-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

627.O1.6 627. Aggressive Lymphomas: Clinical and Epidemiological: Aiming for the Right Target: Using CAR-T and Bispecifics in Aggressive Lymphomas Clinically Relevant Abstract

Symposia: Aggressive Lymphomas: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, clinical trials, Biological therapies, Antibody Therapy, epidemiology, Lymphomas, non-Hodgkin lymphoma, Bispecific Antibody Therapy, Clinical Research, B Cell lymphoma, Chimeric Antigen Receptor (CAR)-T Cell Therapies, patient-reported outcomes, Diseases, real-world evidence, aggressive lymphoma, Therapies, Immunotherapy, registries, Lymphoid Malignancies, Transplantation
Sunday, December 10, 2023: 4:30 PM-6:00 PM
Ballroom 20AB (San Diego Convention Center)
Moderators:
Pere Barba, MD, Hospital Universitari Vall D'Hebron and Nina Wagner-Johnston, MD, Johns Hopkins Hospital
Disclosures:
Barba: Incyte: Consultancy, Membership on an entity's Board of Directors or advisory committees; Kite/Gilead: Consultancy, Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees; Pierre-Fabre: Consultancy, Membership on an entity's Board of Directors or advisory committees; Miltenyi Biotech: Consultancy, Membership on an entity's Board of Directors or advisory committees; Nektar: Consultancy, Membership on an entity's Board of Directors or advisory committees; BMS: Consultancy, Membership on an entity's Board of Directors or advisory committees; Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees; Jazz Pharmaceutical: Consultancy, Membership on an entity's Board of Directors or advisory committees; Allogene: Consultancy, Membership on an entity's Board of Directors or advisory committees.
The abstracts in this session will review data regarding the use of CAR-T cell therapy and various bispecific antibodies for the treatment of Aggressive Lymphomas, including Large B Cell Lymphomas, Waldenström Macroglobulinemia, and Richter Transformation.
4:30 PM

Elizabeth Lihua Elizabeth Budde, MD, PhD1, Adam J Olszewski, MD2, Sarit Assouline, MD3, Izidore S. Lossos, MD4, Catherine Diefenbach, MD5*, Manali Kamdar, MD6*, Nilanjan Ghosh, MD, PhD7, Dipenkumar Modi, MD8, Waleed Sabry, MSc, MD, PhD9*, Seema Naik, MD10*, Amitkumar Mehta, MD11*, Shazia K. Nakhoda, MD12*, Stephen D Smith, MD13, Kathleen Dorritie, MD14, Ting Jia, MD15*, Song Pham, MSc16*, Ling-Yuh Huw, PhD17*, Hao Wu, PhD17*, Iris To, PharmD17*, Michael C. Wei, MD, PhD17 and Julio C. Chavez, MD18*

1City of Hope National Medical Center, Duarte, CA
2Legorreta Cancer Center at Brown University, Lifespan Cancer Institute, Providence, RI
3Jewish General Hospital, McGill University, Montreal, QC, Canada
4University of Miami/Sylvester Comprehensive Cancer Center, Miami, FL
5Perlmutter Cancer Center at NYU Langone Health, New York, NY
6University of Colorado, Aurora, CO
7Levine Cancer Institute/Atrium Health, Charlotte, NC
8Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI
9Saskatoon Cancer Centre, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
10Penn State Cancer Institute, Hershey, PA
11University of Alabama at Birmingham, Birmingham, AL
12Fox Chase Cancer Center, Philadelphia, PA
13Fred Hutchinson Cancer Center, University of Washington, Seattle, WA
14UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA
15Roche (China) Holding Ltd., Shanghai, China
16F. Hoffmann-La Roche Ltd., Basel, Switzerland
17Genentech, Inc., South San Francisco, CA
18Moffitt Cancer Center, Tampa, FL

4:45 PM

Chan Y. Cheah, MBBS1,2, Sarit Assouline, MD3, Ross Baker, MBBS4*, Nancy L. Bartlett, MD5, Dima El-Sharkawi, MBBS, FRCPath, PhD6*, Pratyush Giri, MBBS7*, Matthew Ku, MBBS8*, Stephen J. Schuster, MD9, Matthew Matasar, MD, MS10, John Radford, MD11*, Michael C. Wei, MD, PhD12*, Shen Yin, PhD12*, Iris To, PharmD12*, Jiangeng Huang, PhD12*, Antonia Kwan, MBBS, PhD12* and Elizabeth Lihua Elizabeth Budde, MD, PhD13

1The University of Western Australia, Perth, Australia
2Linear Clinical Research, Sir Charles Gairdner Hospital, Nedlands, Australia
3Jewish General Hospital, Montreal, QC, Canada
4Perth Blood Institute, Murdoch University, Perth, Australia
5Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO
6The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
7Royal Adelaide Hospital, Adelaide, Australia
8St Vincent's Hospital, University of Melbourne, Melbourne, Australia
9Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
10Rutgers Cancer Institute of New Jersey, New Brunswick, NJ
11Christie NHS Foundation Trust, Manchester, United Kingdom
12Genentech, Inc., South San Francisco, CA
13City of Hope National Medical Center, Duarte, CA

5:00 PM

Trent Wang, DO, MPH1, Kwang Wooahn, PhD2*, Manmeet Kaur3*, Mazyar Shadman, MD, MPH4, Alex F. Herrera, MD5, Craig S Sauter, MD6, Mehdi Hamadani, MD7 and Antonio M. Jimenez Jimenez, MD, MSc8*

1University of Miami Miller School of Medicine/ Sylvester Comprehensive Cancer Center, Miami Springs, FL
2Medical College of Wisconsin, milwaukee, WI
3Medical College of Wisconsin, Milwaukee, WI
4Fred Hutchinson Cancer Center, Seattle, WA
5City of Hope, Duarte, CA
6Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
7Division of Hematology and Oncology, The Medical College of Wisconsin Inc, Milwaukee, WI
8Sylvester Comprehensive Cancer Center, Miller School of Medicine, Miami, FL

5:15 PM

Eric Durot1*, Damien Roos-Weil2*, Adrien Chauchet3*, Justine Decroocq, MD4*, Roberta Di Blasi, MD, PhD5*, Thomas Gastinne, MD6*, Hedi Bensader7*, Morgane Cheminant8*, Caroline Jacquet, MD9*, Stephanie Guidez10*, François-Xavier Gros11*, Emmanuel Bachy, MD, PhD12*, Pascale Cony-Makhoul, MD13*, Steven P. Treon, MD, PhD, FRCP14, Alain Jacques Delmer, MD15*, Ran Reshef, MD, MSc16, Steven Le Gouill, MD, PhD17, Jorge J. Castillo, MD18 and Roch Houot, MD, PhD19*

1CHU Reims, Reims Cedex, France
2Hôpital Pitié-Salpétrière, Paris, FRA
3Besançon University Hospital, Besançon, France
4Clinical Hematology Department, Hopital Cochin, APHP, Paris, France, Paris, France
5Department of Hematology, Assistance Publique Hôpitaux de Paris - Hôpital Saint-Louis, University of Paris, PARIS, France
6Hématologie, Hôpital Hôtel Dieu, Nantes Cedex 1, France
7CHU de Clermont-Ferrand, Clermont-Ferrand, France
8Department of Hematology, Necker Hospital, APHP, Paris, France
9CHU de Nancy, Vandoeuvre Les Nancy, FRA
10CHU de Poitiers, Poitiers, FRA
11Hôpital Du Haut-Lévèque, CHU de Bordeaux, Pessac, FRA
12Hematology Department, Lyon Sud Hospital, Pierre-Bénite, France
13Department of Hematology, Annecy-Genevois Hospital Centre, Pringy, France
14Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, MA
15Hôpital Robert Debré CHU de Reims, Reims Cedex, -, FRA
16Columbia University Medical Center, New York, NY
17Hematology Department, Institut Curie, Paris, France
18Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA
19Centre Hospitalier Universitaire Rennes, Université de Rennes, Rennes Cedex, FRA

5:30 PM

Peter A Riedell, MD1, Connor Grady, MPH2*, Loretta J. Nastoupil, MD3, Alejandro Luna, MD, PhD4,5*, Nausheen Ahmed, MD6, Richard T Maziarz, MD7, Marie Hu, MD8, Jamie Brower, MS9*, Wei-Ting Hwang, PhD10*, Stephen J Schuster, MD11, Andy Chen, MD, PhD7, Olalekan O. Oluwole, MBBS12, Veronika Bachanova, MD, PhD8, Joseph P McGuirk, DO6, Miguel-Angel Perales, MD13,14, Michael R. Bishop, MD1 and David L. Porter, MD9

1David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago, IL
2Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
3MD Anderson Cancer Center, Houston, TX
4Memorial Sloan Kettering Cancer Center, New York, NY
5Hospital Universitario Ramon y Cajal, Department of Adult Bone Marrow Transplantation, Madrid, Spain
6Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Medical Center, Westwood, KS
7Knight Cancer Institute, Oregon Health & Science University, Portland, OR
8Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
9Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
10Department of Biostatistics, Epidemiology, and Informatics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
11Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
12Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN
13Department of Medicine, Weill Cornell Medical College, New York
14Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

5:45 PM

Emil Ramsø Kyvsgaard1,2,3*, Michael Roost Clausen, MD, PhD4*, Anna Caroline Hasselbalch Riley, MD1,2*, Carsten Utoft Niemann, MD, PhD1,5*, Kirsten Grønbæk, MD, DMSc1,3,5, Martin Hutchings, MD PhD1,2* and Simon Husby, MD, PhD1,2,3*

1Department of Hematology, Rigshospitalet, Copenhagen, Denmark
2Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark
3Grønbæk Group, Biotech Research and Innovation Centre, BRIC, University of Copenhagen, Copenhagen, Denmark
4Department of Hematology, Vejle Hospital, Vejle, Denmark
5Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

*signifies non-member of ASH