65th ASH Annual Meeting & Exposition: 603. Lymphoid Oncogenesis: Basic: Epigenetic, Immune-Related, and Signaling Mechanisms of Lymphomagenesis

Symposia: Lymphoid Oncogenesis: Basic Oral and Poster Abstracts
Oral

Research, Fundamental Science, Hodgkin lymphoma, Translational Research, Lymphomas, non-Hodgkin lymphoma, Diseases, Lymphoid Malignancies

Pacific Ballroom Salons 15-17 (Marriott Marquis San Diego Marina)

Moderators:

Michael R. Green, PhD, University of Texas MD Anderson Cancer Center and Coraline Mlynarczyk, PhD, Weill Cornell Medicine

Disclosures:

Green: KDAc Therapeutics: Current equity holder in private company; Sanofi: Research Funding; Abbvie: Research Funding; Kite/Gilead: Research Funding; Allogene: Research Funding; Daiichi Sankyo: Honoraria; BMS: Consultancy; Abbvie: Honoraria.

10:30 AM

715

Classic Hodgkin Lymphomas Display Neuronal-Glial Lineage Transdifferentiation

Mirca S. Saurty-Seerunghen, PhD¹^*, Sara Moein, PhD¹^*, Tsega-Ab Abera¹^*, Xiaotian Sun²^*, Sohani Sharma¹^*, Chhiring Lama¹^*, Mansi Totwani¹^*, Shira Rosenberg, MSc¹^*, Qi Gao, DCLS²^*, Neelang Parghi³^*, Amy Chadburn, MD⁴, Kui Nie, PhD¹^*, Vicenta Trujillo Alonso¹^*, Elizabeth Bier¹^*, Jenny Xiang¹^*, Ethel Cesarman, MD, PhD¹, Wayne Tam, MD⁵, Mikhail Roshal, MD, PhD²^*, Lisa Giulino Roth, MD¹ and Anna S Nam, MD¹^*

¹Weill Cornell Medicine, New York
²Memorial Sloan Kettering Cancer Center, New York
³New York University, New York
⁴Northwestern School Feinberg School of Medicine Northwester Memorial Hospital, New York, NY
⁵Northwell Health, New York

10:45 AM

716

Lymphoma-Derived IL-10 Is a Key Immunomodulatory Factor at the Tumor Microenvironment of Activated B-Cell Diffuse Large B-Cell Lymphoma and Influences In Vivo Responses to Immunotherapy

Marcos Garcia-Lacarte, PhD^1,2^*, Sara C Grijalba^1,2^*, Francisco J Novo, MD PhD^1,2^*, Adrián Arnaiz-Leché^1,2^*, Javier Melchor, PhD^1,3^*, Marién Pascual, PhD³^*, Enrique Goñi^2,4^*, Sandra Morales-Sánchez⁵^*, María A Burrell, PhD⁵^*, Oscar Blanco, MD PhD⁶^*, Iñigo Clemente-Larramendi¹^*, Jose A Martinez-Climent, MD PhD^2,3,7, Noelia Casares, PhD^2,8^*, Juan J Lasarte, PhD^2,8^*, Pablo Sarobe, PhD^2,8,9^*, Miguel Canales^2,10^* and Sergio Roa, PhD^1,2,7^*

¹Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain
²Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
³Hemato-Oncology Program, Cima Universidad de Navarra, Pamplona, Spain
⁴Computational Biology Program, Cima Universidad de Navarra, Pamplona, Spain
⁵Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain
⁶Institute of Biomedical Research of Salamanca (IBSAL), Department of Pathology, University of Salamanca, Salamanca, Spain
⁷Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
⁸Immunology and Immunotherapy Program, Cima Universidad de Navarra, Pamplona, Spain
⁹Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Enfermedades hepáticas y digestivas (CIBERehd), Madrid, Spain
¹⁰Clínica Universidad de Navarra Cancer Center (CCUN), Pamplona, Spain

11:00 AM

717

Emergence of Highly-Plastic B Cell States Cooperates with Early Immune Microenvironment Remodeling to Drive Follicular Lymphomagenesis

Gabriel Brisou^1,2^*, Sabrina Baaklini, PhD¹^*, Noushin Mossadegh-Keller, PhD¹^*, Alicia Beyou¹^*, Manon Zala³^*, Laurine Gil¹^*, Camille Soun¹^*, Caroline Huber¹^*, Iñaki Cervera-Marzal¹^*, Agnés Bru¹^*, Delphine Potier, PhD⁴^*, Stéphanie Gon, PhD⁴^*, Lionel Chasson¹^*, Asier Antoranz, PhD⁵^*, Jon Pey Perez, PhD⁵^*, Anita K. Gandhi, PhD⁶, Yumi Nakayama, PhD⁶^*, Patrick R Hagner, PhD⁷^*, Pierre Milpied, PhD¹^*, Bertrand Nadel, PhD⁸ and Sandrine Roulland, PhD⁹^*

¹Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France
²Institut Paoli-Calmettes, Department of Hematology, Marseille Cedex 09, France
³Université Lyon 1, Centre International De Recherche En Infectiologie, Pierre-Benite, France
⁴Cancer Research Center of Marseille, CNRS, INSERM, Aix Marseille University, Marseille, France
⁵Intelligent Biodata Ltd, San Sebastian, Spain
⁶Bristol Myers Squibb, Princeton, NJ
⁷Translational Development and Diagnostics, Bristol Myers Squibb, Summit, NJ
⁸Centre D'Immunologie De Marseille-Luminy, Marseilles, France
⁹Centre d' Immunologie de Marseille - Luminy, Marseille, Cedex 09, France

11:15 AM

718

SWI/SNF Chromatin Remodeling Complex Orchestrates Sequential Binding of Key Transcription Factors in B Cells and Restricts Aggressive Lymphoma

Darko Barisic, PhD¹, Christopher Chin, PhD²^*, Cem Meydan³^*, Matthew Teater, PhD⁴^*, Ioanna Tsialta⁵^*, Coraline Mlynarczyk, PhD⁵, Amy Chadburn, MD⁶, Min Xia, PhD⁴, Christian Steidl, MD, PhD⁷, David W. Scott, MBChB, PhD^8,9, Andrew P. Weng, MD¹⁰^*, Christopher Mason³^*, Michael R. Green, PhD¹¹ and Ari M Melnick, MD⁴

¹Hematology and Oncology, Weill Cornell Medicine, New York, NY
²Department of Medicine, Weill Cornell Medicine, New York, NY
³Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY
⁴Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
⁵Weill Cornell Medicine, New York, NY
⁶Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
⁷Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
⁸Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada
⁹Centre for Lymphoid Cancer, BC Cancer Research Centre, Vancouver, BC, Canada
¹⁰BC Cancer Agency, Terry Fox Laboratory, Vancouver, BC, Canada
¹¹Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Friendswood, TX

11:30 AM

719

Dynamic Recruitment of Inhibitory Complexes Controls Oncogenic Signaling in B-Cell Malignancies

Ruifeng Sun¹^*, Jaewoong Lee, PhD^1,2^*, Mark E Robinson, PhD¹^*, Kohei Kume, PhD¹^*, Ning Ma, PhD³^*, Kadriye Nehir Cosgun, PhD¹^*, Lai N Chan, PhD¹, Irina Antoshkina¹^*, Dhruv Khanduja¹^*, Etienne Leveille, MD-PhD¹^*, Samuel G. Katz, MD-PhD⁴^*, Jianjun Chen, PhD³, Elisabeth Paietta, PhD⁵^*, Nagarajan Vaidehi, PhD³^* and Markus Müschen, MD¹

¹Center of Molecular and Cellular Oncology, Yale University, New Haven, CT
²School of Biosystems and Biomedical Sciences, Korea University, Seoul, Korea, Republic of (South)
³Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA
⁴Department of Pathology, Yale School of Medicine, New Haven, CT
⁵Montefiore Medical Ctr. North Div, Bronx, NY

11:45 AM

720

[CANCELED] Mechanistic Elucidation of the Tumor-Promoting Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in B-Cell Receptor Signaling in Mantle Cell Lymphoma

Serene Xavier, PhD¹^*, Vivian Nguyen, BS¹^*, Vishal Khairnar, PhD¹^*, An Phan¹^*, Lu Yang, PhD¹^*, Michael Nelson¹^*, Elizabeth Tseng¹^*, Aimin Li, PhD¹^*, Joo Y Song, MD²^*, Dennis D. Weisenburger, MD³, Wing C. Chan, MD⁴, Markus Müschen, MD⁵ and Vu N. Ngo, PhD¹^*

¹City of Hope Beckman Research Institute, Monrovia, CA
²Department of Pathology, City of Hope National Medical Center, Duarte, CA
³University of Nebraska Medical Center, Elkhorn, NE
⁴Beckman Research Institute, City of Hope, Duarte, CA
⁵Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT

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^*signifies non-member of ASH

603.O1.6 603. Lymphoid Oncogenesis: Basic: Epigenetic, Immune-Related, and Signaling Mechanisms of Lymphomagenesis