-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

653.O1.6 653. Multiple Myeloma: Prospective Therapeutic Trials: Smoldering and Newly Diagnosed Myeloma

Symposia: Multiple Myeloma: Prospective Therapeutic Trials Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, clinical trials, Biological therapies, Antibody Therapy, adult, Bispecific Antibody Therapy, elderly, Clinical Research, Plasma Cell Disorders, Diseases, Therapies, Immunotherapy, Lymphoid Malignancies, Adverse Events, Monoclonal Antibody Therapy, Study Population, Human, Minimal Residual Disease
Saturday, December 9, 2023: 2:00 PM-3:30 PM
Harbor Ballroom (Manchester Grand Hyatt San Diego)
Moderators:
Muthalagu Ramanathan, MD, UMass Memorial Medical Center University Campus and Fredrik Schjesvold, MD, PhD, OSLO Univeristy Hospital
Disclosures:
Schjesvold: Abbvie: Consultancy, Other: Honoraria for lectures and educational material; GlaxoSmithKline: Consultancy, Honoraria, Research Funding; Celgene: Consultancy, Other: Honoraria for lectures and educational material, Research Funding; Takeda: Consultancy, Other: Honoraria for lectures and educational material; Janssen-Cilag: Consultancy, Other: Honoraria for lectures and educational material, Research Funding; Oncopeptides: Consultancy, Other: Honoraria for lectures and educational material, Research Funding; Sanofi: Consultancy, Other: Honoraria for lectures and educational material, Research Funding; Bristol Myers Squibb: Consultancy, Other: Honoraria for lectures and educational material; Targovax: Research Funding; Amgen: Other: Honoraria for lectures and educational material; Novartis: Other: Honoraria for lectures and educational material; Pfizer: Other: Honoraria for lectures and educational material; Skylite DX: Other: Honoraria for lectures and educational material; Daiichi Sankyo: Other: Honoraria for lectures and educational material; Schain: Other: Honoraria for lectures and educational material.
Prospective therapeutic trials in smoldering myeloma, newly diagnosed myeloma and maintenance therapy.
2:00 PM

Sara Bringhen, MD, PhD1, Elisabetta Antonioli, MD2*, Barbara Gamberi, MD3*, Benedetto Bruno, MD, PhD4,5, Daniele Derudas6*, Patrizia Tosi, MD7*, Francesca Fazio, MD, PhD8*, Rita Mazza, MD9*, Sonia Ronconi, MD10*, Paolo Corradini, MD11, Flavia Lotti, MD12*, Claudia Cellini, MD, PhD13*, Antonietta Pia Falcone, MD, PhD14*, Piero Galieni, MD15*, Roberto Ria, MD16*, Angelo Belotti, MD17*, Donato Mannina, MD18*, Anna Maria Cafro, MD19*, Clotilde Cangialosi, MD20*, Iolanda Donatella Vincelli, MD21*, Alessandra Lombardo, MD22*, Alessandra Larocca, MD, PhD1,5, Mario Boccadoro, MD23 and Mattia D'Agostino, MD4,5*

1SSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Department of Oncology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy
2Hematology Unit, AOU Careggi, Florence, Italy
3Azienda USL - IRCCS di Reggio Emilia, Reggio Emilia, Italy
4Division of Hematology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy
5Division of Hematology, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy
6SC di Ematologia e CTMO, Ospedale Oncologico di Riferimento Regionale "A. Businco", ARNAS "G. Brotzu", Cagliari, Italy
7UO Ematologia, Ospedale di Rimini, Rimini, Italy
8Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
9Department of Oncology and Hematology, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Italy
10IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy
11University of Milan. Hematology Division, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
12Sezione di Ematologia e Immunologia Clinica, Ospedale Santa Maria della Misericordia, località Sant’Andrea delle Fratte, Perugia, Italy
13AUSL Romagna, U.O.C. Ematologia, Ospedale Santa Maria delle Croci, Ravenna, Italy
14Hematology, IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy
15UOC Ematologia e Terapia cellulare, Ospedale C. e G. Mazzoni, Ascoli Piceno, Italy
16Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro Medical School, Bari, Italy
17Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
18Oncology-Hematology Department, Papardo Hospital, Messina, Italy
19SC Ematologia, ASST GOM Niguarda, Milano, Italy
20U.O.C. Ematologia, A.O. Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
21Hematology Unit, Department of Hemato-Oncology and Radiotherapy, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", Reggio Calabria, Italy
22S.C. di Oncoematologia, A.O. Santa Maria di Terni, Terni, Italy
23European Myeloma Network, EMN, Italy

2:15 PM

Omar Nadeem, MD1, Sophie Magidson, BS1*, Shonali Midha, MD, BS1*, Elizabeth K. O'Donnell, MD1, Monique A Hartley-Brown, MD2, Adam S. Sperling, MD, PhD1, Robert A. Redd, MS3*, Marjorie Marto1*, Christine Davie1*, Caroline Ricciardi1*, Dechen Choden1*, Ashlee Strutevant1*, Jillian Alberti1*, Clifton C. Mo, MD1, Jacob Laubach4, Paul G. Richardson, MD1, Kenneth C. Anderson, MD5, Nikhil C Munshi, MD1*, Lorenzo Trippa1* and Irene M. Ghobrial, MD1

1Dana-Farber Cancer Institute, Boston, MA
2DFCI, Boston, MA
3Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
4Dana-Farber/Partners CancerCare, Harvard Medical School, Boston, MA
5Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

2:30 PM

Cyrille Touzeau, MD, PhD1*, Aurore Perrot, MD, PhD2*, Cyrille Hulin, MD3*, Salomon Manier, MD, PhD4, Margaret Macro, MD5*, Marie-Lorraine Chretien, MD6*, Lionel Karlin7*, Olivier Decaux, MD, PhD8*, Caroline Jacquet, MD9*, Mourad Tiab, MD10*, Xavier Leleu, MD11, Jill Corre, PharmD, PhD12*, Alexandra Jobert13*, Lucie Planche14*, Herve Avet-Loiseau, MD, PhD15* and Philippe Moreau, MD, PhD16*

1Centre Hospitalier Universitaire de Nantes, Nantes, France
2Toulouse, and CRCT, Toulouse, France, Toulouse, France
3Centre Hospitalier Universitaire de Bordeaux, Pessac Cedex, FRA
4Centre Hospitalier Universitaire - Hôpital Huriez, Lille, France
5Hopital Cote De Nacre, Caen, France
6CHU Dijon, DIJON, FRA
7CH Lyon Sud, Pierre Benite Cedex, FRA
8Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou, Rennes, France
9CHU de Nancy, Vandoeuvre Les Nancy, FRA
10Centre Hospitalier Departemental, La Roche Sur Yon Cedex 9, FRA
11Service D'Hématologie Et Thérapie Cellulaire, Poitiers, France
12Institut universitaire du cancer de Toulouse Oncopole,, Toulouse, France
13Centre Hospitalier Universitaire, Nantes, France
14Chu Nantes, Nantes, FRA
15Institut universitaire du cancer de Toulouse Oncopole, Toulouse, France
16Hematology Clinic, University Hospital Hotel-Dieu, Nantes, France

2:45 PM

Niels W.C.J. van de Donk, MD, PhD1, Cyrille Touzeau, MD, PhD2*, Evangelos Terpos, MD, PhD3, Aurore Perrot, MD, PhD4*, Roberto Mina, MD5,6*, Maaike de Ruijter, MANP, MSc7*, Elisabetta Antonioli, MD8*, Eirini Katodritou, MD9*, Norbert Pescosta, MD10*, Paulus A.F. Geerts, MD, PhD11*, Cécile Sonntag, MD12*, Ruth Wester, MD13*, Angelo Belotti, MD14*, Silvia Mangiacavalli, MD15*, Massimo Offidani, MD16*, Mattia D'Agostino, MD5,6*, Mark van Duin, PhD13*, Michele Cavo, MD17*, Sara Aquino, MD, PhD18*, Alessandra Lombardo, MD19*, Mark-David Levin, MD, PhD20, Cyrille Hulin, MD21*, Mario Boccadoro, MD22, Pieter Sonneveld, MD, PhD13* and Francesca Gay, MD, PhD5,6

1Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, Amsterdam, Netherlands
2Department of Hematology, University Hospital Hôtel-Dieu, Nantes, France
3Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
4Service d’Hématologie, CHU de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Université de Toulouse, Toulouse, France
5Division of Hematology, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy
6Division of Hematology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy
7Amsterdam UMC, VUmc, Department of Hematology, Amsterdam, Netherlands
8Hematology Unit, AOU Careggi, Florence, Italy
9Theagenion Cancer Hospital, Thessaloniki, Greece
10Reparto Ematologia e TMNO, Ospedale Provinciale Bolzano, Bolzano, Italy
11Isala Klinieken, Zwolle, Netherlands
12University Hospital, Hôpital Hautepierre, Strasbourg, France
13Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
14Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
15Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
16AOU delle Marche, Ancona, Italy
17IRCCS Azienda Ospedaliero-Universitaria di Bologna, Seràgnoli Institute of Hematology and the Department of Medical and Surgical Sciences, Bologna University School of Medicine, Bologna, Italy
18Ematologia e Terapie cellulari, IRCCS Ospedale Policlinico San Martino, Genova, Italy
19A.O. Santa Maria di Terni – Università degli Studi di Perugia, Terni–Perugia, Italy
20Albert Schweitzer hospital, Dordrecht, Netherlands
21Centre Hospitalier Universitaire Bordeaux, Bordeaux, France
22European Myeloma Network, EMN, Italy

3:00 PM

Maria-Victoria Mateos1,2, Bruno Paiva3*, Maria Teresa Cedena Romero, MD, PhD4*, Noemi Puig, MD, PhD5, Anna Maria Sureda Balari, MD, PhD6, Albert Oriol7*, Enrique M Ocio, MD, PhD8, Laura Rosiñol, MD, PhD9*, Yolanda González-Montes, MD10*, Juan Jose Bargay, MD11*, Esther Gonzalez Garcia, MD12*, Miguel Teodoro Hernández Garcia, MD, PhD13*, Angel Ramirez, MD14*, Alexia Suarez-Cabrera, MD, PhD15*, María-Jesús Blanchard16*, Sebastián Garzón, MD17*, Luis Felipe Casado Montero, MD18, Valentin Cabanas Perianes, MD19*, Jaime Pérez De Oteyza, MD, PhD20*, Mercedes Gironella21*, Joaquin Martinez-Lopez, MD, PhD22*, Ana-Isabel -Teruel, MD, PhD23*, Pilar Delgado, MD, PhD24*, Elena Prieto, MD, PhD25*, Juan Jose Lahuerta Palacios4*, Joan Bladé, MD, PhD26* and Jesus San Miguel3*

1Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBASL), Centro de Investigación del Cáncer (IBMCC-USAL,CSIC), Salamanca, Spain
2University Hospital of Salamanca/IBSAL/CIC/CIBERONC, Salamanca, Spain
3Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain
4Hospital Universitario 12 de Octubre, CIBER-ONC CB16/12/00369, CNIO, Madrid, Spain
5Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC), CIBERONC, Salamanca, Spain
6Clinical Hematology, Instituto Catalán de Oncología, L'Hospitalet De Llobregat, IDIBELL, Universitat de Barcelona, Barcelona, Spain
7Catalan Institute of Oncology and Josep Carreras Institute, Hospital Germans Trias i Pujol, Badalona, Spain
8Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain
9Hematopoietic Cell Transplantation Unit,, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain
10Institut d'Oncologia Dr. Josep Trueta, Girona, Spain
11Hematology, Hospital Universitario Son LLatzer, IdIsBa, Palma de Mallorca, Spain
12University Hospital Cabueñes, Gijón, Spain
13Hospital Universitario de Canarias, Tenerife, Spain
14Hematology, Hospital Central de Asturias, Oviedo, Spain
15Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas De Gran Canaria, Spain
16Hematology, Hospital Universitario Ramon y Cajal, Madrid, Spain
17Hematology, Hospital Universitario De Jerez, Jerez De La Frontera, Spain
18Hospital General Universitario de Toledo, Toledo, Spain
19Department of Hematology, IMIB-Virgen de la Arrixaca University Hospital. University of Murcia., Murcia, Spain
20Hematology, Hospital Universitario HM Sanchinarro, Madrid, Spain
21Hospital Universitari Vall d'Hebron, Barcelona, Spain
22Hospital Universitario 12 de Octubre, I+12, CNIO, Complutense University, CIBERONC, Madrid, Spain
23Hematology, Hospital Clínico Universitario de Valencia, Valencia, Spain
24Hematology, Hospital Universitario Miguel Servet, Zaragoza, Spain
25Hematology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
26Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and GEM/PETHEMA, Barcelona, Spain

3:15 PM

Ola Landgren, MD1, Ajai Chari, MD2*, Yael C. Cohen3*, Andrew Spencer, MBBS, MD, FRACP, FRCPA4*, Peter M. Voorhees, MD5, Irwindeep Sandhu6*, Matthew W. Jenner7*, Dean Smith8*, Michele Cavo, MD9*, Niels W.C.J van de Donk, MD, PhD10*, Meral Beksac, MD11, Philippe Moreau, MD, PhD12*, Hartmut Goldschmidt13, Linlin Sha, PhD14*, Liang Li14*, Els Rousseau15*, Robyn Dennis16*, Robin Carson, MD, BA17 and Craig C. Hofmeister, MD18

1Sylvester Comprehensive Cancer Center, Myeloma Division, University of Miami, Miami, FL
2Icahn School of Medicine at Mount Sinai, New York, NY
3Department of Hematology, Tel-Aviv Sourasky (Ichilov) Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
4Malignant Haematology and Stem Cell Transplantation Service, Alfred Health-Monash University, Melbourne, VIC, Australia
5Levine Cancer Institute, Atrium Health Wake Forest University School of Medicine, Charlotte, NC
6Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada
7University Hospital Southampton, Southampton, United Kingdom
8Department of Clinical Haematology, Nottingham University Hospitals, Nottinghamshire, United Kingdom
9IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna, Italy
10Department of Hematology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
11Ankara University, Ankara, Turkey
12Hematology Department, University Hospital Hôtel-Dieu, Nantes, France
13GMMG-Study Group at University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany
14Janssen Research & Development, LLC, Shanghai, China
15Janssen Research & Development, Beerse, Belgium
16Janssen Research & Development, LLC, Raritan, NJ
17Janssen Research & Development, LLC, Spring House, PA
18Department of Hematology & Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA

*signifies non-member of ASH