Stefano Rebellato^1*, Claudia Saitta^1*, Laura Rachele Bettini, MD^1*, Daniela Silvestri^1*, Orietta Spinelli^2*, Agata Pastorczak, MD, PhD^3*, Danielle Brandes^4*, Ute Fischer, PhD^4*, Arndt Borkhardt⁵, Sabine Strehl, PhD^6*, Luca Lo Nigro, MD⁷, Barbara Buldini, MD, PhD⁸, Julia Hauer^9*, Franziska Auer, PhD^10*, Lennart Kester^11*, Roland P. Kuiper, PhD^11,12, Luciana Vinti, MD, PhD¹³, Franco Locatelli, MD, PhD^13,14, Andrea Biondi, MD^1,15, Grazia Fazio, PhD^1* and Giovanni Cazzaniga, PhD^1,16

¹Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
²Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy
³Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Lodz, Poland
⁴Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University, Medical Faculty, Duesseldorf, Germany
⁵Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical faculty, Heinrich Heine University Düsseldorf, Duesseldorf, Germany
⁶St. Anna Children’s Cancer Research Institute, Vienna, Austria
⁷Cytogenetic-Cytofluorimetric-Molecular Biology Laboratory Center of Pediatric Hematology Oncology, Azienda Policlinico "G. Rodolico",, Catania, Italy
⁸Department of Pediatric Hematology and Oncology, University-Hospital of Padova, Padova, Italy
⁹Technical University of Munich, School of Medicine, Department of Pediatrics, Munich, Germany
¹⁰Technical University of Munich, School of Medicine, Department of Pediatrics, Neufahrn Bei Freising, Bavaria, Germany
¹¹Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands
¹²Department of Genetics, Utrecht University Medical Center, Utrecht, Netherlands
¹³IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy
¹⁴Catholic University of the Sacred Heart, Roma, Italy
¹⁵Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
¹⁶Medical Genetics, Università di Milano Bicocca, Monza, Italy

Noushin Farnoud, PhD^1*, Konstantinos Liosis^2*, Daniel Leongamornlert, PhD^3*, Jesús Gutiérrez-Abril^4*, Juan E. Arango Ossa^5*, Gunes Gundem^5*, Anu Amallraja^5*, Dylan Domenico^5*, Joseph McCarter^5*, Amy A Kirkwood^6*, Laura Clifton-Hadley^6*, Bela Patel Wrench, MD^7*, Anthony Moorman^8*, Adele Kay Fielding, MBBS, PhD⁹ and Elli Papaemmanuil, PhD⁵

¹Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York
³Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, United Kingdom
⁴Department of Epidemiology & Biostatistics, Universidad De Oviedo, Oviedo, Spain
⁵Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Cancer Research UK & UCL Cancer Trials Centre, UCL Cancer Institute, University College London, London, United Kingdom
⁷Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⁸Leukaemia Research Cytogenetics Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
⁹UCL Cancer Institute, London, United Kingdom

Laura N Eadie, BSc, PhD^1,2*, Caitlin E Schutz, BSc(hons)^2*, Elyse C Page, BSc(hons), PhD^1,2*, Tace S Conlin, BSc^1,2*, Susan L Heatley, PhD^1,2*, Elias Lagonik, BSc(hons)^1,2*, Jacqueline A Rehn, BEd, MBiotech^1,2*, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^3,4,5,6, Timothy P Hughes, MD, MBBS, FRACP, FRCPA^1,4,7,8 and Deborah L White, PhD^1,2,4

¹Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
²Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia
³Blood Cancer, Precision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia
⁴Australasian Leukaemia and Lymphoma Group (ALLG), Melbourne, Australia
⁵Haematology, Central Adelaide Local Health Network (CALHN), Adelaide, SA, Australia
⁶Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
⁷Haematology Department, Royal Adelaide Hospital, Adelaide, Australia
⁸South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia

Abhishek Vallabhbhai Koladiya, PhD¹, Astraea Jager^2*, Anthony Culos^3*, Milton Merchant^2*, Yuxuan Liu, PhD², Lucille Stuani, PhD^4*, Jolanda Sarno, PhD⁵, Pablo Domizi, PhD², Charles G. Mullighan, MBBS, MD⁶, Nima Aghaeepour, PhD^7*, Sean Bendall, PhD^8* and Kara L. Davis, DO²

¹Department of Pediatrics, Hematology, Oncology, and Stem Cell Transplant and Regenerative Medicine, Stanford School of Medicine, Palo Alto, CA
²Department of Pediatrics, Hematology, Oncology, and Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, CA
³Department of Computer Science, Columbia University, New York, NY
⁴Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM, Montpellier, France
⁵Department of Pediatrics, Hematology, Oncology, and Stem Cell Transplant and Regenerative Medicine, Stanford University, Palo Alto, CA
⁶Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁷Departments of Anesthesiology, Pediatrics, and Biomedical Data Sciences, Stanford University, Stanford, CA
⁸Department of Pathology, Stanford University, Stanford, CA

Shaohua Lei, PhD¹, Sujuan Jia^1*, Sunitha Takalkar^1*, Ti-Cheng Chang^1*, Gang Wu, PhD^1*, Xiaotu Ma, PhD¹, Selene C. Koo^1*, Paul E. Mead^1*, Jeffery M. Klco, MD, PhD¹, Ruth G. Tatevossian^1* and Charles G. Mullighan, MBBS, MD²

¹St. Jude Children's Research Hospital, Memphis, TN
²Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

Lenka Hovorkova, MSc, PhD^1*, Lucie Winkowska, PhD^1*, Justina Krotka, MD^1*, Manuela Krumbholz^2*, Claus Meyer, PhD^3*, Rosemary Sutton, BSC, PhD^4*, Michelle Henderson, BSc(hons), PhD^4*, Emmanuelle Clappier, PhD, PharmD^5*, Sabina Chiaretti, MD, PhD⁶, Lucie Sramkova, MD, PhD^7*, Jan Stary, MD, DSc^7*, Adela Benesova, PhD^8*, Katerina Machova Polakova^8*, Rolf Marschalek, PhD^3*, Markus Metzler, MD^9*, Giovanni Cazzaniga, PhD¹⁰, Gunnar Cario, MD^11*, Jan Trka, MD, PhD¹², Marketa Zaliova, MD, PhD^13* and Jan Zuna, MD, PhD¹³

¹CLIP, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic
²Pediatric Oncology and Hematology, Department of Pediatrics and Adolescent Medicine, University Hospital, Erlangen, Germany
³Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia, Goethe-University, Frankfurt, Germany
⁴Children's Cancer Institute, Randwick, Australia
⁵Hôpital Saint-Louis, APHP, Paris, FRA
⁶Division of Hematology, Department of Translational and Precision Medicine, Division of Hematology, Rome, Italy
⁷Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic
⁸Institute of Hematology and Blood Transfusion, Prague, Czech Republic
⁹Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany
¹⁰Clinica Pediatrica Univ. Milano Bicocca Ospedale San Gerardo, Monza, MB, ITA
¹¹Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany
¹²Charles University, Prague, Prague, Czech Republic
¹³CLIP, Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic

Margo Aertgeerts, MD^1,2,3*, Sofie Demeyer^1,4,5*, Jochen Lamote^1,6*, Jolien De Bie^7*, Lucienne Michaux^4,5,7*, Jan Cools^1,4,5 and Heidi Segers^2,4,8*

¹Center for Cancer Biology, VIB, Leuven, Belgium
²Department of Oncology, KU Leuven, Leuven, Belgium
³Leuven Cancer Institute (LKI), KU Leuven - UZ Leuven, Leuven, Belgium
⁴Leuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven, Belgium
⁵Department of Human Genetics, KU Leuven, Leuven, Belgium
⁶VIB Flow Core Leuven, VIB Technologies, Leuven, Belgium
⁷Center for Human Genetics, UZ Leuven, Leuven, Belgium
⁸Department of Pediatric Oncology, UZ Leuven, Leuven, Belgium

Kefei Wu, MD^1*, Zhen Wang, MD^2*, Yangyang Xie, MD, PhD^1*, Xiang Wang, PhD^1*, Wenting Hu, MD^1*, Jiaoyang Cai, PhD³, Lixia Ding, Bachelor^1*, Benshang Li, MD, PhD^1* and Shuhong Shen, MD, PhD¹

¹Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
²Department of Pediatrics, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei, China
³Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology & Oncology, Shanghai Children's Medical Center, Shanghai, China

Colin Fortner, MSc^1*, Maren Wichert^2*, Alexandra Niedermayer, MSc^2*, Klaus-Michael Debatin, Prof. Dr.², Lüder Hinrich Meyer, Prof. Dr.^2* and Felix Seyfried^2*

¹Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, AL, Germany
²Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany

Deborah L White, PhD^1,2,3, Jacqueline A Rehn, BEd, MBiotech^1,3*, Caitlin E Schutz, BSc(hons)^3*, Susan L Heatley, PhD^1,3*, Laura N Eadie, BSc, PhD^1,3*, Ashlee Thomson^1,3*, Elyse C Page, BSc(hons), PhD^1,3*, Michael Osborn, MBBS, FRACP, FRCPA^1,2,4,5*, Shane Gangatharan, MBBS, FRACP, FRCPA^2,6, Ashley P Ng, PhD, MBBS, FRACP, FRCPA^2,7*, Shaun Fleming^2,8,9*, Pasquale Fedele, MBBS, PhD^2,8, Toby Trahair, BSc(Med) hons, MBBS, PhD, FRACP^2,10,11*, John Casey, MBBS, BPharm(hons), FRACP, FRCPA, MHM^2,12*, Sally Mapp, MD^2,13*, Carol CY Cheung, PhD, FRACP, FRCPA, MBBS^2,14, Tasman Armytage, MBBS^2,15*, Michelle Henderson, BSc(hons), PhD^2,11,16*, Rosemary Sutton, BSC, PhD^2,11,16*, Stephen Robert Larsen, MBBS^2,17, Peter Presgrave, MBBS^2,18, John Kwan, MBBS, FRACP, FRCPA^2,19*, Samuel Bennett, MBBS, FRACP, FRCPA^2,20*, Chun Yew Fong, MBBS, FRACP, FRCPA, PhD^2,21, Luciano Dalla-Pozza, MD^2,22, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^{2,23,24,25,26} and Matthew Greenwood^2,26,27

¹Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
²Australasian Leukaemia and Lymphoma Group (ALLG), Melbourne, Australia
³Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia
⁴The Women's and Children's Hospital, Adelaide, Australia
⁵Haematology Department, Royal Adelaide Hospital, Adelaide, Australia
⁶St John of God Murdoch Hospital, Murdoch, Australia
⁷Clinical Haematology, Peter MacCallum Cancer Centre & the Royal Melbourne Hospital, Melbourne, VIC, Australia
⁸Monash Health, Clayton, Australia
⁹The Alfred Hospital, Melbourne, VIC, Australia
¹⁰Sydney Children's Hospital, Randwick, Australia
¹¹Children's Cancer Institute, Randwick, Australia
¹²The Townsville Hospital, Townsville, Australia
¹³Princess Alexandra Hospital, Woolloongabba, Australia
¹⁴Prince of Wales Hospital, Randwick, Australia
¹⁵Gosford Hospital, Gosford, Australia
¹⁶School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia
¹⁷Royal Prince Alfred Hospital, Camperdown, Australia
¹⁸Wollongong Hospital, Wollongong, Australia
¹⁹Westmead Hospital, Westmead, Australia
²⁰Canberra Hospital, Garren, Australia
²¹Austin Hospital, Heidelberg, Australia
²²The Children's Hospital at Westmead, Westmead, Australia
²³Blood Cancer, Precision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia
²⁴Haematology, Central Adelaide Local Health Network (CALHN), Adelaide, SA, Australia
²⁵Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
²⁶Equal contributions, Australia, Australia
²⁷Royal North Shore Hospital, St Leonards, Australia

Ming Liu^1*, Yang Zhang, MD^1,2*, Xue Chen, MD^1*, Fang Wang, MD^1*, Jiaqi Chen, PhD^1,2*, Panxiang Cao, MS^1,2*, Xiaoli Ma, MD^1*, Jiancheng Fang, MD^1*, Xiaosu Zhou, PhD^3*, Tong Wang, MD^1* and Hongxing Liu^1,2,4,5

¹Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
²Molecular Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, China
³Molecular Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, AL, China
⁴Department of Oncology, Capital Medical University, Beijing, China
⁵Division of Pathology & Laboratory Medicine, Beijing Lu Daopei Hospital, Beijing, China

Po Yee Chung^*, Kathy Yuen Yee Chan, PhD^*, Chi Zhang^*, Yaqun Xu^*, Wing Hei Ng, BSc^*, Chi Kong Li and Kam Tong Leung^*

Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong

Zhao Defeng^1*, Tong Wu, MD², Chunrong Tong, MD^3*, Lin Yuehui, MD^4* and Qinlong Zheng, MD^5,6*

¹Beijing Gobroad Boren Hospital, Beijing,China, AL, China
²Department of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China
³Department of Hematology, Beijing Gaobo Boren Hospital, Beijing, China
⁴Beijing Gobroad Boren Hospital, beijing,China, China
⁵Department of Medical Laboratory, Beijing Gaobo Boren Hospital, Beijing, China
⁶Laboratory of Molecular Diagnostics, Beijing GoBroad Boren Hospital, Beijing, China

Anna Ostergaard^1*, Femke M. Hormann, PhD^1,2*, Stijn Van Den Broek^1*, Aurelie Boeree^1*, Cesca Van De Ven, PhD^1*, Gabriele Escherich, MD^3*, Edwin Sonneveld, PhD^1*, Judith M. Boer, PhD¹ and Monique L. Den Boer, PhD^1,2

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Department of Pediatric Oncology/Hematology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, Netherlands
³Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Irina Pushel, PhD^1*, Byunggil Yoo, MS^1*, Daniel Louiselle, MS^1*, Margaret Gibson, MB(ASCP)^1*, Alan S Gamis, MD, MPH², Keith J. August, MD, MS², Terrie Flatt, DO, MA^2*, Tomi Pastinen, MD, PhD^1*, Erin M. Guest, MD² and Midhat S Farooqi, MD, PhD^1*

¹Genomic Medicine Center, Children's Mercy Kansas City, Kansas City, MO
²Hematology/Oncology/BMT, Children's Mercy Kansas City, Kansas City, MO

Inge Van Outersterp^1*, Caitlin E.J. Reichert^2*, Aurelie Boeree^2*, Cesca Van De Ven, PhD^2*, Brian Kruisinga^2*, Hester A. de Groot-Kruseman, PhD^2*, Gabriele Escherich, MD^3*, Anita W. Rijneveld, M.D.⁴, Judith M. Boer, PhD² and Monique L. den Boer, PhD^2,5

¹Princess Máxima Center for Pediatric Oncology, Utrectht, Netherlands
²Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
³Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁴Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands
⁵Department of Pediatric Oncology/Hematology, Erasmus University Medical Center - Sophia Children’s Hospital, Rotterdam, Netherlands

Josgrey Del Valle Del Valle Navas Acosta^1*, Teresa González, PhD^2*, Inmaculada Serramito-Gómez, PhD^2*, Angela Villaverde Ramiro^2*, Cristina Miguel-García^2*, Sandra Santos-Mínguez^2*, Jordi Ribera^3*, Isabel Granada, MD^3*, Mireia Morgades^3*, Ricardo Sanchez, PhD, MD^4*, Esperanza Such, PhD^5*, Susana Barrera^6,7*, Juana Ciudad^6,7*, Alberto Orfao, MD, PhD^6,7*, Julio Davila Valls^8*, Natalia De Las Heras, MD^9*, José Fuster^10*, Alfonso Garcia de Coca^11*, Jorge Labrador^12*, Jose Antonio Queizan Hernandez, MD^13*, María Carmen Mendoza^14*, Susana Riesco^14*, Sandra Martín^15*, Josep-Maria Ribera, MD, PhD³, Maria Rocio Benito Sanchez, PhD^2* and Jesús María Hernández-Rivas, PhD²

¹University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, SALAMANCA, AL, Spain
²University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain
³ICO-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, Spain
⁴Doce de Octubre Hospital, Madrid, Spain
⁵Department of Hematology, Hospital Universitari i Politecnic La Fe, Valencia, Spain
⁶Cancer Research Center (IBMCC-CSIC/USAL-IBSAL), Cytometry Service (NUCLEUS) and Department of Medicine, University of Salamanca, Salamanca, Spain
⁷Centro de Investigación Biomédica en Red de Cáncer (CIBER-ONC) CB16/12/00400, Instituto de Salud Carlos III, Madrid, Spain
⁸Hematology Service-Hospital Nuestra Señora de Sonsoles, Ávila, Spain
⁹Hospital Universitario de León, Leon, Spain
¹⁰Section of Pediatric Oncohematology, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain
¹¹Hematology Department - Hospital Clínico de Valladolid, Valladolid, Spain
¹²Department of Hematology-Hospital Universitario Burgos, Burgos, Spain
¹³Hematology Department - Hospital General de Segovia, Segovia, Spain
¹⁴Pediatric Service - Hospital Universitario de Salamanca, Salamanca, Spain
¹⁵Molecular Biology Unit - Hospital Regional Universitario de Málaga, Málaga, Spain