Michal Krawczyk^1*, Lina Zelinger, PhD^2*, Cynthie Wong, PhD^2*, Hyunjun Nam, PhD.^3*, Brad Thomas, PhD.^4*, Nathan D Montgomery, MD, PhD², Derek D Lyle, MD^2* and Fernando Lopez-Diaz, PhD^3*

¹Neogenomics inc, Aliso Viejo, CA
²NeoGenomics, Fort Myers, FL
³Neogenomics inc, San Diego, CA
⁴Neogenomics inc., Houston, TX

Denis Ohlstrom, MSc^1,2*, Hope Mumme, BSc³, Sean C Jordan, BS^3*, Swati Bhasin, PhD^4,5 and Manoj Bhasin, PhD^3,4,5,6

¹Emory University Medical School, Atlanta, GA
²Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA
³Department of Biomedical Informatics, Emory University, Atlanta, GA
⁴Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
⁵Department of Pediatrics, Emory University, Atlanta, GA
⁶Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA

Nam Nguyen, MS, PharmD¹, Phani Krishna Parcha, PhD^2*, Abderrahmane Tagmount, PhD^3*, Bailey Gregory^4*, Jeffrey E. Rubnitz, MD, PhD⁵, Raul C. Ribeiro, MD⁵, Xueyuan Cao, PhD^6*, Todd A. Alonzo, PhD^7*, Richard Aplenc, MD, PhD⁸, Alan S Gamis, MD, MPH⁹, Todd Cooper, DO¹⁰, E. Anders Kolb, MD¹¹, Soheil Meshinchi, MD, PhD¹², Stanley Pounds, PhD^13*, Christopher Vulpe, MD, PhD^14* and Jatinder K. Lamba, PhD¹⁵

¹Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL
²Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL
³University of Florida, Gainesville, FL
⁴University of Florida College of Pharmacy, Gainesville
⁵Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁶Department of Health Promotion and Disease Prevention, University of Tennessee Health Science Center, Memphis, TN
⁷Univ. of Southern California Keck School of Med., Monrovia, CA
⁸Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁹Hematology/Oncology/BMT, Children's Mercy Kansas City, Kansas City, MO
¹⁰Division of Pediatric Hematology, Oncology, Bone Marrow Transplant & Cellular Therapy, Seattle Children's Hospital, Seattle, WA
¹¹Leukemia & Lymphoma Society, Bronx, NY
¹²Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA
¹³Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
¹⁴University of Florida College of Veterinary Medicine, Gainesville, FL
¹⁵Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL

Jesse M. Tettero, MD^1,2*, Maaike Heidinga^2,3*, Tim R. Mocking^1,2*, Glenn Fransen^2,3*, Ezra S Beerman^2,3*, Angèle Kelder^1,2*, Willemijn Scholten^1,2*, Alexander N. Snel^1,2*, Lok Lam Ngai, MD^1,2*, Costa Bachas, PhD^1,2*, Arjan A. Van de Loosdrecht, MD, PhD³, Gert Ossenkoppele, MD, PhD³, David C. de Leeuw, MD, PhD^3*, Jeroen J.W.M. Janssen, MD, PhD⁴ and Jacqueline Cloos, MD^1,2*

¹Department of Hematology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands
²Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands
³Department of Hematology, Amsterdam UMC, location Vrije Universiteit, Amsterdam, Netherlands
⁴Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands

Anders Östlund^1*, Anna Staffas, PhD^2*, Ulrika Norén-Nyström, MD, PhD^3*, Henrik Hasle⁴, Linda Fogelstrand, MD, PhD^5,6, Jonas Abrahamsson^7* and Lars Palmqvist, MD, Professor^8,9

¹Institute of Biomedicine, Department of Laboratory Medicine, University of Gothenburg, GÖTEBORG, Västra Götaland, Sweden
²Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden
³Department of Clinical Sciences, Pediatrics, Umeå University Hospital, Umeå, Sweden
⁴Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
⁵Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
⁶Department of Clinical Chemistry, Sahlgrenska University, Gothenburg, Sweden
⁷Institute of Clinical Sciences, Department of Pediatrics, Queen Silvias Childrens Hospital, Gothenburg, Sweden
⁸Institute of Biomedicine, Department of Laboratory Medicine, University of Gothenburg, Gothenburg, Sweden
⁹Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden

Xinqi Li, M.D^1*, Xiaoyan Liu, Ph.D^1*, Jinxian Wu, Ph.D^1*, Nan Zhang, Ph.D^1* and Fuling Zhou, PhD²

¹Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China
²Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

Masayuki Umeda, MD, PhD¹, Nicole Michmerhuizen, PhD², Ryan Hiltenbrand^2*, Juan Barajas, PhD², Bright Arthur^2*, Michael P Walsh, PhD^2*, Guangchun Song^1*, Jing Ma, PhD^1*, Tamara Westover^3*, Cristina Mecucci⁴, Danika Di Giacomo, PhD^5*, Franco Locatelli, MD, PhD⁶, Riccardo Masetti, MD, PhD^7*, Salvatore Bertuccio^8*, Martina Pigazzi, PhD^9*, Ilaria Iacobucci, PhD¹, Charles G. Mullighan, MBBS, MD¹ and Jeffery M. Klco, MD, PhD²

¹Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
²St. Jude Children's Research Hospital, Memphis, TN
³St. Jude Children's Research Hospital, Memphis
⁴University of Perugia, Perugia, PG, ITA
⁵University of Perugia, Perugia, Italy
⁶Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Bambino Gesù Children's Hospital, Catholic University of the Sacred Heart, Roma, Italy
⁷Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
⁸IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
⁹Department of Women's and Children's Health, Onco-hematology lab and clinic, University of Padova, Padova, Italy

