Domenico Russo, MD, PhD^1*, Nicola Polverelli, MD¹, Stella Santarone, MD^2*, Francesco Onida, MD^3*, Luca Castagna, MD^4*, Stefania Bramanti^5*, A. M. Carella, MD^6,7*, Roberto Sorasio, MD^8*, Attilio Olivieri^9*, Germana Beltrami, MD^10*, Antonio Curti, MD, PhD¹¹, Calogero Vetro, MD^12*, Valentina Mancini, MD^13*, Elisabetta Terruzzi, MD^14*, Massimo Bernardi, MD^15*, Piero Galieni, MD^16*, Pellegrino Musto, MD^17*, Raffaella Cerretti, MD, PhD^18*, Luisa Giaccone, MD, PhD^19*, Cristina Skert^20*, Erika Borlenghi, MD^21*, Mirko Farina, MD^1*, Alessandro Leoni^1,22*, Vera Radici, MD^1*, Simona Bernardi, PhD^1,23*, Marika Vezzoli^24*, Stefano Calza^24*, Angela Gheorghiu^25*, Michele Malagola^1*, Massimo Martino, MD^26* and Fabio Ciceri^27*

¹Unit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy
²Centro Trapianti Midollo Osseo; Azienda Sanitaria Locale di Pescara, Pescara, ITA
³Hematology Unit - ASST Fatebenefratelli-Sacco - University of Milan, Milan, Italy
⁴Bone Marrow Transplantation Unit, Palermo, Italy, ITA
⁵Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy
⁶Azienda Ospedaliera San Martino, Genova, ITA
⁷Casa Sollievo Della Sofferenza, San Giovanni Rotondo (FG), Italy
⁸Department of Hematology, S. Croce e Carle Hospital, Cuneo, CN, ITA
⁹Clinica di Ematologia Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy
¹⁰U.O. Ematologia e terapie cellulari, IRCCS Azienda Ospedaliera Universitaria San Martino, Genova, Italy
¹¹IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
¹²Division of hematology, A.O.U. Policlinico G.Rodolico – S. Marco, Catania, Italy
¹³Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
¹⁴Hematology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
¹⁵Unit of Hematology and Bone Marrow Transplantation, I.R.C.C.S. Ospedale San Raffaele, Milan, Italy
¹⁶UOC Hematology, Mazzoni Hospital-Ascoli Piceno, Ascoli Piceno, Italy
¹⁷UOC Ematologia, Bari, Italy, ITA
¹⁸Department of Hematology, Stem Cell Transplant Unit, Policlinico Tor Vergata,, Rome, ITA
¹⁹Univesity of Torino, AOU Città Della Salute E Della Scienza Di Torino,, Torino, ITA
²⁰Unit of Haematology/Bone Marrow Transplantation, Unit "ospedale Dell'Angelo", Venezia Mestra, ITA
²¹Hematology, ASST Spedali Civili, Brescia, Italy
²²CREA Laboratory (Hematological-Research AIL Centre), ASST-Spedali Civili Brescia, Brescia, Italy
²³Centro di Ricerca Emato-Oncologica AIL (CREA), ASST Spedali Civili, Brescia, Italy
²⁴Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
²⁵Trials Office GITMO Gruppo Italiano per il Trapianto di Midollo Osseo, cellule staminali emopoietiche e terapia Cellulare, Genova, Italy
²⁶Centro Unico Trapianti A, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy
²⁷Unit of Hematology and Stem Cell Transplantation, Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy

Adriano Venditti, MD¹, Alfonso Piciocchi, MS^2*, Stefano Soddu^3*, Marco Frigeni, MD^4*, Raffaele Palmieri, MD^5*, Erika Borlenghi, MD^6*, Nicola Fracchiolla, MD^7*, Maria Paola Martelli, MD, PhD^8*, Ernesta Audisio, MD^9*, Giacomo Gianfaldoni^10*, Calogero Vetro, MD^11*, Nicola di Rienzo^12*, Daniela Esposito, MD^13*, Ambra Di Veroli, MD^14*, Carmine Selleri, MD¹⁵, Federica Gigli, MD^16*, Antonio Curti, MD, PhD¹⁷, Antonino Mulè, MD^18*, Catello Califano, MD^19*, Sara Bigliardi, MD^20*, Massimo Breccia^21*, Claudio Fozza, MD^22*, Monica Bocchia, MD^23*, Albana Lico, MD^24*, Federico Simonetti^25*, Elisabetta Pierdomenico, MD^26*, Francesco Buccisano, MD, PhD²⁷, Maria Ilaria Del Principe, MD^28*, Luca Maurillo, MD^29*, Paola Fazi, MD^3*, Marco Vignetti, MD^30*, Felicetto Ferrara, MD^31*, Roberto Cairoli, MD^32*, Giuseppe Rossi, MD^33* and Alessandro Rambaldi^34*

