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615 Chimeric Antigen Receptor (CAR) T Cell Infusion for Large B Cell Lymphoma in Complete Remission: A Center for International Blood & Marrow Transplant Research (CIBMTR) Analysis

Program: Oral and Poster Abstracts
Type: Oral
Session: 627. Aggressive Lymphomas: Clinical and Epidemiological: Aiming for the Right Target: Using CAR-T and Bispecifics in Aggressive Lymphomas
Hematology Disease Topics & Pathways:
Research, Biological therapies, Clinical Practice (Health Services and Quality), Lymphomas, non-Hodgkin lymphoma, Clinical Research, B Cell lymphoma, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Diseases, real-world evidence, aggressive lymphoma, Therapies, registries, Lymphoid Malignancies
Sunday, December 10, 2023: 5:00 PM

Trent Wang, DO, MPH1, Kwang Wooahn, PhD2*, Manmeet Kaur3*, Mazyar Shadman, MD, MPH4, Alex F. Herrera, MD5, Craig S Sauter, MD6, Mehdi Hamadani, MD7 and Antonio M. Jimenez Jimenez, MD, MSc8*

1University of Miami Miller School of Medicine/ Sylvester Comprehensive Cancer Center, Miami Springs, FL
2Medical College of Wisconsin, milwaukee, WI
3Medical College of Wisconsin, Milwaukee, WI
4Fred Hutchinson Cancer Center, Seattle, WA
5City of Hope, Duarte, CA
6Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
7Division of Hematology and Oncology, The Medical College of Wisconsin Inc, Milwaukee, WI
8Sylvester Comprehensive Cancer Center, Miller School of Medicine, Miami, FL

Axicabtagene ciloleucel (axi-cel), tisagenlecleucel (tisa-cel), and lisocabtagene maraleucel (liso-cel) have been approved for the treatment of relapsed/refractory large B-cell lymphoma (LBCL). In some cases, patients are identified as being in radiographic complete remission (CR) after CAR T cell manufacturing. However, there are limited studies with small sample sizes that have reported outcomes for this specific group, and prospective data are lacking. We hypothesize that patients with LBCL who are in CR prior to CAR T cell infusion have favorable progression-free survival (PFS) and overall survival (OS) with lower toxicity.

We analyzed CIBMTR registry data from adult patients with LBCL who received commercial axi-cel, liso-cel, or tisa-cel infusion between 2018 and 2021 while in radiographic CR. Kaplan-Meier estimators were used to assess PFS and OS. The cumulative incidence of relapse, non-relapse mortality (NRM), cytokine release syndrome (CRS), and immune effector cell-associated neurotoxicity syndrome (ICANS) was reported according to the consensus ASTCT criteria. Univariable hazard ratios (HR) for PFS and OS were analyzed using a Cox regression model to evaluate the prognostic impact of each variable. A forest plot was generated to display relevant factors.

A total of 134 LBCL patients in CR prior to CAR T cell infusion were identified across 53 centers. The median follow-up was 24.3 months (range 0.9-49.4). Baseline demographics are presented in Table 1. After CAR T infusion, 7/134 patients (5.2%) proceeded to subsequent transplant (6 allogeneic, 1 autologous). At two years post-infusion, the probability of PFS and OS was 43.5% (95% CI 34.4-52.8) and 63.8% (95% CI 54.4-72.6), respectively. The cumulative incidence of NRM at two years was 9% (95% CI 4.5-15.4), and the incidence of relapse/progression was 47.3% (95% CI 38.2-56.6).

The rate of grade 3 or higher CRS was 3/134 (2.2%), with median time to onset of 3 days (range 1-16). Grade 3 or higher ICANS occurred in 11/134 (8.2%) with a median time to onset of 6 days (range 2-15). On univariate analyses, PFS was worse in patients with 5 or more lines of prior therapy before CAR T cell infusion (HR 2.39, 95% CI 1.18-484) (see Figure 1).

The most common cause of death was relapse or disease progression, accounting for 26/46 (56.5%) deaths, followed by infection (8/46, 17.4%, including 4 (8.7%) from COVID-19), ICANS (2 out of 46, 4.3%), and other causes.

CAR T cell infusion in patients with LBCL who are in CR after receiving two or more lines of prior therapy is feasible, with a subset of patients remaining free of progression at two years. The high NRM rate of 9% at two years highlights the importance of continued follow-up in this at-risk population.

The CIBMTR is supported primarily by the Public Health Service U24CA076518 from the National Cancer Institute (NCI), the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious Diseases (NIAID); 75R60222C00011 from the Health Resources and Services Administration (HRSA); N00014-21-1-2954 and N00014-23-1-2057 from the Office of Naval Research.

Disclosures: Wang: Sanofi: Consultancy; Kite: Consultancy; Incyte: Consultancy. Shadman: Fate Therapeutics: Consultancy; Eli Lilly: Consultancy; AbbVie: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; AstraZeneca: Consultancy, Research Funding; Kite, a Gilead Company: Consultancy; Mustang Bio: Consultancy, Research Funding; Genmab: Consultancy, Research Funding; BeiGene: Consultancy, Research Funding; Pharmacyclics: Consultancy, Research Funding; ADC therapeutics: Consultancy; Vincerx: Research Funding; Bristol Myers Squibb: Consultancy, Research Funding; MorphoSys/Incyte: Consultancy, Research Funding; Janssen: Consultancy; MEI Pharma: Consultancy; Regeneron: Consultancy; TG Therapeutics: Research Funding. Herrera: Genentech/Roche: Consultancy, Research Funding; ADC Therapeutics: Consultancy, Research Funding; Regeneron: Consultancy; Merck: Consultancy, Research Funding; Kite, a Gilead Company: Research Funding; Allogene Therapeutics: Consultancy; Takeda: Consultancy; Karyopharm Therapeutics: Consultancy; AbbVie: Consultancy; Seattle Genetics: Consultancy, Research Funding; AstraZeneca/MedImmune: Consultancy; BMS: Consultancy, Other: Travel/Accommodations/Expenses, Research Funding; Pfizer: Consultancy; Genmab: Consultancy; Tubulis GmbH: Consultancy; Caribou Biosciences: Consultancy; Adicet Bio: Consultancy; Gilead Sciences: Research Funding; AstraZeneca: Research Funding. Sauter: Kite/a Gilead Company, Celgene/BMS, Gamida Cell, Karyopharm Therapeutics, Ono Pharmaceuticals, MorphoSys, CSL Behring, Syncopation Life Sciences, CRISPR Therapeutics and GSK.: Consultancy; Juno Therapeutics, Celgene/BMS, Bristol-Myers Squibb, Precision Biosciences, Actinium Pharmaceuticals, Sanofi-Genzyme and NKARTA.: Research Funding. Hamadani: CRISPR: Consultancy; AstraZeneca: Speakers Bureau; Bristol Myers Squibb: Consultancy; Legend Biotech: Consultancy; Kite, a Gilead Company: Consultancy, Speakers Bureau; Incyte: Consultancy; Gamida Cell: Consultancy; BeiGene: Speakers Bureau; ADC therapeutics: Consultancy, Honoraria, Research Funding, Speakers Bureau; MorphoSys: Consultancy; Genmab: Consultancy; Kadmon: Consultancy; Abbvie: Consultancy; Genmab: Consultancy; Omeros: Consultancy; Genentech: Honoraria; Myeloid Therapeutics: Honoraria; Takeda: Research Funding; Astellas: Research Funding; Spectrum Pharmaceuticals: Research Funding; Sanofi Genzyme: Speakers Bureau; BeiGene: Speakers Bureau; Astra Zeneca: Speakers Bureau; SeaGen: Consultancy; Novartis: Consultancy; Caribou: Consultancy. Jimenez Jimenez: Abbvie: Research Funding.

*signifies non-member of ASH