Zanshe Thompson, PhD, MS¹, Li Z Luo, PhD^2*, Liping Li, MD, PhD^3*, Bowen Wang, MS^3*, Jung-Hyun Kim, PhD^3*, Hyunsung Woo, BS^4*, Bailey West, BS^5*, Anandi Krishnan, PhD^6*, Leslie Cope, PhD^7*, Alison R. Moliterno, MD⁸, Jerry L. Spivak, MD⁹ and Linda Resar, MD¹⁰

¹Division of Hematology, The Johns Hopkins University School of Medicine, Baltimore, MD
²Department of Medicine, Division of Hematology, The Johns Hopkins University School of Medicine, Baltimore, MD
³The Johns Hopkins University School of Medicine, Baltimore, MD
⁴Whiting School of Engineering, The Johns Hopkins University, Baltimore, MD
⁵Pathobiology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD
⁶Stanford University, Palo Alto, CA
⁷Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
⁸Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
⁹Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
¹⁰Division of Hematology, Departments of Medicine, Oncology & Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD

Jani Huuhtanen, M.D.^1,2,3*, Shady Adnan-Awad, M.D., Ph.D^4*, Jason Theodoropoulos, M.Sc.^5*, Sofia Forstén, M.Sc.^4*, Rebecca Warfvinge, M.Sc.^6*, Olli Dufva, M.D., Ph.D.^7*, Jonas Bouhlal^7*, Parashar Dhapola, M.Sc.^8*, Hanna Duàn, M.Sc.^9*, Essi Laajala, Ph.D.^7*, Tiina Kasanen^4*, Jay Klievink, M.Sc.^10*, Mette Ilander, Ph.D.^4*, Taina Jaatinen, Ph.D.^11*, Ulla Olsson-Strömberg, M.D., Ph.D.^12*, Henrik Hjorth-Hansen, M.D., Ph.D.¹³, Andreas Burchert, MD¹⁴, Göran Karlsson, Ph.D.^15*, Anna Kreutzman, Ph.D.^4*, Harri Lähdesmäki, Ph.D.^16* and Satu Mustjoki, MD, PhD⁴

¹Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
²iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland
³Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁴University of Helsinki, Helsinki, Finland
⁵Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁶Labratory Medicine, Lund, SWE
⁷ICAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland
⁸Lund University, Lund, SWE
⁹Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
¹⁰Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Ca, Helsinki, FIN
¹¹Finnish Red Cross Blood Service (histocompatibility Testing Laboratory), Helsinki, FIN
¹²Uppsala Uninversity, Uppsala, Sweden
¹³St. Olav's Hospital - Trondheim Univ. Hosp., Trondheim, NOR
¹⁴Department of Hematology, Oncology and Immunology, University Hospital Marburg, Marburg, Germany
¹⁵Lund Univeristy, Lund, SWE
¹⁶Department of Computer Science, Aalto University, Espoo, Finland

Linda Resar, MD¹, Zanshe Thompson, PhD, MS², Li Z Luo, PhD^3*, Donna Marie Williams, PhD^4*, Liping Li, MD, PhD^5*, Leslie Cope, PhD^6*, Iliana Herrera, BS^5*, Ophelia Rogers^4*, Alison R. Moliterno, MD⁴ and Jerry L. Spivak, MD¹

¹Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
²Hematology, The Johns Hopkins University School of Medicine, Baltimore, MD
³Department of Medicine, Division of Hematology, The Johns Hopkins University School of Medicine, Baltimore, MD
⁴Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
⁵The Johns Hopkins University School of Medicine, Baltimore, MD
⁶Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD

Mirielle Nauman, PhD^1*, Daniele Vanni, MD^1,2*, Nicole Arellano, BA^1,3, Thao Trang Nguyen^4*, James LaBelle⁵, Caner Saygin, MD^6*, Silvia Catricalà, PhD^7*, Ilaria Carola Casetti, MD, PhD^2*, Oscar Borsani, MD², Elisa Rumi, MD^2*, Daniela Pietra, PhD^8* and Shannon Elf, PhD^9,10,11

¹Ben May Department for Cancer Research, University of Chicago, Chicago, IL
²Department of Molecular Medicine, University of Pavia, Pavia, Italy
³Committee on Cancer Biology, University of Chicago, Chicago, IL
⁴Department of Pediatrics, Section of Hematology and Oncology, University of Chicago, Chicago, IL, Chicago, IL
⁵University of Chicago, Chicago, IL
⁶Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
⁷Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁸U.O.C Ematologia 1, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁹Division of Biological Sciences, The University of Chicago, Chicago, IL
¹⁰University of Chicago, The Ben May Department for Cancer Research, Chicago, IL
¹¹University of Chicago, The Committee on Cancer Biology, Chicago, IL

Alissa Oakes, BS^1*, Dennis M Bonal, MSc, BSc², Zoe Creane^1*, Hyunju Oh, BS^3*, Anna Dorota Chorzalska, PhD^4*, Brooke Sadler, PhD⁵, John L. Reagan, MD^6,7, Rabin Niroula^8*, Adam J Olszewski, MD^1,9,10,11, Gabriel Haller, PhD^12*, Stephen Donnelly, BS^13* and Patrycja M Dubielecka, PhD^14,15*

¹Brown University, Providence, RI
²Pathobiology Graduate Program, Brown University, Douglas, MA
³Warren Alpert Medical School, Brown University, Providence, RI
⁴Signal Transduction Lab, Rhode Island Hospital, Providence, RI
⁵Pediatrics, Washington University School of Medicine, Saint Louis, MO
⁶Legorreta Cancer Center of Brown University, Providence, RI
⁷Warren Alpert Medical School of Brown University, Providence, RI
⁸Lifespan Cancer Institute, The Warren Alpert Medical School of Brown University, Providence, RI
⁹Lifespan Cancer Institute, Warren Alpert Medical School of Brown University, Providence, RI
¹⁰Lifespan Cancer Institute, Providence, RI
¹¹Legorreta Cancer Center at Brown University, Lifespan Cancer Institute, Providence, RI
¹²Washington University at St. Louis, St. Louis, MO
¹³Lifespan Oncology Clinical Research, Rhode Island Hospital, Providence, RI
¹⁴Rhode Island Hospital and Warren Alpert Medical School At Brown University, Providence, RI
¹⁵Pathobiology Graduate Program, Brown University, Providence, RI

Dennis M Bonal, MSc, BSc^1,2,3, Anna Dorota Chorzalska, PhD^2,3*, Alissa Oakes, BS^2,4*, Makayla Pardo^2,5*, Zoe Creane^2,4*, Seo-Ho Lee^2,6*, Omonike Oyelola^3*, John L. Reagan, MD^2,3,7, Adam Olszewski, MD^3,8,9*, Rabin Niroula, MBBS^2,7, Stephen Donnelly, BS^10*, Joslyn Mills, PhD^11*, Paul Bertone, PhD^2,3* and Patrycja M Dubielecka, PhD^2,3,5*

¹Pathobiology Graduate Program, Brown University, Douglas, MA
²Legorreta Cancer Center of Brown University, Providence, RI
³Warren Alpert Medical School of Brown University, Providence, RI
⁴Brown University, Providence, RI
⁵Pathobiology Graduate Program, Brown University, Providence, RI
⁶Brown University, Amherst, MA
⁷Legorreta Cancer Center, Lifespan Cancer Institute Providence, Providence, RI
⁸Legorretta Cancer Center of Brown University, Providence, RI
⁹Legorreta Cancer Center at Brown University, Lifespan Cancer Institute Providence, Providence, RI
¹⁰Lifespan Oncology Clinical Research, Rhode Island Hospital, Providence, RI
¹¹Biology Department, Bridgewater State University, Bridgewater, MA

Malin S. Nilsson^1*, Hana Komic, MSc^2*, Johan Gustafsson, PhD^2*, Zahra Sheybani, MSc^2*, Sanchari Paul, MSc^2*, Ola Rolfson, MD, PhD^3*, Kristoffer Hellstrand, MD, PhD^2*, Lovisa Wennström, MD, PhD^4*, Anna Martner, PhD^2* and Fredrik B. Thorén^2*

¹Institute of Biomedicine, Gothenburg, Sweden
²TIMM Laboratory at Sahlgrenska Center for Cancer Research, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
³Department of Orthopaedics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden
⁴Department of Hematology, Sahlgrenska University Hospital, Gothenburg, Sweden

Fang Chen^1*, Dandan Zhao¹, Yi Zhang^1,2*, Yongfang Xu^1*, Min-Hsuan Chen^3*, Khyatiben V. Pathak^4,5*, Yong Liang^6*, Wei-Le Wang^7*, Katrina Estrella^1*, Xiwei Wu, PhD, MD^3*, Lucy Y. Ghoda, PhD^1*, Ya-Huei Kuo, PhD¹, Haris Ali, MD¹, Jianhua Yu, PhD⁸, Michael A Caligiuri, MD⁹, Mark Boldin^7*, Piotr Swiderski^6*, Marcin Kortylewski, PhD^10*, Patrick Pirrotte^4,5*, Le Xuan Truong Nguyen, PhD^1,4*, Guido Marcucci, MD¹ and Bin Zhang^1*

¹Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
²Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
³City of Hope National Medical Center, Integrative Genomics Core, Department of Computational and Quantitative Medicine, Beckman Research Institute, Duarte, CA
⁴Cancer & Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ
⁵Integrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA
⁶DNA/RNA Peptide Shared Resources, Beckman Research Institute, Duarte, CA
⁷Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA
⁸Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
⁹Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA
¹⁰Department of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA

Izabela Aparecida Lopes^1*, Camila Araújo Bernardino Garcia^1*, Leticia Olops Marini^1*, Amanda Fernandes Oliveira Costa^1*, Larissa Sarri Binelli^1*, Mariana Medeiros^1*, Josiane Lillian Schiavinato^1*, Priscila Santos Scheucher, PhD^2*, Cleide Lúcia Araújo Silva^3* and Lorena Lobo Figueiredo-Pontes¹

¹Division of Hematology, Hemotherapy, and Cellular Therapy, Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirao Preto, SP, Brazil., Ribeirão Preto, Brazil
²Division of Hematology, Hemotherapy, and Cellular Therapy, Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirao Preto, SP, Brazil., Ribeirao Preto, BRA
³Blood Center of Ribeirao Preto, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Ribeirão Preto, Brazil

David Frankhouser^1*, Dandan Zhao^2*, Russell C. Rockne, PhD^3*, Sergio Branciamore, PhD^3*, Lisa Uechi^3*, Denis O'Meally, PhD^3*, Ya-Huei Kuo, PhD⁴, Bin Zhang^2* and Guido Marcucci, MD⁵

¹Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, Beckman Research Institute, Duarte, CA
²Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
³Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁴Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁵Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA

Hung Chang, MD^1,2*, Hsiao-Wen Kao, MD^2*, Ming-Chung Kuo^2*, Jin-Hou Wu^2*, Ying-Jung Huang^2*, Ting-Yu Huang^2*, Tung-Huei Lin^2* and Lee-Yung Shih, MD^1,2

¹Chang Gung University, Taoyuan, Taiwan
²Chang Gung Memorial Hospital, Taoyuan, Taiwan

Meenu Kesarwani^1*, Mohammad Azhar^2*, Sekhu Ansari^3*, Zachary Kincaid, BS^2* and Mohammad Azam, PhD^2,4

¹Cincinnati Childrens Hospital Medical Center, Mason, OH
²Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Cincinnati Childrens Hospital Medical Center, Cincinnati, OH
⁴Cincinnati Children's Hospital, Cincinnati, OH

Kei Nakajima, MD^1* and Keita Kirito, MD²

¹Hematology and Oncology, University of Yamanashi, CHUO-SHI, YAMANASHI, Japan
²Department of Hematology and Oncology, University of Yamanashi, Chuo, Japan

Si Tuen Lee-Hoeflich^1*, Christopher Brueckner^1*, Lawrence Litalien^1*, Ke Xu^2*, Sharmila Das^2*, Laura Corella^2*, Sherif Daouti^2*, Oriana Esposito^3*, Emma Lees^1*, Yu Liu^1*, Zariana Nikolova^3*, Christopher Tehlirian^1*, Shodeinde Coker² and Bin Wu^1*

¹Bristol Myers Squibb, Cambridge Crossing, MA
²Bristol Myers Squibb, Princeton, NJ
³Bristol Myers Squibb, Neuchatel, Switzerland

Christophe Desterke, PhD^1*, Annelise Bennaceur Griscelli, MD, PhD^2,3,4* and Ali Turhan, MD, PhD^2,5,6

¹Faculty of Medicine, University Paris Saclay, Le Kremlin Bicetre, France
²Inserm U1310, Villejuif, France
³Center for iPSC Therapies, Evry Genopole, France
⁴University Paris Saclay-Division of Hematology, 94805, Villejuif, FRA
⁵Hopital Bicetre-Paris Sud 11 University, Le Kremlin Bicetre, France
⁶CITHERA, Center for iPSC Therapies, Evry, France

Benjamin Rolles, MD¹, Cilomar Martins De Oliveira Filho, MD², Julia Keating, MS^3*, Marlise R. Luskin, MD, MSCE⁴, Daniel J. DeAngelo⁴, Coleman Lindsley, MD, PhD⁴, Annette S. Kim, MD, PhD^5,6, Jessica Hem^7*, Chulwoo J. Kim^8*, Lachelle D. Weeks, MD, PhD⁹, Mohammed Wazir¹⁰, Joan How, MD^9,11, Anna E. Marneth, PhD^11,12, Yiwen Liu, MS^3*, Martin J. Aryee, PhD^3,13*, Harrison K. Tsai, MD, PhD^5,14*, Maximilian Stahl, MD¹⁵ and Ann Mullally, MD^9,11,16

¹Division of Hematology, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA
²Department of Medicine, Mass General Brigham, Salem Hospital, Salem, MA
³Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁴Dana-Farber Cancer Institute, Boston, MA
⁵Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁶Department of Pathology, University of Michigan, Ann Arbor, MI
⁷Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁸Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁰Department of Medicine, Division of General Internal Medicine, Brigham and Women's Hospital, Boston, MA
¹¹Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA
¹²Department of Laboratory Medicine, Division Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
¹³Broad Institute of MIT and Harvard, Cambridge, MA
¹⁴Department of Pathology, Boston Children’s Hospital, Boston, MA
¹⁵Dana Farber Institute, Boston, MA
¹⁶Broad Institute, Cambridge, MA

Laetitia Borderon^1*, Jihyun Song^2*, Soo Jin Kim, MS^2*, Christophe Marzac^3*, Christine Bellanné-Chantelot^4*, Nicolas Papadopoulos^5,6*, Stefan N. Constantinescu, MD, PhD^7,8, William Vainchenker, MD, PhD^1*, Isabelle Plo, MD, PhD^9*, Josef T. Prchal, MD² and Caroline Marty, PhD^1*

¹INSERM UMR1287, Gustave Roussy, Paris-Saclay University, Villejuif, France
²Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
³Laboratoire d'Immuno-Hématologie, INSERM UMR1287, Gustave Roussy, Paris-Saclay University, Villejuif, France
⁴INSERM UMR1287, Gustave Roussy, Villejuif, France
⁵Université catholique de Louvain and de Duve Institute, Brussels, Belgium
⁶Ludwig Institute for Cancer Research, Brussels, Belgium
⁷WELBIO (Wallon Excellence in Life Sciences and Biotechnology), Brussels, Belgium
⁸Oxford University, Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Oxford, United Kingdom
⁹INSERM, Villejuif, France

Jihyun Song, PhD and Josef T. Prchal, MD

Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT

Rodrigo Gil-Manso^1*, Gonzalo Carreño, MD, PhD^1*, Juan Carlos Hernandez Boluda, MD, PhD^2*, Raul Perez Lopez, MD, PhD^3*, Maria Teresa Gómez-Casares, MD, PhD^4*, Francisca Ferrer Marin, MD, PhD⁵, Eduardo Arellano-Rodrigo, MD^6*, Anna Angona, PhD^7*, Valentín García Gutiérrez, PhD⁸, Maria Soledad Noya^9*, María Alicia Senin, MD, PhD^10*, Elena Magro^11*, Irene Pastor^12*, María Isabel Mata^13*, Beatriz Cuevas^14*, Elvira Mora, MD, PhD^15*, Cristina Martinez, PhD^16*, Juan M. Alonso-Dominguez, MD, PhD^17*, Manuel Pérez-Encinas^18*, Gonzalo Caballero Navarro^19*, Miguel A. Cortes Vázquez^20*, Carmen del Río^1*, Joaquin Martinez Lopez, PhD, MD^1*, Rosa Ayala, MD, PhD^21* and Alberto Alvarez-Larran, MD^22*

¹Hospital Universitario 12 de Octubre, Madrid, Spain
²Hospital Clínico Universitario-INCLIVA, Valencia, Spain
³Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
⁴Hospital Universitario de Gran Canaria Dr. Negrín. Universidad de Las Palmas de Gran Canaria., Las Palmas de Gran Canaria, Spain
⁵Hospital Universitario Morales Meseguer. Centro Regional de Hemodonación. Universidad de Murcia. IMIB-Arrixaca, Murcia, Spain
⁶Department of Hemotherapy and Hemostasis, Hospital Clinic, Barcelona, Spain
⁷Hospital Universitario Doctor Josep Trueta - ICO, Girona, Spain
⁸Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Universidad de Alcalá, Madrid, Spain
⁹Hematology Department, University Hospital Juan Canalejo-CHUAC, La Coruña, Spain
¹⁰Institut Català d’Oncologia, Hospital Duran i Reynals. Institut d’Investigació Biomèdica de Bellvitge (IDIBELL). Universitat de Barcelona, Barcelona, Spain
¹¹Hematology Department. Hospital Príncipe de Asturias, Alcalá de Henares, Spain., Alcalá de Henares, Spain
¹²Hematology Department. Hospital Clínico, Valencia, Spain, Valencia, Spain
¹³12. Hematology Department. Hospital Costa del Sol, Marbella, Spain, Marbella, Spain
¹⁴Hospital de Burgos, BURGOS, ESP
¹⁵Hematology Research Group, Instituto de Investigación Sanitaria La Fe, Valencia, Spain
¹⁶Hospital Galdakao-Usansolo, Galdakao, Spain, Galdakao, Spain
¹⁷Instituto De InvestigacióN Sanitaria FundacióN JiméNez D, Madrid, ESP
¹⁸Hospital Clínico Universitario, Santiago de Compostela, Spain., Santiago, Spain
¹⁹18. Hematology Department. Hospital Miguel Servet, Zaragoza, Spain., Zaragoza, ESP
²⁰Hematology Department. Hospital Marqués de Valdecilla, Santander, Spain, Santander, Spain
²¹Hematology Department, Hospital 12 de Octubre (i+12), Centro Nacional de Investigaciones Oncológicas (CNIO), Complutense University, Madrid, Spain
²²Hematology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain