Hanne Due, PhD, MSc^1*, Issa Ismail Issa^1,2*, Martin Thomsen^3*, Maja Zimmer Jakobsen^1,2*, Hulda Haraldsdóttir^1,2*, Rasmus Froberg Brøndum^4* and Karen Dybkaer, PhD, MSC^2*

¹Department of Hematology, Aalborg University Hospital, Aalborg, Denmark
²Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
³Department of Biomedicine, Aarhus University, Aarhus, Denmark
⁴Center for Clinical Data Science (CLINDA), Department of Clinical Medicine, Aalborg University, and Research, Education and Innovation, Aalborg University Hospital, Aalborg, Denmark

Carlota Pages-Geli^1*, Sabela Bobillo, MD, PhD^2*, Pau Abrisqueta, MD, PhD^1,2, Josep Castellvi, MD^3*, Laura Palomo^1*, Damiana Alvarez, PhD^4*, Manel Esteller, MD⁵, Francesc Bosch, MD, PhD^1,2 and Marta Crespo, PhD^1*

¹Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain
²Hematology Department, Vall d'Hebron University Hospital, Barcelona, Spain
³Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain
⁴Cancer Epigenetics, Josep Carreras Leukaemia Research Institute, Badalona, Spain
⁵Josep Carreras Leukaemia Research Institute, Badalona, Spain

Sina Nassiri^1*, Stephan Schmeing^2*, Gabrielle Leclercq^2*, Sylvia Herter, PhD^2*, Llucia Alberti Servera, PhD^1*, Tamara Hüsser^2*, Emilio Yángüez^2*, Diana Dunshee^3*, Koorosh Korfi, PhD⁴, Pablo Umana, PhD⁵, Ann-Marie E. Bröske, PhD^6*, Alessia Bottos, PhD^7* and Marina Bacac, PhD^8*

¹Roche Innovation Center Basel, Roche, Basel, Switzerland
²Roche Innovation Center Zurich, Roche, Schlieren, Switzerland
³Genentech, Inc., South San Francisco, CA
⁴Roche Innovation Center Zurich, Roche, Schlieren, -- Select, Switzerland
⁵Roche Innovation Center Zurich, Roche/Genentech, Schlieren, Switzerland
⁶Roche Innovation Center Munich, Penzberg, Germany
⁷Roche, Basel, Switzerland
⁸Roche Innovation Center Zurich, Roche, Zürich, Zurich, Switzerland

Takeshi Sugio, MD, PhD^1*, Navika Shukla, MD², Michael S Khodadoust, MD, PhD^3*, Monica Nesselbush^4*, Koji Kato, M.D., Ph.D.⁵, Stefan K. Alig, MD⁶, Jan Boegeholz, MD⁷, Joseph G Schroers-Martin, MD⁶, Mohammad Shahrokh Esfahani, PhD^6*, Jurik A. Mutter^8,9*, Andrea Garofalo⁶, Soyeong Jun, PhD^10*, Mark P. Hamilton, MD¹¹, Cédric Rossi, MD, PhD³, Mari Olsen^6*, Chih Long Liu^6*, Koichi Akashi, M.D., Ph.D.^5*, Maximilian Diehn, MD, PhD^10* and Ash A. Alizadeh, MD, PhD⁶

¹Divisions of Oncology and Hematology, Stanford University, Washington, MD
²Department of Medicine, University of Chicago, Chicago, IL
³Stanford University, Stanford, CA
⁴Program in Cancer Biology, Stanford School of Medicine, Stanford, CA
⁵Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan
⁶Department of Medicine, Divisions of Oncology and Hematology, Stanford University, Stanford, CA
⁷Divisions of Hematology and Oncology, Stanford University, Stanford, CA
⁸Divisions of Oncology and Hematology, Stanford University, Stanford, CA
⁹Divisions of Oncology and Hematology, Department of Medicine, Stanford University, Stanford, CA
¹⁰Department of Radiation Oncology, Stanford University, Stanford, CA
¹¹Division of Hematology and Oncology, Stanford University, Palo Alto, CA

