Steffen Koschmieder^1,2,3, Susanne Isfort^1,2,3*, Lino L. Teichmann^4,5*, Philippe Schafhausen^6*, Florian Heidel^7,8, Andreas Hochhaus, MD⁹, Martin Griesshammer^10,11, Katja Sockel, MD^12*, Philipp Jost^13,14*, Denise Wolleschak^15*, Konstanze Döhner¹⁶, Joachim R. Goethert, MD¹⁷, Markus P. Radsak^18*, Marinela Augustin^19*, Heiko Becker, MD^20*, Aristoteles Giagounidis²¹, Markus Schaich^22*, Martine Klausmann^23*, Nikolas Von Bubnoff^24*, Frank Stegelmann^16*, Maike Kortmann^3,25*, Julia Frank^26,27*, Martin Hellmich^26,27* and Tim H. Brümmendorf^1,3

¹Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, NRW, Germany
²Shared first authorship, Aachen, Germany
³Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany
⁴Department of Medicine III, University Hospital Bonn, Bonn, Germany
⁵Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Bonn, Germany
⁶University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁷Internal Medicine C, University Medicine Greifswald, Greifswald, Germany
⁸Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany
⁹Universitätsklinikum Jena, Jena, Germany
¹⁰University of Bochum, Bochum, Germany
¹¹University Clinic for Hematology, Oncology, Hemostasis and Palliative Care, Johannes Wesling Medical Center, University of Bochum, Minden, Germany
¹²Medical Clinic and Policlinic I, University Hospital Dresden, TU Dresden, Dresden, Germany
¹³Division of Clinical Oncology, Internal Medicine, Medical University of Graz, Graz, Austria
¹⁴Medical Department III, Hematology and Oncology, and Center for Translational Cancer Research, Translatum, Technical University of Munich, Munich, DEU
¹⁵Department of Hematology/Oncology, Otto-von-Guericke University Medical Center Magdeburg, Magdeburg, DEU
¹⁶Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
¹⁷Department of Hematology and Stem Cell Transplantation, West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany
¹⁸Department of Hematology and Medical Oncology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
¹⁹Klinikum Nürnberg Nord, Schwerpunkt Onkologie/Hämatologie, Klinik für Innere Medizin 5, Universitätsklinik Der Paracelsus Medizinischen Privatuniversität, Nürnberg, Germany
²⁰Department of Hematology, Oncology and Stem Cell Transplantation, Universitätsklinikum Freiburg, Freiburg, Germany
²¹Dept. Oncology, Hematology and Palliative Care, Marienhospital Düsseldorf, Düsseldorf, Germany
²²Department of Hematology, Oncology and Palliative Medicine, Rems-Murr Klinikum, Winnenden, Germany
²³Gemeinschaftspraxis Aschaffenburg, Aschaffenburg, Germany
²⁴Department of Hematology and Oncology, University of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
²⁵Center for Translational & Clinical Research (CTC-A), Faculty of Medicine, RWTH Aachen University, Aachen, Germany
²⁶Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
²⁷Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Cologne, Germany

Naveen Pemmaraju, MD¹, Adam J Mead, MRCP, FRCPath, PhD^2,3, Tim CP Somervaille, PhD FRCP FRCPath⁴, James K McCloskey, MD⁵, Francesca Palandri, MD^6*, Steffen Koschmieder^7,8, David Lavie^9*, Brian Leber, MD¹⁰, Su-Peng Yeh, MD^11*, Maria Teresa Gómez-Casares, MD, PhD^12*, Emanuele Ammatuna, MD, PhD^13*, Ho-Jin Shin, MD^14*, Keita Kirito, MD¹⁵, Eric Jourdan, MD, PhD^16*, Timothy Devos, MD^17,18*, Hun S Chuah^19*, Atanas Radinoff^20*, Andrija Bogdanovic, Professor^21,22*, Rastislav Moskal, PharmD^23*, Qi Jiang^23*, Avijeet S Chopra^23*, Elektra Papadopoulos^23*, Jalaja Potluri²⁴ and Francesco Passamonti, MD^25*