Talha Badar, MD¹, Keith Knutson^2*, James M. Foran, MD³, Naseema Gangat, MBBS⁴, Kevin Pavelko, Ph.D.^5*, Scott H. Kaufmann, MD, PhD⁵, Mark R. Litzow, MD⁴, Hemant S. Murthy, MD⁶, Davitte Cogen^2*, Margaret Ushman^2*, Arini Arsana^7*, Aref Al-Kali, MD⁴, Hassan Alkhateeb, MD^4*, Ayalew Tefferi, MD⁴, Mrinal M. Patnaik, MD, MBBS⁸ and Mithun V Shah, MD, PhD⁴

¹Division of Hematology-Oncology, Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL
²Mayo Clinic, Jacksonville, FL
³Hematology/Oncology, Mayo Clinic, Jacksonville, FL
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Mayo Clinic, Rochester, MN
⁶Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL
⁷Mayo Clinic, Rochester
⁸Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN

Elisabeth P Nacheva, MD, PhD¹, Temenuzhka Boneva, MD PhD^2*, Jenny O'Nions, MBBCh, PhD, MRCP, FRCPath^3,4*, Andrew J. Wilson, PhD, BSc, MBBS, MRCP, MSc^5*, Ke Xu^6,7, Robert Baker^8* and Rajeev Gupta^9*

¹University College London Medical School, Royal Free Campus, London, Eng, United Kingdom
²HSL Analytics LLP Oncogenomics, London UK and UCL Cancer Institute, London, GBR
³University College London NHS Foundation Trust, London, United Kingdom
⁴Department of Hematology, University College London NHS Foundation Trust, London, United Kingdom
⁵Department of Haematology, University College Hospital, University College of London Hospitals NHS Foundation Trust, London, United Kingdom
⁶Department of Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom
⁷University College London Hospitals NHS Foundation Trust, London, GBR
⁸Health Service Laboratories, UCLH, London, United Kingdom
⁹UCL Cancer Institute, London, GBR

Hyunjun Kang, PhD^1*, Dinh Hoa Hoang^2*, Melissa Valerio^3*, Khyatiben V. Pathak^4,5*, Lianjun Zhang, PhD^6*, Ralf Buettner, PhD^7*, Fang Chen^6*, Katrina Estrella^6*, William Graff^8*, Ya-Huei Kuo, PhD², Bin Zhang^2*, Patrick Pirrotte^4,5*, Le Xuan Truong Nguyen, PhD^9* and Guido Marcucci, MD¹⁰

¹Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte
²Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
³Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research,Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁴Cancer & Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ
⁵Integrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA
⁶Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
⁷Hematology Malignancies Research Institute, Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, CA
⁸Ostentus Therapeutics, Inc., Newport Coast, California, Newport Beach
⁹Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, South El Monte, CA
¹⁰Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA

Xue Chen, MD^1*, Lili Yuan, MD^1*, Yang Zhang, MD^1,2*, Fang Wang, MD^1*, Xiaoli Ma, MD^1*, Jiancheng Fang, MD^1*, Panxiang Cao, MS^1,2*, Yijun Liu, MD^1*, Zhixiu Liu, MD^1*, Ming Liu^1*, Jiaqi Chen, PhD^1,2*, Xiaosu Zhou, PhD^3*, Mingyue Liu^1*, David Jin, MD^2*, Peihua Lu, MD^4,5* and Hongxing Liu, MD^1,2,6,7

¹Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
²Molecular Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, China
³Molecular Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, AL, China
⁴Department of Hematology, Hebei Yanda Lu Daopei Hospital, Langfang, China
⁵Beijing Lu Daopei Institute of Hematology, Langfang, China
⁶Department of Oncology, Capital Medical University, Beijing, China
⁷Division of Pathology & Laboratory Medicine, Beijing Lu Daopei Hospital, Beijing, China

Paola Minetto, MD¹, Fabio Guolo, MD, PhD^1,2*, Sara Rosellini^3*, Alfonso Piciocchi^4*, Giovanni Marconi, MD⁵, Ernesta Audisio, MD^6*, Giorgio Priolo^7*, Cristina Papayannidis, MD⁸, Maurizio Martelli^9*, Francesca Paola Paoloni^4*, Monica Bocchia, MD^10*, Francesco Lanza, MD^11*, Albana Lico, MD^12*, Fabio Ciceri^13,14*, Matteo Giovanni Della Porta, MD^15,16*, Marco Frigeni, MD^17*, Luisa Giaccone, MD, PhD^18*, Germana Beltrami, MD^19*, Erika Borlenghi, MD^20*, Maria Chiara Di Chio^21*, Carmine Selleri, MD²², Enrico Crea, PharmD^4*, Irene Urbino^23*, Chiara Sartor, MD^24*, Clara Minotti^25*, Valentina Arena^4*, Jacopo Nanni, MD^24*, Giorgia Simonetti, PhD^26*, Maria Teresa Bochicchio^26*, Giuseppe Saglio, MD²⁷, Adriano Venditti, MD^28,29, Marco Vignetti, MD^4*, Paola Fazi, MD^30*, Elisabetta Tedone^1*, Giovanni Martinelli, MD^31,32 and Roberto M. Lemoli, MD^1,2*

¹IRCCS Ospedale Policlinico San Martino, Genoa, Italy
²Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy
³Servizio di Citofluorimetria, Dipartimento di Anatomia Patologica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
⁴GIMEMA Foundation, Rome, Italy
⁵Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l., Meldola, Italy
⁶SC Ematologia 2, AOU Città della Salute e della Scienza, Turin, Italy
⁷Haematology 2 - A.O.U San Giovanni Battista, Turin, ITA
⁸Istituto di Ematologia "Seràgnoli", IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy
⁹Division of Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
¹⁰UOC Ematologia, Azienda ospedaliero-universitaria Senese, Siena, Italy
¹¹Division of Hematology, Onco-hematologic Department, AUSL della Romagna, Ravenna, Italy
¹²Hematology Unit, San Bortolo Hospital, Vicenza, Italy, Vicenza, Italy
¹³Unit of Hematology and Bone Marrow Transplantation, I.R.C.C.S. Ospedale San Raffaele, Milan, Italy
¹⁴Vita-Salute San Raffaele University, Milan, Italy
¹⁵Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy
¹⁶Department of Biomedical Sciences, Humanitas University, Milan, Italy
¹⁷Hematology and Bone Marrow Transplant Unit, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
¹⁸Univesity of Torino, AOU Città Della Salute E Della Scienza Di Torino,, Torino, ITA
¹⁹U.O. Ematologia e terapie cellulari, IRCCS Azienda Ospedaliera Universitaria San Martino, Genova, Italy
²⁰UO EMATOLOGIA, ASST Spedali Civili di Brescia, Brescia, ITA
²¹Department of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
²²Department of Medicine and Surgery, Hematology, University Hospital San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy
²³21. Department of Oncology and Hematology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy
²⁴Department of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy
²⁵Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, ITA
²⁶IRCSS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l, Meldola, Italy
²⁷Dept. of Clinical and Biological Sciences, University of Turin, Turin, Italy
²⁸Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
²⁹Department of Onco-Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy, Italy
³⁰GIMEMA Foundation, Data Center and Health Outcomes Research Unit, Rome, Italy
³¹Associate Professor Alma Mater Studiorum, University of Bologna, Institute of Hematology "L. and A. Seràgnoli,”, Bologna, Italy
³²IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"- IRST S.r.l., Meldola, Italy

Xingcheng Yang^1*, Juan Peng, MS^2*, Chunrui Li¹, Yicheng Zhang^1,3,4*, Xia Mao^1*, Jue Wang, MD^1* and Jia Wei^1,5,6*

¹Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, AL, China
³Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China
⁴Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, China
⁵Department of Hematology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China
⁶Sino-German Joint Oncological Research Laboratory, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China

Zhiyao Ren, MD^1,2,3*, Jolien Vanhooren^1,2,3*, Charlotte Derpoorter^1,2,3*, Barbara De Moerloose^2,3,4* and Tim Lammens, PhD, MSc^2,3,5*

¹Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
²Cancer Research Institute Ghent (CRIG), Ghent, Belgium
³Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
⁴Ghent University Hospital, Ghent, Belgium
⁵Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Oost-Vlaanderen, Belgium

Krish Shah^1*, Jing Ma, PhD^2*, Mohamed Djekidel, PhD^1*, Guangchun Song^2*, Masayuki Umeda, MD, PhD², Yiping Fan, PhD^1*, Gang Wu, PhD^1* and Jeffery Klco, MD, PhD²

¹St. Jude Children's Research Hospital, Memphis, TN
²Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

Carmen Gonzalez, MS^1*, Catia Simoes^1*, Beñat Ariceta^1*, David Martinez-Cuadron, PhD^2*, Juan Miguel Bergua Burgues^3*, Susana Vives^4*, Lorenzo Algarra^5*, Mar Tormo, M.D.⁶, Pilar Martinez Sanchez, M.D.^7*, Josefina Serrano, MD^8*, Pilar Herrera^9*, Fernando Ramos, MD, MPH, PhD^10*, Olga Salamero, MD^11*, Esperanza Lavilla^12*, Cristina Gil, MD^13*, Jose Luiz Lopez Lorenzo^14*, Maria Vidriales Vicente^15*, Carmen Chillon^15*, Jorge Labrador^16*, Jose Francisco Falantes^17*, Maria Jose Sayas Lloris^18*, Rosa Ayala, MD, PhD^19*, Joaquin Martinez-Lopez, MD, PhD^19*, Sara Villar^20*, Maria Jose Calasanz, PhD^1,21*, Felipe Prosper, MD, PhD¹, Jesus San Miguel^1*, Miguel A. Sanz, MD, PhD², Pau Montesinos, PhD, MD^22* and Bruno Paiva^1*

¹Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain
²Hospital Universitario y Politécnico La Fe, Valencia, Spain
³Hospital San Pedro de Alcántara, Cáceres, Spain
⁴Hospital Germans Trias i Pujol, Badalona, ESP
⁵Hospital General de Albacete, Albacete, Spain
⁶Hospital Clínico Universitario de Valencia, Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain
⁷Hematology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
⁸Hospital Universitario Reina Sofía, IMIBIC, Cordoba, ESP
⁹Hospital Universitario Ramón y Cajal, Madrid, Spain
¹⁰Hospital Universitario de León, Leon, Spain
¹¹Hospital Universitario Vall d'Hebrón, Barcelona, Spain
¹²Hospital Universitario Lucus Augusti, Lugo, Spain
¹³Hospital General Universitario de Alicante, Alicante, ESP
¹⁴Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
¹⁵Hospital Universitario de Salamanca, IBSAL, CIBER-ONC number CB16/12/00233 y Centro de Investigación, Salamanca, Spain
¹⁶Hospital Universitario de Burgos, Universidad Isabel I, Burgos, ESP
¹⁷Complejo Hospitalario Virgen del Rocío, Sevilla, ESP
¹⁸Hospital Dr. Peset, ZARAGOZA, ESP
¹⁹Hospital Universitario 12 de Octubre, I+12, CNIO, Complutense University, CIBERONC, Madrid, Spain
²⁰Hematology and Cell Therapy Department, Clinica Universidad de Navarra, IdiSNA, Pamplona, Spain
²¹CIMA LAB Diagnostics, Universidad de Navarra, Pamplona, Spain
²²Hospital Universitari i Politecnic la Fe, Valencia, Spain

Lok Lam Ngai, MD^1,2*, Diana Hanekamp, PhD^1,2*, Angèle Kelder^1,2*, Willemijn Scholten^1,2*, Jannemieke Carbaat-Ham^1,2*, Mona M.H.E Fayed^1,2*, Alexander N. Snel^1,2*, Costa Bachas, PhD^1,2*, Jesse M. Tettero, MD^1,2*, Tim R. Mocking^1,2*, Vincent H.J. Van Der Velden, PhD^3*, Jennichjen Slomp, PhD⁴, Willemijn Hobo, PhD^5*, Dimitri Breems, MD, PhD⁶, Thomas Fischer⁷, Bjorn T. Gjertsen, MD, PhD⁸, Laimonas Griškevičius, MD, PhD^9*, Gunnar Juliusson, MD, PhD¹⁰, Johan Maertens, MD, PhD^11*, Markus G. Manz, MD^12,13, Thomas Pabst, MD^13,14, Jakob Passweg Sr.^13,15*, Kimmo Porkka, MD, PhD¹⁶, Peter J. M. Valk, PhD¹⁷, Patrycja Gradowska, PhD^18,19*, Bob Löwenberg, MD, PhD¹⁷, David C. de Leeuw, MD, PhD^1,2*, Arjan A. van de Loosdrecht, MD, PhD^1,20, Gert Ossenkoppele, MD, PhD^1,2 and Jacqueline Cloos, MD^1,2*

¹Department of Hematology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands
²Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands
³Erasmus MC, University Medical Center Rotterdam, Department of Immunology, Rotterdam, Netherlands
⁴Department of Clinical Chemistry, Medisch Spectrum Twente/Medlon, Enschede, Netherlands
⁵Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands
⁶Ziekenhuis Netwerk Antwerpen, Antwerp, Belgium
⁷Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
⁸Haukeland University Hospital, Bergen, Norway
⁹Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania
¹⁰Lund Stem Cell Center Lund University & Hospital, Lund, Sweden
¹¹Department of Hematology, University Hospitals Leuven, Leuven, Belgium
¹²Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland
¹³Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland
¹⁴Institute of Medical Oncology, Berne, Switzerland
¹⁵University Hospital | Basel, Basel, Switzerland
¹⁶Helsinki University Central Hospital Cancer Center, Helsinki, FIN
¹⁷Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
¹⁸HOVON Data Center, Rotterdam, Netherlands
¹⁹Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
²⁰Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, Netherlands

Polina K Derevianko^1*, Laura E. Swart, MSc^1*, Minoo Ashtiani, BSc^1*, Sophie Kellaway, PhD^2*, Anja Krippner-Heidenreich, PhD^1*, Raymond M. Schiffelers, PhD^3,4*, Josef Vormoor, MD PhD¹ and Olaf Heidenreich, PhD^1,5

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Institute of Cancer & Genomic Science, University of Birmingham, Birmingham, United Kingdom
³Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, Netherlands
⁴Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands
⁵Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom

Mohammad Javad Najaf Panah, MS^1*, Tsz-Kwong Man, PhD^1*, Michael Krueger^1*, Pavel Sumazin, PhD^2* and Michele S. Redell, MD¹

¹Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX
²Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer Center, Houston, TX

Yazan Abu-Shihab, MD^1*, Deedra Nicolet^2,3, Krzysztof Mrózek, MD, PhD⁴, Mark Routbort, MD, PhD^5*, Keyur P. Patel, MBBS, PhD⁶, Christopher J. Walker, PhD^3*, Jill Buss, BS⁴, Andrew Stiff, MD, PhD⁷, Andrea Laganson, MS^8*, Courtney D. DiNardo, MD, MSc⁹, Naval Daver, MD⁹, Tapan M. Kadia, MD⁹, Gautam Borthakur, MD⁹, Farhad Ravandi, MD, MBBS⁹, Andrew J Carroll, PhD¹⁰, Jonathan E Kolitz, MD¹¹, Bayard L Powell, MD¹², William Blum, MD¹³, Maria R. Baer, MD¹⁴, Guido Marcucci, MD¹⁵, Geoffrey L Uy, MD¹⁶, Wendy Stock, MD¹⁷, Richard M Stone, MD¹⁸, L. Jeffrey Medeiros, MD⁵, Robert L. Bowman, PhD¹⁹, John C. Byrd, MD²⁰, James S. Blachly²¹, Linde A. Miles, PhD^22,23, Ann-Kathrin Eisfeld, MD*^3,24 and Sanam Loghavi, MD^25,26

¹The Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
²Alliance Statistics and Data Center, The Ohio State University Comprehensive Cancer Center, Columbus, OH
³Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
⁴Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁵Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Depatment of Internal Medicine, Division of Hematology, Ohio State University, Columbus, OH
⁸Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus
⁹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹¹Northwell Health, Lake Success, NY
¹²Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC
¹³Winship Cancer Institute of Emory University, Atlanta, GA
¹⁴Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
¹⁵Hematology/HCT, City of Hope National Medical Center, Duarte, CA
¹⁶Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹⁷University of Chicago Medicine, Chicago, IL
¹⁸Dana-Farber Cancer Institute, Boston, MA
¹⁹Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
²⁰Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
²¹Department of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
²²Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²³Equal contribution, Cinicinnati, OH
²⁴Contributed equally, #
²⁵Hematopathology, MD Anderson Cancer Center, Houston, TX
²⁶Equal contribution, Houston, TX

Xiaosu Zhou, PhD^1*, Xue Chen, MD^2*, Jiaqi Chen, PhD^1,2*, Panxiang Cao, MS^1,2*, Fang Wang, MD^2*, Yang Zhang, MD^1,2*, Xiaoli Ma, MD^2*, Jiancheng Fang^2*, Linya Wang, MD^3*, Lijun Wen, MD^4*, Ping Wu, MD^2*, Ruijie Tang, MD^5*, Wanting He, MD^6*, Siyuan Liu^1*, David Jin, MD^1*, Xian Zhang, MD^5*, Suning Chen, MD^4*, Huyong Zheng, MD, PhD³, Peihua Lu, MD^5* and Hongxing Liu^1,2,7,8

¹Molecular Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, China
²Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
³Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
⁴National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China
⁵Department of Hematology, Hebei Yanda Lu Daopei Hospital, Langfang, China
⁶Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⁷Division of Pathology & Laboratory Medicine, Beijing Lu Daopei Hospital, Beijing, China
⁸Department of Oncology, Capital Medical University, Beijing, China

Sun Loo, MBBS^1,2, Nicola Potter, PhD^3*, Adam Ivey, PhD^4,5*, Jenny O'Nions, MBBCh, PhD, MRCP, FRCPath^6*, Roderick Moon^5*, Chun Yew Fong, MBBS, FRACP, FRCPA, PhD⁷, Natasha Anstee^8*, Ing Soo Tiong, FRACP, FRCPA, MPhil^4,9, Chong Chyn Chua, MBBS, FRACP, FRCPA, PhD^2,4, Jad Othman, MBBS^3,10,11, Hannah Renshaw^6*, Robert Baker^12*, Nigel H. Russell, MD¹⁰, Ashish Bajel, FRACP¹, Hsin-An Hou, MD, PhD¹³, Richard Dillon, PhD, MRCP, FRCPath^3,10* and Andrew H. Wei, MBBS, PhD^14,15

¹Department of Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
²The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
³Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
⁴The Alfred Hospital and Monash University, Melbourne, VIC, Australia
⁵Human Molecular Pathology, The Alfred Hospital, Melbourne, Australia
⁶Department of Hematology, University College London NHS Foundation Trust, London, United Kingdom
⁷Austin Hospital, Heidelberg, Australia
⁸The Walter and Eliza Hall Institute of Medical Research, Parkville, AUS
⁹Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
¹⁰Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
¹¹Royal North Shore Hospital, London, United Kingdom
¹²Health Service Laboratories, UCLH, London, United Kingdom
¹³Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
¹⁴Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia
¹⁵The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

Yutong Zhou^1*, Yu Qian^1* and Jie Jin²

¹Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China;, Hangzhou, China

Somadri Ghosh^1*, Maria Rodriguez Zabala, BSc, MSc^2*, Gladys Telliam Dushime, PhD^3*, Katrin Reinbach^4*, Ramprasad Ramakrishnan, PhD^5*, Ewa Sitnicka, PhD^6* and Marcus Järås, PhD^4*

¹Division of Clinical Genetics, Lund University, Lund, Sweden
²Clinical Genetics, Lund Universitet, Lund, Sweden
³Division of Molecular Hematology, Lund University, Lund, Skane, Sweden
⁴Division of Clinical Genetics, Lund University, Lund, Skåne, Sweden
⁵Lund University, Lund, Skåne, SWE
⁶Division of Molecular Hematology, Lund University, Lund, Sweden

Maddalena Benetton, PhD^1*, Pietro Merli, MD^2*, Nicola Santoro, MD^3*, Luca Lo Nigro, MD⁴, Claudia Tregnago, PhD^1*, Ambra Da Ros, PhD^1*, Katia Polato^1*, Veronica Zampieri, BS^5*, Barbara Michielotto, BS^1*, Samuela Francescato, MSc^5*, Anna Leszl, MSc^5*, Riccardo Masetti, MD, PhD^6*, Barbara Buldini, MD, PhD⁷, Alessandra Biffi, MD, PhD^1*, Franca Fagioli, MD^8*, Carmelo Rizzari, MD^9*, Franco Locatelli, MD, PhD¹⁰ and Martina Pigazzi, PhD^1,11*

¹Department of Women's and Children's Health, Onco-hematology lab and clinic, University of Padova, Padova, Italy
²Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy
³Department of Pediatric Hemato-Oncology, University of Bari, Bari, Italy
⁴Azienda Policlinico OVE - Center of Pediatric Hematology Oncology, Catania, Italy, Italy
⁵Pediatric Onco-hematology Unit, Azienda Ospedaliera di Padova, Padova, Italy
⁶Department of Pediatrics, "Lalla Seràgnoli", Hematology-Oncology Unit, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
⁷Department of Pediatric Hematology and Oncology, University of Padova, Padua, Italy
⁸Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, University of Turin, Turin, Italy
⁹Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation c/o ASST Monza, Milan, Italy
¹⁰IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy
¹¹Foundation Istituto Ricerca Pediatrica (IRP), Padova, Italy

Eduardo Sabino de Camargo Magalhaes, MD^1*, Stefan Hubner^2*, Brandon D. Brown, MD^3*, Yihua Qiu^4* and Steven M. Kornblau, MD⁴

¹Department of Ageing Biology/ERIBA, University Medical Center Groningen, Groningen, Netherlands
²John Sealy School of Medicine, The University of Texas Medical Branch (UTMB), Galveston, TX
³Department of Pediatrics, MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Daniel Lopes De Menezes, PhD^1*, Manuel Ugidos Guerrero, PhD^2*, Arnaud Amzallag, PhD^3*, Wendy L. See, PhD^4*, Alberto Risueno, PhD^5*, Charalampos Kyriakopoulos, PhD^3*, Rajasekhar N.V.S. Suragani, PhD⁶, Barry S. Skikne, MD^7*, C.L. Beach, PharmD^8*, Thomas Prebet, MD, PhD^9*, Maria Teresa Voso, MD¹⁰, Andre C. Schuh, MD, FRCPC¹¹, Gail J. Roboz, MD¹², Hartmut Döhner, MD¹³, Andrew H. Wei, MBBS, PhD¹⁴ and Anita K. Gandhi, PhD¹⁵

¹Translational Medicine, Hematology, Bristol Myers Squibb, San Francisco, CA
²BMS Center for Innovation and Translational Research Europe (CITRE, a Bristol Myers Squibb Company), Bristol Myers Squibb, Seville, Spain
³Bristol Myers Squibb, Princeton, NJ
⁴Hematology, Translational Medicine, Bristol Myers Squibb, San Francisco, CA
⁵Bristol Myers Squibb, Lawrenceville, NJ
⁶Hematology, Translational Medicine and Disease Team, Bristol Myers Squibb, Summit, NJ
⁷Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Medical Center, Westwood, KS
⁸Bristol Myers Squibb (former affiliation), Summit, NJ
⁹Bristol Myers Squibb, Summit, NJ
¹⁰Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
¹¹Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹²Division of Hematology and Medical Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
¹³Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
¹⁴Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia
¹⁵Translational Development and Diagnostics, Bristol Myers Squibb, Summit, NJ

Fumiya Wada, MD^1,2*, Shoya Kato^1*, Shruti Bhagat^1*, Shigeki Hirabayashi, MD, PhD^3*, Raku Son^4*, Akiko Oguchi^4*, Kazuhiro Takeuchi^1*, Sho Sekito^1*, Tomoya Hirai^4*, Zhiwei Zhang^1,5*, Yoshihito Horisawa^2*, Makoto Iwasaki, MD, PhD^6*, June Takeda, MD^2*, Junya Kanda², Takashi Sakamoto^2*, Kotaro Shirakawa, MD, PhD², Akifumi Takaori-Kondo, MD, PhD² and Yasuhiro Murakawa^1,4,7*

¹ASHBi Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan
²Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
⁴RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁵Department of Human Genetics, Faculty of Medicine and Health Science, McGill University, Montreal, Canada
⁶Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Nara, NAR, Japan
⁷IFOM ETS - the AIRC Institute of Molecular Oncology, Milan, Italy

Jessica Lynn Root, MS Biomedical Informatics^1*, Poonam N Desai², Patrick K Reville, MD, MPH², Christopher Ly^1*, Bofei Wang, Ph.D.^2*, Fatima Z Jelloul^3*, Jing Zhou^4*, Sean Gregory Mackay^4*, Mansour Alfayez, MD, MS⁵, Jairo Matthews, BA^6*, Sherry Pierce, BSN, BA^2*, Naval Daver, MD² and Hussein A Abbas, MD, PhD²

¹Department of Leukemia, The University of Texas at MD Anderson Cancer center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴IsoPlexis Corporation, Branford, CT
⁵Dept of Hematology, Stem Cell Transplantation and Cellular Therapy , KFSHRC, Riyadh, Saudi Arabia
⁶The University of Texas at MD Anderson Cancer center, Houston, TX

Nika Panahi^1*, Tiffany Hylkema, BS^2*, Grace Hawkins^1*, Makia K Manselle^1*, Jack H Peplinski, BS^2*, Logan K Wallace^1*, Rhonda E Ries, MA^2*, Soheil Meshinchi, MD, PhD³ and Danielle C Kirkey, MD^1,4

¹Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
²Translational Sciences and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
³Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Division of Pediatric Hematology/Oncology, Seattle Children's Hospital, Seattle, WA

Dominique Sternadt^1*, Diego Pereira-Martins, PhD^2,3*, Douglas RA Silveira, MD, PhD^4*, Isabel Weinhaeuser, PhD^1,2*, Ming Yang, PhD^5*, Prodromos Chatzikyriakou^2*, Pilar Casares Alaez^6*, Emanuele Ammatuna, MD, PhD^1*, Lieve Oudejans, MSc^3*, Gerwin A. Huls, PhD³, Christian Frezza, PhD^5*, Lynn Quek, MD, PhD^2* and Jan Jacob Schuringa, PhD⁷

¹Department of Experimental Hematology, University Medical Centre Groningen, Groningen, Netherlands
²Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
³Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
⁴School of Cancer and Pharmaceutical Sciences, King's College London, London, ENG, United Kingdom
⁵University of Cologne, Cologne Excellence Cluster on Stress Responses in Ageing-Associated Diseases, Cologne, Germany
⁶Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
⁷Department of Experimental Hematology, University Medical Center - Groningen, Groningen, Netherlands

Paula Rothämel^1*, Semjon Willier, MD^2*, Jonas Wilhelm^1*, Fiona AG Becker-Dettling^1*, Theresa Kaeuferle^1*, Franziska Blaeschke¹, Meino Rohlfs^1*, Irene Schmid^1*, Vera Binder^1*, Christoph Klein^1,3, Thomas Walzthoeni^4,5*, Matthias Heinig^5,6,7* and Tobias Feuchtinger, MD^2,8,9

¹Department of Pediatrics, Dr. von Hauner Children’s Hospital, LMU University Hospital, LMU Munich, Munich, Germany
²Department of Pediatric Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich, Munich, Germany
³Gene Center, LMU Munich, Munich, Germany
⁴Core Facility Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany
⁵Institute of Computational Biology (ICB), Helmholtz Center Munich, German Research Center for Environmental Health, Oberschleißheim, Germany
⁶Department of Computer Science, TUM School of Computation, Information and Technology, Technical University of Munich, Garching, Germany
⁷German Centre for Cardiovascular Research (DZHK), Munich Heart Association, Partner Site Munich, Berlin, Germany
⁸German Center for Translational Cancer Research (DKTK), Partner Site Munich, Munich, Germany
⁹German Center for Infection Research (DZIF), Munich, Germany

Evgeny Klyuchnikov^1*, Anita Badbaran^2*, Radwan Massoud, BS, MD^3*, Petra Freiberger^4*, Christine Wolschke^5*, Francis A. Ayuk, MD^6*, Ulrike Bacher^7* and Nicolaus Kroeger, MD⁵

¹Department of Stem Cell Transplantation,, University Medical Center Hamburg Eppendorf, Hamburg, DEU
²Department of stem cell transplantation, University Hospital Hamburg Eppendorf, Hamburg, DEU
³Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
⁴Department for Stem Cell Transplantation, University Cancer Center Hamburg-Eppendorf, Hamburg, Germany
⁵Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁶University Hospital Hamburg, Hamburg, Germany
⁷Department of Hematology and Central Hematology Laboratory, Bern, CHE

Jan Philipp Bewersdorf, MD¹, Shai Shimony, MD^2*, Rory M. Shallis, MD³, Yiwen Liu, MS^4*, Eva Johanna Schaefer, MD^5*, Amer M. Zeidan, MBBS, MHS⁶, Aaron D. Goldberg, MD, PhD⁷, Eytan M. Stein¹, Guido Marcucci, MD⁸, R. Coleman Lindsley⁹, Evan C. Chen, MD⁵, Jorge Ramos, MD^10*, Anthony Selwyn Stein, MD¹¹, Daniel J. DeAngelo¹², Donna S. Neuberg, ScD⁴, Richard M Stone, MD¹², Brian J. Ball, MD¹⁰ and Maximilian Stahl, MD¹³

¹Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³Section of Hematology, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT
⁴Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁵Medical Oncology, Dana Farber Cancer Institute, Boston, MA
⁶Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, Yale University, New Haven, CT
⁷Memorial Sloan Kettering Cancer Center, New York City, NY
⁸Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
⁹Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
¹⁰City of Hope Cancer Center, Duarte, CA
¹¹City of Hope National Medical Center, Duarte, CA
¹²Dana-Farber Cancer Institute, Boston, MA
¹³Dana Farber Institute, Boston, MA

Barbara Buldini, MD, PhD¹, Pietro Merli, MD^2*, Elena Varotto, MD, PhD^3*, Riccardo Masetti, MD^4*, Maria Gabelli, MD, PhD^5*, Marco Zecca, MD^6*, Franca Fagioli, MD^7*, Pamela Scarparo, PhD^8*, Mattia Algeri, MD^2*, Alessandra Biffi, MD, PhD^9*, Martina Pigazzi, PhD^10*, Daria Pagliara, MD, PhD^2* and Franco Locatelli, MD, PhD¹¹

¹Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, Università degli Studi di Padova, Padova, Italy
²Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Rome, Italy
³Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, University of Padova, Padova, Italy, University of Padua, Padova, Italy
⁴Pediatric Oncology and Hematology Unit "lalla Seràgnoli," Department of P, Bologna, ITA
⁵Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department,, University of Padova, Padova, Italy
⁶Pediatric Hematology-Oncology,, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁷Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, University of Turin, Turin, Italy
⁸Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, University of Padova, Padova, Italy
⁹Padua University Hospital, Pediatric Hematology, Oncology and Stem Cell Transplant Division, Padova, Italy
¹⁰Department of Women's and Children's Health, Onco-hematology lab and clinic, University of Padova, Padova, Italy
¹¹Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Bambino Gesù Children's Hospital, Catholic University of the Sacred Heart, Roma, Italy

Maria Sirenko, PhD^1,2,3,4,5, Soobeom Lee^2,4,5,6*, Zhengxi Sun^2,4,5*, Ronan Chaligne, PhD^7*, Georgios Asimomitis^3,8*, Charlotte K Brierley, bmbch⁹, Elsa Bernard, PhD^3*, Sheng F. Cai, MD, PhD^10*, Robert M Myers, PhD¹¹, Bettina Nadorp, PhD^4,12*, Max F Levine^3*, Dylan Domenico^3*, Juan E Arango Ossa^3*, Juan Santiago Medina Martinez^3*, Kamal Menghrajani, MD¹⁰, Audrey Lasry, PhD^4*, Alice Mims, MD^13,14, Helee Desai^13,14*, Andrea Laganson, MS^13,14*, Christopher Famulare, MS^15*, Minal Patel, BA^15*, Gerard Lozanski, MD^16*, Sanam Loghavi, MD¹⁷, Kelly L. Bolton, MD^10,18, Aaron D. Viny, MD, MS^19,20, Mikhail Roshal, MD, PhD^21*, Ross L Levine, MD²², Eytan M. Stein¹⁰, Dan A. Landau, MD, PhD^23,24,25,26*, Ann-Kathrin Eisfeld, MD*^14,26,27,28, Iannis Aifantis, PhD^4,26,29 and Elli Papaemmanuil, PhD^3,26

¹Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY
²Contributed equally, *
³Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Pathology, NYU Grossman School of Medicine, New York, NY
⁵Laura & Isaac Perlmutter Cancer Center, NYU Langone, New York, NY
⁶Department of Biology, New York University, New York
⁷Program for Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Biomedical Systems Laboratory, Department of Mechanical Engineering, National Technical University of Athens, Athens, Greece
⁹Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
¹⁰Leukemia Service, Department of Medicine, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
¹¹Tri-Institutional MD-PhD Program, Weill Cornell Medicine, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Division of Precision Medicine, Department of Medicine, NYU Grossman School of Medicine, New York, NY
¹³Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹⁴Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹⁵Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁶Department of Pathology, The Ohio State University, Columbus, OH
¹⁷Hematopathology, MD Anderson Cancer Center, Houston, TX
¹⁸Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, Saint Louis, MO, Washington University In St Louis, St Louis, MO
¹⁹Leukemia Service, Department of Medicine, Center for Hematologic Malignancies,, Memorial Sloan Kettering Cancer Center, New York, NY
²⁰Columbia Stem Cell Initiative, Columbia University, New York, NY
²¹Memorial Sloan Kettering Cancer Center, New York
²²Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²³New York Genome Center, New York
²⁴Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York
²⁵Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York
²⁶Corresponding author, #
²⁷Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
²⁸Pelotonia Institute for Immuno-Oncology, OSUCCC – James, The Ohio State University, Columbus, OH
²⁹New York University, Grossman School of Medicine, New York, NY

Hui Zeng, MD, PhD¹, Suqi Deng^2*, Juan Du^2*, Huien Zhan^2*, Kexiu Huang^1*, Xue Zheng^2*, Ying Xu^1* and Lu Wang^3*

¹The First Affiliated Hospital of Jinan University, Guangzhou, China
²The First Affiliated Hospital of Jinan University, Guangzhou, CHN
³Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, China

Andy G.X. Zeng^1,2, Ilaria Iacobucci, PhD³, Sayyam Shah^1*, Gordon Wong, BS^1,2*, Amanda Mitchell, PhD^1*, Qingsong Gao, PhD^3*, Hyerin Kim^1*, Mark D. Minden^1,4*, Torsten Haferlach, MD, PhD⁵, Charles G. Mullighan, MBBS, MD³ and John E. Dick, PhD^1,2

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
⁵MLL Munich Leukemia Laboratory, Munich, Germany

Andrea B Moffitt, PhD¹, Joan Alexander, MD^2*, Asya Stepansky^2*, Erin Boyle, MS^3*, Danielle Stauder^2*, Carlos Alberto Lopez, MD, MPH⁴, Vernon Wu, MD^5*, Nausheen Hakim, MD^6*, Zihua Wang, PhD^2*, Jonathan E Kolitz, MD^7,8, Nicholas Chiorazzi, MD⁹, David W Chitty, DO, MSc¹⁰, Steven L. Allen, MD^8,11, Dan Levy, PhD^2* and Michael Wigler^2*

¹Winship Cancer Institute, Emory University, Atlanta, GA
²Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
³Feinstein Institutes for Medical Research, Northwell Health, Manhassett, NY
⁴Emory University, Atlanta, GA
⁵Northwell Health, New Hyde Park, NY
⁶Northwell Health, Manhasset, NY
⁷Zucker School of Medicine at Hofstra/Northwell, Zuckerberg Cancer Center, Lake Success, NY
⁸Department of Medicine, Northwell Health, Manhasset, NY
⁹Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Manhasset, NY
¹⁰Zuckerberg Cancer Center, Northwell Health, New Hyde Park, NY
¹¹Monter Cancer Center, North Shore University Hospital, Lake Success, NY

Josephine Anne Lucero, MD^1,2, Aniket Bankar, MD, MBBS, MSc, DM^1,2, Marta Beata Davidson, MD, PhD¹, Guillaume Richard-Carpentier, MD, FRCPC¹, Aaron D. Schimmer, MD³, Andre C. Schuh, MD, FRCPC^2,4, Dawn C. Maze, MD, FRCPC, MSc¹, Karen Yee, MD, FRCPC^1*, Mark D. Minden^1*, Steven M. Chan, MD, PhD^1,2, Jonas Mattsson, MD, PhD^1,2*, Rajat Kumar, MD, FRCPC^1,2, Vikas Gupta, MD^1,2, Jose-Mario Capo-Chichi, PhD^2,5*, Tracy Stockley, PhD^2,6*, Hassan Sibai, MD¹, Anne Maria Tierens, MD, PhD^2,7 and Dennis Dong Hwan Kim, MD, PhD^1,2

¹Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Measurable Residual Disease Working Group, Princess Margaret Cancer Centre, Toronto, ON, Canada
³Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
⁴Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁵Advanced Molecular Diagnostics Laboratory, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁶Division of Clinical Laboratory Genetics and Laboratory Medicine Program, University Health Network, Toronto, ON, Canada
⁷Division of Hematology and Transfusion Medicine, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada

Livius Penter, MD^1,2,3,4, Mehdi Borji, MS^2,3,5*, Adi Nagler, PhD^2*, Haoxiang Lyu, BS^5*, Wesley S Lu, BS^5*, Nicoletta Cieri, MD, PhD^2,3,4, Alexandria Maurer, MD, PhD^2,3,4, Giacomo Oliveira, PhD^2,3,4*, Aziz M. Al'Khafaji, PhD^6*, Kiran Garimella, DPhil^7*, Shuqiang Li, PhD^3,5*, Donna S. Neuberg, ScD⁸, Jerome Ritz, MD^2,4, Robert J. Soiffer, MD^2,4, Jacqueline S. Garcia, MD^4,9, Kenneth J. Livak, PhD^2,5* and Catherine J Wu, MD^2,3,4

¹Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Germany
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Harvard Medical School, Boston, MA
⁵Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
⁶Methods Development Lab, Broad Institute of MIT and Harvard, Cambridge, MA
⁷Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA
⁸Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁹Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Ravindu De Silva^1,2*, Matthew Markham, PhD^2*, Rebecca S Maynard, MSc^3*, Katherine Hampton, MSc, BSc^2*, Charlotte Hellmich, PhD, BSc, MBBChir^1,2, Dominic Fowler-Shorten^3*, Kristian Bowles, MBBS, PhD^1,2 and Stuart Rushworth, PhD²

¹Norfolk and Norwich University Hospital, Norwich, United Kingdom
²Norwich Medical School, University of East Anglia, Norwich, United Kingdom
³Norwich Medical School, University of East Anglia, Norwich, ENG, United Kingdom

Dorian Forte^1*, Filippo Maltoni, PhD Student^1*, Samantha Bruno, PhD^1*, Paulina Garcia-Gonzalez, PhD^2*, Gianluca Cristiano, MD^1*, Chiara Sartor, MD^1*, Simona Soverini, PhD³, Lucia Catani, PhD^1,4*, Rafael José Argüello, PhD^2*, Michele Cavo, MD^1,4* and Antonio Curti, MD, PhD⁵

¹Department of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy
²Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France
³Department of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Castel Maggiore, Bologna, Italy
⁴IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
⁵Istituto di Ematologia "Seràgnoli", IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy

Shin-Ichi Tsujimoto, MD, PhD^1*, Shota Kato, MD^2*, Shotaro Iwamoto, MD, PhD^3*, Hidefumi Hiramatsu, MD, PhD⁴, Yusuke Okuno, MD, PhD^5*, Tatsuya Kamitori, MD^6*, Kentaro Ohki, MD, PhD^7*, Takao Deguchi, MD, PhD⁸, Nobutaka Kiyokawa, MD, PhD^9*, Motohiro Kato, MD¹⁰, Junko Takita, MD, PhD^11*, Souichi Adachi, MD, PhD^12*, Daisuke Tomizawa, MD, PhD¹³ and Norio Shiba, MD, PhD¹⁴

¹Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
²Department of Pediatrics, The University of Tokyo, Tokyo, JPN
³Department of pediatrics, Mie University Graduate School of Medicine, Tsu, JPN
⁴Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁵Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⁶Department of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto, Japan
⁷Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan
⁸Division of Cancer Immunodiagnostics, Children’s Cancer Center, National Center for Child Health and Development, Tokyo, JPN
⁹Department of Pediatric Hematology and Oncology Research, National Research Institute For Child Health and Development, Tokyo, JPN
¹⁰Department of Pediatrics, The University of Tokyo, Tokyo, Japan
¹¹Department of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto, JPN
¹²Human Health Science, Graduate School of Medicine Kyoto University, Kyoto, JPN
¹³Division of Leukemia and Lymphoma, Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan
¹⁴Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, JPN