65th ASH Annual Meeting & Exposition: 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Cell Fate Decisions and Fitness

Symposia: Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational Oral and Poster Abstracts
Oral

Fundamental Science, Research, hematopoiesis, immune mechanism, Biological Processes, molecular biology

Room 24 (San Diego Convention Center)

Moderators:

Kenichi Miharada, PhD, Lund University and Robert Signer, PhD, UC San Diego

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

397

Extracellular Vesicle Trafficking Regulates Hematopoietic Stem and Progenitor Cell Fitness

Stephanie N Hurwitz, MD, PhD^1,2, Seul K Jung, BS³^*, Danielle R Kobulsky, PSM⁴^* and Peter Kurre, MD^3,5

¹Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
²Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
³Comprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁴Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
⁵Department of Pediatrics, University of Pennsylvania, Philadelphia, PA

9:45 AM

398

B4galt1 Regulates the WNT-β-Catenin Axis to Control Hematopoietic Stem and Progenitor Cells (HSPCs) Fitness

Alejandro Roisman, PhD¹^*, Leonardo Rivadeneyra, PhD²^*, Lindsey Conroy, PhD³^*, Simon Glabere¹^*, Grace Kelly¹^*, Natalia Weich, PhD²^*, George Steinhardt, PhD¹^*, Shikan Zheng, PhD¹^*, Anthony Veltri, PhD¹^*, Joseph T. Lau, PhD⁴^*, Hartmut Weiler, PhD⁵, Ramon Sun, PhD³^* and Karin M. Hoffmeister, MD^1,6

¹Versiti Blood Research Institute, Milwaukee, WI, Milwaukee, WI
²Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI
³Department of Biochemistry & Molecular Biology, College of Medicine, University of Florida, Gainesville, FL
⁴Roswell Park Cancer Institute, Buffalo, NY
⁵Thrombosis and Hemostasis, Versiti Blood Research Institute, Milwaukee, WI
⁶Departments of Biochemistry and Medicine, Medical College of Wisconsin, Milwaukee, WI

10:00 AM

399

CUX1 Levels Control Hematopoietic Stem Cell Fate and Plasticity

Tanner C. Martinez^1,2,3^*, Matthew R. M. Jotte^2,4,5 and Megan E. McNerney, MD, PhD^2,4

¹Department of Pathology, University of Chicago, Chicago, IL
²Comprehensive Cancer Center, The University of Chicago Medicine, Chicago, IL
³Medical Scientist Training Program, The University of Chicago, Chicago, IL
⁴Department of Pediatrics, Section of Hematology/Oncology, Chicago, IL
⁵The University of Chicago Medical Scientist Training Program, Chicago, IL

10:15 AM

400

Divergent Roles of MLL3 and MLL4 in Hematopoietic Stem Cell Fate Decision

Helen C. Wang¹, Ran Chen, PhD²^*, Wei Yang, PhD³^*, Riddhi M. Patel²^*, Emily B. Casey²^*, Elisabeth Denby²^* and Jeffrey Magee, MD, PhD⁴

¹Department of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, St Louis, MO
²Department of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, MO
³Department of Genetics, Washington University School of Medicine, St. Louis, MO
⁴Washington University School of Medicine, Saint Louis, MO

10:30 AM

401

Lung Megakaryocytes Arise from a Flt3^- Cell Lineage and Contribute to Recovery of Platelet Counts in Thrombocytopenic States

Alison C. Livada, MS¹, Kathleen E. McGrath, PhD¹, Sara Blick-Nitko¹^*, Chen Li¹, Paul D. Kingsley, PhD¹^*, Leah A. Vit¹^*, Sara Ture, B.S¹^*, Anne Koniski¹^*, James Palis, MD² and Craig Morrell, DVM, PhD¹

¹University of Rochester, Rochester, NY
²University of Rochester Medical Center, Rochester, NY

10:45 AM

402

Characterization of Hematopoietic Stem Cell Diversity Using Spatiotemporal Quantitative Phase Imaging

Takao Yogo, MD, PhD¹, Tomomasa Yokomizo, PhD²^*, Toshio Suda, MD, PhD³^* and Satoshi Yamazaki, PhD^4,5^*

¹The Institute of Medical Science, The University of Tokyo, Minato-ku, TKY, Japan
²Kumamoto University, Kumamoto, JPN
³National University of Singapore, Singapore, SGP
⁴University of Tsukuba, Tsukuba, JPN
⁵The University of Tokyo, Tokyo, Japan

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^*signifies non-member of ASH

501.O2.6 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Cell Fate Decisions and Fitness