Armin Riecke^1,2*, Eugen Tausch, MD^3*, Deyan Y. Yosifov, PhD^4*, Christof Schneider, MD^5*, Sandra Robrecht, PhD^6*, Adam Giza^6*, Lothar Müller^7*, Ursula Vehling-Kaiser, MD^8*, Michael J. Eckart, MD^9*, Werner Freier^10*, Björn Schöttker^11*, Tobias Gaska, MD¹², Marcel Reiser^13*, Anna-Maria Fink, MD^6*, Barbara F. Eichhorst, MD¹⁴, Kirsten Fischer, MD^6*, Michael Hallek, MD^15*, Petra Langerbeins^6* and Stephan Stilgenbauer, MD³

¹Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, AL, Germany
²Internal Medicine, Division of Hematology, German Military Hospital Ulm, Ulm, Germany
³Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany
⁴Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Baden-Württemberg, Germany
⁵Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany
⁶Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany
⁷Study Centrum Unter Ems, Practice for Oncology and Hematology, Leer, Germany
⁸Outpatient Clinic, Landshut, Germany
⁹Onkologische Schwerpunktpraxis Erlangen, Erlangen, Germany
¹⁰Medicinum, Hildesheim, Germany
¹¹Hämatologisch-onkologische Schwerpunktpraxis Würzburg, Würzburg, Germany
¹²Brüderkrankenhaus St. Josef, Paderborn, Germany
¹³Praxis für internistische Onkologie und Hämatologie (PIOH), Frechen, Germany
¹⁴University of Cologne, Cologne, Germany
¹⁵Faculty of Medicine and Cologne University Hospital, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany, Cologne, Germany

Sarka Pavlova, PhD, MSc^1,2*, Jitka Malcikova^1,2*, Lenka Radova^1*, Silvia Bonfiglio^3,4*, Jack B. Cowland, PhD, MS^5*, Christian Brieghel, MD, PhD^6*, Mette Klarskov Andersen, MD, PhD^5*, Maria Karypidou^7*, Bella V Biderman, PhD^8*, Michael Doubek^1,2,9, Gregory Lazarian, PharmD^10,11*, Inmaculada Rapado, PhD^12*, Matthijs Vynck^13*, Naomi Porret, PhD¹⁴, Martin Andres^14*, Dina Rosenberg^15*, Dvora Sahar^15*, Carolina Martinez-Laperche^16*, Ismael Buño Borde^16,17,18*, Andrew Hindley^19*, Julio Bravo Sánchez^20*, José García-Marco^20*, Alicia Serrano, PhD^21*, Blanca Ferrer Lores, MD^21*, Concepción Fernández-Rodriguez, PhD^22*, Beatriz Bellosillo^23*, Stephan Stilgenbauer, MD²⁴, Eugen Tausch, MD^24*, Hero Nikdin^25*, Fiona Quinn^26*, Emer Atkinson^26*, Lisette Van De Corput^27*, Cafer Yildiz^27*, Cristina Bilbao, PhD^28*, Yanira Florido^28*, Christian Thiede^29*, Caroline Schuster^29*, Anastazja Stoj^30*, Sylwia Czekalska^30*, Anastasia Chatzidimitriou^7*, Stamatia Laidou^7*, Audrey Bidet, MD^31*, Charles Dussiau^31*, Friedel Nollet^13*, Giovanna Piras^32*, Tereza Borosova^1*, Terezia Kurucova^1,33*, Maria Monne^32*, Svetlana Smirnova^8*, Evgeny Nikitin, MD^34*, Ivan Sloma, PhD, PharmD^35,36*, Marie-Helene Delfau, MD PhD^36,37*, Laetitia Largeaud^38*, Loic Ysebaert^38*, Peter J. M. Valk, PhD³⁹, Amy Christian^40*, Renata Walewska, MD, PhD^40*, Marta Sebastião, MD^41*, Maria Gomes da Silva, MD^41*, Piero Galieni, MD^42*, Mario Angelini^42*, Davide Rossi⁴³, Valeria Spina^44*, Sónia Matos^45*, Vânia Martins^45*, David Donaldson^19*, Tomasz Stoklosa, MD, PhD⁴⁶, Monika Pepek^46*, Panagiotis Baliakas, MD^47*, Rafa Andreu^48*, Irene Luna^48*, Tiina Kahre^49,50*, Ülle Murumets^49*, Sophie Laird^51*, Daniel Ward^51*, Miguel Alcoceba, PhD^52*, Ana Balanzategui^52*, Lydia Scarfo, MD^3,53, Francesca Gandini^3*, Ettore Zapparoli^4*, Adoracion Blanco^54,55,56*, Pau Abrisqueta Costa, MD, PhD^55,56,57*, Ana E. Rodriguez, PhD^58*, Maria Rocio Benito Sanchez, PhD^59*, Frédéric Davi^60*, Clothilde Bravetti^60*, Paula Gameiro^41*, Joaquin Martinez-Lopez, MD, PhD^61*, Barbara Tazon, PhD^55,56,62*, Fanny Baran-Marszak^10,11*, Zadie Davies^40*, Mark Caterwood^19*, Andrey B Sudarikov, PhD, DSc^8*, Richard Rosenquist, MD²⁵, Carsten Utoft Niemann, MD, PhD^63*, Kostas Stamatopoulos⁶⁴, Paolo Ghia^3,53* and Sarka Pospisilova, Prof PhD^1,2,9*

¹Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
²Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
³B-Cell Neoplasia Unit, Division of Experimental Oncology, Università Vita-Salute San Raffaele, Milan, Italy
⁴Center for Omics Sciences, IRCCS Ospedale San Raffaele, Milan, Italy
⁵Department of Clinical Genetics, Centre of Diagnostic Investigations, Copenhagen University Hospital, Copenhagen, Denmark
⁶Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
⁷Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece
⁸National Medical Research Center for Hematology, Moscow, Russian Federation
⁹Institute of Medical Genetics and Genomics, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
¹⁰GHUPSSD Hôpital Avicenne AP-HP, Bobigny, France
¹¹INSERM U978 Université Sorbonne Paris Nord, Bobigny, France
¹²Department of Hematology, Hospital Universitario 12 de Octubre, Spanish National Cancer Research Center (CNIO), Complutense University Madrid, Madrid, Spain
¹³Department of Laboratory Medicine, AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium
¹⁴Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
¹⁵Hematology Laboratory, Rambam Medical Center, Haifa, Israel
¹⁶Department of Hematology, Gregorio Marañón General University Hospital, Gregorio Marañón Health Research Institute (IiSGM), Madrid, Spain
¹⁷Genomics Unit, Gregorio Marañón General University Hospital, Gregorio Marañón Health Research Institute (IiSGM), Madrid, Spain
¹⁸Department of Cell Biology, Medical School, Complutense University of Madrid, Madrid, Spain
¹⁹Haematology Department, Belfast City Hospital, Belfast, United Kingdom
²⁰Molecular Cytogenetics Unit, Hematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain
²¹Department of Hematology, Hospital Clínico Universitario-INCLIVA, Valencia, Spain
²²Laboratori de Biologia Molecular, Servei de Patologia, Hospital del Mar, IMIM, Barcelona, Spain
²³Pathology Department, Hospital del Mar, Barcelona, Spain
²⁴Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany
²⁵Karolinska Institutet, Stockholm, Sweden
²⁶Cancer Molecular Diagnostics Dept., Centre for Laboratory Medicine and Molecular Pathology, St. James Hospital, Dublin, Ireland
²⁷Central Diagnostic Laboratory (CDL), Unit HLA, University Medical Center Utrecht, Utrecht, Netherlands
²⁸Hospital Universitario de Gran Canaria Dr. Negrín, Servicio de Hematología. Departamento de Morfología de La Universidad de Las Palmas de Gran Canaria, Las Palmas De Gran Canaria, Spain
²⁹AgenDix GmbH, Dresden, Germany
³⁰University Hospital in Krakow, Krakow, Poland
³¹Laboratoire d’Hématologie Biologique, CHU Bordeaux, Bordeaux, France
³²Laboratorio specialistico UOC ematologia, Ospedale San Francesco, ASL Nuoro, Nuoro, Italy
³³Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
³⁴Moscow City Clinical Hospital named after S.P. Botkin, Moscow, Russian Federation
³⁵Univ Paris Est Creteil, INSERM, IMRB, Creteil, France
³⁶Departement d’Hematologie et Immunologie, AP-HP, Hopital Henri Mondor, Creteil, France
³⁷Hemato-biology, Henri Mondor University Hospital, Créteil, France
³⁸Laboratoire d'Hématologie, Institut Universitaire de Cancérologie de Toulouse, Toulouse, France
³⁹Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
⁴⁰Molecular Pathology, University Hospitals Dorset, Bournemouth, United Kingdom
⁴¹Laboratório Hemato-Oncologia, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
⁴²UOC Hematology, Mazzoni Hospital-Ascoli Piceno, Ascoli Piceno, Italy
⁴³Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
⁴⁴Laboratorio di Diagnostica Molecolare, Servizio di Genetica Medica EOLAB, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
⁴⁵Genomed - Diagnósticos de Medicina Molecular, iMM - Instituto de Medicina Molecular, Faculdade de Medicina, Lisbon, Portugal
⁴⁶Department of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland
⁴⁷Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
⁴⁸Hematology Department, Hospital Universitari i Politècnic la Fe, Valencia, Spain
⁴⁹Department of Laboratory Genetics, Genetics and Personalized Clinic, Tartu University Hospital, Tartu, Estonia
⁵⁰Department of Clinical Genetics, Institute of Clinical Medicine, Tartu University, Tartu, Estonia
⁵¹Wessex Genomics Laboratory Service, Salisbury NHS Foundation Trust, Salisbury, United Kingdom
⁵²Department of Hematology, University Hospital of Salamanca (HUS/IBSAL), CIBERONC and Cancer Research Center of Salamanca-IBMCC (USAL-CSIC), Salamanca, Spain
⁵³Strategic Research Program on CLL, IRCCS Ospedale San Raffaele, Milan, Italy
⁵⁴Department of Hematology, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain
⁵⁵Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
⁵⁶Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁵⁷Department of Hematology, Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁵⁸Institute of Biomedical Research of Salamanca (IBSAL), Cancer Research Centre (IBMCC, USAL-CSIC) and University of Salamanca, Salamanca, Spain
⁵⁹University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain
⁶⁰Department of Biological Hematology, Hopital Pitié-Salpêtrière & Sorbonne Université, Paris, France
⁶¹Department of Hematology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Complutense University, CNIO, CIBERONC, Madrid, Spain
⁶²Department of Hematology, Vall d'Hebron University Hospital, Barcelona, Spain
⁶³Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
⁶⁴Institute of Applied Biosciences, Centre for Research and Technology Hellas, Asvestohori, Greece

Andy Itsara, MD, PhD¹, Clare Sun, MD², Emily Bryer, DO³, Inhye E Ahn, MD⁴, Susan Soto, MSN^2*, Hao-Wei Wang, MD, PhD^5*, Constance M. Yuan, MD, PhD^5* and Adrian Wiestner, MD²

¹National Heart, Lung, and Blood Institute, National Institutes of Health, Huntsville, AL
²National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
³Pennsylvania Hospital, University of Pennsylvania, Philadelphia, PA
⁴Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁵Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD

Jennifer R. Brown, MD, PhD¹, Barbara F. Eichhorst, MD², Nicole Lamanna, MD³, Susan M. O'Brien⁴, Constantine S. Tam, MD, MBBS⁵, Luqui Qiu⁶, Maciej Kaźmierczak, MD^7*, Wojciech Jurczak, MD, PhD⁸, Keshu Zhou, MD^9*, Martin Simkovic, MD^10*, Jiri Mayer, MD¹¹, Amanda L. Gillespie-Twardy, MD¹², Alessandra Ferrajoli, MD¹³, Peter S. Ganly, PhD¹⁴, Robert Weinkove, MBBS, PhD, FRACP, FRCPA^15*, Sebastian Grosicki, MD, PhD^16*, Andrzej Mital^17*, Tadeusz Robak^18*, Anders Osterborg, MD, PhD^19*, Habte A. Yimer, MD²⁰, Megan (Der Yu) Wang^21*, Tommi Salmi, MD^22*, Liping Wang^23*, Jessica Li, MSc^21*, Kenneth Wu^21*, Aileen Cleary Cohen, MD, PhD²¹ and Mazyar Shadman, MD, MPH²⁴

¹Chronic Lymphocytic Leukemia Center, Division of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
²Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf German CLL Study Group University of Cologne, University Hospital Cologne, Cologne, Germany
³Herbert Irving Comprehensive Cancer Center, Columbia University, New York
⁴Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA
⁵Alfred Hospital and University of Melbourne, Melbourne, VIC, Australia
⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Hematological Disorders, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, CHN
⁷Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Krakow, Poland
⁸Dpt of Clinical Oncology, MSC National Research Institute of Oncology, Kraków, Poland
⁹Department of Hematology, Cancer Hospital Affiliated to Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
¹⁰4th Department of Internal Medicine – Haematology, Faculty of Medicine in Hradec Králové, University Hospital and Charles University in Prague, Hradec Kralove, Czech Republic
¹¹Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital, Brno, Czech Republic
¹²Blue Ridge Cancer Care, Roanoke, VA
¹³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁴Department of Haematology, Christchurch Hospital, Christchurch, New Zealand
¹⁵Te Rerenga Ora Wellington Blood & Cancer Centre, Te Whatu Ora Health New Zealand Capital, Coast & Hutt Valley, Wellington, New Zealand
¹⁶Department of Hematology and Cancer Prevention, Faculty of Health Sciences, Medical University of Silesia, Katowice, Poland
¹⁷Department of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland
¹⁸Medical University of Lodz, Lodz, Poland
¹⁹Oncology-Pathology, Karolinska Institute, Stockholm, Sweden
²⁰Texas Oncology-Tyler/US Oncology Research, Tyler, TX
²¹BeiGene USA, Inc, San Mateo, CA
²²BeiGene International GmbH, Basel, Switzerland
²³BeiGene (Beijing) Co, Ltd, Beijing, China
²⁴Fred Hutchinson Cancer Center, Seattle, WA

Moritz Furstenau, MD^1*, Adam Giza^2*, Anna-Maria Fink, MD^2*, Sandra Robrecht, PhD^2*, Jonathan Weiss^3*, Fanni Kleinert^3*, Christof Schneider, MD^4*, Eugen Tausch, MD^5*, Kirsten Fischer, MD^2*, Petra Langerbeins^6*, Othman Al-Sawaf, MD², Johannes Schetelig, MD, MSc⁷, Peter Dreger, MD⁸, Sebastian Böttcher^9*, Karl-Anton Kreuzer^10*, Matthias Ritgen^11*, Anke Schilhabel^12*, Monika Brüggemann, MD^13*, Stephan Stilgenbauer, MD⁵, Barbara F. Eichhorst, MD¹⁴, Michael Hallek, MD^15* and Paula Cramer, MD^2*

¹Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Koeln, Germany
²Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany
³Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Cologne, Germany
⁴Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany
⁵Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany
⁶Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf; Cologne, University of Cologne, Cologne, Germany
⁷Department of Internal Medicine 1, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁸Universitätsklinikum, Heidelberg, DEU
⁹Department of Medicine III Hematology, Oncology and Palliative Care, University Hospital, Rostock, Germany
¹⁰Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Cologne, DEU
¹¹Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany
¹²2nd Department of Internal Medicine, University of Schleswig-Holstein, Campus Ki, Kiel, DEU
¹³Clinic for Internal Medicine II - Haematology, Oncology, University Clinic Schleswig-Holstein, Kiel, Germany
¹⁴University of Cologne, Cologne, Germany
¹⁵Faculty of Medicine and Cologne University Hospital, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany, Cologne, Germany

Othman Al-Sawaf, MD¹, Rudy Ligtvoet, PhD^1*, Sandra Robrecht, PhD^1*, Janina Stumpf^1*, Anna Maria Fink, MD^1*, Eugen Tausch, MD^2*, Christof Schneider, MD^3*, Sebastian Böttcher^4*, Martin Mikusko^5*, Matthias Ritgen^6*, Johannes Schetelig, MD, MSc⁷, Julia Von Tresckow, MD^8*, Ursula Vehling-Kaiser, MD^9*, Clemens-Martin Wendtner, MD^10*, Kirsten Fischer, MD^1*, Karl Anton Kreuzer^11*, Stephan Stilgenbauer, MD¹², Philipp Bernhard Staber, MD, PhD¹³, Carsten Utoft Niemann, MD, PhD^14*, Michael Hallek, MD^15,16* and Barbara F. Eichhorst, MD¹⁷

¹Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany
²Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany
³Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany
⁴Department of Medicine III Hematology, Oncology and Palliative Care, University Hospital, Rostock, Germany
⁵University Hospital Magdeburg, Magdeburg, DEU
⁶Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany
⁷TU Dresden, Dresden, Saxony, Germany
⁸Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁹Outpatient Clinic, Landshut, Germany
¹⁰Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, German CLL Study Group, Munich Clinic Schwabing, Munich, Germany
¹¹Department I of Internal Medicine, University of Cologne, Cologne, Germany
¹²Department of Internal Medicine III, Division of CLL, University Hospital Ulm, Ulm, Germany
¹³Department of Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria
¹⁴Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
¹⁵CECAD, Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, Center for Molecular Medicine Cologne, Cologne, Germany, Cologne, Germany
¹⁶Center of Integrated Oncology Aachen Bonn Cologne Duesseldorf (ABCD), University Hospital Cologne, Cologne, Germany, Cologne, Germany
¹⁷University of Cologne, Cologne, Germany