Marius Bill, MD, PhD^1*, Jan-Niklas Eckardt^1*, Christian Rausch^2*, Klaus H Metzeler, MD³, Karsten Spiekermann, MD^4*, Sebastian Stasik, PhD^5*, Tim Sauer, MD^6*, Sebastian Scholl, MD^7*, Andreas Hochhaus, MD⁸, Martina Crysandt, MD^9*, Tim H. Brümmendorf¹⁰, Utz Krug, MD^11*, Bernhard Wörmann, MD^12*, Wolfgang Hiddemann, MD^4*, Dennis Görlich, PhD¹³, Maria Cristina Sauerland, MD^13*, Björn Steffen, MD^14*, Hermann Einsele, MD, PhD^15*, Andreas Neubauer, MD¹⁶, Andreas Burchert, MD¹⁷, Kerstin Schaefer-Eckart, MD¹⁸, Wolfgang E. Berdel, MD¹⁹, Christoph Schliemann, MD^20*, Stefan W. Krause, MD^21*, Mathias Hanel, MD²², Maher Hanoun, MD, PhD^23*, Martin Kaufmann, MD²⁴, Lars Fransecky^25*, Jan Braess, MD^26*, Leo Ruhnke, MD^27*, Johannes Schetelig, MD, MSc^28,29, Jan Moritz Middeke, MD^1*, Hubert Serve, MD³⁰, Claudia D Baldus, MD^31*, Uwe Platzbecker, MD³², Carsten Müller-Tidow, MD^6*, Martin Bornhäuser, MD^5*, Tobias Herold, MD^4*, Christian Thiede, MD⁵ and Christoph Röllig, MD, MSc^27*

¹Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
²Laboratory for Leukemia Diagnostics, Department of Medicine III,, LMU University Hospital, LMU Munich, Munich, Germany
³Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, NA, Germany
⁴Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany
⁵Department of Internal Medicine 1, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁶Heidelberg University Hospital, Heidelberg, Germany
⁷Klinik für Innere Medizin II, Jena University Hospital, Jena, Germany
⁸Department Hematology and Oncology, Klinik für Innere Medizin II, Jena, Germany
⁹Department of Hematology and Oncology, University Hospital RWTH Aachen and Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf (CIOABCD), Aachen, Germany
¹⁰Center for Integrated Oncology - Aachen Bonn Cologne Duesseldorf (CIO-ABCD), Aachen, Germany
¹¹Department of Medicine III, Hospital Leverkusen, Leverkusen, DEU
¹²Department of Hematology, Oncology and Tumor Immunology, Charité, Berlin, Germany
¹³Institute of Biostatistics and Clinical Research, University of Münster, Muenster, Germany
¹⁴Department of Hematology and Oncology, Unversity Hospital Frankfurt, Frankfurt, Frankfurt am Main, Germany
¹⁵Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
¹⁶Department of Hematology, Oncology and Immunology, Phillips-University Marburg, Marburg, Germany, Marburg, Germany
¹⁷Hämatologie, Onkologie und Immunologie, Universitätsklinikum Gießen und Marburg, Standort Marburg, Marburg,, Germany
¹⁸Med. Clinic 5, BMT Unit, Nurnberg, DEU
¹⁹Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany
²⁰Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany
²¹Universitätsklinikum Erlangen, Erlangen, Germany
²²Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany
²³Department of Hematology, University Hospital Essen, Essen, Germany
²⁴Department of Hematology, Oncology and Palliative Care, Robert Bosch Hospital, Stuttgart, Germany
²⁵Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
²⁶Hospital Barmherzige Brueder Regensburg, Regensburg, Germany
²⁷Department of Internal Medicine I, University Hospital Dresden, Dresden, Germany
²⁸TU Dresden, Dresden, Saxony, Germany
²⁹DKMS Group gGmbH, Dresden, Germany
³⁰Department of Internal Medicine II, Hematology and Oncology, Goethe University Hospital Frankfurt, Frankfurt, Germany
³¹University Hospital Schleswig-Holstein, Department of Hematology and Oncology, Campus Kiel, Kiel, Germany
³²University Leipzig Medical Center, Leipzig, Germany

Yazan Abu-Shihab, MD^1*, Deedra Nicolet^2,3, Krzysztof Mrózek, MD, PhD⁴, Andrew Stiff, MD, PhD⁵, Christopher J. Walker, PhD^2,6*, Jill Buss, BS^4,6, Alice Mims, MD⁷, Christopher C. Oakes, PhD⁸, Karilyn T. Larkin, MD⁹, James S. Blachly¹⁰, Andrew J Carroll, PhD¹¹, William Blum, MD¹², Bayard L Powell, MD¹³, Jonathan E Kolitz, MD¹⁴, Richard M Stone, MD¹⁵, Geoffrey L Uy, MD¹⁶, Wendy Stock, MD¹⁷, Jennifer A. Woyach, MD⁶, John C. Byrd, MD¹⁸, Dimitrios Papaioannou, MD*^19,20, Ann-Kathrin Eisfeld, MD*^2,20 and Kellie Archer, PhD*^20,21*

¹The Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
²Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
³Alliance Statistics and Data Center, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁵Depatment of Internal Medicine, Division of Hematology, Ohio State University, Columbus, OH
⁶The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁷Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁸OSU, Columbus, OH
⁹Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹⁰Department of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹¹Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹²Winship Cancer Institute of Emory University, Atlanta, GA
¹³Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC
¹⁴Northwell Health, Lake Success, NY
¹⁵Dana-Farber Cancer Institute, Boston, MA
¹⁶Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹⁷University of Chicago Medicine, Chicago, IL
¹⁸Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
¹⁹Department of Medicine, Division of Hematology/Oncology, NYU Grossman School of Medicine, New York, NY, New York, NY
²⁰Equal contribution, Equal Contribution
²¹The Ohio State University Comprehensive Cancer Center, Columbus, OH, Columbus, OH

Alex Bataller, MD, PhD^1*, Hagop M. Kantarjian, MD¹, Tapan M. Kadia, MD¹, Naval Daver, MD¹, Courtney D. DiNardo, MD, MSc¹, Gautam Borthakur, MD¹, Nicholas J. Short, MD¹, Musa Yilmaz, MD^1*, Ghayas C. Issa², Yesid Alvarado Valero, MD¹, Guillermo Montalban-Bravo, MD¹, Abhishek Maiti, MD³, Hussein A Abbas, MD, PhD¹, Elias Jabbour⁴, William G. Wierda, MD, PhD², Guillermo Garcia-Manero, MD² and Farhad Ravandi, MD, MBBS¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴University of Texas M.D. Anderson Cancer Ctr., Houston, TX

Niek G. Van Der Maas, MSc^1*, Dimitri Breems, MD, PhD², Clara Klerk, MD, PhD^3*, Thomas Pabst, MD^4,5, Patrycja Gradowska, PhD^1,6*, Bart J. Biemond⁷, Jurgen Kuball, MD⁸, Janine Van Elssen, MD, PhD^9*, Otto Visser, MD PhD^10*, Marie-Christiane Vekemans, MD^11*, Carlos Graux^12*, Johan Maertens, MD, PhD^13*, H. Berna Beverloo, PhD^1*, Peter J. M. Valk, PhD¹, Gert J. Ossenkoppele, MD, PhD^14*, Bob Lowenberg, MD, PhD¹, Gerwin A. Huls, Prof.¹⁵, Jan J. Cornelissen, MD, PhD^1* and Jurjen Versluis, MD, PhD^1*

¹Erasmus Medical Center Cancer Institute, Rotterdam, Netherlands
²Ziekenhuis Netwerk Antwerpen, Antwerp, Belgium
³Dijklander Hospital, Amsterdam, Netherlands
⁴Institute of Medical Oncology, Berne, Switzerland
⁵Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland
⁶HOVON Foundation, Rotterdam, Netherlands
⁷Department of Hematology, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, Netherlands
⁸Utrecht University, University Medical Centre, Utrecht, Netherlands
⁹Maastricht University Medical Center, Maastricht, Netherlands
¹⁰Department of Hematology, Isala Hospital, Zwolle, Netherlands
¹¹Cliniques Universitaires Saint-Luc, Brussels, Belgium
¹²University Hospital Center Namur (Godinne), Université Catholique de Louvain, Yvoir, Belgium
¹³Department of Hematology, University Hospitals Leuven, Leuven, Belgium
¹⁴Cancer Center Amsterdam, Amsterdam UMC, location VUMC, Amsterdam, Netherlands
¹⁵University Medical Center, University Groningen, Groningen, Netherlands

Constance Regina Baer, PhD, Sandra Huber, PhD^*, Gregor Hoermann, MD, PhD, Manja Meggendorfer, PhD, Stephan Hutter, PhD^*, Wolfgang Kern, MD, Torsten Haferlach, MD, PhD and Claudia Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

Richard Aplenc, MD, PhD¹, Yimei Li, PhD^2*, Julianne Ani, MPH^3*, Caitlin W. Elgarten, MD¹, Lisa D'Errico^3*, Todd Cooper, DO⁴, E. Anders Kolb, MD⁵, Maria Monica Gramatges, MD, PhD⁶, Meret Henry, MD⁷, Tamara P. Miller, MD⁸, Rajen Mody, MD, MS^9*, Elaine Morgan, MD¹⁰, Regina M. Myers, MD³, Jessica A. Pollard, MD¹¹, Alix Seif, MD, MPH³, Brian T. Fisher, DO, MPH, MSCE^12* and Kelly D. Getz, PhD^13*

¹Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
³Children's Hospital of Philadelphia, Philadelphia, PA
⁴Division of Pediatric Hematology, Oncology, Bone Marrow Transplant & Cellular Therapy, Seattle Children's Hospital, Seattle, WA
⁵Leukemia & Lymphoma Society, Bronx, NY
⁶Texas Children's Hospital, Houston, TX
⁷Children's Hospital of Michigan, Detroit, MI
⁸Department of Pediatrics, Emory University School of Medicine, Decatur, GA
⁹University of Michigan, Ann Arbor, MI
¹⁰Children's Memorial Hosp., Chicago, IL
¹¹Dana Farber Cancer Institute/Boston Children's Hospital, Boston, MA
¹²Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA
¹³Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA