Mark Gower, PhD¹, Ximing Li, BS², Alicia Aguilar-Navarro^1*, Brian Lin, BS^1*, Minerva Fernandez, MSc^1*, Gibran Edun, BS^3*, Mursal Nader^4*, Andrea Arruda^5*, Anne Maria Tierens, MD, PhD⁶, Elvin Wagenblast, PhD⁷, Lin Yang, BS^1*, Ho Seok Lee, BS^1*, Sanam Loghavi, MD⁸, John E. Dick, PhD^9,10, Mark D. Minden^9*, Johann K. Hitzler, MD¹¹, Courtney L Jones, PhD¹², Gregory Schwartz, PhD^1*, Igor Dolgalev, PhD^13*, Soheil Jahangiri, PhD^9* and Anastasia N. Tikhonova, PhD⁹

¹University Health Network, Toronto, ON, Canada
²University of Toronto, Toronto, ON, CAN
³University of Guelph, Guelph, ON, Canada
⁴University Health Network, Toronto, ON, CAN
⁵Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⁶Laboratory Medicine Program, University Health Network, Toronto, ON, Canada
⁷The Mount Sinai Hospital, Icahn School of Medicine, New York
⁸Hematopathology, MD Anderson Cancer Center, Houston, TX
⁹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹⁰Department of Molecular Genetics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, CAN
¹¹Division Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, CAN
¹²Princess Margaret Cancer Centre, University Health NetworkCin, Toronto, ON, Canada
¹³NYU Grossman School of Medicine, New York, NY

Laura Oksa^1*, Sanni Moisio, MSc^2*, Khurram Maqbool, PhD^3,4*, Hassan Foroughi-Asl^4,5*, Roger Kramer^2*, Atte Nikkilä, MD, PhD^1*, Kaisa Vepsäläinen, MD, PhD^6*, Jesus Duque-Afonso, MD^7*, Julia Hauer^8*, Jessica Nordlund^9*, Valtteri Wirta^4,5*, Olli Lohi¹ and Merja Heinäniemi^2*

¹Tampere Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
²Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
³Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Stockholm, AL, Sweden
⁴Clinical Genomics facility, Science for Life Laboratory, Stockholm & Uppsala, Stockholm, Sweden
⁵Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Stockholm, Sweden
⁶Kuopio University Hospital, Kuopio, FIN
⁷Univ. of Freiburg, Freiburg, DEU
⁸Technical University of Munich, School of Medicine, Department of Pediatrics, Munich, Germany
⁹Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Junyu Wang, PhD^1*, Tuantuan Gui, Master^1*, Tong Yin, MD, PhD^1*, Yuting Dai, PhD^1*, Jing Qiao, Master^1*, Jianfeng Li, PhD^1*, Jie Xu¹, Yuanfang Liu^1*, Yan Wang, MD, PhD^1*, Yun Tan, PhD^1*, Bo Jiao, PhD^1*, Yongmei Zhu^1*, Zhu Chen, MD, PhD^1*, Wenlian Chen, PhD^2*, Hai Fang, PhD^1*, Jian Hou, MD, PhD^3*, Jian-Qing Mi, MD, PhD^1*, Jin Wang^1* and Sai-Juan Chen, MD, PhD^1*

¹National Research Center for Translational Research at Shanghai, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine (SJTUSM), Shanghai, China
²Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
³Department of Hematology, Renji Hospital, SJTUSM, Shanghai, China

Carol Fries Simpson, MD¹, Yuxuan Liu, PhD², Lucille Stuani, PhD^3*, Astraea Jager^2*, Cameron Baker^4*, Diana G. Adlowitz, PhD^5*, Philip J Rock^6*, Richard Burack, MD, PhD⁶ and Kara L. Davis, DO²

¹Department of Pediatrics, University of Rochester, Rochester, NY
²Department of Pediatrics, Hematology, Oncology, and Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, CA
³Stanford University, Stanford, CA
⁴Genomics Research Center, University of Rochester, Rochester, NY
⁵Department of Pediatrics; Department of Pathology & Laboratory Medicine, University of Rochester, Rochester, NY
⁶Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY

Chi Zhang^1*, Kathy Yuen Yee Chan, PhD^1*, John Tak Kit Cheung^2*, Wing Hei Ng, BSc^2*, Chi Kong Li¹ and Kam Tong Leung^1*

¹Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong
²Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong, Hong Kong

Lai N Chan, PhD^1,2, Kohei Kume, PhD^1*, Christian Hurtz, PhD³, Mark E Robinson, PhD^1*, Kadriye Nehir Cosgun, PhD^1* and Markus Müschen, MD¹

¹Center of Molecular and Cellular Oncology, Yale University, New Haven, CT
²Department of Cancer Biology, Cleveland Clinic, Cleveland, OH
³Lewis Katz School of Medicine, Temple University, Philadelphia, PA

Guanglan Lin, MS^1*, Kathy Yuen Yee Chan, PhD^2*, Qiwei SUN^3*, Wing Kwan Leung, MD^4*, Chi Kong Li² and Kam Tong Leung^2*

¹Chinese university of HongKong, Hongkong, AL, Hong Kong
²Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong
³Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong, Hong Kong
⁴Chinese university of HongKong, Hong Kong, HKG

Ntasha Roy^1*, Zhengwei (Jenny) Mao, MD (co-first author)^2*, Chang Xu, PhD^2*, David T. Teachey, MD³, Zhiguo (Bruce) Chen, MS^4*, Meenakshi Devidas, PhD, MBA⁵, Xueyan Chen, MD, PhD^6*, Elizabeth A. Raetz, MD⁷, Mignon L. Loh, MD⁸, Stephen P. Hunger, MD⁹ and Brent L. Wood, MD, PhD^1,10

¹Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
²Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA
³Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Biostatistics, University of Florida, Gainesville, FL
⁵St Jude Children's Research Hospital, Memphis, TN
⁶Fred Hutchinson Cancer Center, Seattle, WA
⁷Department of Pediatrics, NYU Langone Health, New York, NY
⁸Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Seattle, WA
⁹Childrens Hospital of Philadelphia, Philadelphia
¹⁰Department of Laboratory Medicine, University of Washington, Seattle, WA

Kohei Kume, PhD^1*, Zhengshan Chen, MD-PhD^2*, Mark E Robinson, PhD^1*, Lai N Chan, PhD¹, Etienne Leveille, MD-PhD^1*, Kadriye Nehir Cosgun, PhD^1*, Zhangliang Cheng^1*, David Fonseca Arce^1*, Dhruv Khanduja^1*, Thomas Graeber, PhD^2* and Markus Müschen, MD¹

¹Center of Molecular and Cellular Oncology, Yale University, New Haven, CT
²Metabolomics Center, University of California Los Angeles, Los Angeles, CA

Louise Ahlgren, PhD^1*, Mattias Pilheden, PhD^1*, Helena Sturesson, PhD^1*, Varsha Singh, PhD^1*, Qirui Zhang, PhD^1*, Michael Walsh, MD^2*, Guangchun Song^2*, Anders Castor^3*, Cornelis Jan Pronk, MD, PhD^3*, Pauline Schneider^4*, Ronald W. Stam, PhD^4*, Gisela Barbany^5*, Katja Pokrovskaja Tamm, PhD^6*, Jonas Abrahamsson^7*, Linda Fogelstrand, MD, PhD⁸, Olli Lohi, MD, PhD⁹, Jing Ma, PhD^2*, Jinghui Zhang, PhD^10* and Anna K. Hagstroem-Andersson, PhD¹

¹Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden
²Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
³Childhood Cancer Center, Skåne University Hospital, Lund, Sweden
⁴Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁵Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
⁶Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
⁷Institution for Clinical Sciences, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden
⁸Department of Clinical Chemistry, Sahlgrenska University, Gothenburg, Sweden
⁹Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
¹⁰Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN

Min Sui^1*, Huideng Long^2*, Chunhua Song, MD, PhD^3,4 and Zheng Ge, MD, PhD²

¹Department of Hematology, Zhongda Hospital, School of Medicine, Southeast University, Institute of Hematology Southeast University, Nanjing, China, China
²Department of Hematology, Zhongda Hospital, School of Medicine, Southeast University, Institute of Hematology Southeast University, Nanjing, China
³Hershey Medical Center, Pennsylvania State University Medical College, Hershey, PA
⁴Division of Hematology, The Ohio State University Wexner Medical Center and The James Cancer Hospital, Columbus, OH

Estelle Balducci^1,2*, Mathieu Simonin, MD, PhD^1,2*, Nicolas Duployez, PharmD, PhD^3,4*, Thomas Steimlé, MD^1,2*, Marie-Emilie Dourthe, MD, PhD^1,2*, Patrick Villarese, PhD^1,2*, Stéphane Ducassou, MD, PhD^5*, Isabelle Arnoux, PharmD^6*, Jean-Michel Cayuela, PharmD, PhD^7*, Marie Balsat, MD^8*, Lucien Courtois, PharmD^1,2*, Guillaume P Andrieu, PhD^1,2*, Aurore Touzart, MD, PhD^1,2*, Françoise Huguet, M.D.^9*, Arnaud Petit, MD, PhD^10*, Norbert Ifrah, MD, PhD¹¹, Hervé Dombret, MD, PhD¹², André Baruchel, MD, PhD^13,14, Claude Preudhomme, PharmD, PhD^3,4*, Nicolas Boissel, MD, PhD^12* and Vahid Asnafi, MD, PhD^1,2*

¹Laboratory of Onco-Hematology, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
²INSERM U1151, Institut Necker Enfants Malades (INEM), Paris, France
³INSERM U1277 CANTHER, Univ. Lille, Lille, France
⁴Laboratory of Hematology, Centre Hospitalier Universitaire (CHU) Lille, Lille, France
⁵Service d'onco-hématologie pédiatrique, Hôpital Pellegrin Tripode, Bordeaux, France
⁶Laboratory of Hematology, La Timone University Hospital, Assitance Publique des Hôpitaux de Marseille (AP-HM), Marseille, France
⁷Laboratory of Hematology and EA 3518 University Hospital Saint-Louis, AP-HP and Université de Paris, Paris, France
⁸Clinical Hematology Department, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France, Lyon, France
⁹Hematology Department, Institut Universitaire du Cancer-Oncopole, CHU de Toulouse, Toulouse, France
¹⁰Department of Pediatric Hematology and Oncology, Assistance Publique-Hôpitaux de Paris (AP-HP), GH HUEP, Armand Trousseau Hospital, Paris, France
¹¹PRES LUNAM, CHU Angers Service des Maladies du Sang and INSERM U 892, Angers, France
¹²Université Paris Diderot, Institut Universitaire d'Hématologie, EA-3518, Assistance Publique-Hôpitaux de Paris, University Hospital Saint-Louis, Paris, France
¹³Institut Universitaire d'Hématologie, EA-3518, University Hospital Saint-Louis, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France
¹⁴Department of Pediatric Hematology and Immunology, University Hospital Robert Debré, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France

Jacob J. Junco, PhD^1*, Raushan Rashid^1*, Maci Terrell^1*, Michelle Alozie^1*, Max Rochette^1*, Barry Zorman, PhD^1*, Pavel Sumazin, PhD^1*, Lauren Rowland^2*, Gino Dettorre^2*, Reid T. Powell, PhD^3*, Clifford C. Stephan, PhD^3*, Peter J. Davies, MD, PhD^3*, Margie M. Moczygemba, PhD^3*, Jun J. J. Yang, PhD⁴ and Karen R. Rabin, MD, PhD⁵

¹Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer Center, Houston, TX
²Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
³Institute of Biosciences and Technology, Texas A&M University, Center for Translational Cancer Research, Houston, TX
⁴Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, MEMPHIS, TN
⁵Department of Pediatrics, Baylor College of Medicine, Baylor College of Medicine TX Children's Cancer Center, Houston, TX

Luca Lo Nigro, MD¹, Daria La Cognata, MD^2*, Nellina Andriano, B.S.^3*, Emanuela Cannata, MD, PhD^4*, Manuela La Rosa, B.S.^5*, Marta Arrabito, MD^6* and Giovanna Russo, Professor^7*

¹Cytogenetic-Cytofluorimetric-Molecular Biology Laboratory Center of Pediatric Hematology Oncology, Azienda Policlinico "G. Rodolico",, Catania, Italy
²School of Residency in Pediatrics - University of Catania, Catania, Italy
³Ph Program in Translational Medicine - University of Catania - Italy, Catania, Italy
⁴Azienda Policlinico - San Marco, Catania, Catania, Italy
⁵Cytogenetic, Cytofluorimetric and Molecular Biology Lab - Center of Pediatric Hematology Oncology, Azienda Policlinico - San Marco, Catania, Catania, Italy
⁶Center of Pediatric Hematology Oncology, University of Catania - Azienda Policlinico - San Marco Catania, Catania, Italy
⁷Pediatric Hematology/Oncology Unit, University of Catania, Catania, Italy

Irina Pushel, PhD^1*, Byunggil Yoo, MS^1*, Daniel Louiselle, MS^1*, Margaret Gibson, MB(ASCP)^1*, Erin M. Guest, MD², Midhat S Farooqi, MD, PhD^1* and Keith J. August, MD, MS²

¹Genomic Medicine Center, Children's Mercy Kansas City, Kansas City, MO
²Hematology/Oncology/BMT, Children's Mercy Kansas City, Kansas City, MO

Kathrin Liszt, PhD^1,2*, Maximilian von der Linde, MS^1,2*, Dagmar Schinnerl, PhD^2*, Karin Nebral, PhD^1,2*, Sabine Strehl, PhD^3*, Andishe Attarbaschi, Prof., MD^2,4*, Oskar A. Haas, MD⁵ and Stefan Koehrer, MD^1,2,6*

¹Clinical Genetics, Labdia Labordiagnostik, Vienna, Austria
²St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria
³St. Anna Children’s Cancer Research Institute, Vienna, Austria
⁴Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University Vienna, Vienna, Austria
⁵St. Anna Children's Hospital, Vienna, Austria
⁶Department of Laboratory Medicine, Klinik Donaustadt, Vienna, Austria