¹Department of Leukemia, MD Anderson Cancer Center, Houston, TX
²Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR, Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
³Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁴Cancer Research UK Manchester Institute, The University of Manchester and The Christie NHS Foundation Trust, Manchester, United Kingdom
⁵Department of Leukemia, John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ
⁶Istituto di Ematologia "Seràgnoli", IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
⁷Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany
⁸Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany
⁹Hadassah Medical Center, Jerusalem, Israel
¹⁰Division of Hematology, Juravinski Cancer Center, Hamilton, ON, Canada
¹¹Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
¹²Hospital Universitario de Gran Canaria Dr. Negrín. Universidad de Las Palmas de Gran Canaria., Las Palmas de Gran Canaria, Spain
¹³Department of Hematology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
¹⁴Department of Hematology-Oncology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea, Republic of (South)
¹⁵Department of Hematology and Oncology, University of Yamanashi, Chuo, Japan
¹⁶Hematologie Clinique, CHU de Nimes, Nimes, France
¹⁷Department of Hematology, University Hospitals Leuven, Leuven, Belgium
¹⁸Department of Microbiology and Immunology, Laboratory of Molecular Immunology (Rega Institute), KU Leuven, Leuven, Belgium
¹⁹Department of Haematology, Royal Perth Hospital, Perth, Australia
²⁰Clinic of Haematology, St.Ivan Rilski University Multidisciplinary Hospital, ., Bulgaria
²¹Faculty of Medicine, University of Belgrade, Belgrade, Serbia
²²Clinic of Hematology, University Clinical Center Serbia, Belgrade, Serbia
²³AbbVie Inc., North Chicago, IL
²⁴AbbVie Inc, North Chicago, IL
²⁵Dipartimento di Oncologia ed Ematologia, Università degli Studi di Milano, Policlinico di Milano, Ospedale Maggiore, Fondazione I.R.C.C.S. Ca Granda, Milano, Italy

Harinder Gill, MD, MBBS, FRCP, FRCPath¹, Lester Au^1*, Garret Man Kit Leung^1*, Dorothy Tsai^1*, Rita Yim, PhD^1*, Lynn Chin^1*, Vivian Li^1*, Paul Lee^1*, Rock Yuk Yan Leung^2*, Elaine Lee, MD^3*, Hugh Young Rienhoff Jr., MD⁴ and Yok Lam Kwong, MD^1*

¹Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
²Department of Pathology, The University of Hong Kong, Hong Kong, Hong Kong
³Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong
⁴Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., Rahway, NJ

Srinivas K. Tantravahi, MBBS¹, Ashwin Kishtagari, MBBS², Keri Maher, DO³, Sanjay Mohan, MD, MSCI⁴, Josef T. Prchal, MD⁵, Xulong Wang^6*, Kamal Chamoun^6*, Christopher J Walker, PhD^6*, Pietro Taverna, PhD⁷ and Haris Ali, MD⁸

¹Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, The University of Utah, Salt Lake Cty, UT
²Division of Hematology & Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Franklin, TN
³Massey Cancer Center, Virginia Commonwealth University, Richmond, VA
⁴Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN
⁵Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁶Karyopharm Therapeutics, Newton, MA
⁷Karyopharm Therapeutics Inc., Newton, MA
⁸Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA

David Lavie^1*, Vincent Ribrag, MD², Michael Loschi, MD, PhD^3*, Costas K. Yannakou, MBBS (Hons), FRACP, FRCPA, PhD^4*, Maan Alwan^5*, Adi Schacham Abulafia^6*, Jesús María Hernández-Rivas, PhD⁷, Yulia Volchek^8*, Chun Yew Fong^9*, Massimiliano Bonifacio, MD^10*, Jean-Jacques Kiladjian, MD, PhD¹¹, Jean-Christophe Ianotto, MD, PhD^12*, Valentín García Gutiérrez, PhD¹³, Alessandra Tucci, MD¹⁴, Blanca Xicoy, MD^15*, Haifa Kathrin Al-Ali, MD/Prof^16*, Moshe Talpaz, MD¹⁷, Jonathan M. Gerber, MD¹⁸, Indu Raman^4*, Ciprian Tomuleasa^19*, Si Tuen Lee-Hoeflich^20*, Sharmila Das^21*, Bin Wu^20*, Qian Zhao^22*, Eunhee Kim^23*, Oriana Esposito^24*, Yu Liu^20*, Zariana Nikolova^24*, Christopher Tehlirian^20*, Shodeinde Coker^22* and Rosa Ayala, MD^25*

¹Hadassah Medical Center, Jerusalem, Israel
²Département d'Innovation Thérapeutique et d'Essais Précoces (DITEP), Gustave Roussy Institute of Cancer,, Villejuif, France
³Centre Hospitalier Universitaire de Nice, Nice, France
⁴Epworth HealthCare, Melbourne, VIC, Australia
⁵Perth Blood Institute, West Perth, Western Australia, Australia
⁶Davidoff Cancer Center, Institute of Hematology, Petach Tikva, Israel
⁷Department of Medicine, Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain
⁸Department of Hematology, Assaf Harofeh Medical Center, Tzrifin, Israel
⁹Department of Hematology, Austin Health, Heidelberg, VIC, Australia
¹⁰Department of Medicine, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy
¹¹Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, INSERM, Centre d'Investigations Cliniques (CIC 1427), Paris, France
¹²Centre Hospitalier Universitaire de Brest,, Brest, France
¹³Hospital Universitario Ramon y Cajal, Alcala University, Translational Hematology Group, IRYCIS, Madrid, Spain
¹⁴Hematology, ASST Spedali Civili, Brescia, Italy
¹⁵Hematology Service, Hospital Germans Trias I Pujol, Institut Català Oncologia, Josep Carreras Leukemia Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain
¹⁶Krukenberg Cancer Center Halle, University Medicine Halle, Halle, Germany
¹⁷Division of Hematology-Oncology, University of Michigan Rogel Cancer Center, Ann Arbor, MI
¹⁸UMass Chan Medical School, Worcester, MA
¹⁹Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
²⁰Bristol Myers Squibb, Cambridge, MA
²¹Bristol Myers Squibb, Princeton, NJ
²²Bristol Myers Squibb, Lawrenceville, NJ
²³Bristol Myers Squibb, Berkeley Heights, NJ
²⁴Centre for Innovation and Translational Research Europe, A Bristol Myers Squibb Company, Seville, Spain
²⁵Hospital Universitario 12 de Octubre, Madrid, Spain

Sanjay Mohan, MD, MSCI¹, Stephen Oh, MD, PhD^2*, Jean-Jacques Kiladjian, MD, PhD³, Masahiro Takeuchi, MD, PhD^4*, Jason Gotlib, MD^5*, Ellen K. Ritchie, MD⁶, Taizo Shimomura, MD, PhD^7*, Paola Guglielmelli, MD, PhD⁸, Anthony M. Hunter, MD^9*, Francesca Palandri, MD^10*, Francoise Boyer, MD^11*, Alessandro Rambaldi, M.D.¹², Takehiko Mori, MD, PhD^13*, Tomoki Ito, MD, PhD¹⁴, Betty Lamothe, PhD^15*, Yan-Ou Yang, PhD^15*, Yi Cui, PhD^15*, Francis Seguy, MSc^16*, Amanda McBride, MD, PhD^15* and Prithviraj Bose, MD¹⁷

¹Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN
²Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO
³Hopital Saint-Louis, Paris, France
⁴Chiba Cancer Center, Chiba, JPN
⁵Division of Hematology, Stanford Cancer Institute/ Stanford University School of Medicine, Stanford, CA
⁶Weill Cornell Medical College, Cornell University, New York, NY
⁷Kumamoto Shinto General Hospital, Kumamoto, KUM, JPN
⁸Centro Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, Florence, Italy
⁹Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta
¹⁰IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy, Bologna, Italy
¹¹Centre Hospitalier Universitaire Angers, Angers, France
¹²Department of Oncology and Hematology, University of Milan and Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo BG, Italy
¹³Department of Hematology, Tokyo Medical and Dental University School of Medicine, Bunkyo-Ku, JPN
¹⁴Kansai Medical University Hospital, Hirakata, JPN
¹⁵Incyte Corporation, Wilmington, DE
¹⁶Incyte Biosciences International Sàrl, Morges, Switzerland
¹⁷The University of Texas MD Anderson Cancer Center, Houston, TX