Apeksha Singh¹, Jennifer J Chia, MD, PhD^1,2, Yu-Sheng Eason Lin, PhD^1*, Dinesh S. Rao, MD, PhD² and Alexander Hoffmann, PhD^1*

¹Signaling Systems Laboratory, UCLA, Los Angeles, CA
²Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA

Nassima Messali, PhD¹, Mia Yabut, MS^1*, Pouneh Kermani, PhD^1*, Shahin Rafii, MD^2,3,4* and Joseph M. Scandura, MD, PhD, MS^5,6

¹Weill Cornell Medicine, New York, NY
²Cornell-Weil Medical College, New York, New York, NY
³Weill-Cornell Medical College, New York, NY
⁴Weill Cornell Medical College, New York, NY
⁵Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY
⁶Richard T. Silver, MD Myeloproliferative Neoplasms Center, Leukemia Program, New York, NY

Tessa Schmachtel^1*, Marius Külp^1*, Weijia Yu^1*, Hana Komic, MSc^2*, Catia Simoes^3*, Malin S. Nilsson^4*, Felipe Prosper, MD, PhD³, Timm Schroeder^5*, Halvard Bonig⁶, Bruno Paiva^3*, Fredrik B. Thorén^2* and Michael A. Rieger^1*

¹Department of Medicine 2, Hematology/Oncology, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
²TIMM Laboratory at Sahlgrenska Center for Cancer Research, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
³Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain
⁴Institute of Biomedicine, Gothenburg, Sweden
⁵Department of Biosystems Sciences and Engineering, ETH Zurich, Basel, Switzerland
⁶Faculty of Medicine, Institute for Transfusion Medicine and Immunohematology, Goethe University, Frankfurt, Germany

Priyasmita Chakrabarti¹, Nicola K. Wilson, PhD^2*, Abhishek K. Singh, PhD^3*, Iwo Kucinski, PhD^2*, Lizeth-Alejandra Ordonez-Moreno, PhD^1*, Sony Sharma, MSc^1*, Sarah J. Kinston, PhD^2*, Montaser B. Haddad, MSc^1*, Orit Kollet, PhD^1*, Ekaterina Petrovich-Kopitman, PhD^4*, Avik Choudhuri, PhD^5*, Leonard I. Zon, MD⁵, Jose A. Cancelas, MD³, John E. Dick, PhD⁶, Stephanie Xie, PhD⁷, Bertie Göttgens, PhD^2* and Tsvee Lapidot, PhD^1*

¹Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel
²Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
³Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel
⁵Harvard Stem Cell Institute, Cambridge, MA
⁶Department of Molecular Genetics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, CAN
⁷Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

Si Xie^1*, Fan Wu, PhD^1*, Xinying Zhao^1*, Qiuyu Yue^1*, Shicong Zhu^1*, Ling-Hui Yan^1*, Yuan Zhou^1*, Tong Xing^2*, Qi Hu^1*, Dong Li, PhD^1*, Jin-Song Jia, MD, PhD^2*, Yuan Kong, MD, PhD^2*, Xiao-Jun Huang, MD², Xiaofei Gao, PhD^3* and Hsiang-Ying Lee, PhD¹

¹School of Life Sciences, Peking University, Beijing, China
²Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China
³School of Life Sciences, Westlake University, Hangzhou, China

Devyani Sharma, MS^1,2,3*, Juying Xu^4* and Marie-Dominique Filippi, PhD¹

¹Cincinnati Children's Hospital Research Foundation, Cincinnati, OH
²Cincinnati Children's Hospital Medical Centre, Division of Experimental Hematology and Cancer Biology, Cincinnati, OH
³University of Cincinnati College of Medicine, Graduate Program of Cancer and Cell Biology, Cincinnati, OH
⁴Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Shuyang Cai^1,2,3,4,5*, Honghu Li, MD^4,6,7,8*, Ruxiu Tie, MD^9*, Wei Shan^6*, Qian Luo, PhD^4,6,7,8,10*, Shufen Wang, PhD^11*, Huiqiao Chen^12*, Meng Zhang^{4,6,7,8,10,13*}, Xu Yulin, PhD^9*, Jiahui Lu^2*, Pengxu Qian, PhD^4,7,8,10,14* and He Huang^3,4,6,7,15*

¹Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, AL, China
²Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
³Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China
⁴Institute of Hematology, Zhejiang University, Hangzhou, China
⁵Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Hangzhou, China
⁶Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁷Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University, Hangzhou, China
⁸Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Zhejiang University, Hangzhou, China
⁹Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Hangzhou, China
¹⁰Liangzhu Laboratory, Zhejiang University, Hangzhou, China
¹¹Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
¹²Sir Run Run Shaw Hospital, Hangzhou, CHN
¹³Bone Marrow Transplantation Center, First Affiliated Hospital Zhejiang University, HANGZHOU, China
¹⁴Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
¹⁵Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China

Habin Bea^1,2*, Jungwoo Kim, BS^1*, Haruna B. Choijilsuren, BS^1*, Katelyn Fong^1*, Sangmoo Jeong, PhD^2,3,4 and Moonjung Jung, MD, MS^1,4

¹Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
²Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD
³Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD
⁴Department of Oncology, Sidney Kimmel Comprehensive Cancer Research Center, Baltimore, MD

Xuan Cai^1*, Ruoyun Gui^1*, Jin Wu, MD^1*, Chen-Cong Wang^2*, Xiaolu Zhu, MD^3*, Haixia Fu, MD^4*, Kai-yan Liu, MD, PhD⁵ and Xiaohui Zhang, MD^6*

¹Peking University People's Hospital, Beijing, CHN
²Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
³Peking University People’s Hospital, Beijing, China
⁴Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, Beijing, China
⁵Peking University People's Hospital, Beijing, China
⁶Peking University Institute of Hematology, Peking University people hospital, Beijing, China

Mayuri Tanaka-Yano, PhD¹, Dahai Wang, PhD^2*, Diana Chen^3*, Biju Isaac, PhD^4*, Tianxin Scarlett Liu, PhD^2,5,6*, Liang Sun, PhD^4*, Edroaldo Lummertz da Rocha, PhD^7*, Berkley Gryder, PhD^3*, Stuart H Orkin, MD^1,5,6,8,9 and Robert Grant Rowe^1,2,5,6,10

¹Department of Hematology/Oncology, Harvard Medical School/Boston Children's Hospital, Boston, MA
²Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA
³Genetics & Genome Sciences, Case Western Reserve University, Cleveland, OH
⁴Research Computing, Boston Children's Hospital, Boston, MA
⁵Harvard Medical School, Boston, MA
⁶Dana-Farber Boston Children’s Cancer and Blood Disorders Center, Boston, MA
⁷Graduate Program of Pharmacology, Federal University of Santa Catarina, Florianopolis, Brazil
⁸Dana-Farber Cancer Institute, Inc., Boston, MA
⁹Howard Hughes Medical Institute, Boston
¹⁰Stem Cell Transplantation Program, Boston Children’s Hospital, Boston, MA

Marlise L Guerrero Schimpf, PhD, Michael S Pannullo^*, Courtney C Sparger, BS^*, Hsuan-Ting Huang, PhD, Dean L Wade^* and Maria Ken E Figueroa, MD

University of Miami Miller School of Medicine, Miami, FL

Maria Alejandra Kanashiro^1*, Sudip Kumar Paul, MSc^1*, Masamitsu Sone, PhD^1*, Ikuyo Yoshino^1*, Kyoko Tsujimura^1*, Makoto Ikeya, PhD^2*, Sou Nakamura, PhD^2*, Koji Eto, MD, PhD^1,2 and Naoya Takayama, MD, PhD^1*

¹Department of Regenerative Medicine, Chiba University, Chiba, Japan
²Centre of iPS Cell Research and Application, Kyoto University, Kyoto, Japan

Maria Florencia Florencia Tellechea, PhD^1*, Jalila Chagraoui, PhD^2*, Nadine Mayotte, MS^2* and Guy Sauvageau, MD/PhD^2,3,4,5

¹Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC, Canada
²Institut de recherche en Immunologie et Cancer, Université de Montréal, Montreal, QC, Canada
³University of Montreal, Montreal, QC, CAN
⁴Universite de Montreal, Montreal, QC, CAN
⁵Université De MontréAl, Montreal, QC, CAN

Yan Yan^*, Hiroki Kato^*, Sayaka Sano^*, Eijiro Furukawa^*, Daigo Michimata^*, Yuya Tanaka^*, Kazuki Sakurai^*, Koichi Onodera^*, Satoshi Ichikawa^*, Tohru Fujiwara, Yasushi Onishi^*, Noriko Fukuhara, Hisayuki Yokoyama^* and Hideo Harigae

Department of Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan

Zhigang Li^1*, Jiankun Fan^1*, Yuanze Zhou^1* and Yu Hou, PhD²

¹institute of life sciences, Chongqing Medical University, Chongqing, China
²Institute of Life Sciences, Chongqing Medical University, CHONGQING, Chongqing, China

Akhilesh Kumar^1*, Colin Fischer, MS^2*, Alexander Lenvik^2*, Ojas Singh^2*, Jeffrey S Miller, MD³ and Frank Cichocki, PhD³

¹Division of Hematology, Oncology, and Transplantation, Department of Medicine,, University of Minnesota, Minneapolis, Minnesota., MINNEAPOLIS, MN
²Masonic Cancer Center, University of Minnesota, Minneapolis, MN
³Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN

Kaoru Takasaki, MD¹, Christopher S. Thom, MD, PhD², David Smith, PhD^3*, Sara S. Kumar^4*, Ying Ting Sit, PhD^4*, Alyssa Gagne^4*, Deborah L. French, PhD^5* and Stella T. Chou, MD^5,6

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Children's Hospital of Philadelphia, Philadelphia, PA
⁵Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
⁶Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA

Katherine Sturgess, MBBS^1,2,3*, Vijay Shanmugiah^1,2*, Tomoya Isobe, MD^1,2*, Melania Barlie, PhD^1,2*, Nicola K. Wilson, PhD^1,2* and Berthold Gottgens^1,2

¹Department of Haematology, University of Cambridge, Cambridge, United Kingdom
²Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
³Department of Haematology, Cambridge University Hospitals NHSFT, Cambridge, United Kingdom

Alexandre Fagnan, PhD¹, Roy Drissen, PhD^2*, Cristina Di Genua^3*, Yiran Meng⁴ and Claus Nerlov, PhD^4*

¹MRC - Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, ENG, United Kingdom
²MRC - Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
³University of Oxford, Oxford, ENG, GBR
⁴Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom