Daniel Medina, MSc, BSc^1,2*, Laura Palomo, PhD^2,3*, Víctor Navarro^4*, Oriol Castells^1,2*, Belén Sánchez^1,2*, Pau Marc Muñoz Torres^5*, Carlota Pagès Geli^1,2*, Cristina Hernández^1,2*, Gemma Pujadas, PhD^1,2*, Alba Cabirta Touzón, MD^2,6*, Christelle Ferrà, PhD^7*, Miguel Alcoceba, PhD^8*, María José Terol, MD^9*, Rafael Andreu, MD, PhD^10*, Francesc Bosch, MD, PhD^1,2, Pau Abrisqueta, MD, PhD^1,2 and Marta Crespo, PhD^2,11*

¹Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
²Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain
³Experimental Hematology Unit,Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁴Oncology Data Science (ODysSey), Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁵Bioinformatic Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁶Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, AL, Spain
⁷Hematology Department, Institut Català d’Oncologia – Hospital Germans Trias i Pujol, Josep Carreras Research Institute, Badalona, Spain
⁸Department of Hematology, University Hospital of Salamanca (HUS/IBSAL), CIBERONC and Cancer Research Center of Salamanca-IBMCC (USAL-CSIC), Salamanca, Spain
⁹Hematology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain
¹⁰Hematology Service, Hospital Universitario Politécnico "La Fe", Valencia, Spain
¹¹Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain

Claudia Minici^1*, Paolo G. Cocomazzi^2*, Can Akpınaroğlu^3*, Anastasia Iatrou^4*, Maria Gounari, PhD^5*, Michela Frenquelli^6*, Lydia Scarfo, MD^7,8, Christian Buske, MD⁹, Andreas Agathangelidis^10*, Hassan Jumaa, PhD^11*, Palash Maity, PhD^12*, Paolo Ghia, MD, PhD¹³, Kostas Stamatopoulos¹⁴ and Massimo Degano, PhD^2,15*

¹Biocrystallography Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, ITA
²Biocrystallography Unit, Division of Immunology, Transplantation and Infectious, IRCCS San Raffaele Scientific Institute, Milano, Italy
³Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany
⁴Centre for Research and Technology Hellas, Institute of Applied Biosciences, Thessaloniki, Greece
⁵Centre for Research and Technology Hellas, Institute of Applied Biosciences, Thermi-Thessaloniki, Greece
⁶San Raffaele Scientific Institute, Milan, Italy
⁷Strategic Research program on CLL, Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy
⁸Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy
⁹Comprehensive Cancer Center Ulm, University Hospital Ulm, Ulm, Germany
¹⁰School of Biology, National and Kapodistrian University of Athens, Athens, Greece
¹¹Institute of Immunology, University Hospital of Ulm, Ulm, Germany
¹²Institute of Experimental Cancer Research, Medical Faculty, University Ulm, Ulm, Germany
¹³Universita' Vita-Salute San Raffaele C.F. 97187560152, Milano, MI, Italy
¹⁴Institute of Applied Biosciences, Centre for Research and Technology Hellas, Asvestohori, Greece
¹⁵Università Vita-Salute San Raffaele, Milano, MI, Italy

Pauline Robbe, PhD^1*, Kate Ridout, PhD^2*, Niamh Appleby^2*, Georgeta Ciuban^2*, Gagandeep Batth^2*, Helene Dreau, MSc^2*, Thomas Wenban-Smith^2*, Melinda Kormandy^3*, Grigore-Aristide Gafencu^2*, Piero Carninci^1*, Clare Freestone^3*, Daniel McAleese^2*, Dimitrios Vavoulis^2* and Anna Schuh, MD, PhD, FRCP, FRCPath⁴

¹Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan
²Department of Oncology, University of Oxford, Oxford, United Kingdom
³University of Oxford, Oxford, United Kingdom
⁴Oxford National Institute for Health Research Biomedical Research Centre/Molecular Diagnostic Centre, University of Oxford, Oxford, United Kingdom

Katia Pini^1*, Alessio Bruscaggin^1*, Maria Cristina Pirosa^1,2*, Gabriela Forestieri^1*, Joyce Marques de Almeida^1,2*, Georg Stüssi^2,3*, Mathias Oertli, PhD^4*, Xenia Schmidt^4*, Johannes Huelsenbeck^5*, Thomas Noesslinger^6*, Ingo Schwaner^7*, Monica Gallucci^8*, Heidi Simmons, PhD⁹, Davide Rossi^2,3,10 and Adalgisa Condoluci^1,2

¹Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland
²Clinic of Hematology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
³Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland
⁴AbbVie AG, Cham, Switzerland
⁵AbbVie Deutschland GmbH & Co. KG, Hämatologie, Wiesbaden, Germany
⁶Medizinische Abteilung für Hämatologie und Onkologie; Hanusch Krankenhaus, Vienna, Austria
⁷Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin, Germany
⁸Adaptive Biotechnologies Corporation, Seattle
⁹Adaptive Biotechnologies Corporation, Seattle, WA
¹⁰Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

Zhiquan Wang, PhD¹, Olivia M. Depies^1*, Sutapa Sinha, PhD^1*, Weiguo Han, PhD^1*, Sameer A. Parikh, MD² and Neil E. Kay, MD^1,3

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
³Department of Immunology, Mayo Clinic, Rochester, MN

Anita Ng, PhD¹, Andrew Shih^2*, Martina Cardillo^3*, Kristin Lynn Sticco, DO⁴, Houman Khalili^2*, Lita Crichton^5*, William Plunkett, PhD⁶, Varsha Gandhi, PhD⁷ and Nicholas Chiorazzi, MD⁸

¹Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
²Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, Manhasset, NY
³Irccs-Ospedale Policlinico San Martino, Genoa, ITA
⁴Stony Brook University Hospital, Stony Brook, NY
⁵Brown University, Providence, RI, Providence, RI
⁶M.D. Anderson Cancer Center, Houston, TX
⁷Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸The Feinstein Institute For Medical Research, Manhasset, NY

Muhammed B. Sabdia, BSc¹, Melinda Burgess^2,3*, Soi Cheng Law, PhD^1*, Lauren A Thurgood, PhD^4*, Stephen Kazakoff^5*, Fiona Swain^2,3*, Joshua W.D. Tobin, MD, PhD^1,3*, Peter Mollee, FRACP, MBBS, MSc, FRCPA⁶, Ann-Marie Patch, PhD^5* and Maher K. Gandhi, MBChB, PhD^1,3

¹Mater Research Institute, The University of Queensland, Woolloongabba, QLD, Australia
²Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia
³Department of Haematology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia
⁴Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia
⁵QIMR Berghofer Medical Research Institute, Herston, QLD, Australia
⁶Department of Haematology, Princess Alexandra Hospital, Brisbane, QLD, Australia

Sutapa Sinha, PhD^1*, Tammy Price-Troska, BS^1*, Shulan Tian, PhD^2*, R. Leo Sakemura, MD, PhD¹, Huihuang Yan, PhD^2*, Justin Boysen^1*, Zhiquan Wang, PhD¹, Xiaosheng Wu, MD^1*, Rong He, MD³, Min Shi, MD^3*, Yucai Wang, MD, PhD¹, Eric W Klee, PhD^2*, Sameer A. Parikh, MD⁴, Paul J Hampel, MD¹, Timothy G. Call, MD¹, Jose F. Leis, MD, PhD⁵, Tait D. Shanafelt, MD⁶, Stephen M Ansell, MD, PhD¹, Saad S. Kenderian, MD¹, Neil E. Kay, MD¹ and Wei Ding, MD, PhD^1*

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Computational Biology, Mayo Clinic, Rochester, MN
³Division of Hematopathology, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁵Division of Hematology and Oncology, Mayo Clinic Arizona, Scottsdale, AZ
⁶Department of Medicine, Division of Hematology, Stanford University, Stanford, CA

Shanmugapriya Thangavadivel, PhD^1*, Shrilekha Misra, PhD^2*, Samon Benrashid, BS^2*, Britten Gordon, BS², Alexander He, BS^2*, Tzung-Huei Lai, PhD^2*, Kerry A Rogers, MD¹, Seema A Bhat, MD¹, Adam S Kittai, MD¹, John C. Byrd, MD³, James S. Blachly⁴, Jennifer A. Woyach, MD⁵ and Bradley Wayne Blaser, MD, PhD⁶

¹Division of Hematology, The Ohio State University, Columbus, OH
²The Ohio State University, Columbus, OH
³Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
⁴Department of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁵The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁶Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

Eniko Papp^1*, Sahar Ansari, PhD^1*, Jason Wall, PhD^1*, Ethan Thompson, PhD^1*, Yizhe Chen^2*, Tanya Siddiqi, MD^3*, William G. Wierda, MD, PhD⁴, Serena K. Perna^2*, Sherilyn A. Tuazon^1*, Abood Okal, PhD^2* and Leanne Peiser, DPhil^1*

¹Bristol Myers Squibb, Seattle, WA
²Bristol Myers Squibb, Princeton, NJ
³City of Hope National Medical Center, Duarte, CA
⁴MD Anderson Cancer Center, Houston, TX

Ivo Veletic, MD^1*, David M. Harris, PhD^1*, Uri Rozovski, MD², Ping Li, PhD^1*, Zhiming Liu, BS^1*, Taghi Manshouri, PhD^1*, Maria Teresa S. Bertilaccio, PhD^3*, George A. Calin, MD, PhD^4*, Rares-Constantin Drula, MSc^4*, Koichi Takahashi, MD, PhD¹, Ken Furudate, DMD, PhD^1*, Muharrem Muftuoglu, MD⁵, Anwar Hossain, PhD^6*, Alessandra Ferrajoli, MD¹, Jan A. Burger, MD, PhD ⁷, Nitin Jain, MD¹, William G. Wierda, MD, PhD¹, Srdan Verstovsek, MD, PhD¹, Michael J. Keating, MBBS¹ and Zeev Estrov, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petach-Tikva, Israel
³Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, MD Anderson Cancer Center, Houston, TX

Marina Gerousi^1*, Georgios Gavriilidis^1*, Sofoklis Keisaris^1*, Artemis Kourouni^1*, Aspasia Orfanou^1*, Anastasia Iatrou^1*, Athanasios Pseftogkas^2,3*, George Mosialos^4*, Eleni Theodosiou^1*, Anastasia Chatzidimitriou^1*, Fotis Psomopoulos^1*, Paolo Ghia, MD, PhD^2,3, Kostas Stamatopoulos¹ and Konstantinos Xanthopoulos^1,5*

¹Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece
²Vita-Salute San Raffaele University, Milan, Italy
³Division of Experimental Oncology, B cell neoplasia, IRCCS Ospedale San Raffaele, Milan, Italy
⁴School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
⁵School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece