhD¹, Kris Richardson, PhD^1*, Nickolas Tsakmaklis, BA^1*, Amanda Kofides^1*, Shirong Liu, MD, PhD^1*, Christopher J Patterson^1*, Eugenio Morelli, MD², Jorge J. Castillo, MD¹, Shayna R Sarosiek¹, Catherine A. Flynn, NP^1*, Kirsten Meid, MPH^1*, Andrew R. Branagan, MD³, Ruben D. Carrasco, MD, PhD^4*, Kenneth C. Anderson, MD², Nikhil C Munshi, MD^2*, Steven P. Treon, MD, PhD, FRCP¹ and Xia Liu, MD^1*

¹Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, MA
²Dana-Farber Cancer Institute, Harvard Medical School, The Jerome Lipper Multiple Myeloma Center, Boston, MA
³Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center, Boston, MA
⁴Dana-Farber Cancer Institute, Harvard Medical School, Department of Oncologic Pathology, Boston, MA

Ciara Louise L. Freeman, MD, PhD, MSc¹, Xiaohong Zhao, MD, PhD^2*, Mark B Meads, PhD^2*, Jerald Noble, PhD^1,3*, Raghunandan Reddy Alugubelli^2*, Rafael Renatino-Canevarolo, PhD^4*, Oliver Hampton, PhD, MSc^5*, Praneeth Reddy Sudalagunta, PhD^6*, Ariosto Siqueira Silva, PhD^6*, Rachid Baz, MD⁶, Melissa Alsina, MD^7*, Doris K. Hansen, MD⁸, Xiaofei Song, PhD^9* and Kenneth H. Shain, MD, PhD¹⁰

¹Moffitt Cancer Center, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
³Department of Clinical Science, H Lee Moffitt Cancer Center, Tampa, FL
⁴Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center, Tampa, FL
⁵Science and Innovation Division, Aster Insights, Tampa, FL
⁶H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁷H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁸Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL
⁹Department of Bioinformatics, Moffitt Cancer Center, Tampa, FL
¹⁰H. Lee Moffitt Cancer Center & Research Institute, Saint Petersburg, FL

Habib Hamidi, MPH, PhD^*, Rin Nakamura, MS^*, Sumi Roy, PhD^*, Kamalakannan Rajasekaran^*, Giovanni Diaz, PhD^*, Cedric Dos Santos, PhD and Teiko Sumiyoshi^*

Genentech, Inc., South San Francisco, CA

Ieuan Walker, MBBS, MSc, BSc, MRCP¹, Venetia D'Arcy, MA, MBBChir, MRCP, FRCPath^1*, Kane Foster, MSc^2*, Garima Khandelwal, PhD^2*, Georgina S.F. Anderson, PhD^3*, William Wilson^4*, Evie Fitzsimons^2*, Daria Galas-Filipowicz^2*, Rakesh Popat^5,6*, Karthik Ramasamy⁷, Matthew Streetly^8*, Ceri Bygrave, MD, FRCPath, MPhil^9*, Reuben Benjamin^10*, Ruth M de Tute, MSc, PhD, FRCPath^11*, Marquita Camilleri, MD^12*, Selina J Chavda, MBBS, BSc, MRCP^13*, Gavin Pang^14*, Sumaiya Kamora^14*, James D. Cavenagh, MD¹⁵, Elizabeth Phillips, MD¹⁶, Laura Clifton-Hadley^17*, Charlotte Tyson^14*, Fuad Fananapazir^14*, Krupali Parikh^14*, Roger Owen, MD, MRCP, FRCPath^18*, Javier Herrero^2*, Kwee Yong^19,20 and Michael A. Chapman, MD PhD¹

¹MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom
²Cancer Institute, University College London, London, United Kingdom
³MRC Toxicology Unit, University of Cambridge, Cambridge, ENG, United Kingdom
⁴Cancer Research UK & UCL Cancer Trials Centre, University College London Cancer Institute, London, United Kingdom
⁵NIHR UCLH Clinical Research Facility, University College London Hospitals NHS Foundation Trust, London, United Kingdom
⁶University College London, London, United Kingdom
⁷Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁸Guy´s and St Thomas´NHS Foundation Trust, London, United Kingdom
⁹Haematology, University Hospital Wales, Cardiff, United Kingdom
¹⁰King´s College Hospital, King’s College Hospital NHS Foundation Trust, London, United Kingdom
¹¹Institute of Oncology, Leeds, GBR
¹²Department of Haematology, Addenbrooke's Hospital, Cambridge, ENG, GBR
¹³University College London, London, GBR
¹⁴Cancer Research UK and UCL Cancer Trials Centre, University College London, London, United Kingdom
¹⁵Department of Haematology, St. Bartholomew's Hospital, London, GBR
¹⁶The Christie NHS Foundation Trust and The University of Manchester, Manchester, United Kingdom
¹⁷Cancer Research UK & UCL Cancer Trials Centre, UCL Cancer Institute, University College London, London, United Kingdom
¹⁸Leeds Teaching Hospitals NHS Trust, Haematological Malignancies Diagnostics Service, Leeds, United Kingdom
¹⁹Department of Haematology, University College London, London, United Kingdom
²⁰Research Department of Haematology, University College London Cancer Institute, London, United Kingdom

Matt Costello, MS^1*, Nina Park, BS^1*, Alyssa Neill, MS^1*, Edmond Wong, PhD^2*, Karin Müller, PhD^3*, Andrew Proffitt, MS^1*, Richie Huynh, BS^1*, Vishwa Rao, PhD^1*, Fang Sun, MD^1*, Aaron Bozzi, PhD^1*, Meera Ramanujam, PhD^1* and Sahar Usmani-Brown, PhD^1*

¹Alexion AstraZeneca Rare Disease, New Haven, CT
²AstraZeneca R&D Biologics Engineering, Biomedical Campus, Cambridge, United Kingdom
³Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, United Kingdom

Jiahui Li^1*, Michael Thomas Gambles^1*, Shannuo Li^1*, Jindřich Kopeček^1,2*, Douglas Sborov, MD, MS^3,4 and Jiyuan Yang^1*

¹Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT
²Department of Biomedical Engineering, University of Utah, Salt Lake City, UT
³Division of Hematology and Hematological Malignancies, University of Utah, Salt Lake City, UT
⁴Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT

Yan Cheng, PhD^1*, Fumou Sun^1*, Wancheng Guo, MD^2*, Hongwei Xu, DDS^1*, Prasanth Viswanathan, PhD^3*, Mark Manzano, PhD^3*, Eric Siegel^4*, Samer Al Hadidi, MD, MSc⁵, Carolina Schinke, MD⁵, Maurizio Zangari, MD⁵, Marta Chesi, PhD⁶, P. Leif Bergsagel, MD⁷, Frits van Rhee, MD, PhD⁵, Guido Tricot, MD^8*, John D Shaughnessy, Jr, PhD^8* and Fenghuang Zhan, MD, PhD⁵

¹Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical, Little Rock, AR
²Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for medical science, Little Rock, AR
³Department of Microbiology and Immunology, University of Arkansas for Medical, Little Rock, AR
⁴Department of Biostatistics, University of Arkansas For Medical Sciences, Little Rock, AR
⁵Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR
⁶Mayo Clinic Arizona, Scottsdale, AZ
⁷Division of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ
⁸Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas For Medical Sciences, Little Rock, AR

Leonie Rieger^1,2*, Kilian Irlinger^1,2*, Franziska Fuechsl^1,2*, Nicolas Barbian^1,2*, Marlene Tietje^1,2*, Melanie Faber^1,2*, Tobias Schulze^1,2*, Piero Giansanti^2,3*, Lenka Besse^4*, Christoph Driessen, MD⁴, Angela Krackhardt, MD^1,2,5*, Bernhard Kuster^2,5,6* and Florian Bassermann, MD^1,2,5*

¹Department of Hematology and Oncology, Technical University of Munich, Munich, Germany
²TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany
³Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, Munich, Germany
⁴Division of Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
⁵German Cancer Consortium of Translational Cancer Research (DKTK), Heidelberg, Germany
⁶Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany

Mariateresa Fulciniti, PhD¹, Shuhui Deng^2,3*, Sanika Dereibal^3*, Vera Joy Weiler^3*, Madhumouli Chatterjee^3*, Jessica Ng Fong^3*, Chandraditya Chakraborty, PhD^3*, Rao Prabhala, PhD^3*, Masood A. Shammas, PhD^3,4*, Anil Aktas-Samur, PhD^3*, Mehmet K. Samur, PhD^3*, Annamaria Gulla, MD³, Kenneth C. Anderson, MD¹ and Nikhil C Munshi, MD^4,5*

¹Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tianjin, CHN
³Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁴VA Boston Heathcare System, Boston, MA
⁵Harvard Medical School, Boston, MA

Yuji Hattori, PhD^1*, Takanori Kubo, PhD^2*, Seiji Nagano, MD, PhD^3*, Takahiko Miyama, MD, PhD^4*, Yoshitaka Taniguchi, MSc^1*, Yoshitaka Iba, MSc^1*, Nobuko Ohshima, PhD^1*, Rie Kanehara, MSc^4*, Takakazu Kawase, MD, PhD^4*, Masahide Takahashi, MD, PhD^1,4*, Hiroshi Kawamoto, MD, PhD^3* and Keichiro Mihara, MD, PhD⁵

¹Department of Cellular Immunotherapies for Cancer/Division of Translational Research, International Center for Cell and Gene Therapy, Fujita Health University, Toyoake, Japan
²Department of Life Science, Faculty of Pharmacy, Yasuda Women’s University, Hiroshima, Japan
³Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan
⁴Division of Immune Regenerative Medicine, International Center for Cell and Gene Therapy, Fujita Health University, Toyoake, Japan
⁵Department of Cellular Immunotherapies for Cancer/Division of Translational Research, International Center for Cell and Gene Therapy, Fujita Health University, Toyoake-Shi, AIC, Japan

Haruya Okamoto, MD^1*, Shinsuke Mizutani, MD, PhD^1*, Taku Tsukamoto, MD, PhD^1*, Yoko Katsuragawa-Taminishi, MD^1*, Reiko Isa, MD, PhD^2*, Kentaro Mizuhara, MD^1*, Ayako Muramatsu, MD^1*, Yuka Kawaji-Kanayama^1*, Takahiro Fujino, MD, PhD^1*, Yuji Shimura, MD, PhD^1* and Junya Kuroda, MD, PhD¹

¹Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan
²Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

Charlotte L.B.M. Korst^1,2*, Carolien Duetz, MD^1,2*, Wassilis S.C Bruins, MD, MSc^1,2*, A. Vera de Jonge, MD^1,2*, Kaz Groen, MD^1,2*, Christie P.M. Verkleij, MD^1,2*, Kristine A. Frerichs, MD^1,2*, Meliha Cosovic^1,2*, Inoka Twickler^1,2*, Rosa Rentenaar^1,2*, Merve Eken^1,2*, Paola Homan-Weert^1,2*, Philippe Moreau, MD, PhD^3*, Pieter Sonneveld, MD, PhD⁴, Sonja Zweegman, MD, PhD^1,2, Tuna Mutis, MD PhD^1,2* and Niels W.C.J. Van De Donk^1,2*

¹Department of Hematology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands
²Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, Netherlands
³University Hospital Hôtel-Dieu, Nantes, France
⁴Erasmus University Medical Center Cancer Institute, Rotterdam, Netherlands

Jinna Zhang^1,2*, Mengmeng Dong^1*, Anyong Xie, PhD^2,3* and Zhen Cai, PhD, MD^1*

¹Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Institute of Translational Medicine, Zhejiang University School of Medicine and Zhejiang University Cancer Center, Hangzhou, China
³Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

Gurpanna Saggu, PhD^1*, Min Young Lee^1*, Faith Dunbar^1*, Reshma Singh^2*, Kris Sachsenmeier^1*, Dan T. Vogl, MD, MSCE³, Shebli Atrash, MD^4*, Sarah A. Holstein, MD, PhD⁵, Omar Nadeem, MD⁶, Jonathan L. Kaufman, MD⁷, Adarsh Joshi^2*, Kaveri Suryanarayan^1* and Sabrina Collins^1*

¹Takeda Development Center Americas, Inc. (TDCA), Lexington, MA
²Takeda Development Center Americas, Inc., Lexington, MA
³Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
⁴Levine Cancer Institute, Charlotte, NC
⁵University of Nebraska Medical Center, Omaha, NE
⁶Dana-Farber Cancer Institute, Boston, MA
⁷Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA

Ping Zhou, MD, PhD^1*, Tanya Karagiannis, PhD^2*, Albert Tai, PhD^3*, Xun Ma, DDM, PhD^1*, Denis Toskic, BS^4*, Teresa Fogaren, NP^5*, Nancy Coady Lyons, NP^5*, Monika Pilichowska, MD, PhD^6*, Xia Wu, MD^5*, Stephanie Scalia, MS^1* and Raymond Comenzo, MD⁷

¹The John Davis Myeloma and Amyloid Program, Tufts Medical Center, Boston, MA
²Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA
³Data Intensive Studies Center, Tufts University, Medford, MA
⁴The John Davis Myeloma and Amyloid Program, Tufts Medical Center, Revere, MA
⁵Division of Hematology-Oncology, Department of Medicine, Tufts Medical Center, Boston, MA
⁶Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA
⁷Box 826, Tufts Medical Center, Boston, MA

Tracy T. Chow^1*, Michael Amatangelo^1*, Peilin Ma^2*, Chad C. Bjorklund^1*, Krista Wollerman^2*, Tiziana Civardi^3*, Phillip Koo^1*, Yue Zhu^1*, Paulo Maciag^1*, Jessica Katz¹, Aparna Raval^1*, Albert Oriol^4*, Robert Z. Orlowski, MD, PhD⁵, Darrell White⁶, Paul G. Richardson, MD⁷ and Anita K. Gandhi, PhD⁸

¹Bristol Myers Squibb, Princeton, NJ
²Formerly Bristol Myers Squibb, Princeton, NJ
³Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
⁴Catalan Institute of Oncology and Josep Carreras Institute, Hospital Germans Trias i Pujol, Badalona, Spain
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada
⁷Dana-Farber Cancer Institute, Boston, MA
⁸Bristol Myers Squibb, Summit, NJ

Connor Williams, BSc^1,2*, Jacqueline Noll, PhD^1,2*, Dylan Harnas^1,2*, Hayley Parkinson, BSc^1,2*, Duncan Hewett, PhD^1,2*, Kaitlin Wyllie^3*, Thomas Cox, PhD^3*, Andrew Zannettino, PhD^1,2*, Kate Vandyke, PhD^1,2* and Vasilios Panagopoulos, PhD^1,2*

¹Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia
²Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia
³Matrix & Metastasis Lab, The Garvan Institute, Sydney, NSW, Australia

Brian Van Ness, PhD¹, Amit K Mitra, PhD, MSc^2*, Lisa Wiesen^3*, Linda Banovic Baughn, PhD^4,5, Shaji Kunnathu Kumar, MD⁶, Joachim Petit^7*, Jeremiah Pfizer^8* and Kelli Gyotoku^5*

¹Department of Genetics, Cell biology & Development, University of Minnesota, Twin Cities, Minneapolis, MN
²Dept Drug Discovery and Development, Auburn University, Auburn, AL
³Cancer Center, Universiyt of Minnesota, Minneapolis, MN
⁴Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN
⁵Mayo Clinic, Rochester, MN
⁶Division of Hematology, Mayo Clinic, Rochester, MN
⁷Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁸Drug Discovery and Development, Auburn University, Auburn, AL

