65th ASH Annual Meeting & Exposition: 321. Coagulation and Fibrinolysis: Basic and Translational: Poster I

Symposia: Coagulation and Fibrinolysis: Basic and Translational Oral and Poster Abstracts
Poster

Halls G-H (San Diego Convention Center)

Transcriptomic Profiling to Understand Inhibitor Development in Previously Untreated Patients with Severe Hemophilia a

Paul Batty^1,2^*, David Watson³^*, Eva Wozniak¹^*, Charles Mein¹^* and Michael Barnes¹^*

¹Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
²Research Department of Haematology, Cancer Institute, Royal Free Hospital, University College London, London, United Kingdom
³Department of Informatics, King's College London, King's College London, London, United Kingdom

1229

Discovery of BT-114143, a Novel and Potent Small-Molecule Plasminogen Inhibitor for Hyperfibrinolysis

Jun Tang, PhD^1,2^*, Sen Ji, PhD²^*, Xiao Hu, MSc²^*, Yan Wang, MSc²^*, Jun Qi, MSc²^*, Xiao Wang, BSc²^*, Hao Wang, MSc²^*, Jianzong Li, PhD²^*, Zhiqiang Li, MSc²^*, Min Li, MSc²^*, Shaomei Zeng, MSc²^*, Xiong Yuan, MD PhD^1,2^* and Xiaodong Zhang, PhD^1,2^*

¹Chengdu Brilliant Pharmaceutical Co., Ltd., Chengdu, Sichuan, China
²ScinnoHub Pharmaceutical Co., Ltd., Chengdu, Sichuan, China

1230

Tranexamic Acid Reduces Large Traumatic Bleeding and Mortality in Murine Iron Deficiency Anemia By Mechanisms Beyond Control of Fibrinolysis

Bilgimol Chumappumkal Joseph, PhD¹, Tro Sekayan, MD¹, Nicca Falah, BS¹^* and Annette von Drygalski, MD, PharmD²

¹Department of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego, CA
²Department of Medicine, Division of Hematology/Oncology, University of California San Diego, SAN DIEGO, CA

1231

Pomab, a Novel Monoclonal Type-I Antiphospholipid Antibody, Reduces Thrombin Generation By Selectively Binding to the Open Form of Prothrombin

Suresh Kumar, PhD¹^*, Glenn Merrill-Skoloff²^*, Vittorio Pengo, MD³^*, Robert Flaumenhaft, MD, PhD⁴ and Nicola Pozzi, PhD⁵

¹Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO
²Beth Israel Deaconess Medical Center, Boston, MA
³University of Padova, Padova, PD, ITA
⁴Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA
⁵Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, Saint Louis, MO

1232

Effective Gene Therapy for Hemophilia a: Novel Re-Dosable Non-Viral Formulation That Provides Stable, and Durable FVIII Expression with Improved Tolerability

Brian Truong, PhD¹^*, Khal Hajj, PhD¹^*, Johannes Schwerk, PhD¹^*, Dongyang Zhang, PhD¹^*, Johnnatan Tamayo¹^*, Gizem Guzelsoy, PhD¹^*, Joseph Kubicki¹^*, Alicia Davis, PhD¹^*, Lijun Huang, PhD¹^*, Gopi Vemuri, PhD¹^*, Kevin Johnson¹^*, Dan Smith¹^*, Jordan Bendor¹^*, Mu Li¹^*, Manjunath Goolyam, PhD²^*, Daniel Abernathy, PhD³^*, Pranav Nyshadham¹^*, Fernando Espinoza¹^*, Michelle Burrascano¹^*, James Yen¹^*, Kevin Briseno¹^*, Min Tong¹^*, Jen Beck¹^*, Joseph Lucas¹^*, Pavan Battiprolu, PhD¹^*, Michael Bennett, PhD¹^*, Blair Madison, PhD¹^*, Brent Warner¹^*, Eric Ostertag, MD, PhD¹^* and Joshua Rychak, PhD¹^*

¹Poseida Therapeutics, San Diego, CA
²Rare Disease Drug Discovery, Takeda Therapeutics, Cambridge, MA
³Takeda Therapeutics, Cambridge, MA

1233

Thrombosis Caused By a Novel Coagulation Factor IX Mutation (FIX Shanghai II)

Wenman WU, MD¹^*, Rui Wang²^*, Qin Xu³^*, Guanzheng Wang⁴^*, Shifeng Jiang⁵^*, Can Lou²^*, Xi Wu²^*, Yanyan Shao, PhD⁶^*, Yeling Lu, MD, PhD⁷^*, Yu Liu²^*, Guanquan Xu²^*, Qiulan Ding⁸^*, Xiaobo Hu⁹^*, Xuefeng Wang²^* and Jing Dai, PhD⁶^*

¹Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, CHN
²Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
³State Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai, China
⁴Department of Laboratory Medicine, Ruijin Hospital, Shanghai, China
⁵State Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, Shanghai, China
⁶Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁷Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, CHN
⁸Hospital, Shanghai, CHN
⁹Shanghai Center for Clinical Laboratory, Shanghai, CHN

1234

Biophysical Characterization of the Thermodynamic Basis and Binding Orientation for Factor VIII Membrane Association

Nathan G Avery, BS^*, Kenneth C Childers, PhD^*, Selena Lu^*, Patrick Korus, BS^*, Justin McGlone, BS^*, Mady Jacobs^*, Tera Richardson^*, Juliet McGill^*, Kayla Croney, BS^*, Jordan Vaughan, MS^*, James McCarty, PhD^* and P. Clint Spiegel Jr., PhD

Chemistry Department, Western Washington University, Bellingham, WA

1235

Prediction of Venous Thromboembolism in Patients with Cancer Using Neural Network

Romy De Laat-Kremers¹^*, Scott Tagawa²^*, Madeline Young²^*, Christine Garcia²^*, Manish Shah³^*, Pashtoon Murtaza Kasi²^*, Jacob H Rand⁴, Bas De Laat⁵ and Maria T DeSancho, MD, MSc²

¹Department of Data Analysis and Artificial Intelligence, Synapse Research Institute, Maastricht, Netherlands
²Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
³Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York
⁴Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, United States, New York, NY
⁵Department of Functional Coagulation, Synapse Research Institute, Maastricht, Netherlands

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^*signifies non-member of ASH

321.P1.27 321. Coagulation and Fibrinolysis: Basic and Translational: Poster I