¹Department of Onco-Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy, Italy
²Data Center and Health Outcomes Research Unit, GIMEMA Foundation, Rome, Italy
³GIMEMA Foundation, Data Center and Health Outcomes Research Unit, Rome, Italy
⁴Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy, Bergamo, Italy
⁵Hematology, Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy
⁶UO EMATOLOGIA, ASST Spedali Civili di Brescia, Brescia, ITA
⁷UOC Ematologia, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano, Italy
⁸Dipartimento di Medicina e Chirurgia, Hematology, Department of Medicine and Surgey, University of Perugia and "Santa Maria della Misericordia" Hospital, Perugia, ITA
⁹SC EMATOLOGIA 2, AOU CITTA DELLA SALUTE E DELLA SCIENZA, OSPEDALE S. GIOVANNI BATTISTA MOLINETTE, Torino, ITA
¹⁰AOU Careggi, Florence, Italy
¹¹Division of hematology, A.O.U. Policlinico G.Rodolico – S. Marco, Catania, Italy
¹²UO EMATOLOGIA, ASL LECCE, OSPEDALE V. FAZZI, Lecce, Italy
¹³UO ONCOEMATOLOGIA, ASL CASERTA, PRESIDIO OSPEDALIERO S.G.MOSCATI - AVERSA, Aversa, Italy
¹⁴UOC EMATOLOGIA, ASL DI VITERBO, COMPLESSO OSPEDALIERO DI BELCOLLE, Roma, ITA
¹⁵Department of Medicine and Surgery, Hematology, University Hospital San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy
¹⁶Divisione di Oncoematologia, European Institute of Oncology, Milan, Italy
¹⁷IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
¹⁸UOC di Oncoematologia,, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
¹⁹EMATOLOGIA, ASL SALERNO, PRESIDIO OSPEDALIERO TORTORA PAGANI, Pagani, ITA
²⁰DH Oncologico Nuovo Ospedale Civile, Nuovo Ospedale Civile, Sassuolo, ITA
²¹Department of Translational and Precision Medicine, Hematology-Sapienza University, Rome, Italy
²²Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy
²³UOC Ematologia, Azienda ospedaliero-universitaria Senese, Siena, Italy
²⁴Hematology Unit, San Bortolo Hospital, Vicenza, Italy, Vicenza, Italy
²⁵UO EMATOLOGIA, UOC Ematologia ATNO - Ospedale Versilia, Lido Di Camaiore, ITA
²⁶Oncoematologia, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy
²⁷Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
²⁸Hematology, Department of Biomedicine and Prevention, University Tor Vergata, Roma, Italy
²⁹Department of Onco-Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy
³⁰Data Center and Health Outcomes Research Unit, GIMEMA foundation, Rome, Italy
³¹Divisione di Ematologia, Ospedale Cardarelli, Napoli, Italy
³²Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
³³Hematology, ASST Spedali Civili, Brescia, Italy
³⁴Department of Oncology and Hematology, University of Milan and Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy

Uma M. Borate, MD¹, Yazan F. Madanat, MD², Cristina Tognon, PhD^3*, Shikha Mishra^4*, Andy Kaempf, MS^5*, Prapti A. Patel, MD⁶, Stephen E. Kurtz^7*, Kara Johnson^3*, Sumithira Vasu, MD, MBBS⁸, Sharyn D. Baker, PharmD⁹, Bridget A Robinson, PhD^3*, Tania Q Vu, PhD^3*, Christopher A. Eide^7*, Jessica Minnier, PhD^3*, Yiqing Zhang^10*, Peter Clement^11*, Sammantha Avaylon^11*, Thomas Jacob, PhD^3*, Rachel J. Cook, MD¹², Arpita Gandhi, MD^11*, Jessica T. Leonard, MD¹³, Brandon Hayes-Lattin, MD¹⁴, Laura F. Newell, MD⁷, Richard T Maziarz, MD⁷, Elie Traer, MD, PhD¹⁵, Ronan T. Swords, MD, PhD, FRCP, FRCPath¹⁶, Jeffrey W Tyner, PhD¹⁶, Brian J. Druker, MD⁷ and Jennifer N. Saultz, DO³

¹Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
²Hematologic Malignancies and Cellular Therapy, University of Texas Southwestern Medical Center, Dallas, TX
³Oregon Health & Science University, Portland, OR
⁴OHSU, Portland
⁵Department of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR
⁶University of Texas Southwestern Medical Center, Dallas, TX
⁷Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁸Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH
⁹Ohio State University, Columbus, OH
¹⁰UTSW, Dallas, TX
¹¹OHSU, Portland, OR
¹²Oregon Health and Science University, Portland, OR
¹³Department of Hematology & Medical Oncology, Oregon Health and Science University, Portland, OR
¹⁴Knight Cancer Institute, Oregon Health Science University, Portland, OR
¹⁵Knight Cancer Institute, Oregon Health & Sciences University, Portland, OR
¹⁶Knight Cancer Institute, Oregon Health and Science University, Portland, OR

Eric Deconinck¹, Berengere Gruson, MD, PhD^2*, Sabeha Biichle^3*, Anne Roggy^4*, Florian Renosi^5*, Thomas Fournet^6*, Maxime Desmarets, MD, PhD^7*, Gregory Tio^8*, Tony Marchand, MD^9*, Mikael Roussel^10*, Thibaut Leguay, MD^11*, Jean-Philippe Vial, MD^12*, Francoise Huguet, MD^13*, Francois Vergez^14*, Emilie Chalayer, MD, PhD^15*, Khaoula Mahfoudi^16*, Fressia Honeyman^17*, Sebastien Maury^18*, Nicolas Freynet^19*, Caroline Bonmati, MD^20*, Veronique Latger-Cannard^21*, Eve Gehlkopf, MD^22*, Caroline Bret^23*, Damien Roos Weil, MD, PhD^24*, Magali Le Garff-Tavernier^25*, Sophie Rigaudeau, MD^26*, Gandhi Laurent Damaj, MD, PhD^27*, Edouard Cornet, MD^28*, Remy Gressin, MD^29*, Marie-Christine Jacob^30*, Delphine Martineau, MD^31*, Aguirre Mimoun^32*, Alice Garnier, MD^33*, Marion Eveillard^34*, Alban Villate, MD^35*, Emmanuelle Rault^36*, Fanny Delettre, PhD^3* and Francine Garnache Ottou, PhD^37*

¹Besançon University Hospital, Besançon, France
²Clinique de l'Europe, Amiens, FRA
³INSERM, UMR1098-RIGHT, EFS Bourgogne Franche-Comté, Université Bourgogne Franche-Comté, BESANCON, France
⁴CHU Besançon, Besancon, France
⁵Université de Franche-Comté, CHU Besançon, EFS, INSERM, UMR RIGHT, BESANCON, France
⁶CHU Besançon, Besancon, FRA
⁷Université de Franche-Comté, CHU Besançon, EFS, INSERM, UMR RIGHT, Besançon, France
⁸Université de Franche-Comté, CHU Besançon, Inserm CIC 1431, Besançon, France
⁹Hematology Department, CHU Rennes, Rennes, France
¹⁰CHU Rennes, Rennes, France
¹¹Hematology, CHU Bordeaux, Hôpital du Haut-Lévêque, Pessac, France
¹²CHU Bordeaux, PESSAC, France
¹³IUCT-Oncopole, Toulouse, France
¹⁴Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
¹⁵Institut de Cancerologie Lucien Neuwirth, CHU Saint Etienne, Saint Etienne, FRA
¹⁶Institut de cancérologie Loire, Saint Priest en Jarez, France
¹⁷Institut de cancérologie de la loire, ST PRIEST EN JAREZ CEDEX, FRA
¹⁸Hematology Department, Hôpitaux universitaires Henri Mondor AP-HP & Université Paris Est Créteil, Créteil, France
¹⁹Hôpitaux universitaires Henri Mondor AP-HP, Creteil, France
²⁰Service D'Hématologie, Centre Hospitalier Universitaire De Nancy, Nancy, FRA
²¹Centre Hospitalier De Nancy, Vandoeuvre-lès-Nancy, FRA
²²Hematology, CHU Montpellier, Montpellier, FRA
²³Hôpital saint Eloi, CHU Montpellier, MONTPELLIER, France
²⁴Clinical Hematology, APHP, La Pitié Salpétriere, Sorbonne Universite, Paris, FRA
²⁵Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Pitie-Salpetriere Hospital, Paris, France
²⁶CH Versailles, Le Chesnay Rocquencourt, FRA
²⁷CHU Caen, Caen, Normandy, FRA
²⁸CHU de Caen, Caen Cedex9, FRA
²⁹HOPITAL ALBERT MICHALLON, Department of Hematology, University Hospital Grenoble, Grenoble, France
³⁰CHU Grenoble Alpes, La Tronche, France
³¹CH Côte Basque, Bayonne, FRA
³²Service D'hématologie Biologique, CHU De Bordeaux, Bordeaux, FRA
³³Hematology clinic, Nantes University Hospital, Nantes, France
³⁴Hematology biology, CHU Nantes, Nantes, FRA
³⁵CHU Bretonneau, Tours, France
³⁶CHU Tours, Tours, France
³⁷CHU Besancon, Cellular immunology and hematology laboratory, Université de Franche-Comté, CHU Besançon, EFS, INSERM, UMR RIGHT, Besançon, France

Zepin Zhou, PhD^1*, Xingli Zhao^2*, Xiaohui Suo^3*, Guanchen Bai^4*, Zeyan Shi^5*, Yunya Luo^6*, Yaxian Tan^1*, Xinxiao Lu^7*, Linyu Yuan^7*, Congcong Zhang^3*, Yinling Li^3*, Sifeng Gao^4*, Jilei Zhang^4*, Heng Li^6*, Weihua Zhao, MD, PhD^5*, Hongling Peng^6*, Pengxiang Guo^8*, Yingchang Mi, MD^9,10 and Kaiqi Liu^10,11*

¹Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China, Kunming, China
²Tianjin People's Hospital, Tianjin, China
³Department of Hematology, Handan Central Hospital, Handan, Hebei, China, 056000,, Handan, China
⁴Department of Hematology, The Affiliated Tai'an City Central Hospital of Qingdao University, Taian, Shandong, China, 271000., Taian, China
⁵Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
⁶Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China, Changsha, China
⁷Department of Hematology, Oncology Center, Tianjin People's Hospital, No. 190 jieyuan Road, Hongqiao District, Tianjin 300121, P R China., Tianjin, China
⁸Department of Hematology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, Guiyang, China
⁹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
¹⁰Tianjin Institutes of Health Science, Tianjin, China
¹¹National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China

Haiping Dai^1*, Jia Chen^2*, Xiebing Bao^3*, Depei Wu, M.D.⁴ and Suning Chen, MD^4*

¹Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Suzhou, China
²National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow Univers, Suzhou, China
³National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China
⁴National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China

Kuo-Kai Chin, MD¹, Andriy Derkach, PhD^2*, Christopher Famulare, MS^1*, Gaurav Gupta, MD, PhD^3*, Prabhakar Borge, MD, PhD^1*, Ellin Berman, MD¹, Mark Blaine Geyer, MD⁴, Aaron D. Goldberg, MD, PhD¹, Tamanna Haque, MD^1*, Raajit K. Rampal, MD, PhD¹, Jae H. Park, MD¹, Lindsey E. Roeker, MD¹, Martin S. Tallman, MD⁵ and Eytan M. Stein¹

¹Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
³Transfusion Medicine and Cell Therapy, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Highland Park, IL

Ramy Rahmé, MD, MSc^1,2*, Valérie Vidal, MD^1,2*, Thomas Hueso, MD, PhD^1,2*, Lucie Le Meur, PharmD^3*, Marthe Rigal, PharmD^3*, Sarah Ivanoff, MD^1,2*, Sabine Brechignac, MD^1,2*, Regis Peffault De Latour^4*, Claude Gardin, MD, PhD^2,5* and Thorsten Braun, MD, PhD^1,2

¹Clinical Hematology, Avicenne University Hospital, Assistance Publique – Hôpitaux de Paris, Bobigny, France
²UFR SMBH, Sorbonne Paris Nord University, Bobigny, France
³Secteur UPC, Pharmacy Department, Avicenne University Hospital, Bobigny, France
⁴Hematology and Transplantation Unit, Hôpital Saint Louis, AP-HP, Paris, France
⁵Hôpital Avicenne, Hematology Department, AP-HP, Bobigny, France

Amelie Polutta^1*, Dirk Reinhardt, MD², Andre Baruchel, MD^3*, Henrik Hasle⁴, Franco Locatelli, MD, PhD⁵, C. Michel Zwaan, MD^6,7*, Michael Frühwald, MD, PhD^8*, Silke Westphal, MD^8*, Michael Dworzak^9,10*, Heidrun Boztug^9*, Gabriele Escherich, MD^11*, Thomas Lehrnbecher, MD^12*, Bianca F. Goemans, MD, PhD¹³, Brigitte Strahm, MD^14*, Markus Schneider, PhD^2*, Lina Hoffmeister^15* and Katharina Waack^16*

¹Pediatric Research Network, Essen, AL, Germany
²Department of Pediatrics III, University Children’s Hospital Essen, University of Duisburg-Essen, Essen, Germany
³Hôpital Universitaire Robert Debré (APHP and Université Paris Cité), Paris, France
⁴Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
⁵Department of Pediatrics, Catholic University of the Sacred Heart, Rome, Italy
⁶Prinses Máxima Center for Pediatric Oncology Research, Utrecht, Netherlands
⁷Erasmus University Medical Center, Rotterdam, Netherlands
⁸Peadiatric and Adolescent Medicine, Swabian Children's Cancer Center, University Medical Center Augsburg, Augsburg, Germany
⁹Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, St. Anna Children's Hospital, Vienna, Austria
¹⁰St. Anna Children's Cancer Research Institute, Vienna, Austria
¹¹Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
¹²Department of Pediatrics, Division of Hematology, Oncology and Hemostaseology, Goethe University Frankfurt, Frankfurt/Main, Germany
¹³Princess Maxima Centre for Pediatric Oncology, Utrecht, Netherlands
¹⁴Center for Pediatrics, Department of Pediatric Hematology and Oncology, Medical Center University of Freiburg, Freiburg, Germany
¹⁵University Hospital Essen, Essen, Germany
¹⁶Pediatric Research Network, Essen, Germany

Jianyu Weng, M.D., Ph.D.^1*, Xin Huang, M.D., Ph.D.^1*, Ping Wu, M.D., Ph.D.^1*, Chengxin Deng, M.D.^1*, Minming Li, M.D.^1*, Xiaomei Chen, M.D., Ph.D.^1*, Chengwei Luo, M.D.^2*, Hui Zeng, MD, PhD³, Yuming Zhang, M.D.^4*, Caixia Wang, M.D.^5*, Tingfen Deng, M.D.^5*, Lie Lin, MD^6*, Zhenqian Huang, Ph.D.^7*, Bingyi Wu, M.D., Ph.D.^8*, Guozheng Wang, M.D.^9*, Runhui Zheng, M.D.^10*, Xu Ye, M.D., Ph.D.^11*, Peilong Lai, M.D., Ph.D.^1*, Yang Liang, MD, PhD¹², Huo Tan, M.D., Ph.D.^10*, Yangqiu Li, M.D., Ph.D.³ and Xin Du, M.D., Ph.D.^1*

¹Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
²Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Guangzhou, China
³The First Affiliated Hospital of Jinan University, Guangzhou, China
⁴Department of Hematology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
⁵Department of Hematology, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou, China
⁶Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China
⁷Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
⁸Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China
⁹Department of Hematology，Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, China
¹⁰Department of Hematology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
¹¹Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
¹²Sun Yat-sen University Cancer Center, Guangzhou, China

Silvia Park^1*, Sung-Soo Park^2*, Byoung Sik Cho^3*, Sungwon Lim, PhD^4,5*, Kwan Hyun Kim, PhD^5*, Gyucheol Choi^5*, Seunghyeok Ham^5*, Seongjoon Lee^5*, Sesun Park^5*, Gunjae Lee^6*, Junyoung Lee^7*, Edward Song^8*, Jamin Koo, PhD^4,6* and Heeje Kim, MD, PhD³

¹Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, AL, South Korea
²Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
³Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁴ImpriMed, Inc., Mountain View, CA
⁵ImpriMedKorea, Inc., Seoul, Korea, Republic of (South)
⁶Department of Chemical Engineering, Hongik University, Seoul, Korea, Republic of (South)
⁷Department of Computer Science, KAIST, Seoul, Korea, Republic of (South)
⁸Department of Computer Science, Carnegie Mellon University, Pittsburgh, PA

Yuanyuan Zhu, PhD^1*, Weijia Huang^2*, Jinya Lin^3*, Zhen Cai^4*, Xiujin Ye^5*, Shanshan Pei, PhD^6*, Ying Xie^7*, Xiaoqing Zou^8*, Shaoqi Zhang^3*, He Huang^9* and Jie Sun^10*

¹The First Affiliated Hospital, Zhejiang University School of Medicine, HANGZHOU, CHN
²Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, HangZhou, China
³The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁴Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁵Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, hangzhou, CHN
⁶Liangzhu Laboratory, Zhejiang University, hangzhou, CO, China
⁷the First Affiliated Hospital, Zhejiang University School of Medicine, hangzhou, China
⁸Liangzhu Laboratory, Zhejiang University, hangzhou, China
⁹The First Affiliated Hospital, College of Medicine, Zhejiang University, Hematology, Hangzhou, China
¹⁰Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China

Wen-Jing Yu, MD^1*, Ying Wu^1*, Qi Chen, MD^1*, Xiaolu Zhu, MD^1*, Xu-Ying Pei, PhD^1*, Jin-Song Jia, MD, PhD^2*, Jing Wang, MD^1*, Xiao-Su Zhao^1*, Ying-Jun Chang^1*, Yue-Yun Lai, MD^1*, Hong-Xia Shi, MD^1*, Guo-Rui Ruan, MD^1*, Ya-Zhen Qin, MD^1*, Xiao-Hong Liu, MD^1*, Xiao Jun Huang, MD^1,3 and Hao Jiang^1*

¹Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
²Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China
³Peking-Tsinghua Center for Life Sciences, Beijing, China

Nuttavut Sumransub, MD¹, Gabriel K Steinwand, PharmD^2*, Yoonkyu Lee, MS, BS^1,3,4, Qing Cao, MSc^5*, Jeremy R. Allred, MD^1,4, Vidhyalakshmi Ramesh^4*, Chad L Myers, PhD^3* and Zohar Sachs, MD, PhD^1,3,4

¹Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
²University of Minnesota Medical Center, Department of Pharmacy, M Health Fairview, Minneapolis, MN
³Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN
⁴Masonic Cancer Center, University of Minnesota, Minneapolis, MN
⁵Biostatistics and Informatics, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN

Xinjie Chen^1*, Diyaer Abuduaini^1,2*, Hongming Zhu^1*, Jun Long^3*, Jiong Hu¹, Wen Wu^1* and Yang Shen^1*

¹Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
²Department of Hematology, The Second People's Hospital of Kashi, Kashi, China
³Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China

Qian Wu^1*, De-Pei Wu^2,3, Suning Chen, MD^4*, Xiaofei Yang^5*, Jingren Zhang^6*, Mengxing Xue, PhD^7*, Xueqing Dou^8*, Sheng-Li Xue^9*, Huiying Qiu^10*, Xiaowen Tang^11*, Yue Han, MD^12*, Jianhong Fu^1* and Xuefeng He^2*

¹National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China, Suzhou, China
²Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Suzhou, China
³National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, the First Affiliated Hospital of Soochow University, Soochow University,, Suzhou, China
⁴Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China
⁵National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China
⁶National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China, Suzhou, CHN
⁷The First Affiliated Hospital of Soochow University, Suzhou, CHN
⁸National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China
⁹The First Affiliated Hospital of Soochow University, Suzhou, China
¹⁰Department of Hematology, National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China
¹¹The First Affilliated Hospital of Soochow University, Suzhou, China
¹²Jiangsu Institute of Hematology, Suzhou, Jiangsu, CHN

Yadith Karina Lopez-Garcia, MD^1*, Fernando De La Garza, MD^2*, Gerardo Alexis De la Rosa-Flores, MD^2*, Edgar Ulises Coronado Alejandro, MD^2*, Antonio Vega-Mateos, MD^3*, Ana Cristina Tejada Vasquez^2*, Gerardo Garcia-Salas, MD², Valeria García-Zárate^2*, Perla R. Rocio Colunga-Pedraza, MD², David Gomez-Almaguer, MD² and Andres Gomez-De Leon, MD⁴

¹Servicio de Hematología, Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Universidad Autónoma de Nuevo León, Monterrey, Mexico
²Servicio de Hematologia, Universidad Autonoma de Nuevo Leon, Hospital Universitario "Dr. José Eleuterio Gonzalez", Monterrey, Mexico
³Servicio de Hematología, Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico
⁴Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Mexico, Monterrey, Mexico

Sijian Yu^1*, Qifa Liu, MD², Yu Zhang^3*, Guopan Yu, MD, PhD^3*, Yu Wang, MD^4*, Ruoyang Shao, MD^3* and Qiong Liu^5*

¹Nanfang Hospital,Southern Medical University, Guangzhou, China
²Nanfang Hospital, Southern Medical University, Guangzhou, China
³Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⁴Peking University People’s Hospital, Beijing, China
⁵Nangfang Hospital, Guangzhou, China

Joshua A Fein, MD¹, Sanjay Patel, MD, MSc, MPH², Neela Easwar, MD^3*, Michal Bar-Natan, MD⁴, Amy Chadburn, MD², Pinkal Desai, MD, MPH⁵, Julia Geyer, MD^2*, Michael Kluk^2*, Madhu M Ouseph, MD, MBBS, PhD^2*, Ellen K. Ritchie, MD⁴, Michael Samuel, MD^4*, Paul Simonson, MD, PhD^2*, Gail J. Roboz, MD⁴ and Justin D. Kaner, MD⁴

¹Division of Hematology & Medical Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
²Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
³Department of Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
⁴Division of Hematology and Medical Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
⁵Division of Hematology and Medical Oncology, EIPM Molecular Aging Institute, Weill Cornell Medicine, New York, NY

Gertjan J.L. Kaspers, MD, PhD^1,2, Noa E. Wijnen^1,2*, Joost B. Koedijk^3,4*, Sae Ishimaru, MD, PhD^2*, Renske Benedictus^2*, Ellen C. Van Opstal^2*, Harm Van Tinteren^2*, C. Michel Zwaan, MD^5,6*, Noha Biserna, MSc^7*, Pamela Downs^8*, Yvonne Duong^9*, Yasser Mostafa Kamel^9*, Jonas Abrahamsson^10*, Nira Arad-Cohen^11*, Nicole Bodmer, MD^12*, Luis Castillo, PhD^13*, Daniel Cheuk^14*, Vitor Costa^15*, Barbara De Moerloose^16*, Jose Maria Fernandez Navarro^17*, Linda Fogelstrand, MD, PhD^18,19, Bianca F. Goemans, MD, PhD², Henrik Hasle²⁰, Olafur G. Jonsson, MD^21*, Zhanna Kovalova^22*, Monica C. Munthe-Kaas^23*, Ulrika Norén-Nyström, MD, PhD^24*, Sauli Palmu, MD, PhD^25,26*, Ramune Pasauliene^27*, Kadri Saks^28*, Anne Maria Tierens, MD, PhD²⁹, Dominik Turkiewicz^30* and Cornelis Jan Pronk, MD, PhD^30*

¹Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
²Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
³Princess Maxima Centre for Pediatric Oncology, Utrecht, Netherlands
⁴Department of Pediatric Oncology, Erasmus MC/Sophia Children's Hospital, Rotterdam, Netherlands
⁵Prinses Máxima Center for Pediatric Oncology Research, Utrecht, Netherlands
⁶Erasmus University Medical Center, Rotterdam, Netherlands
⁷Daiichi Sankyo Inc., Basking Ridge, NJ
⁸Daiichi Sankyo, Inc., Basking Ridge, NJ
⁹Daiichi Sankyo, Inc., Basking Ridge
¹⁰Institute of Clinical Sciences, Department of Pediatrics, Queen Silvias Childrens Hospital, Gothenburg, Sweden
¹¹Department of Pediatric Hemato-Oncology, Rambam Health Care Campus, Haifa, Israel
¹²Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland
¹³Centro Hospitalario Pereira Rossell, Montevideo, Uruguay
¹⁴Department of Pediatrics and Adolescent Medicine, Hong Kong Children's Hospital, University of Hong Kong, Hong Kong, China
¹⁵Department of Pediatrics, Instituto Português de Oncologia, FG-Porto, Portugal
¹⁶Ghent University Hospital, Ghent, Belgium
¹⁷Department of Pediatric Hemato-Oncology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
¹⁸Department of Clinical Chemistry, Sahlgrenska University, Gothenburg, Sweden
¹⁹Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
²⁰Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
²¹Department of Pediatrics, Landspitali University Hospital, Reykjavik, Iceland
²²Department of Pediatric Oncology/Hematology, Children's Clinical University Hospital, Riga, Latvia
²³Department of Pediatric Oncology, Oslo University Hospital, Oslo, Norway
²⁴Department of Clinical Sciences, Pediatrics, Umeå University Hospital, Umeå, Sweden
²⁵Department of Pediatrics, Tampere University Hospital, Tampere, Finland
²⁶Faculty of Medicine and Health Technology, Center for Child, Adolescent and Maternal Health Research, Tampere University, Tampere, Finland
²⁷Center for Pediatric Oncology and Hematology, Vilnius University Children’s Hospital, Vilnius, Lithuania
²⁸Department of Hematology Oncology, Tallinn Children´s Hospital, Tallinn, Estonia
²⁹Laboratory Medicine Program, University Health Network, University of Toronto, Toronto, ON, Canada
³⁰Childhood Cancer Center, Skåne University Hospital, Lund, Sweden

Giovanni Marconi, MD¹, Petros Kountouris, PhD^2*, Jiri Mayer, MD³, Lars Bullinger⁴, Dirk Reinhardt, MD⁵, Pau Montesinos, PhD, MD^6*, Pietro Merli, MD^7*, Marco Vignetti, MD^8*, Jos Dumortier^9*, Jesús María Hernández-Rivas, PhD¹⁰, Michael Heuser, MD¹¹, Rolandas Gerbutavicius, PhD^12*, Antonio Francesco Maturo^13*, Gianni D'Errico^14*, Samantha Nier, MSc^15*, Chiara Zingaretti^16*, Irene Azzali^17*, Federica Campacci^18*, Maria Del Mar Mañú-Pereira^19*, Franco Locatelli, MD, PhD²⁰, Rüdiger Hehlmann, MD ²¹, Dietger W. Niederwieser, MD²² and Giovanni Martinelli, MD, PhD^23*

¹IRCCS Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”,, Meldola, Italy
²The Cyprus Institute of Neurology and Genetics, Nicosia, CYP
³Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital, Brno, Czech Republic
⁴Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany
⁵Department of Pediatrics III, University Children’s Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁶Hospital Universitari i Politecnic la Fe, Valencia, Spain
⁷Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy
⁸GIMEMA Foundation, Rome, Italy
⁹Time.lex, Brussels, Belgium
¹⁰University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain
¹¹Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹²Department of Oncology and Hematology, Institute of Oncology, Lithuanian University of Health Sciences, Kaunas, Lithuania
¹³Sociology, University of Bologna, Bologna, Italy
¹⁴Fondazione Toscana Life Sciences, Firenze, Italy
¹⁵Acute Leukemia Advocates Network, Bern, Switzerland
¹⁶Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST), Meldola, Italy
¹⁷Biostatistics and Clinical Trials Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy
¹⁸IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy
¹⁹Vall d'Hebrón Institut de Recerca, Hospital Universitari Vall d'Hebron, Barcelona, AL, ESP
²⁰Department of Pediatrics, Catholic University of the Sacred Heart, Rome, Italy
²¹ELN-Foundation, Weinheim, Germany
²²Universitaetsklinikum Leipzig Aor, Leipzig, DEU
²³IRCCS Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”, Meldola, Italy

Michael P Ozga, MD¹, Kaitlyn M. Dvorak-Kornaus, PhD^2*, Qiuhong Zhao, MS^2*, Jill Buss, BS³, Andrea Laganson, MS^3*, Ethan Hamp^4*, Yazan F. Madanat, MD⁵, Daniel A. Pollyea, MD, MS⁶, Eytan M. Stein⁷, Joshua F. Zeidner, MD⁸, Elaine R Mardis, PhD^9*, Ann-Kathrin Eisfeld, MD*¹⁰ and Alice Mims, MD²

¹The Ohio State University, Columbus, OH
²Division of Hematology, The Ohio State University, Columbus, OH
³Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴The Ohio State University Comprehensive Cancer Center, Columbus
⁵Hematologic Malignancies and Cellular Therapy, University of Texas Southwestern Medical Center, Dallas, TX
⁶Division of Hematology, University of Colorado School of Medicine, Aurora, CO
⁷Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁸University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC
⁹Nationwide Children's Hospital, Columbus, OH
¹⁰Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH

Uma M. Borate, MD¹, Ying Huang, MS, MA², Mary F. Johnson, PhD^3*, Joshua F. Zeidner, MD⁴, Ronan T. Swords, MD, PhD, FRCP, FRCPath⁵, Kristin L Koenig, MD⁶, Eytan M. Stein⁷, Maria R. Baer, MD⁸, Wendy Stock, MD⁹, Yazan F. Madanat, MD¹⁰, Rebecca Olin, MD¹¹, William Blum, MD¹², Gary J. Schiller, MD¹³, Tara L Lin, MD¹⁴, Robert L. Redner, MD¹⁵, Emily K Curran, MD¹⁶, Nyla A. Heerema, PhD^17*, Molly Martycz^18*, Leonard Rosenberg^19*, Sonja Gullen Marcus, MPH^19*, Timothy Chen, PhD^18*, Mona Stefanos, MD¹⁸, Ross L Levine, MD²⁰, Brian J. Druker, MD²¹, Ashley Owen Yocum, PhD¹⁹, Amy Burd, PhD²², Alice Mims, MD²³ and John C. Byrd, MD²⁴

¹Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
²Division of Hematology, The Ohio State University, Columbus, OH
³MJBiostat, Spring Lake, NJ
⁴University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC
⁵Knight Cancer Institute, Oregon Health and Science University, Portland, OR
⁶Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
⁷Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
⁹University of Chicago Medicine, Chicago, IL
¹⁰Hematologic Malignancies and Cellular Therapy, University of Texas Southwestern Medical Center, Dallas, TX
¹¹University of California San Francisco, San Francisco, CA
¹²Winship Cancer Institute of Emory University, Atlanta, GA
¹³Hematological Malignancy/ Stem Cell Transplant Program, David Geffen School of Medicine, UCLA, Los Angeles, CA
¹⁴Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Medical Center, Westwood, KS
¹⁵University of Pittsburgh Medical Center, Pittsburgh, PA
¹⁶University of Cincinnati, Cincinnati, OH
¹⁷Ohio State University, Columbus, OH
¹⁸The Ohio State University, Columbus, OH
¹⁹Leukemia and Lymphoma Society, Rye Brook, NY
²⁰Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²¹Oregon Health & Science University, Portland, OR
²²Leukemia and Lymphoma Society, White Plains, NY
²³Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH
²⁴Department of Internal Medicine, University of Cincinnati, Cincinnati, OH