Ing Soo Tiong, FRACP, FRCPA, MPhil^1,2,3, Tamia Nguyen^4,5*, Charis Teh, MPH, PhD^6,7*, Chong Chyn Chua, MBBS, FRACP, FRCPA, PhD^1,6,8, Sarah Ftouni, BSc, MSc^4*, Thomas E Lew, MBBS^9,10*, Fiona C. Brown, PhD^11,12*, Donia Moujalled, PhD^13*, Christine Muttiah, MBBS, FRACP, MPhil^13*, Daniel Gray, PhD^6*, Mary Ann Anderson, MBBS, PhD, FRACP, FRCPA^9,10*, Philip A. Thompson, MBBS^14*, Constantine S. Tam, MD, MBBS¹, John F. Seymour, MBBS, PhD, FRACP¹⁵, Sarah-Jane Dawson, MBBS, FRACP, PhD^3,5*, Andrew H. Wei, MBBS, PhD^11,16, Geoffrey Lindeman^13,17* and Piers Blombery, MBBS^18,19

¹The Alfred Hospital and Monash University, Melbourne, VIC, Australia
²Austin Health and Olivia Newton John Cancer Research Institute, Melbourne, Australia
³Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
⁴Peter MacCallum Cancer Centre, Melbourne, Australia
⁵The University of Melbourne, Parkville, Australia
⁶The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
⁷Department of Medical Biology, The University of Melbourne, Melbourne, Australia
⁸Northern Hospital, Epping, VIC, Australia
⁹Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia
¹⁰The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
¹¹The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
¹²Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
¹³The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
¹⁴Peter MacCallum Cancer Center, Royal Melbourne Hospital and University of Melbourne, Melbourne, Australia
¹⁵Peter MacCallum Cancer Center, Royal Melbourne Hospital and University of Melbourne, Melbourne, VIC, Australia
¹⁶Peter Maccallum Cancer Centre, Melbourne, VIC, Australia
¹⁷Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia
¹⁸Peter Maccallum Cancer Centre, East Melbourne, VIC, Australia
¹⁹Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia

Robert Vanner, MD, PhD¹, Andy G.X. Zeng¹, Michelle Chan-Seng-Yue, BSc^1*, Suraj Bansal^1*, Elisa Donato, PhD^2*, Liqing Jin, MD^1*, Sofia Genta, MD^1*, Enrique Sanz Garcia, MD^1*, Steven M. Chan, MD, PhD¹, Andreas Trumpp² and John E. Dick, PhD¹

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²HI-STEM gGmbH, Heidelberg, Germany

Rosalie Griffin, PhD^1,2, Aswin Sekar, MD, PhD³, Sameer A. Parikh, MD⁴, Giulio Genovese^5*, Dennis P. Robinson, PhD^6*, Aaron D. Norman^2*, Janet E. Olson, PhD^2*, Kari G. Rabe, MS^6*, Nicholas J. Boddicker, PhD¹, Paul J. Hampel, MD⁷, Neil E. Kay, MD^8,9, Timothy G. Call, MD⁹, James R. Cerhan, MD, PhD¹⁰, Esteban Braggio, PhD¹¹, Curtis A. Hanson, MD^12*, Caline M. Vachon, PhD², Tait D. Shanafelt, MD¹³, Benjamin L. Ebert, MD, PhD¹⁴ and Susan L. Slager, PhD^9,10

¹Division of Computational Biology, Mayo Clinic, Rochester, MN
²Division of Epidemiology, Mayo Clinic, Rochester, MN
³Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
⁴Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁵Department of Genetics, Harvard Medical School, Boston, MA
⁶Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN
⁷Mayo Clinic, Rochester, MN
⁸Department of Immunology, Mayo Clinic, Rochester, MN
⁹Division of Hematology, Mayo Clinic, Rochester, MN
¹⁰Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
¹¹Department of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
¹²Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, Rochester, MN
¹³Department of Medicine, Division of Hematology, Stanford University, Stanford, CA
¹⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Olisaemeka Ogbue¹, Tariq Kewan, MBBChir², Omar Mehkri^3*, Francois Fadell^3*, Ishani Nautiyal, BS^1*, Megan Reynold^1*, Arda Durmaz, PhD^1*, Jennifer VanOudenhove, PhD², Hussein Awada^1*, Serhan Unlu, MD^1*, Abhay Singh, MD, MPH⁴, Valeria Visconte, PhD¹, Lourdes Mendez, MD^2*, David S. Bosler, MD^5*, Abhijit Duggal^3*, Stephanie Halene, MD², Jaroslaw P. Maciejewski, M.D., Ph.D., FACP¹, Mohammed J Al-Jaghbeer,^3* and Carmelo Gurnari, MD^1,6

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Yale Cancer Center, Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT
³Department of Pulmonary and Critical Care Medicine, Respiratory institute, Cleveland Clinic, Cleveland, OH
⁴Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁵Pathology and Laboratory Medicine Institute (Robert J. Tomsich), Cleveland, OH
⁶Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

Raffaella Molteni, PhD^1,2,3*, Martina Fiumara, MSc^3,4,5*, Corrado Campochiaro, MD^1*, Alessandro Tomelleri, MD^1*, Elisa Diral, MD^6*, Angelica Varesi, MSc^7*, Alessandra Weber, MD^1,5*, Davide Stefanoni, PhD^2*, Roberta Alfieri, PhD^8*, Luisa Albano, MSc^7*, Maddalena Panigada, PhD^2*, Eleonora Cantoni, MSc^2*, Daniele Canarutto, MD, PhD^9,10*, Luca Basso-Ricci, MSc^5*, Pamela Quaranta, PhD^5*, Angelo D'Alessandro, PhD¹¹, Marco Matucci-Cerinic, MD^12*, Raffaella Di Micco^5*, Serena Scala, PhD^5*, Alessandro Aiuti, MD, PhD^1,5,10*, Fabio Ciceri^1,13*, Ivan Merelli, PhD^5,8*, Lorenzo Dagna, MD^1*, Simone Cenci, MD^1*, Giulio Cavalli, MD, PhD^1,2,12,14*, Luigi Naldini, MD, PhD^1,14 and Samuele Ferrari, PhD^5,14

¹Vita-Salute San Raffaele University, Milan, Italy
²Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
³co-first author, Milan, Italy
⁴Vita-Salute San Raffaele University, Milan, ITA
⁵San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy
⁶Unit of Hematology and Stem Cell Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy
⁷San Raffaele Telethon Institute For Gene Therapy, IRCCS San Raffaele Scientific, Milan, Italy
⁸Institute for Biomedical Technologies, National Research Council, Segrate, Italy
⁹San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Italiy, Italy
¹⁰Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy
¹¹Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
¹²Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
¹³Unit of Hematology and Stem Cell Transplantation, Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy
¹⁴co-last author, Milan, Italy

Daniel C. Cole¹, Zhengrui Xiao, MD², Varun Gupta^3*, Jesus D. Anampa Mesias, MD^4*, Noelle Townsend^5*, Gretchen Mackie^5*, Ami Sanghvi^3*, Rahul Thakur, MBBS⁶, Herbert Lachman, MD^3* and Irina Murakhovskaya, MD⁷

¹Albert Einstein College of Medicine - Montefiore Medical Center, Bronx, NY
²Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
³Albert Einstein College of Medicine, Bronx, NY
⁴Montefiore Medical Ctr./Albert Einstein College of Medicine, Bronx, NY
⁵Division of Hematology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY
⁶Department of Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY
⁷Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY

Shweta Singh, PhD¹, Tanmoy Sarkar, PhD¹, Holly Morris^1*, Kristbjorn Gudmundsson, PhD^1,2* and Jonathan Keller, PhD^1,2

¹Mouse Cancer Genetics Program - Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD
²Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD

Tran Bich Nguyen, MD, PhD^1*, Ai Nhan Thi Le^2*, YuanJiao Duan^2*, Yoshiaki Abe^3,4*, Yen Nguyen^4*, Mizuho Nakayama^5*, Masanobu Oshima^5*, Yuya Sasaki^3,4*, Tatsuhiro Sakamoto^3,4*, Manabu Fujisawa^3,6*, Shigeru Chiba^3,4* and Mamiko Sakata-Yanagimoto^3,4,7

¹Department of Hematology, Institute of Medicine, University of Tsukuba, Tsukuba, IBA, Japan
²Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
³Department of Hematology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan
⁴Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan
⁵Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
⁶Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, Canada
⁷Division of Advanced Hemato-Oncology, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Japan

Monique Chavez, BS^1*, Sridhar N Srivatsan^2*, Christopher A Miller, PhD^3*, Andrew J. Menssen, PhD⁴, Ajay Khanna^5*, Jin Shao^6*, Catrina Fronick^7*, Robert Fulton^8*, Sharon E Heath^9*, Constantine Logothetis, MD¹⁰, Tasha Burton^9*, Victoria Donaldson^9*, Claudia Cabrera, BS¹¹, Raya Saba, MD, MS¹², Kiran R. Vij¹³, Eric J. Duncavage^14*, Meagan Jacoby^15* and Matthew J. Walter, MD¹⁶

¹Department of Medicine, Division of Oncology, Washington University In St. Louis School of Medicine, Saint Louis, MO
²Washington University in St. Louis, St. Louis, MO
³Department of Internal Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University in St. Louis School of Medicine, Saint Louis, MO
⁴Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO
⁵Washington University In St Louis, Saint Louis, MO
⁶Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO
⁷McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, Saint Louis, MO
⁸McDonnell Genome Institute, St Louis, MO
⁹Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO
¹⁰Washington University, Saint Louis, MO
¹¹Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹²Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, Kansas City, MO
¹³Washington University School of Medicine, Saint Louis, MO
¹⁴Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO
¹⁵Washington University-School of Medicine, St. Louis, MO
¹⁶Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO

Konradin F. Müskens, MD, MSc, MA^1*, Maaike G.J.M. van Bergen, PhD^2*, Aniek O. de Graaf, PhD^2*, Nienke Wieringa, MD^3*, Brigit M. te Pas^4*, Anne P.J. de Pagter, MD PhD^5*, Joëll E. Bense, MD PhD^5*, Arjan C. Lankester, MD PhD^5*, Leontien C.M. Kremer, MD PhD^3*, Joop H. Jansen, PhD^2*, Gerwin A. Huls, Prof.⁶, Stefan Nierkens, PhD^3*, Caroline A. Lindemans, MD PhD^3,7 and Mirjam E. Belderbos, MD, PhD³

¹Princess Máxima Center for Pediatric Oncology, UTRECHT, Netherlands
²Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
³Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁴Princess Maxima Centre for Pediatric Oncology, Utrecht, Netherlands
⁵Division of Stem cell Transplantation, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands
⁶Department of Hematology, University Medical Center Groningen, Groningen, Netherlands
⁷Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands

Emil Hiitola^1,2*, Juuso Korhonen^1,2*, Jukka Koskela^3*, Matti Kankainen^1,2*, Milla Alakuijala^1,2*, Heidi Kokkonen^4*, Aoxing Liu^3*, Paavo Häppölä^3*, Paula Savola^1,2,5*, Tiina Kelkka^1,2*, Marjatta Leirisalo-Repo^6*, Ritva Peltomaa^6*, Laura Pirilä^7*, Pia Isomäki^8*, Markku Kauppi^9,10*, Oili Kaipiainen-Seppänen^11*, FinnGen Consortium^12*, Giulio Genovese^13,14,15*, Andrea Ganna^3*, Solbritt Rantapää-Dahlqvist^4*, Satu Mustjoki, MD, PhD^1,2 and Mikko Myllymäki, M.D., Ph.D.^1,2

¹Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
²Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
³Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
⁴Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden
⁵Department of Clinical Chemistry, HUS Diagnostic Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
⁶Inflammation Center, Department of Rheumatology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
⁷Center for Rheumatology and Clinical Immunology, Turku University Hospital, Turku, Finland
⁸Molecular Immunology Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
⁹Päijät-Häme Central Hospital, Lahti, Finland
¹⁰Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland
¹¹Kuopio Univerisity Hospital, Kuopio, Finland
¹²University of Helsinki, Helsinki, Finland
¹³Department of Genetics, Harvard Medical School, Boston, MA
¹⁴Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Cambridge, MA
¹⁵Stanley Center, Broad Institute of Harvard and MIT, Cambridge, MA

Peter Geon Kim, MD^1*, Christopher B. Hergott, MD, PhD^2*, Justin CT Loke, MD PhD¹, Wesley Shin^1*, Marie E McConkey, PhD^1* and Benjamin L. Ebert, MD, PhD^3,4,5

¹Dana Farber Cancer Institute, Boston, MA
²Dana-Farber Cancer Institute, Boston, MA
³Broad Institute of MIT and Harvard University, Cambridge, MA
⁴Howard Hughes Medical Institute, Boston, MA
⁵Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA