Satyavardhan Rao Nittu, PharmD^1*, Francisco Marchi², Nam Nguyen, MS, PharmD³, Vivek M. Shastri, PhD⁴, Xueyuan Cao, PhD^5*, Raul C. Ribeiro, MD⁶, Jeffrey E. Rubnitz, MD, PhD⁶, Alan S Gamis, MD, MPH⁷, E. Anders Kolb, MD⁸, Richard Aplenc, MD, PhD⁹, Jeffery Klco, MD, PhD¹⁰, Stanley Pounds, PhD^11*, Todd A. Alonzo, PhD^12*, Soheil Meshinchi, MD, PhD¹³ and Jatinder K. Lamba, PhD¹⁴

¹University of Florida, GAINESVILLE, FL
²Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL
³Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL
⁴Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL
⁵University of Tennessee Health Science Center, Memphis, TN
⁶Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁷Hematology/Oncology/BMT, Children's Mercy Kansas City, Kansas City, MO
⁸Leukemia & Lymphoma Society, Bronx, NY
⁹Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
¹¹Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
¹²Univ. of Southern California Keck School of Med., Monrovia, CA
¹³Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA
¹⁴University of Florida, College of Pharmacy, Pharmacotherapy and Translational Re, Gainesville, FL

Ida Vänttinen, MSc^1,2*, Tanja Ruokoranta, MSc^1*, Joseph J Saad, MSc^1,2*, Sari Kytölä, MD^3*, Monica Hellesøy, PhD^4*, Stein-Erik Gullaksen, PhD^4*, Pia-Sofia Ettala, MD^5*, Marja Pyörälä, MD, PhD^6*, Johanna Rimpiläinen, MD^7*, Timo Siitonen, MD, PhD^8*, Krister Wennerberg, PhD^9*, Bjorn T. Gjertsen, MD, PhD^4,10, Caroline A. Heckman, PhD^1,2, Mika Kontro^1,2,3,11* and Heikki Kuusanmäki, PhD^1,2,9,11*

¹Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
²iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland
³Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁴Department of Medicine, Hematology section, Helse Bergen, Bergen, Norway
⁵Department of Clinical Hematology, Turku University Hospital, Turku, Finland
⁶Department of Medicine, Kuopio University Hospital, Kuopio, Finland
⁷Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
⁸Cancer Center, Hematology, Oulu University Hospital, Oulu, Finland
⁹Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
¹⁰Center for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway
¹¹Foundation for the Finnish Cancer Institute, Helsinki, Finland

Nancy BJ Arthur, PhD¹, Agata Gruszczynska^2*, Ma Xenia G Illagan^3*, Michael Prinsen^3*, Sharon E Heath^2*, Tasha Burton^2*, Victoria Donaldson^2*, Cara Lunn Shirai^4*, Eric J. Duncavage^4*, Amanda F Cashen⁵, Geoffrey L Uy, MD⁵, David H Spencer², Stephen M Sykes⁶, Timothy J Ley² and Francesca Ferraro⁷

¹Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, ST Louis, MO
²Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO
³Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St Louis, MO
⁴Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO
⁵Division of Oncology, Washington University School of Medicine, Saint Louis, MO
⁶Department of Pediatrics, Division of Hematology-Oncology, Washington University School of Medicine, St Louis, MO
⁷Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO

Fabiola Traina, MD, PhD¹, Lorena Lobo Figueiredo-Pontes, MD, PhD¹, Maria Isabel Ayrosa, M.D.^1*, Katia B Pagnano, MD, PhD², Ana Beatriz F Gloria, MD^3*, Elvira Deolinda Rodrigues Pereira Velloso, MD, PhD⁴, Elenaide C. Nunes, MD^5*, Marcia Higashi, MD^6*, Bruno Kosa Lino Duarte, MD, PhD^2*, Evandro M Fagundes, MD, MSc^3*, Wellington F Silva, MD PhD⁴, Brunno Gilberto Santos Macedo, BSc^1*, Rita de Cássia Cavaglieri Medeiros, PhD^7*, Ana Sílvia Gouvêa Lima Yamada, PhD^1*, Patricia C Ruy, PhD^1*, Melissa Rijken^8*, Bob Lowenberg, MD, PhD⁸, Torsten Haferlach, MD, PhD⁹, Arnold Ganser¹⁰, Richard Dillon¹¹, Nancy Berliner, MD¹², Peter J. M. Valk, PhD⁸ and Eduardo Magalhães Rego, MD, PhD⁷

¹Department of Medical Images, Hematology, and Oncology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
²Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
³Clinical Hospital of the Federal University of Minas Gerais, Minas Gerais, Brazil
⁴Department of Internal Medicine and State of Sao Paulo Cancer Institute, School of Medicine, University of São Paulo, São Paulo, Brazil
⁵Clinical Hospital of the Federal University of Paraná, Curitiba, Brazil
⁶Amaral Carvalho Hospital, Jaú, Brazil
⁷Hematology Service, LIM-31 and State of Sao Paulo Cancer Institute, School of Medicine, University of São Paulo, São Paulo, Brazil
⁸Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
⁹MLL Munich Leukemia Laboratory, Munich, Germany
¹⁰Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹¹Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
¹²Brigham and Women's Hospital, Boston, MA

Isolde Summerer^1*, Wencke Walter, PhD^2*, Manja Meggendorfer, PhD², Torsten Haferlach, MD, PhD², Frank Dicker, PhD², Stephan Hutter, PhD^2*, Niroshan Nadarajah^2*, Constance Regina Baer, PhD², Anna Stengel, PhD², Wolfgang Kern, MD², John M. Bennett, MD³, Claudia Haferlach, MD² and Christian Pohlkamp, MD^2*

¹MLL Munich Leukemia Laboratory, Munich, AL, Germany
²MLL Munich Leukemia Laboratory, Munich, Germany
³Hematopathology Division, Department of Pathology, University of Rochester Medical Center, Rochester, NY

Yi June Kim^1*, Zongrui Li^2*, Abhishek Maiti, MD¹, Tomoyuki Tanaka, MD, PhD^2*, Hidetaka Uryu, MD, PhD^2*, Ken Furudate, DMD, PhD^1*, Kala Hayes, PhD^1*, Naval Daver, MD¹, Naveen Pemmaraju, MD³, Tapan M. Kadia, MD¹, Farhad Ravandi, MD, MBBS¹, Nicholas J. Short, MD¹, Maro Ohanian, DO^1*, Gautam Borthakur, MD¹, Nitin Jain, MD¹, Ghayas C. Issa⁴, Lucia Masarova, MD¹, Steven M. Kornblau, MD¹, William G. Wierda, MD, PhD⁵, Sanam Loghavi, MD⁶, Sa A. Wang⁷, Guillermo Garcia-Manero, MD⁸, Hagop Kantarjian, MD⁴, Courtney D. DiNardo, MD, MSc¹, Marina Y. Konopleva^1,9 and Koichi Takahashi, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Leukemia, MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴The University of Texas MD Anderson Cancer Center, Houston, TX
⁵University of Texas M.D. Anderson Cancer Center, Houston, TX
⁶Hematopathology, MD Anderson Cancer Center, Houston, TX
⁷Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸University of Texas MD Anderson Cancer Center, Houston, TX
⁹Albert Einstein College of Medicine, Bronx, NY

Garrett Diltz, MD¹, Paul Sackstein, MD^2*, Sarah Elizabeth Mudra, MD^2*, Lacey Scott Williams, MD³, Rachel Zemel, MD^2*, Kimberley Doucette, MD², Purnima Sravanti Teegavarapu, MD⁴ and Gustavo A. Rivero, MD^2,4*

¹Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Boston, MA
²Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC
³Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Alexandria, VA
⁴Section of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX

Muharrem Muftuoglu, MD¹, Li Li, MD^1*, Mahesh Basyal, BSc^2*, Edward Ayoub, PhD^1*, Jiangxing Lv^1*, Andrea Bedoy^1*, Tallie Patsilevas^1*, Aram Bidikian, MD^3*, Ghayas C. Issa⁴ and Michael Andreeff, MD PhD³

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴The University of Texas MD Anderson Cancer Center, Houston, TX

Christian Rausch^1*, Roman Hornung^2*, Aarif M. N. Batcha^2,3*, Maja Rothenberg-Thurley, PhD^1*, Stefanos A. Bamopoulos, MD^4*, Vindi Jurinovic, MSc^1,2,5*, Bianka Ksienzyk^1*, Stephanie Schneider, PhD^1,6*, Annika Maria Dufour, PhD, MSC^1*, Michaela Neusser, PhD^1*, Maria Cristina Sauerland, MD^7*, Dennis Görlich, PhD⁷, Utz Krug, MD^8*, Wolfgang E. Berdel, MD⁹, Bernhard J. Woermann, MD¹⁰, Jan Braess, MD^11*, Wolfgang Hiddemann, MD^1,12,13*, Manja Meggendorfer, PhD¹⁴, Wolfgang Kern, MD¹⁴, Torsten Haferlach, MD, PhD¹⁴, Johannes Schetelig, MD, MSc¹⁵, Moritz Middeke, MD^15*, Sebastian Stasik, PhD^15*, Katharina Egger-Heidrich, MD^15*, Christoph Röllig, MD, MSc^15*, Martin Bornhäuser, MD^15*, Christian Thiede, MD¹⁵, Claudia D Baldus, MD^16*, Carsten Müller-Tidow, MD^17*, Uwe Platzbecker, MD¹⁸, Hubert Serve, MD¹⁹, Wendy Stock, MD²⁰, Geoffrey L Uy, MD²¹, John C. Byrd, MD²², Deedra Nicolet^23,24, Ann-Kathrin Eisfeld, MD*^23,24,25, Ulrich Mansmann^2,3,12,13*, Karsten Spiekermann, MD^1,12,13*, Klaus H Metzeler, MD^13,26 and Tobias Herold, MD^1*

¹Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany
²Institute of Medical Data Processing, Biometrics and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany
³Data Integration for Future Medicine (DiFuture, www.difuture.de), Faculty of Medicine, LMU Munich, Munich, Germany
⁴Department of Hematology, Oncology and Tumor Immunology (Campus Benjamin Franklin), Charité University Medicine Berlin, Berlin, DEU
⁵Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, German Research Center for Environmental Health (HMGU), Munich, Germany
⁶Institute of Human Genetics, LMU University Hospital, LMU Munich, Munich, Germany
⁷Institute of Biostatistics and Clinical Research, University of Münster, Muenster, Germany
⁸Department of Medicine III, Hospital Leverkusen, Leverkusen, DEU
⁹Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany
¹⁰German Society of Hematology and Oncology, Berlin, Germany
¹¹Department of Oncology and Hematology, Hospital Barmherzige Brueder, Regensburg, DEU
¹²German Cancer Consortium (DKTK) Partner Site Munich, Munich, Germany
¹³German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁴MLL Munich Leukemia Laboratory, Munich, Germany
¹⁵Department of Internal Medicine 1, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
¹⁶Medical Department II, University Cancer Center Schleswig-Holstein, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
¹⁷Heidelberg University Hospital, Heidelberg, Germany
¹⁸Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, Germany
¹⁹Department of Internal Medicine II, Hematology and Oncology, Goethe University Hospital Frankfurt, Frankfurt, Germany
²⁰Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
²¹Division of Oncology, Washington University School of Medicine, Saint Louis, MO
²²Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
²³Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
²⁴Alliance Statistics and Data Center, The Ohio State University Comprehensive Cancer Center, Columbus, OH
²⁵Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
²⁶Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, NA, Germany

Yun Huang^1*, Xuejie Jiang, MD^2*, Ling Jiang^3*, Yujiao Zhang^4*, Fang Liu^4*, Ping Yan^4*, Baoyi Yuan^4*, Quan Wu^4* and Yu Zhao^5*

¹Nanfang Hospital, Southern Medical University, Guangzhou, China
²Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
³Nanfang Hospital, Guangzhou, China
⁴Department of Hematology, Nanfang Hospital, Southern medical university CN, Guangzhou, China
⁵Department of Hematology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China

Mireya Morote Faubel, MD, PhD^1,2, Maria Guaita-Céspedes^1*, Beatriz Fernández-Blanco^1*, Cristina Martínez-Valiente, PhD^1,3*, Cristian García-Ruiz, MSC^1*, Marta Santiago, MD^1*, Alvaro Diaz-Gonzalez^1*, Alejandra Sanjuan-Pla, PhD^1*, Mariam Ibáñez^4*, Eva Barragan, PhD^1,3*, Esperanza Such, PhD^1,3,5*, Guillermo Sanz, MD, PhD^6*, Pau Montesinos, PhD, MD^2,3,7*, Javier De La Rubia^8*, Alessandro Liquori, PhD^1,3* and Jose Cervera, MD, PhD^1,3,9*

¹Hematology Research Group, Instituto de Investigación Sanitaria La Fe, Valencia, Spain
²Servicio de Hematología, Hospital La Fe, Valencia, Spain
³CIBER de Oncología, Madrid, Spain
⁴Hospital General Universitario de Valencia, Valencia, Spain
⁵Department of Hematology, Hospital Universitari i Politecnic La Fe, Valencia, Spain
⁶CIBERONC, Instituto de Salud Carlos III, Valencia, Spain
⁷Programa Español de Tratamientos en Hematologia, PETHEMA, Valencia, Spain
⁸University Hospital La Fe, Valencia, Spain
⁹.., Valencia, Spain

Basil Allen^1*, Daniel Bottomly^2*, Anthony Wang^1*, Thomas Koehnke, MD³, Lindsey Savoy^1*, Peter Ryabini^4*, Reid Chen^5*, Kara Johnson^5*, Stephen E. Kurtz^2*, Anupriya Agarwal, PhD⁶, Michelle Barton^7*, Brian J. Druker, MD⁵, Ravi Majeti, MD⁸, Jeffrey W Tyner, PhD², Shannon K McWeeney, PhD^2* and Haijiao Zhang, MD⁹

¹Division of Oncological Sciences, Oregon Health & Science University, Portland, OR
²Knight Cancer Institute, Oregon Health & Science University, Portland, OR
³Stanford University, Stanford, CA
⁴Division of Bioinformatics and Computational Biology, Oregon Health & Science University, Portland, OR
⁵Oregon Health & Science University, Portland, OR
⁶The Knight Cancer Institute, Oregon Health and Science University, Portland, OR
⁷Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, OR
⁸Stanford University School of Medicine, Stanford, CA
⁹Division of Oncological Sciences, Oregon Health & Science University, Knight Cancer Institute, Portland, OR

Bofei Wang, Ph.D.^1*, Christopher Ly^2*, Enes Dasdemir^3*, Fatima Z Jelloul^4*, Poonam N Desai¹, Pamella Borges^1*, Jessica Lynn Root, MS Biomedical Informatics^2*, Guilin Tang, MD PhD^5*, Preethi Gunaratne^6*, Sreyashi Basu^3*, Sonali Jindal^3*, Yulong Chen^3*, Khalida M Wani^3*, Alexander J Lazar^7*, Padmanee Sharma^3*, Patrick K Reville, MD, MPH¹ and Hussein A Abbas, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas at MD Anderson Cancer center, Houston, TX
³The University of Texas at MD Anderson Cancer center, Houston, TX
⁴Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁶Department of Biology and Biochemistry, University of Houston, Houston, TX
⁷The University of Texas at MD Anderson Cancer centER, Houston, TX

Jad Othman, MBBS^1,2,3, Nicola Potter, PhD^1*, Adam Ivey^4*, Yanis Tazi, MSc, BSc^5*, Elli Papaemmanuil⁶, Jelena Jovanovic, PhD^7*, Sylvie D Freeman⁸, Amanda Gilkes^9*, Ian Thomas^10*, Sean Johnson^10*, Joanna Canham^11*, Jamie Cavenagh^12*, Panos Kottaridis^13*, Claire Arnold^14*, Ulrik Malthe Overgaard^15*, Mike Dennis, MD, MRCP, FRCPath¹⁶, Charlotte Wilhelm-Benartzi^9*, Brian Huntly, PhD^17*, Alan K. Burnett, MD^18*, Richard Dillon, PhD, MRCP, FRCPath^1,2* and Nigel Russell¹⁹

¹Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
²Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
³Faculty of Medicine and Health, University of Sydney, Sydney, Australia
⁴Alfred Health, Melbourne, AUS
⁵Memorial Sloan Kettering Cancer Center, New York
⁶Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
⁷King’s College London, London, United Kingdom
⁸Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
⁹Cardiff University, Cardiff, GBR
¹⁰Cardiff University, Cardiff, United Kingdom
¹¹Cardiff University, Cardiff, WAL, GBR
¹²Department of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London, GBR
¹³University College London Hospital NHS Foundation Trust, London, GBR
¹⁴Belfast City Hospital, Belfast, GBR
¹⁵Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
¹⁶The Christie, Manchester, GBR
¹⁷Cambridge Institute For Medical Research, University of Cambridge, Cambridge, GBR
¹⁸Paul O’Gorman Leukaemia Centre, Glasgow University, Glasgow, United Kingdom
¹⁹Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom

Daniel I. Nathan, MD¹, Ronald Hoffman, MD², Daiva Ahire^3*, John Mascarenhas, MD^1*, Lewis R. Silverman, MD¹, Vesna Najfeld, PhD^1,3 and Jonathan Feld, MD¹

¹Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
²Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY
³Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

Pranay S. Hegde^1*, Georgia Andrew, BSc^1*, Gege Gui, ScM¹, Niveditha Ravindra, MD^1*, Devdeep Mukherjee, PhD^1*, Zoe Wong, BS^1*, Jeffery J. Auletta, MD^2,3, Firas El Chaer, MD⁴, Adam Corner, PhD^5*, Steven M. Devine, MD², Antonio M. Jimenez Jimenez, MD, MSc^6*, Marcos de Lima, MD^7*, Mark R. Litzow, MD⁸, Partow Kebriaei, MD⁹, Wael Saber, MD, MS^2,10, Stephen R. Spellman, MBS^2,10*, Scott L. Zeger, PhD^11*, Kristin M. Page, MD^2,12, Laura W Dillon, PhD^1* and Christopher S. Hourigan, DM, DPhil^1,13

¹Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD
²Center for International Blood and Marrow Transplant Research, Minneapolis, MN
³Hematology/Oncology/Bone Marrow Transplant and Infectious Diseases, Nationwide Children's Hospital, Columbus, OH
⁴Department of Medicine, Division of Hematology and Oncology, University of Virginia Comprehensive Cancer Center, Charlottesville, VA
⁵Bio-Rad Laboratories, Pleasanton, CA
⁶Sylvester Comprehensive Cancer Center, Miller School of Medicine, Miami, FL
⁷Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH
⁸Division of Hematology, Mayo Clinic, Rochester, MN
⁹Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰National Marrow Donor Program, Minneapolis, MN
¹¹Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
¹²Medical College of Wisconsin, Milwaukee, WI
¹³Myeloid Malignancies Program, National Institutes of Health, Bethesda, MD

Oystein Sefland^1,2*, Reidun Kristin Kopperud, PhD^2*, Hester Van Zeeburg^3*, Jeroen Rovers, MD, PhD^3*, Maria Omsland, PhD^4*, Arjan A. Van de Loosdrecht, MD, PhD⁵ and Bjorn T. Gjertsen, MD, PhD^1,6

¹Department of Medicine, Haematology section, Haukeland Universitetssykehus, Bergen, Norway
²University of Bergen, Centre for Cancer Biomarkers CCBIO, Bergen, Norway
³Mendus AB, Leiden, Sweden
⁴Western Norway University of Applied Sciences, Bergen, Norway
⁵Department of Hematology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands
⁶Center for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway

Feven Tameire, PhD^1*, Nicholas Collette, M.S.^1*, Sho Fujisawaa, PhD^1*, Kathryn Bieging-Rolett, PhD^1*, Crissy Dudgeon, PhD^1*, Michael E. Stokes^1*, Ben Harrison, M.S.^1*, Ashley LaCayo, B.A.Sc.^1*, Paulina Wojnarowicz, PhD^1*, Jeremy Drees, PhD^1*, Kirk A. Staschke, PhD^2,3*, David Surguladze, MD^1*, Eric S. Lightcap, PhD^1* and Nandita Bose, PhD^1*

¹HiberCell Inc., New York, NY
²Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, Indianapolis, IN
³Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN

Maximilian Bader, MS^1*, Arba Mahmuti^1*, Jannika Leßmann^1*, Henri C Hupe^1*, Razif Gabdoulline^1*, Martin Wichmann^1*, Letizia Venturini^1*, Michael Stadler^1*, Wolfram Puppe^2*, Walter Fiedler, MD³, Jürgen Krauter^4*, Arne Trummer^5*, Bernd Hertenstein, MD^6*, Matthias Eder^1*, Arnold Ganser¹, Felicitas Thol¹, Michael Heuser, MD^1,7 and Rabea Mecklenbrauck^7,8*

¹Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²Department of Virology, Hannover Medical School, Hannover, Germany
³Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁴Department of Hematology and Oncology, Städtisches Klinikum Braunschweig, Braunschweig, Germany
⁵Department of Hematology, Oncology and Palliative Care, Heidekreis-Klinikum, Walsrode, Germany
⁶Department of Internal Medicine I, Klinikum Bremen Mitte, Bremen, Germany
⁷Shared senior authorship, Hannover, Germany
⁸Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, AL, Germany

Suravi Raychaudhuri, MD, Ted Gooley, PhD^*, Xiaoyu Qu, PhD^*, Carole Shaw^*, Kathryn Russell, ARNP^*, Rutu D. Vyas, CRA^*, Jacob S. Appelbaum, MD, PhD, Anna B. Halpern, MD, Roland B. Walter, MD, PhD, MS, Min Fang, MD, PhD^* and Mary-Elizabeth M. Percival, MD

Fred Hutchinson Cancer Center, Seattle, WA

Li Chen^1*, Hongming Zhu^1*, Fangyi Dong^1*, Yan Li^2*, Qifa Liu, MD³, Yu Hu, MD^4*, Yicheng Zhang^5*, Jie Jin⁶, Jianda Hu, PhD⁷, Ting Liu, MD⁸, Depei Wu⁹, Jieping Chen^10*, Yongrong Lai, MD, PhD^11*, Jianxiang Wang, MD¹², Juan Li, PhD¹³, Jianyong Li, MD¹⁴, Xin Du, PhD^15*, Xin Wang, MD, PhD¹⁶, Mingzhen Yang, PhD, MD¹⁷, Jinsong Yan, MD^18*, Guifang Ouyang^19*, Li Liu^20*, Ming Hou^21*, Xiaojun Huang, MD^22*, Wen Jin^1*, Yongmei Zhu^23*, Jian Li^24*, Kankan Wang, MD, PhD^1*, Zhu Chen, MD, PhD^1*, Sai-Juan Chen, MD, PhD^1* and Junmin Li^1*

¹Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
²Department of Hematopathology, The First Affiliated Hospital of China Medical University, Shenyang, China
³Nanfang Hospital, Southern Medical University, Guangzhou, China
⁴Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⁵Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⁶The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
⁷Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
⁸Department of Hematology and Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China
⁹National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China
¹⁰Department of Hematology, Southwest Hospital, Third Military Medical University, chongqing, China
¹¹Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
¹²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Hematologic Disorders, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
¹³The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou , Guangdong, China
¹⁴Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, China
¹⁵Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, WA, China
¹⁶Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
¹⁷Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
¹⁸Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China
¹⁹Department of Hematology, Ningbo First Hospital, Ningbo, China
²⁰Department of Hematology, Tangdu Hospital, Fourth Military Medical University, xian, China
²¹Qilu Hospital of Shandong University, Jinan, China
²²Peking University People’s Hospital,Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China
²³Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
²⁴linical Research Center, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Jacopo Nanni, MD^1*, Jayakumar Vadakekolathu, PhD^2*, Lorenza Bandini, MSc^1*, Samantha Bruno, PhD^3*, Letizia Zannoni, MD^1*, Chiara Sartor, MD^4*, Gianluca Cristiano, MD^1*, Sarah Parisi, MD, PhD^5*, Federico Zingarelli, MD^3*, Raffaele Ciruolo, MD^3*, Giovanni Marconi, MD⁶, Claudia Venturi, MSc^7*, Marilena Ciciarello, PhD^3*, Aisi Kanapari^3*, Gaia Mazzocchetti^3*, Giorgia Simonetti, PhD^8*, Martina Ghetti, MSc^8*, Nicoletta Testoni, BSc^9*, Stefania Paolini, MD^5*, Simona Soverini, PhD¹⁰, Emanuela Ottaviani, MSc^11*, Cristina Papayannidis, MD⁵, Michele Cavo, MD^3,5*, Sergio Rutella, MD, PhD, FRCPath² and Antonio Curti, MD, PhD¹¹

¹Department of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy
²John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom
³Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, Bologna, Italy
⁴Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Università di Bologna, Bologna, Italy
⁵Istituto di Ematologia "Seràgnoli", IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy
⁶IRCCS Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori” - IRST S.r.l, Meldola, Italy
⁷Istituto di Ematologia “Seràgnoli”, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
⁸IRCSS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l, Meldola, Italy
⁹Institute of Hematology "L. and A. Seràgnoli", Department of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy
¹⁰Department of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Castel Maggiore, Bologna, Italy
¹¹IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy

Adriano Venditti, MD¹, Michal Kicinski^2*, Ernesta Audisio, MD^3*, Mario Luppi, MD^4*, Gianluca Gaidano, MD, PhD⁵, Robin Foà, MD^6*, Anna Candoni, Professor, MD^7*, Andrea Mengarelli, MD^8*, Attilio Olivieri^9*, Annalisa Imovilli, MD^10*, Maurizio Musso^11*, Paolo De Fabritiis, MD^12*, Eliana Zuffa, MD^13*, Nicola Cascavilla, MD^14*, Agostino Tafuri, MD¹⁵, Maria Ilaria Del Principe, MD^16*, Stefan Suciu, PhD^2*, Anne Giraut, PhD^17*, Stéphanie Antunes^18*, Pierre W. Wijermans, MD, PhD^19*, Michael Lübbert, MD²⁰, Gerwin A. Huls, Prof.²¹, Marco Vignetti, MD^22* and Francesco Buccisano, MD, PhD²³

¹Department of Onco-Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy, Italy
²EORTC Headquarters, Brussels, BEL
³SC EMATOLOGIA 2, AOU CITTA DELLA SALUTE E DELLA SCIENZA, OSPEDALE S. GIOVANNI BATTISTA MOLINETTE, Torino, ITA
⁴Hematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy
⁵Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Novara, ITA
⁶Division of Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
⁷Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Modena, Italy
⁸Regina Elena National Cancer Institute, Rome, ITA
⁹Clinica di Ematologia Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy
¹⁰Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy
¹¹Division of Onco-Hematology and Stem Cell Transplantation, Clinica La Maddalena, Palermo, Italy
¹²Hematology Unit, Sant'Eugenio Hospital, Rome, Italy
¹³Hematology Unit, Ravenna, RA, ITA
¹⁴Casa Sollievo Della Sofferenza IRCCS, San Giovanni Rotondo, Italy
¹⁵Azienda Ospedaliera Sant'Andrea, Rome, Italy
¹⁶Hematology, Department of Biomedicine and Prevention, University Tor Vergata, Roma, Italy
¹⁷The European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium
¹⁸The European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussel, Belgium
¹⁹Department of Hematology, Haga Teaching Hospital, The Hague, The Netherlands;, The Hague, Netherlands
²⁰University Medical Center Freiburg, Freiburg, Germany
²¹Department of Hematology, University Medical Center Groningen, Groningen, Netherlands
²²GIMEMA Foundation, Rome, Italy
²³Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

Xiaosu Zhou, PhD^1*, Xue Chen, MD^2*, Ya-Zhen Qin, MD^3*, Zhanglin Zhang, MD^4*, Jiaqi Chen, PhD^1,2*, Lijun Wen, MD^5*, Panxiang Cao, MS^1,2*, Yingchang Mi, MD⁶, Wei Wang, MD^7*, Huanling Wu, MD^8*, Guangsen Zhang, MD^9*, Ji Li, MD^9*, Zhifen Zhang, MD^8*, Jian Zhang, MD^8*, Zhan Su, MD^10*, Fang Wang, MD^2*, Yang Zhang, MD^1,2*, Xiaoli Ma, MD^2*, Jiancheng Fang^2*, Ping Wu, MD^2*, Tong Wang, MD^2*, Ruijie Tang, MD^11*, Wanting He, MD^7*, Yang Zhao, MD^12*, Ran Gao, MD^13*, Honghu Zhu, MD^14*, Siyuan Liu^1*, David Jin, MD^1*, Xian Zhang, MD^11*, Leping Zhang^12*, Peihua Lu, MD^11*, Suning Chen, MD^5* and Hongxing Liu, MD^1,2,15,16

¹Molecular Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, China
²Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
³Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Peking University People’s Hospital, Beijing, China
⁴Department of Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang, China
⁵National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China
⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
⁷Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⁸Department of Clinical Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
⁹Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China
¹⁰Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, China
¹¹Department of Hematology, Hebei Yanda Lu Daopei Hospital, Langfang, China
¹²Department of Pediatrics, Peking University People's Hospital, Beijing, China
¹³Department of Hematology, The First Hospital of China Medical University, Shenyang, China
¹⁴Department of Hematology, Beijing Chao-Yang Hospital of Capital Medical University, Beijing, China
¹⁵Division of Pathology & Laboratory Medicine, Beijing Lu Daopei Hospital, Beijing, China
¹⁶Department of Oncology, Capital Medical University, Beijing, China

Noa E. Wijnen^1,2*, Bianca de Boer^1,2*, Kim Klein^1,3*, Jonas Abrahamsson^4*, Barbara De Moerloose^5*, Bernward Zeller, PhD^6*, Henrik Hasle⁷, Zhanna Kovalova^8*, Nira Arad-Cohen^9* and Gertjan J.L. Kaspers, MD, PhD^1,2

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
³Wilhelmina Children’s Hospital/University Medical Center Utrecht, Utrecht, Netherlands
⁴Institute of Clinical Sciences, Department of Pediatrics, Queen Silvias Childrens Hospital, Gothenburg, Sweden
⁵Ghent University Hospital, Ghent, Belgium
⁶Department of Pediatric Hematology-Oncology, Oslo University Hospital, Oslo, Norway
⁷Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
⁸Department of Pediatric Oncology/Hematology, Children's Clinical University Hospital, Riga, Latvia
⁹Department of Pediatric Hemato-Oncology, Rambam Health Care Campus, Haifa, Israel

Catia Simoes^1*, Carmen Gonzalez, MS^2*, Leire Burgos^1*, Sarai Sarvide^1*, Diego Alignani^1*, Aitziber Lopez^1*, Ivan Quispe, MD^3*, Jose A. Pérez-Simón⁴, María García-Fortes^5*, Teresa Bernal Del Castillo, MD, PhD^6*, Mercedes Colorado^7*, Teresa Olave, MD^8*, Ana Alfonso Pierola, M.D., Ph.D.^1*, Felipe Prosper, MD, PhD¹, Pau Montesinos, PhD, MD^9* and Bruno Paiva^1*

¹Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain
²Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, AL, Spain
³Navarra Complex Hospital, Pamplona, Navarra, ESP
⁴Hospital Universitario Virgen del Rocío, Sevilla, Spain
⁵Hospital Universitario Virgen De La Victoria, Málaga, Spain
⁶Servicio de Hematología, Hospital Universitario Central de Asturias Instituto de Investigación del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias, (IUOPA), Oviedo, Spain
⁷Hospital Universitario Marqués De Valdecilla, Santander, Spain
⁸Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
⁹Hospital Universitari i Politecnic la Fe, Valencia, Spain

Natalia Baran, MD, PhD, MSc¹, Lina Han, MD PhD^2*, Lucille Stuani, PhD^3*, Antonio Cavazos, MSc^4*, Laurie Cooper^2*, Cassandra L. Ramage^5*, Vinitha MARY Kuruvilla, MSc^6*, Qi Zhang, PhD^5*, Marie Sabtier^7*, Emeline Boet^7*, Jason P Gay^8*, Ninping Feng^8*, Venkata Lokesh Battula, PhD⁹, Emeline Chu-Van^10*, Florence Castelli^10*, Martin Carroll^11*, Sergej Naumovich Konoplev, MD, PhD^12*, Beenu Thakral^13*, Naval Daver, MD⁵, Joseph R Marszalek^8*, Yubin Ge, PhD¹⁴, Michael Andreeff, MD PhD⁵, Jean-Emmanuel Sarry, PhD^15* and Marina Y. Konopleva^5,16

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²The University of Texas MD Anderson Cancer Center, Houston
³Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM, Montpellier, France
⁴The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶The University of Texas, MD Anderson Cancer Center, Houston
⁷INSERM, Toulouse, FRA
⁸TRACTION, The University of Texas MD Anderson Cancer Center, Houston
⁹Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
¹⁰CEA/DSV/iBiTec-S/SPI, Laboratoire d’Etude du Métabolisme des Médicaments, MetaboHUB-Paris, Paris, France
¹¹Department of Medicine, The University of Pennsylvania, Philadelphia, PA
¹²UT M.D. Anderson Cancer Center, Houston, TX
¹³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston
¹⁴Karmanos Cancer Institute Wayne State Univ., Detroit, MI
¹⁵Inserm, Toulouse, FRA
¹⁶Department of Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY

Lianjun Zhang, PhD^1*, Dinh Hoa Hoang^2*, Hyunjun Kang, PhD^3*, Ying-Chieh Chen, PhD^1*, Yu-Hsuan Fu, MS¹, Khyatiben V. Pathak^4,5*, Melissa Valerio^6*, Fang Chen^7*, Katrina Estrella^1*, Ralf Buettner, PhD^8*, Bin Zhang^2*, Patrick Pirrotte^4,5*, Guido Marcucci, MD⁹, Ya-Huei Kuo, PhD² and Le Xuan Truong Nguyen, PhD^2,4*

¹Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
²Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
³Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte
⁴Cancer & Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ
⁵Integrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA
⁶Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research,Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁷Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research,Beckman Research Institute, City of Hope National Medical Center, Monrovia, CA
⁸Hematology Malignancies Research Institute, Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, CA
⁹Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA

Richard J Marrero, PharmD¹, Deedra Nicolet², Vivek M. Shastri, PhD³, Krzysztof Mrózek, MD, PhD⁴, Christopher J. Walker, PhD^2*, William Blum, MD⁵, Bayard L Powell, MD⁶, Jonathan E Kolitz, MD⁷, Joseph O Moore, MD⁸, Geoffrey L Uy, MD⁹, Wendy Stock, MD^10,11, Andrew J Carroll, PhD¹², John C. Byrd, MD¹³, Ann-Kathrin Eisfeld, MD*² and Jatinder K. Lamba, PhD^3,14

¹Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, GAINESVILLE, FL
²Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
³Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL
⁴Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁵Winship Cancer Institute of Emory University, Atlanta, GA
⁶Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC
⁷Zucker School of Medicine at Hofstra/Northwell, Zuckerberg Cancer Center, Lake Success, NY
⁸Duke University Medical Center, Durham, NC
⁹Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹⁰University of Chicago Medicine, Chicago, IL
¹¹Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
¹²Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹³Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
¹⁴UF Health Cancer Center, University of Florida, Gainesville, FL

Jack H Peplinski, BS^1*, Logan K Wallace^2*, Rhonda E Ries, MA^1*, Benjamin J Huang, MD³, Amanda R Leonti, MS^2*, Danielle C Kirkey, MD², Xiaotu Ma, PhD⁴, Scott N Furlan, MD^2,5* and Soheil Meshinchi, MD, PhD⁶

¹Translational Sciences and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
²Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
³Department of Pediatrics, University of California, San Francisco, San Francisco, CA
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Pediatrics, University of Washington, Seattle, WA
⁶Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA

Benjamin J Huang, MD¹, Hamid Bolouri, PhD^2*, Colin Y. Smith^1*, Jim Wang, MS^3*, Rhonda E Ries, MA^4*, Elizabeth Conran^1*, Alan S Gamis, MD, MPH⁵, Richard Aplenc, MD, PhD⁶, Todd A. Alonzo, PhD^7*, Xiaotu Ma, PhD⁸, Timothy Junius Triche, PhD⁹, Jason E. Farrar, MD¹⁰ and Soheil Meshinchi, MD, PhD¹¹

¹Department of Pediatrics, University of California, San Francisco, San Francisco, CA
²Benaroya Research Institute, Seattle, WA
³Children's Oncology Group, Monrovia, CA
⁴Translational Sciences and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁵Hematology/Oncology/BMT, Children's Mercy Kansas City, Kansas City, MO
⁶Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁷Univ. of Southern California Keck School of Med., Monrovia, CA
⁸St. Jude Children's Research Hospital, Memphis, TN
⁹University of Southern California, Grand Rapids, MI
¹⁰Arkansas Children's, University of Arkansas For Medical Sciences, Little Rock, AR
¹¹Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA

Hester Van Zeeburg^1*, Eva Wagner Drouet, MD^2*, Uwe Platzbecker, MD³, Tobias A.W. Holderried, MD^4*, Catharina Van Elssen, MD, PhD^5*, Aristoteles Giagounidis⁶, Soren Lehmann, MD, PhD^7*, Jeroen Rovers, MD, PhD^8*, Bjorn T. Gjertsen, MD, PhD⁹ and Arjan A. van de Loosdrecht, MD, PhD¹⁰

¹Mendus AB, Leiden, Netherlands
²Universitätsmedizin der Johannes Gutenberg-Universität, Mainz, Germany
³University Leipzig Medical Center, Leipzig, Germany
⁴Universitaetsklinikum Bonn (UKB), Bonn, Germany
⁵Maastricht University Medical Centre, Maastricht, Netherlands
⁶Dept. Oncology, Hematology and Palliative Care, Marienhospital Düsseldorf, Düsseldorf, Germany
⁷Department of Medical Sciences, Hematology, Uppsala University, University Hospital Uppsala, Uppsala, Sweden
⁸Mendus AB, Leiden, Sweden
⁹Department of Medicine, Haematology section, Haukeland Universitetssykehus, Bergen, Norway
¹⁰Department of Hematology, Amsterdam UMC, location VUmc, CCA, Amsterdam, Netherlands

Ana Alfonso Pierola, M.D., Ph.D.^1*, Beñat Ariceta^2*, Amaia Vilas-Zornoza^2*, Paula Aguirre-Ruiz^2*, Sarai Sarvide^2*, Patxi San-Martin^2*, Maria-Antonia Fortuño, PhD^3*, Catia Simoes^2*, Leire Burgos^4*, Maria Jose Larrayoz^5*, Carmen Chillon^6*, Olga Arce^7*, Teresa Bernal Del Castillo, MD, PhD^8*, Mercedes Colorado^9*, Laida Cuevas Palomares^10*, Inmaculada Marchante^11*, Maria Carmen Mateos^12*, Mayte Olave, MD^13*, Jose A. Pérez-Simón¹⁴, Maria Jose Calasanz, PhD^5*, Ramon Garcia-Sanz⁶, Bruno Paiva^2,4*, Pau Montesinos, PhD, MD^15* and Felipe Prosper, MD, PhD^1,2,16

¹Hematology and Cell Therapy Department, Clinica Universidad de Navarra, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain
²Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain
³Biobank of Universidad de Navarra, Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain
⁴Flow Cytometry Core, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain
⁵Hematological Disease Laboratory, CIMA LAB Diagnostics, Universidad de Navarra, Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain
⁶Department of Hematology, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain
⁷Hospital Universitario de Basurto, Bilbao, Spain
⁸Hospital Universitario Central de Asturias, Oviedo, Spain
⁹Hospital Universitario Marqués De Valdecilla, Santander, Spain
¹⁰Hospital Universitario De Alava, Vitoria, Spain
¹¹Hospital Universitario Puerta del Mar, Cadiz, Spain
¹²Hospital Universitario de Navarra, Pamplona, Spain
¹³Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
¹⁴Hospital Universitario Virgen del Rocío, Sevilla, Spain
¹⁵Hospital Universitari i Politecnic la Fe, Valencia, Spain
¹⁶Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain

Joost B. Koedijk^1*, Inge Van Der Werf^2*, Marijn A. Vermeulen, MD, PhD^2*, Alicia Perzolli, MSc^2*, Marta F. Fiocco, Prof. Dr.^2,3,4*, Hester A. de Groot-Kruseman, PhD^2*, Rubina Moeniralam^2*, Kristina B. Christensen^5*, Henrik Hasle⁶, Stefan Nierkens, PhD^7,8*, Mirjam E. Belderbos, MD, PhD², Michel C. Zwaan, Prof. Dr.^1,9* and Olaf Heidenreich, PhD^2,10,11

¹Princess Maxima Centre for Pediatric Oncology, Utrecht, Netherlands
²Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
³Mathematical Instit, Leiden University, Leiden, Netherlands
⁴Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands
⁵Department of Pathology, Aarhus University Hospital, Aarhus, Denmark
⁶Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
⁷Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands
⁸Center for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
⁹Department of Pediatric Oncology, Erasmus MC/Sophia Children's Hospital, Rotterdam, Netherlands
¹⁰Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
¹¹Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, United Kingdom

Juan Miguel Bergua Burgues^1*, Raquel Tarazona, MD. PhD^2*, Javier Garcia Casado, MD. PhD^3*, Juan J Gordillo, PhD^4*, Ignacio Casas Aviles, M.D^5*, Rebeca Rodriguez Veiga, M.D^6*, Isabel Cano^7*, Ferran Vall-Llovera Calmet^8*, Antonio Garcia^9*, Joaquin Gomez Espuch, MD, PhD^10*, Mercedes Colorado^11*, Jordi Esteve, MD, PhD^12,13,14, Victoria Verdugo Cabeza De Vaca, PhD^15*, Maria Antonia Sanpol, MD. PhD^16*, Fernando Ramos, MD, MPH, PhD^17,18*, Marta Valero, M.D^19*, Evelyn Acuña-Cruz, MD^20*, Blanca Boluda^21*, Joaquin Martinez-Lopez, MD, PhD^22,23*, Rosa Ayala, MD, PhD^24*, Eva Barragán, PhD^25,26,27,28*, David Martinez-Cuadron, PhD^29* and Pau Montesinos, PhD, MD^{27,30,31,32,33*}

¹Hematology and Hemotherapy Service, San Pedro de Alcántara Hospital, Cáceres, Spain
²2Immunology Unit, Department of Physiology, Faculty of Veterenay, Universidad de Extremadura, Cáceres, Spain, caceres, Spain
³Facultad de Veterinaria. Universidad de Extremadura, Garcia Casado, Caceres, Spain
⁴2Immunology Unit, Department of Physiology, Faculty of Veterenay, Facultad de Veterinaria. Universidad de Extremadura, caceres, Spain
⁵SERVICIO DE HEMATOLOGIA Y HEMOTERAPIA, Caceres, Spain
⁶Hematology Department, Hospital La Fe. Valencia, Valencia, Spain
⁷Hospital Universitari I PolitèCnic La Fe; Dep. of Hematology, University, Valencia, ESP
⁸Hematology Department, Hospital La Mutua. Tarrassa, Terrassa, ESP
⁹Hospital Universitario Arnau de Vilanova, LLEIDA, ESP
¹⁰University Hospital Virgen De La Arrixaca, Murcia, ESP
¹¹Hematology Department, Hospital Universitario Marques de Valdecilla. Santander, Santander,, Spain
¹²Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain
¹³Hematopoietic Cell Transplantation Unit, Hospital Clínic de Barcelona, ICHMO, Barcelona, Spain
¹⁴Hematology Department, Hospital Clínic Barcelona, Barcelona, Spain
¹⁵Department of Hematology, Hospital Universitario De Jerez de la Frontera., Jerez de la Fronera, Spain
¹⁶Hematology Department, Hospital de Son Llatzer, Palma de Mallorca, Spain
¹⁷Hospital Universitario de León, Leon, Spain
¹⁸Grupo Español de Síndromes Mielodisplásicos (GESMD), Madrid, Spain
¹⁹Hematology Department, Hospital Arnau de Vilanova. Valencia, Valencia, Spain
²⁰Department of Hematology, Hospital Universitari i Politècnic La Fe, Valencia, Spain
²¹Hospital Universitari I Politècnic La Fe, Valencia, ESP
²²Department of Hematology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Complutense University, CNIO, CIBERONC, Madrid, Spain
²³Hospital Universitario 12 de Octubre, Madrid, Spain
²⁴Hematology Department, Hospital 12 de Octubre (i+12), Centro Nacional de Investigaciones Oncológicas (CNIO), Complutense University, Madrid, Spain
²⁵Molecular Biology Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain
²⁶Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
²⁷CIBER de Oncología, Madrid, Spain
²⁸Hematology Research Group, Instituto de Investigación Sanitaria La Fe, Valencia, Spain
²⁹Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain
³⁰Nucleus Global, Teaneck, NJ
³¹Programa Español de Tratamientos en Hematologia, PETHEMA, Valencia, Spain
³²Hospital Universitari i Politecnic la Fe, Valencia, Spain
³³CIBERONC, Instituto Carlos III, Madrid, Spain

Lisa Uechi^1*, Yu-Hsuan Fu, MS², David Frankhouser^3*, Denis O'Meally, PhD^1*, Sergio Branciamore, PhD^1*, Lianjun Zhang, PhD^2*, Man Li, PhD^4*, Guido Marcucci, MD^2,5, Russell C. Rockne, PhD^1* and Ya-Huei Kuo, PhD⁶

¹Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
²Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
³Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, Beckman Research Institute, Duarte, CA
⁴Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁵Hematology/HCT, City of Hope National Medical Center, Duarte, CA
⁶Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA

Yun Wang^1*, Shuzhao Chen^2*, Limei Zhang^3*, Jiangtao Song^4*, Huaze Liao^4*, Mayan Huang^5*, Kunying Xie^6*, Robert Peter Gale, MD⁷ and Yang Liang, MD, PhD¹

¹Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
²Sun Yat-sen University Cancer Center (SYSUCC), Guangzhou, China
³Sun Yat-sen University Cancer Center (SYSUCC), Guangzhou, AL, CHN
⁴Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China
⁵Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, China
⁶Affiliated Hospital of North Sichuan Medical College, Nanchong, China
⁷University of California, Los Angeles, Los Angeles, CA

Sofie Johansson Alm, MD^1*, Gustav Orrsjö, MD^1,2*, Giti Shah Barkhordar, MSc^3*, Anna Rehammar, PhD^4*, Erik Delsing Malmberg, MD, PhD^5*, Per-Ola Andersson, MD, PhD^2*, Mats L. Brune, MD, PhD^2*, Hege Kristin Gravdahl Garelius, MD, PhD^2*, Mats Hardling, MD^6*, Lars Palmqvist, MD, Professor^1,7 and Linda Fogelstrand, MD, PhD^8,9

¹Institute of Biomedicine, Department of Laboratory Medicine, University of Gothenburg, Gothenburg, Sweden
²Section of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg, Sweden
³Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden
⁴School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
⁵Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden
⁶Section of Hematology, NU hospital group, Uddevalla, Sweden
⁷Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
⁸Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
⁹Department of Clinical Chemistry, Sahlgrenska University, Gothenburg, Sweden

Jan Philipp Bewersdorf, MD¹, Shai Shimony, MD^2*, Rory M. Shallis, MD³, Yiwen Liu, MS^4*, Eva Johanna Schaefer, MD^5*, Amer M. Zeidan, MBBS, MHS⁶, Aaron D. Goldberg, MD, PhD⁷, Eytan M. Stein¹, Guido Marcucci, MD⁸, R. Coleman Lindsley⁹, Evan C. Chen, MD⁵, Jorge Ramos, MD^10*, Anthony Selwyn Stein, MD¹¹, Daniel J. DeAngelo¹², Donna S. Neuberg, ScD⁴, Richard M Stone, MD¹², Brian J. Ball, MD¹⁰ and Maximilian Stahl, MD¹³

¹Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³Section of Hematology, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT
⁴Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁵Medical Oncology, Dana Farber Cancer Institute, Boston, MA
⁶Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, Yale University, New Haven, CT
⁷Memorial Sloan Kettering Cancer Center, New York City, NY
⁸Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
⁹Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
¹⁰City of Hope Cancer Center, Duarte, CA
¹¹City of Hope National Medical Center, Duarte, CA
¹²Dana-Farber Cancer Institute, Boston, MA
¹³Dana Farber Institute, Boston, MA

Qiao Liu, MD, PhD^1,2*, Xuechun Wang, PhD^3*, Yuanhua Cai, MD, PhD^4*, Luya Ye, MD^5*, Xianglei Chen, MD, PhD^1,6*, Lili PAN, MD^1*, Zhixiang Chen, MD^4*, Xiaolin Lai, MD, PhD^1*, Xiaofan Li, MD, PhD⁵ and Shaoyuan Wang, MD^1*

¹Fujian Medical University Union Hospital，Fujian Institute of Hematology, Fuzhou, China
²Biotheryx, San Diego, CA, Armenia
³Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, NJ, China
⁴Union Clinical Medical Colleges, Fujian Medical University, Fuzhou, China
⁵Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, China
⁶Yidu Central Hospital of Weifang, Shandong, China

Etsuko Ishikita^1*, Tomoko Kawai, MD, PhD^2*, Genki Yamato, MD, PhD^3*, Norio Shiba, MD, PhD⁴, Kentaro Ohki, MD, PhD^5*, Yusuke Hara, MD, PhD^3*, Taeko Kaburagi, MD, PhD^1*, Takumi Takizawa, MD, PhD^3*, Hirohide Kawasaki, MD, PhD¹, Hiroo Ueno, MD, PhD^6*, Daisuke Tomizawa, MD, PhD⁷, Takashi Taga, MD, PhD^8*, Souichi Adachi, MD, PhD^9*, Yuki Yuza, MD, PhD^10*, Hiroyuki Takahashi, MD, PhD^11*, Seishi Ogawa¹² and Yasuhide Hayashi, MD, PhD^1,13*

¹Department of Hematology/Oncology, Gunma Children’s Medical Center, Gunma, Japan
²Department of Maternal-Fetal Biology, National Research institute for Child Health and Development, Tokyo, Japan
³Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan
⁴Department of Pediatrics, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
⁵Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan
⁶Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⁷Division of Leukemia and Lymphoma, Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan
⁸Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan
⁹Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
¹⁰Department of Hematology and Oncology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan
¹¹Department of Pediatrics, Toho University, Tokyo, Japan
¹²Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Sakyoku, KYO, Japan
¹³Institute of Physiology and Medicine, Jobu University, Gunma, Japan

Richard J Marrero, PharmD¹, Xueyuan Cao, PhD^2*, Huiyun Wu, PhD^3*, Raul C. Ribeiro, MD⁴, Jeffrey E. Rubnitz, MD, PhD⁴, Stanley Pounds, PhD^3* and Jatinder K. Lamba, PhD⁵

¹Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, GAINESVILLE, FL
²Department of Health Promotion and Disease Prevention, University of Tennessee Health Science Center, Memphis, TN
³Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL

Kateryna Fedorov, MD¹, Alexander Sisto, MD^2*, Josette Kamel, MD^3*, Mark Forsberg, MD^1*, Kith Pradhan, PhD^4*, Nishi Shah, MBBS, MPH¹, Aditi Shastri, MD¹, Mendel Goldfinger, MD^1*, Noah Kornblum, MD¹, Alejandro Sica, MD^1*, Dennis L Cooper, MD¹, Kira Gritsman, MD, PhD⁵, Amit K. Verma, MD⁴, Eric J Feldman, MD^1*, Marina Y. Konopleva¹ and Ioannis Mantzaris¹

¹Department of Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY
²Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, New York City, NY
³Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY
⁴Montefiore Einstein Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
⁵Department of Medical Oncology, Montefiore Medical Center, Bronx, NY