Jorge Cortes, MD¹, Michael Deininger, MD, PhD², Elza Lomaia, MD, PhD^3*, Beatriz Moiraghi, MD^4*, Soledad Undurraga, MD⁵, Carolina Pavlovsky, MD^6*, Charles Chuah, MD^7*, Tomasz Sacha, MD, PhD^8*, Jeffrey H. Lipton, MD, PhD⁹, James McCloskey, MD¹⁰, Andreas Hochhaus, MD¹¹, Philippe Rousselot, MD, PhD^12*, Gianantonio Rosti, MD^13*, Hugues de Lavallade, MD, PhD^14*, Anna Turkina, MD^15*, Lori Maness, MD¹⁶, Moshe Talpaz, MD¹⁷, Michael Mauro, MD¹⁸, Vickie Lu, PhD^19*, Alexander Vorog, MD^19* and Jane F Apperley, FRCP, FRCPath, MB²⁰

¹Georgia Cancer Center, Augusta, GA
²Versiti Blood Research Institute, Milwaukee, WI
³Almazov National Medical Research Centre, St. Petersburg, Russian Federation
⁴Hospital Jose Maria Ramos Mejia, Buenos Aires, Argentina
⁵Hospital del Salvador, Santiago, Chile
⁶Fundaleu, Buenos Aires, Argentina
⁷Singapore General Hospital, Duke-NUS Medical School, Singapore, Singapore
⁸Jagiellonian University Hospital in Krakow, Krakow, Poland
⁹Princess Margaret Cancer Centre, Toronto, ON, Canada
¹⁰Hackensack University Medical Center, Hackensack, NJ
¹¹Universitätsklinikum Jena, Jena, Germany
¹²Centre Hospitalier de Verailles, UMR1184, University Versailles Paris-Saclay, Versailles, France
¹³IRST/IRCCS “Dino Amadori”, Meldola (FC), Italy
¹⁴King's College Hospital NHS Foundation, London, United Kingdom
¹⁵National Medical Research Center for Hematology, Moscow, Russian Federation
¹⁶University of Nebraska Medical Center, Omaha, NE
¹⁷Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI
¹⁸Memorial Sloan Kettering, New York, NY
¹⁹Takeda Development Center Americas, Inc., Lexington, MA
²⁰Imperial College London, London, United Kingdom

Michele Malagola^1*, Alessandra Iurlo, MD, PhD^2*, Cristina Bucelli^3*, Elisabetta Abruzzese, MD⁴, Massimiliano Bonifacio, MD^5*, Fabio Stagno, MD, PhD⁶, Gianni Binotto, MD^7*, Mariella D'Adda, MD^8*, Monia Lunghi, MD, PhD^9*, Monica Crugnola, MD^10*, Maria Luisa Ferrari, MD^11*, Francesca Lunghi, MD^12*, Fausto Castagnetti, MD, PhD¹³, Gianantonio Rosti^14*, Roberto Massimo Lemoli, MD^15*, Rosaria Sancetta^16*, Maria Rosaria Coppi, MD^17*, Maria Teresa Corsetti, MD^18*, Matteo Dalmazzo^19*, Atelda Romano, MD^20*, Mario Tiribelli, MD^21*, Antonella Russo Rossi, MD^22*, Sabina Russo, MD^23*, Anna Sicuranza, PhD^24*, Aldo Roccaro, MD, PhD²⁵, Giulia Butturini^26*, Mirko Farina, MD^1*, Simona Bernardi, PhD^27*, Simone Pellizzeri^26*, Nicola Polverelli, MD²⁸ and Domenico Russo, MD, PhD^1*

¹Department of Clinical and Experimental Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST Spedali Civili, Brescia, Italy, Brescia, Italy
²Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
³Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, Milano, MI, ITA
⁴Department of Hematology, S Eugenio Hospital, Tor Vergata University, Roma, I, Italy
⁵U.O.C. di Ematologia, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy
⁶Division of Hematology and Bone Marrow Transplant, AOU Policlinico “Rodolico – San Marco”, Catania, Italy
⁷Department of Medicine, Hematology Unit, University of Padova, Padova, Italy, Padova, ITA
⁸ASST Spedali Civili Di Brescia, Brescia, ITA
⁹Amedeo Avogadro University of Eastern Piedmont, Novara, ITA
¹⁰Hematology Unit and BMT Center Azienda Ospedaliero Universitaria Parma, Parma, Italy
¹¹OSPEDALI RIUNITI DI BERGAMO, BERGAMO, ITA
¹²San Raffaele Institute Milano Italy, Milano, ITA
¹³Institute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy
¹⁴IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, Meldola, Italy, Meldola, ITA
¹⁵Clinic of hematology, Department of Internal medicine (DiMI), University of Genoa, Genoa, Italy
¹⁶Hematology Unit, Dell'Angelo Hospital, Venezia-Mestre, Italy, Mestre, Italy
¹⁷Haematology and BMT Unit "Antonio Perrino" Hospital, Brindisi, Italy, Brindisi, Italy
¹⁸SS. Antonio e Biagio Hospital, Alessandria, ITA
¹⁹Medicina Interna a Indirizzo Ematologico, Ospedale San Luigi, Orbassano, Italy., Torino, Italy
²⁰IRCCS Regina Elena National Cancer Institute, Rome, ITA
²¹Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
²²hematology, University of Bari, Bari, ITA
²³Division of Hematology, Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva,, Policlinico G Martino, University of Messina, Messina, Italy
²⁴Hematology, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy, Siena, Italy
²⁵Clinical Trial Center, Translational Research and Phase I Unit, ASST Spedali Civili di Brescia, Brescia, BS, Italy
²⁶Chair of Hematology, Dep of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy, Brescia, Italy
²⁷Centro di Ricerca Emato-Oncologica AIL (CREA), ASST Spedali Civili, Brescia, Italy
²⁸Unit of Blood Diseases and Bone Marrow Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy

Tomas Hornak, MD^1*, Jiri Mayer, MD^2,3, Petra Cicatkova^1*, Lukas Semerad^1*, Anezka Kvetkova^1*, Hana Klamova^4*, Edgar Faber^5*, Petra Belohlavkova^6*, Michal Karas^7*, Lukas Stejskal^8,9*, Eduard Cmunt^10*, Olga Cerna^11*, Dana Srbova^4*, Hana Zizkova^4*, Lucia Vrablova, MD^12*, Ivana Skoumalova^12*, Jaroslava Voglova^6*, Tereza Jurkova^13*, Marika Chrapava^13*, Tomas Jurcek^1*, Ivana Jeziskova^1*, Marie Jarosova^1*, Katerina Machova Polakova^4*, Tomas Papajik^5*, Pavel Zak^14*, Pavel Jindra^7* and Daniela Zackova, MD^15*

¹Dpt. of Internal Medicine Hematology and Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic
²Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital, Brno, Czech Republic
³Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
⁴Institute of Hematology and Blood Transfusion, Prague, Czech Republic
⁵Department of Hemato-Oncology, Faculty Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
⁶4th Dpt. of Internal Medicine and Hematology, University Hospital Hradec Kralove and Charles University, Hradec Kralove, Czech Republic
⁷Dpt. of Hemato-oncology, University Hospital Pilsen and Charles University, Pilsen, Czech Republic
⁸Dpt. of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic
⁹Dpt. of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
¹⁰1st. Internal Dpt, General University Hospital Prague, Prague, Czech Republic
¹¹Dpt. Of Hematology, University Hospital Kralovské Vinohrady and Charles University, Prague, Czech Republic
¹²Dpt. of Hemato-oncology, University Hospital Olomouc and Palacky University, Olomouc, Czech Republic
¹³Institute of Biostatistics and Analyses, Ltd., Brno, Brno, Czech Republic
¹⁴University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
¹⁵Masaryk University, Brno, Czech Republic

Xiao-shuai Zhang^1*, Bingcheng Liu, MD^2,3,4*, Jian Huang^5*, Xin Du, MD^6*, Yanli Zhang, MD^7,8*, Na Xu^9*, Xiaoli Liu^9*, Li Weiming, MD^10*, Hai Lin^11*, Huanling Zhu^12*, Yunfan Yang^13*, Ling Pan^13,14*, Xiao-jun Huang^1* and Qian Jiang, MD¹⁵

¹Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
³National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
⁴Tianjin Institutes of Health Science, Tianjin, China
⁵Department of Hematology, The First Affiliated Hospital of Zhejiang University, College of Medicine, Zhejiang University. Department of Hematology, The Fourth Affiliated Hospital of Zhejiang University, College of Medicine, Zhejiang University. Zhejiang P, Zhejiang, China
⁶Division of Hematology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
⁷Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
⁸Department of Hematology, Henan Cancer Hospital, Zhengzhou, China
⁹Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
¹⁰Department of Hematology, Union Hospital, Tongji Medical Collage, Huazhong University of Science and Technology, Wuhan, China
¹¹Department of hematology, First Hospital of Jilin University, Jilin, China
¹²Department of Hematology, West China Hospital, Sichuan University, Chengdu, China
¹³Department of Hematology, West China Hospital of Sichuan University, Chengdu, China
¹⁴West China Hospital, Sichuan University, Chengdu, China
¹⁵Peking University Peoples Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, Beijing, China

Valentina Giai, MD, PhD^1*, Fabio Stagno, MD, PhD², Tiziana Rosso, PhD^3*, Fausto Castagnetti, MD, PhD^4,5, Isabella Capodanno, MD^6*, Massimiliano Bonifacio, MD^7,8*, Mario Tiribelli, MD^9*, Sara Galimberti, MD, PhD^10*, Monica Bocchia, MD^11*, Antonella Gozzini, MD^12*, Giovanni Caocci, MD¹³, Andrea Patriarca, MD^14*, Giuseppe Lanzarone, MD^15*, Anna Guella, MD^16*, Federica Sorà, MD^17*, Luigiana Luciano, MD¹⁸, Anna Rita Scortechini, MD^19*, Nicola Di Renzo, MD^20*, Pellegrino Musto, MD^21*, Domenico Pastore, MD^22*, Alessandro Maggi, MD^23*, Carmen Fava, MD, PhD^24,25*, Vincenzo Pavone, MD^26*, Claudio Fozza, MD^27*, Giuseppina Spinosa, MD^28*, Angelo Michele Carella, MD^29*, Giuseppe Tarantini, MD^30*, Bruno Martino, MD^31*, Michele Pizzuti, MD^32*, Clara Mannarella^33*, Fabio Saccona^34*, Gianantonio Rosti, MD^35*, Patrizia Pregno, MD^36*, Massimo Breccia^37*, Fabrizio Pane, MD³⁸, Giovannino Ciccone, MD^39*, Giorgina Specchia, MD, PhD⁴⁰ and Giuseppe Saglio, MD⁴¹

¹Division of Hematology, Città della Salute e della Scienza, Turin, Italy
²Division of Hematology and Bone Marrow Transplant, AOU Policlinico “Rodolico – San Marco”, Catania, Italy
³Clinical Epidemiology Unit and CPO Piemonte, Città della Salute e della Scienza, Turin, Italy
⁴Department of medical and Surgical Sciences, University of Bologna, Bologna, Italy
⁵Hematology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
⁶Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy
⁷Department of Medicine, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy
⁸Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area, University of Verona, Verona, Italy
⁹Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
¹⁰Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy
¹¹Hematology, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy
¹²Hematology, AOU Careggi, University of Florence, Florence, Italy
¹³Department of Medical Sciences and Public Health, University of Cagliari, Businco Hospital, Cagliari, Italy
¹⁴Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
¹⁵Department of Molecular Biotechnology and Health Sciences, Division of Hematology, University of Turin, Turin, Italy
¹⁶Hematology Unit, Santa Chiara Hospital, APSS Trento, Trento, Italy
¹⁷Institute of Hematology, Università Cattolica Sacro Cuore, Roma, Italy
¹⁸Hematology Unit, Federico II University, Napoli, Italy
¹⁹Division of Hematology, Department of Molecular and Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
²⁰Haematology, Ospedale V. Fazzi, Lecce, Italy, Lecce, Italy
²¹Haematology, Department of Precision and Regenerative Medicine and Ionian Area, "Aldo Moro" University School of Medicine, Bari, Italy; Hematology and Stem Cell Transplantation Unit, AOU Consorziale Policlinico, Bari, Italy
²²Haematology, Ospedale A. Perrino, Brindisi, Italy, Brindisi, Italy
²³Haematology, Ospedale S.G. Moscati, Taranto, Italy
²⁴Hematology, Mauriziano Hospital, Torino, Turin, Italy
²⁵Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
²⁶Hematology Unit, Azienda C. Panico, Tricase, Italy
²⁷Hematology Unit – Azienda Ospedaliera Universitaria of Sassari, University of Sassari, Sassari, Italy
²⁸Hematology Unit, Policlinico Riuniti Ospedaliero Universitario, Foggia, Italy
²⁹Hematology Unit, IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Italy
³⁰Haematology, Ospedale "Mons. Dimiccoli", Barletta, Italy
³¹Hematology Unit, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", Reggio Calabria, Italy
³²Department of Onco-Hematology, “San Carlo” Regional Hospital, Potenza, Italy
³³Hematology Unit, Ospedale Madonna delle Grazie, Matera, Italy
³⁴Clinical Epidemiology Unit and CPO Piemonte, Città della Salute e della Scienza, Torino, Italy
³⁵Medical Oncology Unit, IRST/IRCCS “Dino Amadori,”, Meldola (FC), Italy
³⁶Former at Division of Hematology, Città della Salute e della Scienza, Torino, Italy
³⁷Department of Translational and Precision Medicine, Hematology-Sapienza University, Rome, Italy
³⁸Dipartimento Medicina Clinica e Chirurgia, UOC Ematologia e Trapianti di Midollo, Azienda Ospedaliera Universita Federico II, Napoli, Italy
³⁹SSD Epidemiologia Clinica e Valutativa, AOU Città della Salute e della Scienza e CPO Piemonte, Torino, Italy
⁴⁰Former Full Professor of Hematology, University of Bari, Bari, Italy
⁴¹Dept. of Clinical and Biological Sciences, University of Turin, Turin, Italy

Fabrizio Pane, MD^1*, Fausto Castagnetti, MD, PhD², Alfonso Piciocchi, MS^3*, Elisabetta Abruzzese, MD⁴, Renato Bassan^5*, Gianni Binotto, MD^6*, Massimiliano Bonifacio, MD^7*, Giovanni Caocci, MD⁸, Francesco Cavazzini, MD^9*, Giuseppe Cimino, MD^10*, Antonella Gozzini, MD^11*, Monia Lunghi, MD, PhD^12*, Roberto Marasca, MD¹³, Bruno Martino, MD^14*, Francesco Muriano, MD^15*, Gianantonio Rosti, MD^16*, Antonella Russo Rossi, MD^17*, Simona Sica^18*, Agostino Tafuri, MD¹⁹, Daniele Vallisa, MD^20*, Monica Messina, PhD^3*, Francesca Paola Paoloni^21*, Paola Fazi, MD^3*, Peter E Westerweel^22*, Jeroen J.W.M. Janssen, MD, PhD²³, Giuseppe Saglio, MD²⁴ and Massimo Breccia^25*

¹University of Naples, Napoli, Italy
²Institute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy
³GIMEMA Foundation, Data Center and Health Outcomes Research Unit, Rome, Italy
⁴Department of Hematology, S Eugenio Hospital, Tor Vergata University, Roma, I, Italy
⁵Ospedali Riuniti, Mestre-Venezia, ITA
⁶Department of Medicine, Hematology Unit, University of Padova, Padova, Italy, Padova, ITA
⁷Department of Medicine, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy
⁸Department of Medical Sciences and Public Health, University of Cagliari, Businco Hospital, Cagliari, Italy
⁹Division of Hematology, University of Ferrara, Ferrara, Ferrara, ITA
¹⁰University of Rome, Hematology, Rome, ITA
¹¹AOU Careggi, Firenze, FI, ITA
¹²Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
¹³Hematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy
¹⁴Hematology Unit, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", Reggio Calabria, Italy
¹⁵Hematology, University of Naples, Naples, Italy
¹⁶Medical Oncology Unit, IRST/IRCCS “Dino Amadori,”, Meldola (FC), Italy
¹⁷Hematology and Bone Marrow Transplant, University of Bari, Bari, Italy
¹⁸Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy
¹⁹Department of Clinical and Molecular Medicine and Hematology, Sant'Andrea - University Hospital - Sapienza, University of Rome, Rome, Italy
²⁰Civic Hospital of Piacenza, Piacenza, ITA
²¹GIMEMA Data Center, Rome, ITA
²²Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
²³Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
²⁴Dept. of Clinical and Biological Sciences, University of Turin, Turin, Italy
²⁵Department of Translational and Precision Medicine, Hematology-Sapienza University, Rome, Italy

Claudia Haferlach, MD, Wencke Walter, PhD^*, Heiko Mueller, PhD^*, Sandra Huber, PhD^*, Constance Regina Baer, PhD, Stephan Hutter, PhD^*, Manja Meggendorfer, PhD, Gregor Hoermann, MD, PhD, Wolfgang Kern, MD and Torsten Haferlach, MD, PhD

MLL Munich Leukemia Laboratory, Munich, Germany

Li Weiming, MD^1*, Yanli Zhang, MD^2*, Zhiwei Wu^3*, Qin Wen, MD^4*, Qing Leng^5*, Shuting Wu^6*, Xiaodong Wang^7*, Shiming Chen^8*, Guolin Yuan^9*, Sixuan Qian^10*, Suning Chen^11*, Daozi Jiang, MD^12*, Lianjun Diao^13*, Zhenfang Xi^14*, Hui Wu^15*, Hui Sun^16*, Lijie Yang^17*, Hongjuan Wang^18*, Xuefang Zhang^19*, Yanli Xu^20*, Xielan Zhao^21*, Na Xu^22*, Li Meng^23*, Zunmin Zhu, MD, PhD^24*, Youfang Zhao^25*, Meifang Su^26*, Zhuangzhi Yang^27*, Chuancai Liu^28*, Danlei Han^29* and Yu Hu, MD^30*

¹Department of Hematology, Union Hospital, Tongji Medical Collage, Huazhong University of Science and Technology, Wuhan, China
²Department of Hematology, Henan Cancer Hospital, Zhengzhou, China
³Department of Hematology, Jingmen Central Hospital, Jingmen, China
⁴Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, China
⁵Department of Hematology, Anshan Central Hospital, Anshan, China
⁶Department of Hematology, Bazhong Central Hospital, Bazhong, China
⁷Department of Hematology, Sichuan Provincial People's Hospital, Chengdu, China
⁸Department of Hematology, Yellowstone Central Hospital, Huangshi, China
⁹Department of Hematology, Xiangyang Central Hospital, Xiangyang, China
¹⁰Department of Hematology, Jiangsu Provincial People's Hospital, Nanjing, China
¹¹National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China
¹²Department of Hematology, Hubei Provincial People's Hospital, Wuhan, China
¹³Department of Hematology, Datong Fifth People's Hospital, Datong, China
¹⁴Department of Hematology, Linfen People's Hospital, Linfen, China
¹⁵Department of Hematology, Hanchuan People's Hospital, Xiaogan, China
¹⁶Department of Hematology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
¹⁷Department of Hematology, Xi'an International Medical Center Hospital, Xi'an, China
¹⁸Department of Hematology, Yuncheng Hospital of Traditional Chinese Medicine, Yuncheng, China
¹⁹Department of Hematology, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar, China
²⁰Department of Hematology, Nanjing First Hospital, Nanjing, China
²¹Xiangya Hospital Central South University, Changsha, China
²²Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
²³Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²⁴Department of Hematology, Henan Provincial People’s Hospital, Zhengzhou, China
²⁵Department of Hematology, Gezhouba Central Hospital, Yichang, China
²⁶Department of Hematology, Huanggang Central Hospital, Huanggang, China
²⁷Department of Hematology, Suizhou Central Hospital, Suizhou, China
²⁸Department of Hematology, Ezhou Central Hospital, Ezhou, China
²⁹Department of Hematology, Yichang Central Hospital, Yichang, China
³⁰Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

David Andorsky, MD^1*, Ghayas C. Issa², Edward R Broun, MD^3*, Camille N. Abboud, MD⁴, Michael W. Deininger, MD, PhD⁵, Michael Mauro, MD⁶, Andrea Damon, PhD^7*, Natasha Porter^7*, Najma Ashraf^7* and Moshe Levy^8*

¹Rocky Mountain Cancer Centers, Boulder, CO
²The University of Texas MD Anderson Cancer Center, Houston, TX
³Oncology Hematology Care, Cincinnati, OH
⁴Washington University School of Medicine, Saint Louis, MO
⁵Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, UT
⁶Memorial Sloan Kettering Cancer Center, New York, NY
⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁸Baylor Scott & White Health, Dallas, TX

Kelly Schoenbeck, MD¹, Anousheh Afjei^2* and Neil P. Shah, MD, PhD³

¹Division of Hematology and Oncology, University of California San Francisco, San Francisco, CA
²Division of Hospital Medicine, University of California San Francisco, San Francisco, CA
³University of California San Francisco, San Francisco, CA

Meriem Benmerad, MSc, DipEng^1*, Jules Chassetuillier, DipEng^1*, Christophe Bouvier, DM^2,3*, Pierre-Louis Lecoq, MSc^4*, Romain Favier, PharmD^4*, Matthieu Trancart, MSc, Eng^4*, Sandrine Hayette, PhD^3,5*, Julien Bollard, PhD^6*, Audrey Lajoinie^1* and Franck E. Nicolini, MD, PhD^7,8

¹RCTS, Lyon, France
²Equipe Evaluation Médicale et Sarcomes (EMS), Centre Léon Bérard, Lyon, France
³Fi-LMC, Lyon, France
⁴Novartis Pharma S.A.S, Rueil Malmaison, France
⁵Laboratory of Hematology, Centre Hospitalier Lyon Sud, Pierre Benite, FRA
⁶Hematology Department, Centre Leon Berard, Lyon, France
⁷Hematology department & CRCL INSERM U1052, Centre Léon Bérard, Lyon, France
⁸Fi-LMC group, Lyon, France

Ziyu Wen^1*, Ying Zhao^2*, Guowei Li^3*, YongZhong Su^4*, FeiHeng Chen^4*, HongFang Tao^4*, ZhengJin Zheng^5*, Wuqiang Lin^6*, XiuLi Chen^6*, Meili Meng^7*, Lian Yu^8*, LongTian Chen^8*, JianQing Huang^8*, Guocai Wu^9*, Mengxia Zhao^10*, Zhenfang Liu, MD^11*, Hongqian Zhu^12*, Yirong Jiang^10*, Qifa Liu, MD¹³, Xiaoli Liu^14* and Na Xu^14*

¹Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, AL, China
²Department of Hematology, The First People’s Hospital of Foshan, Foshan, China
³Department of Hematology, Huizhou Municipal Central Hospital, Huizhou, China
⁴Department of Hematology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China
⁵Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
⁶Department of Hematology, The First Hospital of Putian City, Putian, China
⁷Department of Hematology, Ganzhou People’s Hospital, Ganzhou, China
⁸Department of Hematology, Longyan First Hospital Affiliated Fujian Medical University, Longyan, China
⁹Department of Hematology, Central People’s Hospital of Zhanjiang, Zhanjiang, China
¹⁰Department of Hematology, Dongguan Hospital Affiliated to Southern Medical University, Dongguan, China
¹¹Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
¹²Department of Hematology, Guizhou Provincial People’s Hospital, Guiyang, China
¹³Nanfang Hospital, Southern Medical University, Guangzhou, China
¹⁴Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China

Cristina Bucelli^1*, Isabella Capodanno, MD^2*, Maria Cristina Miggiano, MD^3*, Francesco Cavazzini, MD^4*, Sabrina Leonetti Crescenzi, MD^5*, Sabina Russo^6*, Ida Carmosino, MD^7*, Mario Annunziata, MD^8*, Federica SORA, MD^9*, Massimiliano Bonifacio, MD^10*, Luigiana Luciano, MD¹¹, Giovanni Caocci, MD¹², Giuseppina Loglisci, MD^13*, Chiara Elena, MD^14*, Francesca Lunghi^15*, Rikard Mullai, MD^16*, Imma Attolico, MD^17*, Gianni Binotto, MD^18*, Elena Crisa'^19*, Paolo Sportoletti, MD^20*, Ambra Di Veroli^21*, Anna Rita Scortechini, MD^22*, Anna Paola Leporace, MD^23*, Alessandro Maggi, MD^24*, Monica Crugnola, MD^25*, Fabio Stagno, MD, PhD²⁶, Rosaria Sancetta^27*, Pamela Murgano, MD^28*, Davide Rapezzi, MD^29*, Debora Luzi, MD^30*, Jolanda Donatella Vincelli, MD^31*, Sara Galimberti, MD, PhD^32*, Monica Bocchia^33*, Carmen Fava, MD, PhD^34*, Alessandra Malato, MD^35*, Elisabetta Abruzzese, MD³⁶, Giuseppe Saglio, MD³⁷, Giorgina Specchia, MD, PhD³⁸, Massimo Breccia^39*, Alessandra Iurlo, MD, PhD^40*, Mario Tiribelli, MD^41* and Roberto Latagliata^42*

¹Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, Milano, MI, ITA
²Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy
³Hematology Department, San Bortolo Hospital, Vicenza, Italy
⁴Division of Hematology, University of Ferrara, Ferrara, Ferrara, ITA
⁵Hematology, San Giovanni Hospital, Rome, ITA
⁶Hematology, University of Messina, Messina, Italy
⁷7. Department of Cellular Biotechnologies and Hematology, “La Sapienza" University, Rome, Rome, Italy
⁸Hematology Unit, Cardarelli Hospital, Naples, Naples, ITA
⁹Institute of Hematology, Policlinico Universitario A. Gemelli, “Cattolica” University, Rome, ROME, ITA
¹⁰Department of Medicine, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy
¹¹Hematology Unit, Federico II University, Napoli, Italy
¹²Department of Medical Sciences and Public Health, University of Cagliari, Businco Hospital, Cagliari, Italy
¹³Hematology, Vito Fazzi Hospital, Lecce, Lecce, ITA
¹⁴Department of Hematology, IRCCS S. Matteo Hospital Foundation, Pavia, Italy
¹⁵Division of Hematology and BMT, IRCCS San Raffaele Hospital, Milan, Italy, Milan, Italy
¹⁶Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Udine, Italy
¹⁷Hematology and Transplantation Unit, University of Bari, Bari, Italy, ITA
¹⁸Department of Medicine, Hematology and Clinical Immunology, University of Padua, Padua, Italy
¹⁹Hematology, Ospedale Maggiore, Novara, Novara, ITA
²⁰Hematology, University of Perugia, Perugia, Italy
²¹Hematology, Belcolle Hospital, Viterbo, Roma, Italy
²²Division of Hematology, Department of Molecular and Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
²³23. Hematology Unit Azienda Ospedaliero Universitaria Sant'Andrea, Rome, Rome, Italy
²⁴Haematology, Ospedale S.G. Moscati, Taranto, Italy
²⁵Hematology Unit and BMT, University Hospital of Parma, Parma, Italy
²⁶Division of Hematology and Bone Marrow Transplant, AOU Policlinico “Rodolico – San Marco”, Catania, Italy
²⁷Hematology Unit, Dell'Angelo Hospital, Venezia-Mestre, Italy, Mestre, Italy
²⁸Division of Hematology, Sant'Elia Hospital, Caltanissetta, Caltanissetta, Italy
²⁹Department of Hematology, S. Croce e Carle Hospital, Cuneo, Italy
³⁰Onco-Hematology Department, AO Santa Maria, Terni, Terni, Italy
³¹Hematology Unit, Hemato-Oncology and Radiotherapy Department, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", 89124 Reggio Calabria, RC, Italy, REGGIO CALABRIA, ITA
³²Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy
³³Hematology, AOU Senese, Siena, Siena, ITA
³⁴Hematology, Mauriziano Hospital, Torino, Turin, Italy
³⁵Hematology Unit, Ospedale "V. Cervello", Palermo, Italy
³⁶Department of Hematology, S Eugenio Hospital, Tor Vergata University, Roma, I, Italy
³⁷Dept. of Clinical and Biological Sciences, University of Turin, Turin, Italy
³⁸University of Bari, Bari, BA, ITA
³⁹Division of Cellular Biotechnologies and Hematology, University Sapienza, Roma, Roma, Italy
⁴⁰Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
⁴¹Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
⁴²Hematology Unit, Ospedale Belcolle, Viterbo, Italy, Rome, ITA

Lucía Pérez-Lamas^1*, Adrian Segura Diaz^2*, Elvira Mora, MD, PhD^3*, Marta Hidalgo Soto^4*, Antonio Paz Coll^5*, Natalia De Las Heras, MD^6*, Montse Cortes, MD^7*, Patricia Velez Tenza, MD^8*, Magdalena Sierra Pacho^9*, María Alicia Senin, MD, PhD^10*, Anna Angona, PhD^11*, Carlos Cervero, MD^12*, Raquel De Paz Arias^13*, Araceli Salamanca Cuenca^14*, Marta Santaliestra^15*, Javier López Marin^16*, Luis Felipe Casado Montero, MD¹⁷ and Valentín García Gutiérrez, PhD¹⁸

¹Hospital Universitario Doctor José Molina Orosa, Madrid, Spain
²Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas, Spain
³Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
⁴Vall d’Hebron Institute of Oncology, Barcelona, Spain
⁵Hospital Universitario Puerto Real, Puerto Real, Spain
⁶Hospital Universitario de León, Leon, Spain
⁷Hospital General de Granollers, Barcelona, Spain
⁸Hospital Del Mar, Barcelona, Spain
⁹Hospital Universitario de Salamanca, Salamanca, Spain
¹⁰Institut Català d’Oncologia, Hospital Duran i Reynals. Institut d’Investigació Biomèdica de Bellvitge (IDIBELL). Universitat de Barcelona, Barcelona, Spain
¹¹Hospital Universitario Doctor Josep Trueta - ICO, Girona, Spain
¹²Hospital Virgen de la Luz, Cuenca, Spain
¹³Hospital Universitario La Paz-Idipaz, Madrid, Spain
¹⁴Hospital de Jerez de la Frontera, Jerez De La Frontera, Spain
¹⁵Hospital Universitari Mútua Terrassa, Barcelona, Spain
¹⁶Hospital General de Alicante, Alicante, Spain
¹⁷Hospital General Universitario de Toledo, Toledo, Spain
¹⁸Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Universidad de Alcalá, Madrid, Spain

Elisabetta Abruzzese, MD¹, Elena Chiara, MD^2*, Fausto Castagnetti, MD, PhD³, Mario Annunziata, MD^4*, Carlo Gambacorti-Passerini, MD⁵, Luigiana Luciano, MD⁶, Antonella Russo Rossi, MD^7*, Alessandra Iurlo, MD, PhD^8*, Isabella Capodanno, MD^9*, Valentina Giai, MD, PhD^10*, Mariella D'Adda, MD^11*, Fabio Stagno, MD, PhD¹², Antonella Gozzini, MD^13*, Mario Tiribelli, MD^14*, Federica Sorà, MD^15*, Sara Galimberti, MD, PhD^16*, Monica Bocchia, MD^17*, Germana Beltrami, MD^18*, Carmen Fava, MD, PhD^19*, Maria Cristina Miggiano, MD^20*, Massimo Breccia^21*, Marco Cerrano, MD^22*, Anna Rita Scortechini, MD^23*, Olga Mulas, MD^24*, Clementina Caracciolo, MD^25*, Stefana Impera, MD^26*, Claudio Fozza, MD^27*, Alessandra Malato, MD^28*, Lucia Mastrullo, MD^29*, Marzia Salvucci, MD^30*, Monia Lunghi, MD, PhD^31*, Filippo Gherlinzoni, MD^32*, Paolo De Fabritiis, MD^33*, Paola Fazi, MD^34*, Sonia Maria Orlando^35*, Alfonso Piciocchi, MS^34* and Fabrizio Pane, MD³⁶

¹Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma2, Rome, Italy
²IRCCS Fondazione Policlinico San Matteo, Pavia, Tennessee, ITA
³Institute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy
⁴Hematology, San Giuseppe Moscati Hospital, Aversa, Italy
⁵Department of Medicine and Surgery, University Milano-Bicocca, Monza, Italy
⁶Hematology Unit, Federico II University, Napoli, Italy
⁷hematology, University of Bari, Bari, ITA
⁸Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
⁹hematology, AUSL Reggio Emilia, Reggio Emilia, ITA
¹⁰Division of Hematology, Città della Salute e della Scienza, Turin, Italy
¹¹ASST Spedali Civili Di Brescia, Brescia, ITA
¹²Division of Hematology and Bone Marrow Transplant, AOU Policlinico “Rodolico – San Marco”, Catania, Italy
¹³Hematology, AOU Careggi, University of Florence, Florence, Italy
¹⁴Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
¹⁵Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy
¹⁶Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy
¹⁷UOC Ematologia, Azienda ospedaliero-universitaria Senese, Siena, Italy
¹⁸U.O. Ematologia e terapie cellulari, IRCCS Azienda Ospedaliera Universitaria San Martino, Genova, Italy
¹⁹Hematology, Mauriziano Hospital, Torino, Turin, Italy
²⁰hematology, Vicenza, vicenza, Italy
²¹Department of Translational and Precision Medicine, Hematology-Sapienza University, Rome, Italy
²²Division of Hematology, Department of Oncology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy
²³Division of Hematology, Department of Molecular and Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
²⁴Department of Medical Sciences and Public Health, University of Cagliari, Businco Hospital, Cagliari, Italy
²⁵Hematology, AOU Policlinico P Giaccone, Palermo, Italy
²⁶UOC Ematologia, ARNAS Garibaldi, Catania, Italy
²⁷Hematology Unit – Azienda Ospedaliera Universitaria of Sassari, University of Sassari, Sassari, Italy
²⁸Hematology Unit, Ospedale "V. Cervello", Palermo, Italy
²⁹ASL Napoli 1 Presidio Ascalesi, NAPOLI, ITA
³⁰Hematology, Ospedale S. Maria delle Croci, Ravenna, ITA
³¹Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
³²Ospedale Ca' Foncello, Treviso, ITA
³³University tor Vergata, Rome, ITA
³⁴GIMEMA Foundation, Data Center and Health Outcomes Research Unit, Rome, Italy
³⁵Gimema Foundation, Rome, ITA
³⁶Dipartimento Medicina Clinica e Chirurgia, UOC Ematologia e Trapianti di Midollo, Azienda Ospedaliera Universita Federico II, Napoli, Italy

Hiroshi Ureshino, MD, PhD^1,2*, Naoto Takahashi, M.D., Ph.D.³, Takayuki Ikezoe, MD, PhD⁴, Ayako Takamori, PhD^5*, Atsushi Kawaguchi, PhD^6*, Tatsuo Ichinohe, M.D.Ph.D.² and Shinya Kimura, MD, PhD⁷

¹Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine (RIRBM), Hiroshima University, Hiroshima, JPN
²Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
³Akita University School of Medicine, Akita, JPN
⁴Fukushima Medical University, Fukushima, Japan
⁵Clinical Research Center, Saga University Hospital, Saga, Japan
⁶Education and Research Center for Community Medicine, Faculty of Medicine, Saga University, Saga, Japan
⁷Saga University, Saga, Japan

Simona Bernardi, PhD^1,2*, Silvia Mutti^1,3*, Alessia Cavalleri^1,3*, Claudia Ielo, MD^4*, Mirko Farina, MD^5*, Federica Re^1,2*, Katia Bosio^1,3*, Alessandro Leoni^1,2*, Cristian Bonvicini, PhD^6*, Nicola Polverelli, MD⁷, Enrico Morello, MD^8*, Vera Radici, MD^8*, Massimo Breccia^9*, Elisabetta Abruzzese, MD¹⁰, Michele Malagola^1* and Domenico Russo, MD, PhD^1*

¹Department of Clinical and Experimental Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST Spedali Civili, Brescia, Italy, Brescia, Italy
²Centro di Ricerca Emato-Oncologica AIL (CREA), ASST Spedali Civili, Brescia, Italy
³Centro di Ricerca Emato-Oncologica AIL (CREA), ASST Spedali Civili, Brescia, Italy, Brescia, Italy
⁴Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
⁵Unit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy., Brescia, Italy
⁶Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, Italy
⁷Unit of Blood Diseases and Bone Marrow Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy
⁸Department of Clinical and Experimental Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST Spedali Civili, Brescia, Italy, BRESCIA, Italy
⁹Division of Cellular Biotechnologies and Hematology, University Sapienza, Roma, Roma, Italy
¹⁰Department of Hematology, S Eugenio Hospital, Tor Vergata University, Roma, I, Italy