Luca Guarnera, MD^1,2*, Soren Lehmann, MD, PhD^3*, Konstanze Döhner⁴, Hartmut Döhner, MD⁴, Uwe Platzbecker, MD⁵, Nigel H. Russell, MD⁶, Richard Dillon, PhD, MRCP, FRCPath^7*, Ian Thomas^8*, Gert Ossenkoppele, MD, PhD⁹, Marco Vignetti, MD^10*, Edoardo la Sala, MSc^11*, Alfonso Piciocchi, MS^12*, Angela Villaverde Ramiro^13*, Laura Tur^14*, Carmelo Gurnari, MD^1,2, Lars Bullinger¹⁵, Jesús María Hernández-Rivas, PhD¹⁶ and Maria Teresa Voso, MD^2,17

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
³Department of Medical Sciences, Hematology, Uppsala University, University Hospital Uppsala, Uppsala, Sweden
⁴Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
⁵Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, Germany
⁶Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
⁷Guy’s Hospital and King’s College, London, United Kingdom
⁸Cardiff University, Cardiff, United Kingdom
⁹Department of Hematology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands
¹⁰GIMEMA Foundation, Rome, Italy
¹¹GIMEMA Foundation, Data Center and Health Outcomes Research Unit, Roma, ITA
¹²GIMEMA Foundation, Data Center and Health Outcomes Research Unit, Rome, Italy
¹³University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain
¹⁴GMV Innovating Solutions, Valencia, Spain
¹⁵Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany
¹⁶Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
¹⁷Neuro-Oncohematology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy

Franco Locatelli, MD, PhD¹, Barbara Buldini, MD, PhD², Martina Pigazzi, PhD^3*, Carmelo Rizzari, MD^4*, Rosanna Cuccurullo, MD^5*, Franca Fagioli, MD^6*, Manuela Tumino, MD^7*, Luca Lo Nigro, MD⁸, Maria Giuseppina Cefalo, MD^9*, Luisa Strocchio, MD^10*, Marco Zecca, MD^11*, Marco Becilli, MD^12*, Andrea Pession, MD^13*, Nicola Santoro, MD^14*, Concetta Micalizzi, MD^15*, Riccardo Masetti, MD^16* and Pietro Merli, MD^17*

¹Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy
²Department of Pediatric Hematology and Oncology, University of Padova, Padua, Italy
³Department of Women's and Children's Health, Onco-hematology lab and clinic, University of Padova, Padova, Italy
⁴Universita Di Milano, Monza, ITA
⁵Pediatric Hemato Oncology, Pausillipon Hospital, Naples, Italy
⁶Ospedale Infantile Regina Margherita and University of Turin, Turin, Italy
⁷University of Padova, Padova, AL, ITA
⁸Azienda Policlinico OVE - Center of Pediatric Hematology Oncology, Catania, Italy, Italy
⁹Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, Bambino Gesù Children Hospital (IRCCS), Rome, Italy
¹⁰Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, Bambino Gesù Children Hospital (IRCCS), Rome, ITA
¹¹Pediatric Hematology-Oncology,, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹²Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Rome, Italy
¹³Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ITA
¹⁴Department of Pediatric Hemato-Oncology, University of Bari, Bari, Italy
¹⁵IRCCS Istituto Giannina Gaslini, Department of Paediatric Haematology and Oncology, Genova, Italy
¹⁶Pediatric Oncology and Hematology Unit "lalla Seràgnoli," Department of P, Bologna, ITA
¹⁷Hematology/Oncology, Cell and Gene Therapy, Bambino Gesù Children Hospital (IRCCS), Rome, Italy

Li Gao^1*, Xiuli Ju, MD PhD^2*, Hua Jiang, MD PhD^3*, Ning Liao, MD^4*, Ningling Wang, MD^5*, Xiaowen Zhai, MD PhD^6*, Chun Li^7*, Yufeng Liu, MD PhD^8*, Qi An, MD PhD^9*, Jixia Luo, MD^10*, Minghua Yang, MD PhD^11*, Liangchun Yang, MD PhD^12*, Xiaojun Yuan, MD PhD^13*, Qianfei Wang, PhD^14*, Yi Wang^1*, Hailong He^1*, Jun Lu^1*, Peifang Xiao^1*, Raul C. Ribeiro, MD¹⁵ and Shaoyan Hu, MD, PhD¹

¹Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China
²Department of Hematology and Oncology, Qilu Hospital of Shandong University, Qingdao, China
³Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China
⁴Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
⁵Department of Hematology and Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
⁶Department of Hematology and Oncology, Children's Hospital of Fudan University, Shanghai, China
⁷Department of Hematology and Oncology, Anhui Provincial Hospital, Hefei, China
⁸Department of Hematology and Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⁹Department of Hematology and Oncology, Xuzhou Children's Hospital, Xuzhou, China
¹⁰Department of Hematology and Oncology, Kaifeng Children's Hospital, Kaifeng, China
¹¹Department of Hematology and Oncology, The Third Xiangya Hospital of Central South University, Changsha, China
¹²Department of Pediatrics, Xiangya Hospital, Changsha, China
¹³Department of Pediatric Hematology/Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
¹⁴CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
¹⁵Division of Leukemia/Lymphoma, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

Andrew Moore, MBBS, PhD, FRACP^1*, Shanna Maycock, MSc^2*, Guy Leverger, MD, PhD^3*, Owen Smith, MD^4*, Andre Baruchel, MD⁵, Yves Bertrand, MD^6*, Phil Ancliff^7*, Nicholas Heaney^8*, Geoff Shenton^9*, Arnaud Petit, MD, PhD^10*, Jean-Pierre Bourquin, MD, PhD¹¹, Aimee Jackson, MSc^2*, Anna Lawson, BSc^2*, Persis Amrolia, FRCP, FRCPath, PhD^12*, Gerard Michel, MD^13*, Jean-Hugues Dalle^14*, Marc Ansari, MD, PhD¹⁵, Hélène Lapillonne, MD, PhD^3*, Richard Dillon, PhD, MRCP, FRCPath^16*, Jelena Jovanovic, PhD^17*, Christophe Roumier, PharmD^18*, Nicolas Duployez, PharmD, PhD^18*, Christine Harrison, PhD, FRCPath^19*, Claire Schwab, PhD^19*, Wendy Cuccuini, MD, PhD^20*, Marina Lafage-Pochitaloff, MD, PhD^21*, Paresh Vyas, FMedSci, DPhil, FRCPath^22*, Pierre Hirsch, MD, PhD^23*, Gareth Veal, PhD^19*, Pam Kearns, MBChB, PhD, FRCPC^2* and Brenda Gibson, MD, PhD^8*

¹Queensland Children's Hospital, South Brisbane, QLD, Australia
²Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom
³Hôpital Trousseau, Paris, France
⁴Children's Health Ireland, Dublin, Ireland
⁵Hôpital Robert Debré, Paris, France
⁶Institut d'Hématologie et Oncologie Pédiatrique, Lyon, France
⁷Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom
⁸Royal Hospital for Children, Glasgow, Glasgow, United Kingdom
⁹Great North Children’s Hospital, Newcastle, United Kingdom
¹⁰Hôpital Armand Trousseau, APHP, Paris, France
¹¹Department of Oncology and Children’s Research Center, University Children's Hospital Zurich, Zurich, Switzerland
¹²Great Ormond Street Children’s Hospital, London, United Kingdom
¹³Hôpital de la Timone, Marseille, France
¹⁴Department of Pediatric Hematology and Immunology, University Hospital Robert Debré, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France
¹⁵Hôpital Universitaire de Genève, Switzerland, Geneve, Switzerland
¹⁶Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
¹⁷King’s College London, London, United Kingdom
¹⁸Hôpital Claude Huriez, Lille, France
¹⁹Newcastle University, Newcastle, United Kingdom
²⁰Hôpital Saint-Louis, Paris, France
²¹CHU Timone Enfants, Marseille, France
²²Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
²³Hôpital Saint-Antoine, Paris, France

Fabio Guolo, MD, PhD^1,2*, Luana Fianchi, MD, PhD^3*, Maria Paola Martelli, MD, PhD^4*, Patrizia Chiusolo^3*, Federico Lussana, MD, PhD^5*, Francesco Grimaldi, MD^6*, Federica Pilo, MD^7*, Michela Rondoni^8*, Carla Fili, MD^9*, Debora Capelli, MD^10*, Massimo Breccia^11*, Sara Mastaglio, MD^12*, Monica Bocchia, MD^13*, Monica Fumagalli, MD^14*, Sara Galimberti, MD, PhD^15*, Valentina Mancini, MD^16*, Anna Lina Piccioni, MD^17*, Luca Maurillo, MD^18*, Raffaele Palmieri, MD^18*, Andrea Corbingi, MD^19*, Calogero Vetro, MD^20*, Alessandra Sperotto, MD^21*, Federica Gigli, MD^22*, Patrizia Zappasodi, MD^23*, Antonio Mulé, MD^24*, Erika Borlenghi, MD^25*, Michelina Dargenio, MD^26*, Federica Lessi, MD^27*, Marco Cerrano, MD^28*, Alessandro Isidori, MD, PhD²⁹, Lorenzo Brunetti, MD^30*, Cristina Papayannidis, MD³¹, Monia Lunghi, MD, PhD^32*, Caterina Alati, MD^33*, Samuele Gatani^34*, Francesco Mannelli, MD^35*, Nicola Fracchiolla, MD^36*, Michele Gottardi, MD^21*, Roberto Cairoli, MD^37*, Felicetto Ferrara, MD^38*, Roberto Massimo Lemoli, MD^39,40*, Adriano Venditti, MD⁴¹, Livio Pagano, MD^3* and Elisabetta Todisco, MD^34*

¹IRCCS Ospedale Policlinico San Martino, Genoa, Italy
²Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy
³Dipartimento di Scienze Radiologiche Radioterapiche ed Ematologiche, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy
⁴Dipartimento di Medicina e Chirurgia, Hematology, Department of Medicine and Surgey, University of Perugia and "Santa Maria della Misericordia" Hospital, Perugia, ITA
⁵Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
⁶Department of Clinical Medicine and Surgery, Hematology Unit, University of Naples Federico II, Naples, ITA
⁷SC di Ematologia e CTMO,, Ospedale Oncologico di Riferimento Regionale "A. Businco", ARNAS "G. Brotzu", Cagliari, Italy
⁸Hematology Unit & Metropolitan Transplant Network, AUSL Romagna, Ravenna, Italy
⁹Division of Hematology and Stem Cell Transplantation, University Hospital ASUF, Udine, Italy
¹⁰Clinica di Ematologia, Azienda Ospedaliero-Universitaria delle Marche, Ospedali Riuniti di Ancona, Ancona, ITA
¹¹Department of Translational and Precision Medicine, Hematology-Sapienza University, Rome, Italy
¹²Hematology and Bone Marrow Transplant, Unit San Raffaele Scientific Institute, Milan, Italy
¹³UOC Ematologia, Azienda ospedaliero-universitaria Senese, Siena, Italy
¹⁴Hematology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
¹⁵Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy
¹⁶Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
¹⁷Dipartimento di Ematologia, Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy
¹⁸Department of Onco-Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy
¹⁹Hematology, Polo Universitario Pontino, "Sapienza", S.M. Goretti Hospital, Latina, Italy
²⁰Division of hematology, A.O.U. Policlinico G.Rodolico – S. Marco, Catania, Italy
²¹Onco Hematology, Department of Oncology, Veneto Institute of Oncology IOV-IRCCS, Castelfranco Veneto, Italy
²²Divisione di Oncoematologia, European Institute of Oncology, Milan, Italy
²³Clinica Ematologica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
²⁴Division of Hematology 1, Azienda Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
²⁵Hematology, ASST Spedali Civili, Brescia, Italy
²⁶Divisione di Ematologia e Centro Trapianti, CSE Vito Lazzi, Lecce, Italy
²⁷Divisione di Ematologia e Centro Trapianti, Azienda Ospedaliera Universitaria di Padova, Padova, Italy
²⁸Division of Hematology, Department of Oncology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy
²⁹Hematology and Stem Cell Transplant Center, AORMN Hospital, Pesaro, Italy
³⁰Clinica di Ematologia, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy
³¹Istituto di Ematologia "Seràgnoli", IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy
³²Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
³³U.O.C. Ematologia, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy
³⁴Hematology Department, ASST Valle Olona, Varese, Italy
³⁵CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
³⁶Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy
³⁷Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
³⁸Divisione di Ematologia, Ospedale Cardarelli, Napoli, Italy
³⁹Clinic of Hematology, Department of Internal medicine (DiMI), University of Genoa, Genoa, Italy
⁴⁰Clinica Ematologica, Dipartimento di Oncologia e Ematologia, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
⁴¹Department of Onco-Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy, Italy

Malin S. Nilsson^1*, Anna Martner, PhD^2*, Fredrik B. Thorén^2* and Kristoffer Hellstrand, MD, PhD^2*

¹Institute of Biomedicine, Gothenburg, Sweden
²TIMM Laboratory at Sahlgrenska Center for Cancer Research, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden