Yue Wei, PhD^1*, Ziyi Li, PhD^2*, Hui Yang, MD, PhD^3*, Hong Zheng^1*, Vicky Appleman^4*, Tiquella Hatten^4*, Yu-Chung Huang^4*, Jeffrey Raizer^4*, Alex Parent^4*, Neil Lineberry^4*, Guillermo Garcia-Manero, MD⁵ and Guillermo Montalban-Bravo, MD³

¹Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Takeda Development Center Americas, Inc, Cambridge, MA
⁵The University of Texas MD Anderson Cancer Center, Houston, TX

Yu-Hung Wang, MD, MSc^1,2*, Chien-Chin Lin, MD, PhD^2,3*, Kristian Gurashi, PhD^1*, Fabio Amaral, PhD^4*, Chi-Yuan Yao, MD^2,3*, Joanna Storer, PhD^1*, Luciano Nicosia, PhD, MS, BS^4*, Bettina Wingelhofer, PhD^4*, Hsin-An Hou, MD, PhD², Andres Jerez, MD, PhD^5*, Wen-Chien Chou, MD, PhD^2,3, Kiran Batta, PhD⁶, Hwei-Fang Tien, MD, PhD^2,7 and Daniel H Wiseman, MBBChir, FRCPath, MRCP, PhD^8*

¹The University of Manchester, Manchester, United Kingdom
²Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
³Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁴Cancer Research UK Manchester Institute, Manchester, United Kingdom
⁵Hematology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁶Division of Cancer Sciences, The University of Manchester, Manchester, ENG, United Kingdom
⁷Department of Internal Medicine, Far-Eastern Memorial Hospital, New Taipei, Taiwan
⁸Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom

Maroof Hasan^1*, Sadanand Vodala^1*, Sheida Hayati^2*, Guillermo Garcia-Manero, MD³, Anita K. Gandhi, PhD⁴ and Rajasekhar N.V.S. Suragani, PhD¹

¹Hematology, Translational Medicine and Disease Team, Bristol Myers Squibb, Summit, NJ
²Informatics and Predictive Sciences, Bristol Myers Squibb, Princeton, NJ
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Translational Development and Diagnostics, Bristol Myers Squibb, Summit, NJ

Lashanale Wallace, PhD¹, Jacquelyn A. Myers^1*, Mark Engelken^1*, David Cullins^2*, Heather Sheppard^3* and Esther A. Obeng, MD, PhD¹

¹Oncology, St. Jude Children's Research Hospital, Memphis, TN
²Hematology, St. Jude Children's Research Hospital, Memphis, TN
³Comparative Pathology Core, St Jude Children's Research Hospital, Memphis, TN

Theo Portlock, PhD^1*, Alessia Campagna^2*, Filippo Viviani, MD^2*, Matteo Zampini, PhD^2*, Francesca Ficara, PhD^3*, Laura Crisafulli, PhD^3*, Marta Ubezio, MD^2*, Antonio Russo, MD^2*, Gabriele Todisco, MD^2*, Elena Torre, MD^4*, Elena Saba, PhD^2*, Rita Antunes Dos Reis^4*, Mathias Uhlen, PhD^1*, Claire N Harrison⁵, Shahram Kordasti, MD, PhD⁶, Matteo Giovanni Della Porta, MD^2* and Saeed Shoaie, PhD^6*

¹Science for Life Laboratory, Royal Institute of Technology (KTH), Stockholm, Sweden
²Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy
³IRCCS Humanitas Research Hospital, Rozzano, Italy
⁴Comprehensive Cancer Centre, King's College London, London, United Kingdom
⁵Guy’s and St. Thomas’ NHS Foundation Trust, London, ENG, United Kingdom
⁶King's College London, London, United Kingdom

Johann-Christoph Jann, MD^1*, Nanni Schmitt, MSc^1*, Alexander Streuer^1*, Qingyu Xu, MD^1*, Vladimir Riabov, PhD^1*, Nadine Weimer^1*, Verena Nowak^1*, Julia Oblaender^1*, Iris Palme^1*, Melda Göl^1*, Marie Demmerle^1*, Felicitas Rapp^1*, Fabian Siegel^1*, Laurenz Steiner^1*, Angelika Duda^1*, Verena Haselmann^1*, Ali Darwich^1*, Ahmed Jawhar^1*, Mohamad Jawhar^1*, Georgia Metzgeroth, MD^2*, Wolf-Karsten Hofmann, MD² and Daniel Nowak^3*

¹Medical Faculty Mannheim of the Heidelberg University, Mannheim, Germany
²Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany
³Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Iva Trsová^1*, Andrea Hrustincova^1*, Monika Belickova^1,2*, Monika Kaisrlikova, PhD^1*, Zuzana Lenertová, MSc^1,3*, David Kundrat^1*, Zdenek Krejcik^1*, Jitka Vesela^1*, Jaroslav Cermak¹, Anna Jonasova, MD, PhD^4* and Michaela Dostalova Merkerova^1*

¹Institute of Hematology and Blood Transfusion, Prague, Czech Republic
²First Faculty of Medicine, Institute of Clinical and Experimental Hematology, Charles University, Prague, Czech Republic
³First Faculty of Medicine, Charles University, Prague, Czech Republic
⁴Charles University General Hospital 1st Department of Medicine, Prague, Czech Republic

Serhan Unlu, MD^1*, Christopher Haddad^2*, Danai Dima, MD³, Tariq Kewan, MBBChir⁴, Olisaemeka Ogbue¹, Waled Bahaj, MD⁵, Carlos Bravo-Perez, MD^1*, Luca Guarnera, MD^1*, Yasuo Kubota, MD, PhD^6*, Hetty E. Carraway, MD, MBA⁷, Carmelo Gurnari, MD^1*, Seth J Corey, MD⁸, Hrishikesh Mukesh Mehta, PhD^9*, Valeria Visconte, PhD¹ and Jaroslaw P. Maciejewski, M.D., Ph.D., FACP¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Westlake, OH
³Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁴Yale Cancer Center, Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT
⁵Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
⁶Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Beachwood, OH
⁷Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁸Departments of Pediatrics and Cancer Biology, Cleveland Clinic, Cleveland, OH
⁹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland, OH

Carmelo Gurnari, MD^1,2, Arda Durmaz^1*, Benjamin Kroger, BS³, Hussein Awada^1*, Jacky Chen^4*, Colin Hercus^5*, Sébastien Hergalant, PhD^6*, Carlos Bravo-Perez, MD^1*, Maria Teresa Voso, MD², Jacob Scott^1,7*, Valeria Visconte, PhD¹, Stephen S. Chung, M.D.³, Jaroslaw P. Maciejewski, M.D., Ph.D., FACP¹ and Simona Pagliuca, MD, PhD^8,9

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
³UT Southwestern Medical Cener, Dallas, TX
⁴Cleveland Clinic Lerner College of Medicine, Cleveland, OH
⁵Novocraft Technologies Sdn Bhd, Kuala Lumpur, Malaysia
⁶Inserm UMRS1256 Nutrition-Génétique et Exposition aux Risques Environnementaux (N-GERE), Université de Lorraine, Vandoeuvre-lès-Nancy, France
⁷Systems Biology and Bioinformatics Department, School of Medicine, Case Western Reserve University, Cleveland, OH
⁸Department of Hematology, Centre Hospitalier Régional Universitaire (CHRU), Nancy, France
⁹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland, OH

Ruohao Xu, Ph.D.^1*, Suxia Geng, M.D., Ph.D.^1*, Lingji Zeng, M.D.^1*, Chengxin Deng, M.D.^1*, Xin Huang, M.D., Ph.D.^1*, Minming Li, M.D.^1*, Ping Wu, M.D., Ph.D.^1*, Peilong Lai, M.D., Ph.D.^1*, Jianyu Weng, M.D., Ph.D.^1* and Xin Du, PhD^2*

¹Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
²Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, WA, China

Jonathan R.A. De Wilde, MD^1*, Titine J.J. Ruiter^1,2*, Brigitte A. van Oirschot^1*, Judith J.M. Jans^2*, Lenny Dang^3*, Megan Wind-Rotolo^3*, Noortje Thielen^4*, Wouter W. van Solinge^1*, Anna van Rhenen^5*, Richard van Wijk¹ and Minke A.E. Rab^1,5*

¹Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht, Netherlands
²Section Metabolic Diagnostics, Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands
³Agios Pharmaceuticals, Inc., Cambridge, MA
⁴Department of Internal Medicine, Diakonessenhuis, Utrecht, Netherlands
⁵Department of Hematology, University Medical Center Utrecht, Utrecht, Netherlands

Maha M Kamel, MBioChem, BScPharm^1,2*, Monika Kutyna, PhD^1,3*, David M. Ross, MBBS, PhD, FRACP, FRCPA^1,2,3,4,5*, Steven W. Lane, MD, PhD⁶, Chloe Thompson-Peach, PhD^1,2*, Chun Yew Fong^7*, Agnes S. M. Yong, MD, PhD^1,8, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^1,3, Timothy P Hughes, MD, MBBS, FRACP, FRCPA^3,9, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^1,3 and Daniel Thomas, MD, PhD^1,3,10

¹Blood Cancer, Precision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia
²Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia
³Haematology, Central Adelaide Local Health Network (CALHN), Adelaide, SA, Australia
⁴Department of Haematology, Flinders Medical Centre and University, Adelaide, SA, Australia
⁵Department of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia
⁶Cancer Program, QIMR BERGHOFER MEDICAL RESEARCH, Herston, Brisbane, AUS
⁷Department of Hematology, Austin Health, Heidelberg, VIC, Australia
⁸Haematology Department, Royal Perth Hospital, Perth, Australia
⁹South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia
¹⁰Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia

Oriol Calvete^1*, Julia Mestre^1*, Guillermo Montalban-Bravo, MD², Koji Sasaki, MD², Courtney D. DiNardo, MD, MSc², Ana Manzanares^1*, Pamela Acha^1*, Blanca Xicoy, MD^3,4*, Lurdes Zamora, PhD^3,4*, Isabel Granada, MD^3*, Alvaro Diaz-Gonzalez^5*, Esperanza Such, PhD^5*, Laura Palomo, PhD^6*, Maria Julia Montoro, MD, PhD^6*, Sara García, MD^7*, Leonor Arenillas, MD, PhD^7*, David Valcarcel Ferreiras, PhD^6*, Andres Jerez, MD, PhD^6*, Maria Diez-Campelo, MD, PhD^8*, Felipe Prosper, MD, PhD⁹, Hui Yang, MD, PhD^2*, Carlos E. Bueso-Ramos¹⁰, Guillermo Garcia-Manero, MD¹¹, Francesc Sole, PhD¹ and Rashmi Kanagal-Shamanna, MD¹²

¹Myelodysplastic Syndromes Research Group, Josep Carreras Leukaemia Research Institute, ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Haematology Department, Hospital Germans Trias i Pujol-Catalan Institute of Oncology., Badalona, Spain
⁴Myeloid Neoplasm Group, Josep Carreras Leukaemia Research Institute, ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
⁵Hematology Research Group, Hospital Universitari I PolitèCnic La Fe; Dep. of Hematology, University, Valencia, Spain
⁶Experimental Hematology. Hematology Department Vall d´Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d’Hebrón, Barcelona, Spain
⁷Hematology Department, Hospital del Mar, Barcelona, Spain
⁸Department of Hematology, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain
⁹Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain
¹⁰Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
¹¹University of Texas MD Anderson Cancer Center, Houston, TX
¹²Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX

Opeyemi Ajibade, MD, MS^1*, Urszula Pakulska, PhD^2*, Emma Rabinovich, MD³, Ariel Fromowitz³, Srabani Sahu^4*, Sarah Aminov, MSc³, Nandini Ramachandra, MS^4*, Srinivas Aluri, PhD^4*, Shanisha Gordon Mitchell^3*, Milagros Carbajal^3*, Kinga Keska-Izworska^5*, Michał Combik, PhD^5*, Marta Obacz, MSc^2*, Elżbieta Adamczyk, PhD^2*, Jan M. Zaucha^6*, Ewa Zarzycka, MD^7*, Przemyslaw Juszczynski, MD, PhD^8*, Jacqueline Boultwood, PhD^9*, Andrea Pellagatti, PhD^9*, Kith Pradhan, PhD^4*, Ulrich Steidl, MD, PhD³, Aditi Shastri, MD³, Rongbao Zhao, PhD^4*, Milena Mazan, PhD^2*, Tomasz Rzymski, PhD^5* and Amit Verma, MD¹⁰

¹Blood Cancer Institute, Department of Oncology, Albert Einstein College of Medicine, Brooklyn, NY
²Ryvu Therapeutics, Kraków, Poland
³Blood Cancer Institute, Department of Oncology, Albert Einstein College of Medicine, Bronx, NY
⁴Montefiore Einstein Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
⁵RYVU Therapeutics, Krakow, Poland
⁶Medical University of Gdansk, Gdansk, Poland
⁷Department of Hematology and Transplantology, Medical University of Gdansk, Gdansk, Poland
⁸Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, POL
⁹Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
¹⁰Department of Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY