Yingying Li^1,2*, Jianghua Wu^2*, Lili Luo^1,2*, Yu Hu, MD^2* and Heng Mei^1,2*

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Hubei Clinical and Research Centre of Thrombosis and Haemostasis, Wuhan, China

Aurelien Lebreton^1*, Véronique Cahoreau^2*, Nicolas Giraud^3*, Stephanie Delienne^4*, Francis Fagnani^5*, Stéphane Bouée^6*, Juliette Cottin^5*, Isabelle Bureau^5*, Jeremie Rudant^7*, Anais Reynaud^8*, Amelie Coumert^8*, Herve Lilliu^9* and Laurent Frenzel, MD, PhD^10*

¹CHU Clermond Ferrand, Clermond Ferrand, France
²CHU de Bordeaux, Bordeaux, France
³Association Française des Hémophiles, Paris, France
⁴CHU Dijon, Dijon, France
⁵Cemka, Bourg-la-Reine, France
⁶CEMKA, Bourg-la-Reine, France
⁷Pfizer France, Paris, France
⁸Pfizer, Paris, France
⁹Inbeeo, London, United Kingdom
¹⁰Department of Haematology, Institut Necker, Paris, FRA

Anna Kiialainen^1*, Steven Pipe, MD², Karin Fijnvandraat^3*, Gili Kenet^4,5*, Christophe Schmitt^1*, Muriel Buri^1*, Víctor Jiménez-Yuste, MD, PhD^6*, Johannes Oldenburg⁷, Maria Elisa Mancuso, MD, PhD^8*, Christophe Dhalluin^1*, Michaela Lehle¹ and Peter Collins^9*

¹F. Hoffmann-La Roche Ltd, Basel, Switzerland
²University of Michigan, Ann Arbor, MI
³University of Amsterdam, Amsterdam, Netherlands
⁴Sheba Medical Center, Ramat Gan, Israel
⁵Tel Aviv University, Tel Aviv, Israel
⁶La Paz University Hospital Idi-Paz, Autónoma University, Madrid, Spain
⁷University of Bonn, Bonn, Germany
⁸Center for Thrombosis and Haemorrhagic Diseases, IRCCS Humanitas Research Hospital, Milan, Italy
⁹School of Medicine, Cardiff University, Cardiff, United Kingdom

Roslyn Mainland, MD^1*, Pallavi Ganguli, MD², Paula James, MD, FRCPC², C. Janet Lui, MD, FRCPC^2*, Natasha Satkunam, MBBS, FRCPC^2* and Jennifer Leung, MD, FRCPC²

¹Department of Medicine, Queen's University, Kingston, ON, Canada
²Division of Hematology, Department of Medicine, Queen's University, Kingston, ON, Canada

Man-Chiu Poon¹, Adrienne Lee², Federico Germini^3*, Arun Keepanasseril^3*, Quazi Ibrahim^3*, Letizia Polito^4*, Katya Moreno^4*, Michelle Santos^5*, Emma Iserman^3*, Davide Matino, MD^6* and Alfonso Iorio, MD, PhD⁷

¹University of Calgary, Calgary, AB, Canada
²University of British Columbia, Victoria, BC, Canada
³McMaster University, Hamilton, ON, Canada
⁴F. Hoffmann-La Roche Ltd, Basel, Switzerland
⁵F. Hoffmann-La Roche Ltd, Mississauga, ON, Canada
⁶Thrombosis and Atherosclerosis Research Institute (TaARI), Hamilton, ON, Canada
⁷Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada

Jaclyn Shelton, MD^1*, Michelle Millions, MD^1*, Roy Khalife, MD, MHPE² and Haowei (Linda) Sun, MD, MHSc³

¹Department of Medicine, University of Alberta, Edmonton, AB, Canada
²Department of Medicine, University of Ottawa, Ottawa, ON, Canada
³Division of Hematology, Department of Medicine, University of Alberta, Edmonton, AB, Canada

Clay Cohen¹, Jacquelyn Powers, MD² and Cristina Tarango³

¹Division of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, Houston, TX
²Baylor College of Medicine/ Texas Children's Hospital, Houston, TX
³Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Adebimpe Adelaja, BS^1*, Joseph R Stanek, MS^2*, Veronica Heather Flood, MD^3,4, Paula James, MD, FRCPC⁵, Sara Vesely, PhD⁶ and Sarah O'Brien, MD, MSc⁷

¹Nationwide Children's Hospital, Canal Winchester, OH
²Division of Biostatistics, Nationwide Children's Hospital, Columbus, OH
³Blood Center of Wisconsin, Milwaukee, WI
⁴Medical College of Wisconsin, Milwaukee, WI
⁵Division of Hematology, Department of Medicine, Queen's University, Kingston, ON, Canada
⁶The Univ. of OK Health Sciences Ctr., Oklahoma City, OK
⁷Nationwide Children's Hospital, Columbus, OH

Anja Strebel^*, Fabrizio Pennacchio^*, Sebastian Lickert^*, Kateryna Selcuk^*, Konstantin Wolf^* and Viola Vogel^*

Laboratory of Applied Mechanobiology, DHEST, ETH Zurich, Zurich, Switzerland

Luciana W. Zuccherato, PhD^1*, Renan P. Souza, PhD^2*, Ricardo M. Camelo, MD, PhD^2,3*, Maise M. Dias, MD^4*, Marcio A. P. Santana, MD^2,5*, Letícia L. Jardim, PhD^2,6*, Andrea G. Oliveira, MD^7*, Claudia S. Lorenzato, MD^8*, Monica H. Cerqueira, MD^9*, Vivian K. B. Franco, MD^10*, Rosangela A. Ribeiro, MD^11,12*, Leina Y. Etto, MD^13,14*, Maria R. F. Roberti, MD^15,16*, Fábia M. R. A. Callado, MD^17*, Maria A. F. Cerqueira, MD^18*, Ieda S. S. Pinto, MD^19,20*, Andrea A. Garcia, MD^21,22*, Tânia H. Anegawa, MD^23,24*, Daniele C. F. Neves, MD^25,26*, Doralice M. Tan, MD^27*, Daniel G. Chaves, PhD^5* and Suely M. Rezende, MD, PhD²⁸

¹Department of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil
²Universidade Federal de Minas Gerais-UFMG, Belo Horizonte, Brazil
³Leiden University Medical Centre, Leiden, Netherlands
⁴Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
⁵Fundação Hemominas, Belo Horizonte, Brazil
⁶University of Leiden, Leiden, Netherlands
⁷Fundação Hemominas, Belo Horizonte, BRA
⁸Hemocentro do Paraná (HEMEPAR), Curitiba, Brazil
⁹Instituto de Hematologia do Estado do Rio de Janeiro (HEMORIO), Rio de Janeiro, Brazil
¹⁰Centro de Hematologia e Hemoterapia de Santa Catarina (HEMOSC), Florianópolis, Brazil
¹¹Centro de Hematologia e Hemoterapia do Ceará (HEMOCE), Fortaleza, Brazil
¹²Universidade Federal do Ceará, Fortaleza, Brazil
¹³Hemocentro da Paraíba (HEMOÍBA), João Pessoa, Brazil
¹⁴Universidade Federal da Paraíba, João Pessoa, Brazil
¹⁵Universidade Federal de Goiás, Goiânia, Brazil
¹⁶Hemocentro de Goiás (HEMOGO), Goiânia, Brazil
¹⁷Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, Brazil
¹⁸Centro de Hematologia e Hemoterapia do Piauí (HEMOPI),, Teresina, Brazil
¹⁹Centro de Hematologia e Hemoterapia do Pará (HEMOPA), Belém, Brazil
²⁰Universidade Federal do Pará, Belém, Brazil
²¹Hemocentro de São José do Rio Preto, São José do Rio Preto, Brazil
²²Faculdade Regional de Medicina de São José do Rio PretoRio Preto,, São José do Rio Preto, Brazil
²³Centro de Hematologia Regional de Londrina (HEMEPAR Londrina), Londrina, Brazil
²⁴Faculty of Medicine, Universidade Estadual de Londrina, Londrina, Brazil
²⁵Fundação Hemocentro de Rondônia (FHEMERON), Porto Velho, Brazil
²⁶Universidade de Rondônia, Porto Velho, Brazil
²⁷Faculdade de Medicina de Marília, Marília, Brazil
²⁸Universidade Federal de Minas Gerais, BELO HORIZONTE, AC, Brazil

Ruayda Bouls, B.S.^1*, Marcio A. Almeida, Ph.D.^2,3*, Vincent P. Diego, Ph.D.^2,3*, Bernadette W. Luu, B.S.^4*, Raja Rajalingam, Ph.D.^5,6*, Afshin Ameri, M.D.⁷, Kevin R. Viel, Ph.D.^8*, Meera Chitlur, MD⁹, Benjamin Kim, M.D., M.Phil.¹⁰, Miguel A. Escobar, M.D.^11*, Sarah Williams-Blangero, Ph.D.^2,12*, Carol K. Kasper, M.D.¹³, Laura Almasy, Ph.D.^14,15*, John Blangero, Ph.D.^2,3* and Tom E. Howard, MD, PhD^2,12

¹University of Texas Rio Grande Valley School of Medicine, Edinburg, TX
²South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX
³Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX
⁴Research and Development, Haplogenics Corporation, Los Angeles, CA
⁵Department of Surgery, University of California San Francisco School of Medicine, San Francisco, CA
⁶Immunogenetics and Transplantation Laboratory, University of California San Francisco School of Medicine, San Francisco, CA
⁷Georgia Health Sciences University, Augusta, GA
⁸R&D, Histonis, Portsmouth, NH
⁹Division of Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI
¹⁰Consultant, San Francisco, CA
¹¹Department of Medicine, Division of Hematology and Oncology, University of Texas Health Sciences Center Houston, Houston, TX
¹²Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, BROWNSVILLE, TX
¹³Department of Hematology, USC Keck School of Medicine, Berkeley, CA
¹⁴Department of Biomedical and Health Informatics, UPenn School of Medicine, Philadelphia, PA
¹⁵Children's Hospital of Philadelphia, Philadelphia

Paola Ibarra, B.S.^1*, Marcio A. Almeida, Ph.D.^2,3*, Vincent P. Diego, Ph.D.^2,3*, Bernadette W. Luu, B.S.^4*, Kevin R. Viel, Ph.D.^5*, Raja Rajalingam, Ph.D.^6,7*, Afshin Ameri, M.D.⁸, Meera Chitlur, MD⁹, Benjamin Kim, M.D., M.Phil.¹⁰, Grecia Castillo^11*, Jerry S. Powell, M.D.¹², Juan M. Peralta, M.S.^3,13*, Miguel A. Escobar, M.D.^14,15*, Sarah Williams-Blangero, Ph.D.^2,16*, John Blangero, Ph.D.^2,3*, Carol K. Kasper, M.D.¹⁷, Laura Almasy, Ph.D.^18,19* and Tom E. Howard, MD, PhD^2,16

¹University of Texas Rio Grande Valley, Edinburg, TX
²South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX
³Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX
⁴Research and Development, Haplogenics Corporation, Los Angeles, CA
⁵R&D, Histonis, Portsmouth, NH
⁶Immunogenetics and Transplantation Laboratory, University of California San Francisco School of Medicine, San Francisco, CA
⁷Department of Surgery, University of California San Francisco School of Medicine, San Francisco, CA
⁸Georgia Health Sciences University, Augusta, GA
⁹Division of Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI
¹⁰Consultant, San Francisco, CA
¹¹Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville
¹²R&D, Haplogenics Corporation, Seattle, WA
¹³South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville
¹⁴Department of Medicine, Division of Hematology and Oncology, University of Texas Health Sciences Center Houston, Houston, TX
¹⁵Gulf States Hemophilia and Thrombophilia Center, Houston
¹⁶Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, BROWNSVILLE, TX
¹⁷Department of Hematology, USC Keck School of Medicine, Berkeley, CA
¹⁸Children's Hospital of Philadelphia, Philadelphia
¹⁹Department of Biomedical and Health Informatics, UPenn School of Medicine, Philadelphia, PA

Bruno U.K. Steiner, DPT, RMSK^1,2*, Mark A Krimmel, DPT, RMSK^1*, Eric Y Chang, MD^3*, Merel A Timmer, PT, PhD^4*, Grace Hernandez, PT^5*, Jeffrey Kallberg, DPT^6*, Osman Khan, MD, MSc⁷, Lorene Schmaderer, MPT^8*, Fred Loeffler, DPT, ATC^9*, Stacie Akins, PT, MHS^9*, Tiffany Kaltenmark, DPT^9*, Stacey Cave, MPT^10*, Jessica Ovans, DPT^11* and Rebecca Kruse-Jarres, MD, MPH²

¹Washington Center for Bleeding Disorders, SEATTLE, WA
²University of Washington, Seattle, WA
³University of California San Diego, San Diego, CA
⁴University Medicine Center Utrecht, Utrecht, NLD
⁵The Center for Inherited Blood Disorders, Orange, CA
⁶University of Texas Health Center San Antonio, San Antonio, TX
⁷Oklahoma Bleeding and Clotting Disorders Center, University of Oklahoma, Oklahoma City, OK
⁸Nebraska Medicine, Omaha, NE
⁹Indiana Hemophilia and Thrombosis Center, Indianapolis, IN
¹⁰Adult Bleeding Disorders Program of BC, St. Paul's Hospital, Vancouver, BC, Canada
¹¹Children's Minnesota, Minneapolis, MN

Dino Mehic, MD^1*, Daniel Kraemmer^2*, Jasmin Sabrina Rast, MD^3*, Silvia Koder^4*, Michelle Fuchs^5*, Helmuth Haslacher^6*, Peter Quehenberger, MD^6*, Cihan Ay, MD^7*, Ingrid Pabinger, MD¹ and Johanna Gebhart, MD^3*

¹Medical University of Vienna, Vienna, Austria
²Medical University Vienna, Vienna, AUT
³Department of Medicine I, Clinical Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
⁴Internal Medicine I, Vienna, AUT
⁵Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
⁶Medical University of Vienna, Vienna, AUT
⁷Department of Medicine I, Clinical Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, AUT

Nicholas L.J. Chornenki, MD¹, Julie Grabell^2*, Mackenzie L Bowman, MSc, PhD^2*, David Good, MD, FRCPC², Lawrence Hookey, MD^3* and Paula James, MD, FRCPC⁴

¹University of British Columbia, Vancouver, BC, Canada
²Queen's University, Kingston, ON, CAN
³Queen's University, Kingston, Canada
⁴Division of Hematology, Department of Medicine, Queen's University, Kingston, ON, Canada

Ghada Araji, MD^1*, Chapman Wei, MD^1*, Muhammad Niazi, MBBS², Anisha Rajavel, DO^1*, Rubal Sharma, MD², Radu Grovu, MD^1*, Fasih Sami Siddiqui, MD^1* and Ahmad Mustafa, MD^1*

¹Department of Internal Medicine, Northwell Health/Staten Island University Hospital, Staten Island, NY
²Department of Hematology and Oncology, Northwell Health/Staten Island University Hospital, Staten Island, NY

Amaury Monard, MD^1,2*, Yvonne Henskens^3,4*, Paul Verhezen^5*, Dave Hellenbrand^6*, Erik AM Beckers, MD, PhD⁷ and Floor Moenen^8*

¹Department of internal medicine, Maastricht University, Maastricht, AL, Belgium
²Carim- school for cardiovascular diseases, Maastricht, Netherlands
³Maastricht UMC+, Maastricht, NLD
⁴CARIM - School for cardiovascular disease, Maastricht, Netherlands
⁵Maastricht University Medical Center, Central Diagnostic Laboratory, Unit For He, Maastricht, NLD
⁶Central Diagnostic Laboratory, Maastricht University Medical Center + (MUMC+), Maastricht, Netherlands
⁷Maastricht University Medical Center, Maastricht, NLD
⁸Department of Hematology, Maastricht University Medical Center, Maastricht and Hemophilia Treatment Center Nijmegen-Eindhoven-Maastricht, Maastricht, Netherlands

Oscar Jaime Jaime Moreno Garcia, MD^1*, Sergio Rodriguez-Rodriguez, MD, MSc², Elia Ixel Apodaca Chavez, MD^2*, Angel Gabriel Vargas Ruiz, MD^3*, Regina Sotelo Diaz, MD^4*, Abigail Daniela Vieyra Santiago, MD^5* and Elena Juventina Tuna Aguilar, MD^6*

¹Hematología y Oncología, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Calexico, CA
²Hematology and Oncology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
³Hematología y Oncología, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Tlalpan, AG, MEX
⁴Medicina Interna, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Ciudad de México, DF, Mexico
⁵Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Ciudad de México, DF, Mexico
⁶Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Daniel Barnett, MD^1* and Danielle Nance, MD²

¹Banner University Medical Center, University of Arizona College of Medicine - Phoenix Campus, Farmington, UT
²Banner MD Anderson Cancer Center, Gilbert, AZ

Robert Klamroth, MD^1*, Robert F Sidonio Jr.^2*, Yesim Dargaud, MD, PhD³, Víctor Jiménez-Yuste, MD, PhD^4*, Rolf Ljung^5*, Guy Young, MD⁶ and Pratima Chowdary^7*

¹Internal Medicine, Vascular Medicine and Coagulation Disorders, Vivantes Clinic Friedrichshain, Berlin, Germany
²Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
³Lyon Hemophilia Center and Clinical Haemostasis Unit, Université Lyon, Lyon, France
⁴La Paz University Hospital Idi-Paz, Autónoma University, Madrid, Spain
⁵Department of Clinical Sciences, Lund University, Lund, Sweden
⁶Hemostasis and Thrombosis Center, Cancer and Blood Disorders Institute, Children’s Hospital Los Angeles, Keck School of Medicine, Los Angeles, CA
⁷Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free Hospital, London, United Kingdom

Ravindra Sarode, MD¹, Stephan Maack, PhD^2*, Cristina Solomon, MBA, MD², Sigurd Knaub^2*, Gita Pezeshki, PhD^3* and Sam Schulman, MD, PhD⁴

¹Division of Transfusion Medicine and Hemostasis, Departments of Pathology and Internal Medicine (Hematology/Oncology), The University of Texas Southwestern Medical Center, Dallas, TX
²Octapharma AG, Lachen, Switzerland
³Octapharma USA, Paramus, NJ
⁴Thrombosis and Atherosclerosis Research Institute and Department of Medicine, McMaster University, Hamilton, ON, Canada