Martina Ferrante^1*, Daniela Drandi^1*, Silvia Zibellini^2*, Luigi Marcheselli^3*, Chiara Varraso^2*, Veronica Peri, MD^4,5*, Irene Dogliotti, MD^5*, Davide Musto^4*, Emilia Cappello^6*, Federica Cavallo^4,7*, Angela Ferrari^8*, Michele Merli^9*, Giulia Zamprogna^10*, Luca Laurenti, MD^11*, Simona Tomasetti^12*, Emanuele Cencini, MD^13*, Giacomo Loseto, MD^14*, Silvia Finotto, MD^15*, Monia Marchetti, MD^16*, Francesca Re, MD^17*, Antonello Sica, MD^18*, Jacopo Olivieri^19*, Giulia Vittoria Facchetti^6*, Cristina Jiménez^20*, Noemi Puig, MD, PhD²⁰, Giulia Turra^6*, Benedetto Bruno, MD, PhD^5,21, Ramon Garcia-Sanz, MD, PhD^20*, Marzia Varettoni^2* and Simone Ferrero, MD^4,5

¹Division of Hematology ,Department of Molecular Biotechologies and Health Sciences, University of Torino, Torino, Italy
²Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
³Fondazione Italiana Linfomi, Clinical Trial Office, Modena, Italy
⁴Division of Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Torino, Torino, Italy
⁵Division of Hematology and Stem Cell Transplant Unit, University Hospital AOU Città della Salute e della Scienza, Torino, Italy
⁶Department of Molecular Medicine, University of Pavia, Pavia, Italy
⁷Division of Hematology and Stem Cell Transplant Unit, AOU Città della Salute e della Scienza, Torino, Italy
⁸IRCCS - Arcispedale Santa Maria Nuova, Hematology, ITA, Reggio Emilia, Italy
⁹Ospedale di Circolo e Fondazione Macchi, Varese, Italy
¹⁰Department of Hematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
¹¹S. Ematologia, Dipartimento Scienze Radiologiche Radioterapiche ed Ematologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
¹²Ematologia, Ospedale degli Infermi di Rimini, Rimini, Italy
¹³Hematology, Azienda Ospedaliera Universitaria Senese & University of Siena, Siena, Italy
¹⁴IRCCS Istituto Tumori “Giovanni Paolo II”, Hematology Unit, Bari, Italy
¹⁵Oncologia1, Dipartimento di Oncologia, Istituto Oncologico Veneto IRCCS, Padova, Italy
¹⁶Ematologia, Ospedale Civile SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
¹⁷UO Ematologia e CTMO, Azienda Ospedaliera Universitaria di Parma, Parma, Italy
¹⁸Oncologia Medica ed Ematologia, AOU Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy
¹⁹Clinica Ematologica, Centro Trapianti e Terapie Cellulari "Carlo Melzi", Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy
²⁰Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC), CIBERONC, Salamanca, Spain
²¹Division of Hematology ,Department of Molecular Biotechologies and Health Sciences, University of Torino,Division of Hematology and Stem cell transplant unit, AOU Città della Salute e della Scienza, Torino, Italy

Karan Chohan, MD¹, Jonas Paludo, MD², Surendra Dasari, PhD^3*, Patrizia Mondello, MD, PhD, MSc⁴, Joseph P. Novak^4*, Jithma Prasad Abeykoon, MD², Kerstin Wenzl, PhD^2*, Zhi-Zhang Yang, MD⁵, Shahrzad Jalali, PhD^2*, Vaishali Bhardwaj, PhD⁴, Jordan Edward Krull^2*, Esteban Braggio, PhD⁶, Michelle Manske, MS, BS^2*, Aneel Paulus, MD, MS^7*, Craig B. Reeder, MD⁸, Sikander Ailawadhi⁷, Asher Alban Chanan-Khan, MD⁷, Prashant Kapoor, MD⁹, Robert Kyle, MD¹⁰, Morie A. Gertz, MD¹¹, Anne J. Novak, PhD² and Stephen M Ansell, MD, PhD⁴

¹Medicine, Mayo Clinic - Rochester, Rochester, MN
²Mayo Clinic, Rochester, MN
³Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Hematology, Mayo Clinic, Rochester, MN
⁶Department of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁷Mayo Clinic Florida, Jacksonville, FL
⁸Hematology, Mayo Clinic, Phoenix, AZ
⁹Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
¹⁰Mayo Clinic, Stabile 6-28, Rochester, MN
¹¹Department of Medicine, Division of Hematology,, Mayo Clinic, Rochester, MN

Beatriz Wills, MD¹, Jahan Rahman^2*, Nivetha Ganesan^3*, Gunjan L. Shah³, Ariela Noy, MD⁴, Heiko Schoder, MD^5*, Joachim Yahalom, MD⁶, Anita Kumar, MD⁷, Lorenzo Falchi, MD⁸, Paul A. Hamlin, MD⁴, Maria Lia Palomba, MD⁴, William Johnson^3*, Andrew M. Intlekofer, MD, DPhil¹, Philip Caron, MD⁹, Theresa Davey, MMSc, PA-C^3*, Helen Hancock, ANP^3*, Natasha Galasso^3*, Brittney Munayirji^3*, Ya Hui Lin^10*, Alayna Santarosa^3*, Ellie Casper^3*, Georgio Pongas, MD^11*, Andrew D. Zelenetz, MD, PhD¹, Craig H. Moskowitz, MD¹², Gilles Salles, MD, PhD¹, Santosha A Vardhana, MD, PhD^4* and Alison Moskowitz, MD³

¹Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²Memorial Sloan Kettering Cancer Center, NY
³Memorial Sloan Kettering Cancer Center, New York, NY
⁴Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York
⁵Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York
⁶Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Short Hills, NJ
⁸Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Memorial Sloan-Kettering, West Harrison, NY
¹⁰Memorial Sloan Kettering, NYC, NY
¹¹Sylvester Comprehensive Cancer Center, Miami
¹²Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, FL

Elisa Mandato, PhD^1*, Eleonora Calabretta, MD^1*, Gali Bai, MS^2,3*, Li Song, PhD^2,4*, Tianfang Ma, PhD^1*, Vignesh Shanmugam, MD^5,6, Julia Paczkowska, PhD^1*, Yanbo Sun, PhD^1,7*, Il-Kyu Choi, PhD^1,8*, Robert A. Redd, MS^2*, Donna S. Neuberg, ScD², Sumbul Jawed Khan, PhD^1*, Franziska Michor, PhD^{2,9,10,11,12*}, Scott Rodig, MD, PhD^5,13, Baochun Zhang, MD, PhD^1* and Margaret A. Shipp, MD¹

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
³Department of Biomolecular Engineering in the Baskin School of Engineering, University of California Santa Cruz, Santa Cruz, CA
⁴Department of Biomedical Data Science, Dartmouth College, Hanover, NH
⁵Department of Pathology, Brigham and Women's Hospital, Boston, MA
⁶Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA
⁷Moderna, Cambridge, MA
⁸Daegu Gyeongbuk Institute of Science and Technology, Daegu, Korea, Republic of (South)
⁹Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA
¹⁰Department of Stem Cell and Regenerative Biology, Harvard University, Boston, MA
¹¹Broad Institute of MIT and Harvard, Cambridge, MA
¹²Ludwig Center at Harvard, Boston, MA
¹³Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA

Leo Meriranta, MD^1,2*, Maare Arffman, MSc^2,3*, Judit Mészáros Jørgensen, MD, PhD^4*, Harald Holte, MD, PhD⁵, Kristina Drott, MD, PhD^6*, Henrikki Almusa^7*, Emma Saarinen^7*, Sari Hannula^7*, Marja-Liisa Karjalainen-Lindsberg, MD, PhD^8*, Klaus Beiske, MD, PhD^9*, Mette Ølgod Pedersen, MD^10*, Øystein Fluge, MD, PhD^11*, Peter de Nully Brown, MD, PhD¹², Sirkku Jyrkkiö, MD, PhD^13* and Sirpa Leppä, Professor^1,2

¹University of Helsinki, Helsinki, Finland
²Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
³University of Helsinki, Helsinki, AL, Finland
⁴Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
⁵Department of Oncology, Oslo University Hospital, Oslo, NOR
⁶Skåne University Hospital, Lund, Sweden
⁷Institute of Molecular Medicine Finland, HILIFE, University of Helsinki, Helsinki, Finland
⁸Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
⁹Oslo University Hospital, Oslo, Norway
¹⁰Herlev hospital, Herlev, Denmark
¹¹Haukeland University Hospital, Bergen, Norway
¹²Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
¹³Turku University Hospital, Turku, Finland

Ákos Nagy, MD^1*, Bence Bátai^1*, Gregory Hogan, PhD^2*, Jacob J. Chabon, PhD^2*, Mikayla Troke^2*, Lance Riley^2*, Andre Schultz, PhD^2*, Sandra Close, PhD^2*, Maximilian Diehn, MD, PhD^3*, Donát Alpár, PhD^1*, Botond Timár, MD, PhD^1*, Ash A. Alizadeh, MD, PhD⁴, David M. Kurtz, MD, PhD^5,6 and Csaba Bödör, PhD^1*

¹HCEMM-SU Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
²Foresight Diagnostics, Aurora, CO
³Department of Radiation Oncology, Stanford University, Stanford, CA
⁴Department of Medicine, Divisions of Oncology and Hematology, Stanford University, Stanford, CA
⁵Division of Oncology, Department of Medicine, Stanford University, Stanford, CA
⁶Stanford University, Palo Alto, CA

Dhruv Khanduja^1*, Mark E Robinson, PhD^1*, David Fonseca Arce^1*, Lars Klemm^1*, Etienne Leveille, MD-PhD^1*, Shalin Kothari, MD^1*, Rebecca Caeser, PhD^2*, Daniel James Hodson, MD-PhD³ and Markus Müschen, MD¹

¹Center of Molecular and Cellular Oncology, Yale University, New Haven, CT
²Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY
³Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, GBR

Zijuan Wu, MD^1*, Wei Zhang^2*, Luqiao Wang^2*, Lei Fan^3*, Jianyong Li, MD^4,5,6,7,8 and Hui Jin^9*

¹Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, AL, China
²Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, China
³Jiangsu Province Hospital, Nanjing, Jiangsu, China
⁴Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
⁵Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, China
⁶Jiangsu Cooperative Lymphoma Group (JCLG)., Nanjing, China
⁷The First Affiliated Hospital With Nanjing Medical University, Nanjing, China
⁸Jiangsu Cooperative Lymphoma Group (JCLG) and Jiangsu Histiocytosis Association Lymphoma Group (JHA-LG), Nanjing, China
⁹Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Alessia Bottos, PhD^1*, Corinna Woestmann^2*, Christopher R. Bolen, PhD^3*, Maria Shin^4*, Patrick Bogard, PhD^5*, Ehsan Tabari, PhD^5*, Andrew S. Davies, BSc (Hons) BM (Hons) PhD FRCP^6*, Andrea Knapp, PhD^1*, Tina Nielsen, MD^7*, Oliver Weigert⁸ and Elicia Penuel, PhD³

¹F. Hoffmann-La Roche Ltd, Basel, Switzerland
²Signature Diagnostics GmbH, Potsdam, Germany
³Genentech, Inc., South San Francisco, CA
⁴Signature Diagnostics GmbH, Potsdam, Germany., Potsdam, Germany
⁵Roche Molecular Solutions, Pleasanton, CA
⁶Southampton General Hospital, Southampton CRUK/NCRI Experimental Cancer Medicines Centre, Southampton, United Kingdom
⁷F. Hoffmann-La Roche Ltd, Basel, Switzerland, Basel, CHE
⁸Study Center, Medical Department III, Munich, DEU

Yuta Ito^1,2*, Joji Shimono, MD, PhD^3*, Keisuke Kawamoto, MD, PhD^4*, Kanako C. Hatanaka^5*, Yasunori Kogure, MD, PhD^1*, Junji Koya, MD^1*, Koichi Murakami, MD, PhD^1,6*, Mariko Tabata^1,7*, Yuki Saito^1,8*, Mitsuhiro Yuasa, MD^1,9*, Kota Mizuno, MD^1,6*, Sara Horie^1,8*, Yosuke Mizukami^1,8*, Takanori Teshima, M.D., Ph.D.³, Yutaka Hatanaka^10*, Hiroaki Miyoshi, MD, PhD^4*, Yoshihiro Matsuno^11*, Koichi Ohshima, MD, PhD^4*, Keisuke Kataoka, MD, PhD^1,6 and Masao Nakagawa, MD, PhD³

¹Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan
²Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
³Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan
⁴Department of Pathology, Kurume University School of Medicine, Kurume, Japan
⁵Center for Development of Advanced Diagnostics, Hokkaido University Hospital, Sapporo, Japan
⁶Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
⁷Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⁸Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan
⁹Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
¹⁰Research Division of Genome Companion Diagnostics, Hokkaido University Hospital, Sapporo, Japan
¹¹Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan

Mark Kaplan^1*, Tara Basavanhally^1*, Yumi Nakayama, PhD^1*, Charalampos Kyriakopoulos, PhD^1*, Arnaud Amzallag, PhD^1*, Argyrios Gkasiamis, MD², Arpankumar Patel^1*, Akshay Sudhindra, MD¹, Grzegorz S. Nowakowski, MD³, Jason Westin, MD⁴ and Anita K. Gandhi, PhD¹

¹Bristol Myers Squibb, Princeton, NJ
²Bristol Myers Squibb, Boudry, Switzerland
³Mayo Clinic Hospital, Rochester, MN
⁴Department of Lymphoma-Myeloma, MD Anderson Cancer Center, Houston, TX

Tomotaka Suzuki^1*, Rui Yokomori^2*, Takaomi Sanda, MD, PhD^1,2, Hiroki Yano^3*, Takaki Kikuchi^4*, Takashi Kanamori^4*, Atsushi Inagaki, MD, PhD^4*, Takashi Yoshida^5*, Satoshi Kayukawa^5*, Yoshiko Oshima^6*, Hirokazu Sasaki^6*, Shiori Kinoshita^6*, Tomoko Narita^1*, Ayako Masaki^7*, Masaki Ri^1*, Shigeru Kusumoto, MD, PhD¹, Hirokazu Komatsu^1*, Hiroshi Inagaki^7* and Shinsuke Iida⁸

¹Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
²Cancer Science Institute of Singapore, National University of Singapore, Singapore, SGP
³Department of Hematology, Kainan Hospital, Yatomi, Japan
⁴Department of Hematology and Oncology, Nagoya City University West Medical Center, Nagoya, Japan
⁵Department of Hematology and Oncology, Nagoya Memorial Hospital, Nagoya, Japan
⁶Department of Hematology, Toyokawa City Hospital, Toyokawa, Japan
⁷Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⁸Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

Rosalie Griffin, PhD¹, Kerstin Wenzl, PhD^2*, Vivekananda Sarangi^2*, Lisa M. Rimsza, MD³, Rebecca King, MD^2*, Andrew L. Feldman, MD⁴, Matthew J. Maurer, DrMed^2*, Grzegorz S. Nowakowski, MD⁵, Brian K. Link, MD^6*, Thomas M. Habermann, MD⁵, Nicholas Stong^7*, C. Chris Huang, PhD^8*, Anita K. Gandhi, PhD⁷, Susan L. Slager, PhD⁹, Anne J. Novak, PhD² and James R. Cerhan, MD, PhD⁹

¹Division of Computational Biology, Mayo Clinic, Rochester, MN
²Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ
⁴Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, Rochester, MN
⁵Division of Hematology, Mayo Clinic, Rochester, MN
⁶University of Iowa, Iowa City, IA
⁷Bristol Myers Squibb, Princeton, NJ
⁸Bristol Myers Squibb, Summit, NJ
⁹Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN

Hui Jin^1*, Xueying Lu^2*, Shunan Wang^1*, Xiao Chen^1*, Lei Cao^1*, Zijuan Wu, MD^1*, Lei Fan, MD^3* and Jianyong Li, MD³

¹Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
²Department of Hematology, The First Affiliated Hospital of Nanjing Medical Univ, Nanjing, China
³Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

Josu Iraola-Truchuelo^1*, Gloria Iacoboni, MD^1*, Laura Palomo, PhD^2*, Victor Navarro Garces^3*, Josep Castellvi^1*, Alba Mas^4*, Lara Nonell^4*, Luis A Mayor^5*, Victoria Dourdil^5*, Tomas Garcia Cerecedo^6*, Oriana López Godino^7*, Mario Sánchez-Salinas^1*, Cecilia Carpio^8*, Marta Crespo, PhD^9*, Angel Serna, MD^1*, Alba Cabirta Touzón, MD^1*, Marc Bosch, MD^1*, Cristina García, MD^1*, Pere Barba, MD¹, Francesc Bosch, MD, PhD^1* and Pau Abrisqueta Costa, MD, PhD^1*

¹Vall d'Hebron University Hospital, Barcelona, Spain
²Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
³Oncology Data Science (ODysSey) Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁴Bioinformatics Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁵Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
⁶University Hospital Arnau de Vilanova, Lleida, Spain
⁷Hospital General Universitario Morales Meseguer, Murcia, Spain
⁸Vall D' Hebron Hospital, Barcelona, Spain
⁹Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain

Catalina Amador, MD^1*, Dennis D Weisenburger, MD^2*, Ana Gomez, MD^3*, Alyssa Bouska, PhD^4*, Francisco Vega, MD, PhD⁵, James R. Cook, MD, PhD⁶, Timothy C. Greiner, MS, MD^2*, Andrew L. Feldman, MD⁷, Elaine S. Jaffe, MD⁸, Sarah L. Ondrejka, DO⁶, German Ott, MD^9*, Neval Ozkaya, MD^10*, Phil Raess, MD, PhD^11*, Andreas Rosenwald, MD^12*, Kerry J. Savage, MD, MSc, BSc¹³, Graham Slack, MD^14*, Joo Y. Song, MD¹⁵, Lisa M. Rimsza, MD¹⁶, Wing C. Chan, MD¹⁷ and Javeed Iqbal, PhD, MSc^2*

¹Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL
²Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
³University of Miami, Miami, FL
⁴Department of Pathology and Microbiology, University of Nebraska Medical Center, OMAHA, NE
⁵Department of Hematopathology, MD Anderson Cancer Center , Houston, TX
⁶Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH
⁷Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁸CCR Lab of Pathology, National Cancer Institute, Bethesda, MD
⁹Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
¹⁰Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, Bethesda, MD
¹¹Department of Pathology and Laboratory Medicine, Oregon Health & Science University, Portland, OR
¹²Institute of Pathology, Julius-Maximilians-Universität Würzburg, Wuerzburg, Germany
¹³Division of Medical Oncology, BC Cancer, Vancouver, BC, Canada
¹⁴BC Cancer, Vancouver, BC, CAN
¹⁵Beckman Research Institute, City of Hope, Duarte, CA
¹⁶Mayo Clinic Scottsdale, Scottsdale, AZ
¹⁷Department of Pathology, City of Hope National Medical Center, Duarte, CA

Aashray Mandala, BS^1*, Carlos Bravo-Perez, MD^1,2*, Nakisha D Williams, MBBS^1*, Christopher Haddad^1*, Luca Guarnera, MD^1,3*, Simona Pagliuca, MD, PhD^4,5, Serhan Unlu, MD^1*, Yasuo Kubota, MD, PhD^1*, Naomi Kawashima, MD, PhD^1*, Carmelo Gurnari, MD^1,3, Valeria Visconte, PhD¹, Arda Durmaz, PhD^1* and Jaroslaw P. Maciejewski, M.D., Ph.D., FACP¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, University of Murcia, IMIB-Pascual Parrilla, CIBERER - Instituto de Salud Carlos III, Murcia, Spain
³Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland, OH
⁵Department of Hematology, Centre Hospitalier Régional Universitaire (CHRU), Vandœuvre-lès-Nancy, France, France

Dimitra Karagkouni^1,2*, Xanthi Lida Katopodi^2,3*, Giulia Cheloni, PhD^4*, Yuling Ma^2,3*, Brodie Miles, PhD^5*, Gayatri Tiwari^5*, Jenny J. Kim, MD, MS⁵, Mike Mattie, PhD^6*, Jacalyn Rosenblatt, MD⁴, David Avigan, MD⁴ and Ioannis Vlachos, PhD^2,3*

¹Department of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Brookline, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³Department of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁴Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁵Kite Pharma, a Gilead Company, Santa Monica, CA
⁶Kite Pharma, a Gilead company, Santa Monica, CA