Lisa B Leypoldt, MD^1,2,3,4*, Torsten Steinbrunn, MD, PhD^1,2,4,5*, Phaik Ju Teoh^1,2,4,6,7*, Ricardo De Matos Simoes, PhD^1,2,4,8*, Ryosuke Shirasaki, MD^1,2,4,8,9* and Constantine S Mitsiades, MD^1,2,4,8

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA
³Department of Hematology, Oncology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁴Department of Medicine, Harvard Medical School, Boston, MA
⁵Department of Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany
⁶Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⁷Cancer Science Institute of Singapore, Singapore, Singapore
⁸Ludwig Center, Harvard Medical School, Boston, MA
⁹Department of Medical Oncology, Teikyo University Hospital, Tokyo, Japan

Elvira Garcia De Paco^1,2*, Caroline Soulet^3*, Guilhem Requirand^4*, Nicolas Robert^4*, Guillaume Cartron, MD, Ph-D^5,6,7*, Laure Vincent, MD^8*, Charles Herbaux, MD, PhD^9,10*, Maria Moriel-Carretero^3* and Jerome Moreaux, PhD^11,12,13,14

¹Institute of Human Genetics, Centre National de la Recherche Scientifique, Montpellier, France
²Department of Biological Hematology, CHU Montpellier, Montpellier, France
³Centre de Recherche en Biologie Cellulaire de Montpellier, Centre National de la Recherche Scientifique, Montpellier, France
⁴Department of Biological Hematology, Montpellier University Hospital Center, Laboratory for Monitoring Innovative Therapies, Montpellier, France
⁵Dept. Biological Hematology, Montpellier University Hospital Center, Montpellier, FRA
⁶Clinical Hematology Department, Montpellier University Hospital Center, Montpellier, France
⁷IGMM UMR 5535 CNRS UM, University of Montpellier, Montpellier, France
⁸Department of Clinical Hematology, Montpellier University Hospital Center, Montpellier, France
⁹Faculty of Medicine, University of Montpellier, Montpellier, France
¹⁰Clinical Hematology Department, Montpellier University Hospital, MONTPELLIER, France
¹¹Faculty of Medicine, University of Medicine, Montpellier, France
¹²Institut Universitaire de France, Paris, France
¹³Institute of Human Genetics, CNRS, Montpellier, France
¹⁴Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, Montpellier University Hospital Center, Montpellier, France

Seungbin Han^1*, Umair Munawar^2*, Larissa Haertle, PhD^3,4*, Cornelia Vogt^3*, Silvia Nerreter^3*, Eva Teufel^3*, Xiang Zhou^3*, Max Steinhardt^3*, Florian Eisele^5*, Peter Raab^6*, Marietta Truger^7*, Sara Dorado^8*, Santiago Barrio, PhD^4,8*, Claudia Haferlach, MD⁷, Joaquin Martínez-López^4*, Hermann Einsele, MD, PhD^9*, Leo Rasche, MD^9*, Johannes M Waldschmidt, MD¹⁰ and K. Martin Kortüm, MD^3*

¹Department of Internal Medicine II, University Hospital Würzburg, Wuerzburg, Germany
²Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany
³Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
⁴Department of Hematology, Hospital Universitario 12 de Octubre, Spanish National Cancer Research Center (CNIO), Complutense University Madrid, Madrid, Spain
⁵Department of Internal Medicine II, University Hospital Würzburg, WüRzburg, Germany
⁶Department of Orthopedic Surgery, Koenig Ludwig Haus, University of Wuerzburg, Wuerzburg, Germany
⁷MLL Munich Leukemia Laboratory, Munich, Germany
⁸Altum Sequencing Co., Madrid, Spain
⁹Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
¹⁰Department of Internal Medicine II, University of Wuerzburg Medical Center, Wuerzburg, Germany