65th ASH Annual Meeting & Exposition: 602. Myeloid Oncogenesis: Basic: RNA Splicing, Transcription, and Chromatin Dynamics

Symposia: Myeloid Oncogenesis: Basic Oral and Poster Abstracts
Oral

Fundamental Science, Translational Research, Myeloid Malignancies

Marriott Grand Ballroom 11-13 (Marriott Marquis San Diego Marina)

Moderators:

Ani J. Deshpande, PhD, Sanford Burnham Prebys Medical Discovery Institute and Olaf Heidenreich, PhD, Princess Maxima Center For Pediatric Oncology

Disclosures:

No relevant conflicts of interest to declare.

RNA Splicing, Transcription, and Chromatin Dynamics

10:30 AM

709

Transcription Defects in SF3B1K700E Induce Targetable Alterations in the Chromatin Landscape

Prajwal Boddu, MD¹^*, Abhishek Gupta²^*, Rahul Roy²^*, Anne Olazabal Herrero³^*, Amit Verma, MD⁴, Karla Neugebauer, PhD⁵^* and Manoj Pillai, MD⁶

¹YALE UNIVERSITY, New Haven, CT
²yale university, new haven
³Georgetown university, Washington D.C, DC
⁴Department of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
⁵Yale University, New Haven, CT
⁶yale university, New Haven, CT

10:45 AM

710

Targeting Super-Enhancers Driving EVI1 Expression in Leukemia By Inhibition of p300/CBP

Dorien Pastoors^1,2^*, Claudia Erpelinck^1,2^*, Stanley Van Herk^1,2^*, Roger Mulet-Lazaro^1,2^*, Marije Havermans^1,2^*, Eric Bindels²^*, Sophie Ottema^1,2^* and Ruud Delwel^1,2

¹Oncode Institute, Utrecht, Netherlands
²Hematology, Erasmus MC, Rotterdam, Netherlands

11:00 AM

711

TRIP13 Is a Fetal-Enriched Therapeutic Target in NUP98-JARID1A⁺ Pediatric Non-Down Syndrome AMKL

Luca Nunzio Cifarelli, MSc¹^*, Hasan Issa, PhD²^*, Konstantin Schuschel²^*, Katja Menge³^*, Lucie Gack³^*, Christian Ihling, PhD⁴^*, Andrea Sinz, PhD⁴^*, Jan-Henning Klusmann, MD² and Dirk Heckl, PhD^3,5^*

¹Department of Pediatric Hematology and Oncology, Martin‐Luther‐University Halle‐Wittenberg, Halle, Sachsen-Anhalt, Germany
²Pediatric Hematology and Oncology, Department of Pediatrics, Goethe University Frankfurt, Frankfurt, Germany
³Department of Pediatric Hematology and Oncology, Martin‐Luther‐University Halle‐Wittenberg, Halle, Germany
⁴Department of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle, Germany
⁵Institute for Experimental Pediatric Hematology and Oncology, Goethe University Frankfurt, Frankfurt, Germany

11:15 AM

712

Ubiquitin Ligase SCF-FBXO11 Controls a Network of RNA-Binding Proteins and Splicing in MDS

Madeline Niederkorn, PhD¹, Lavanya Bezavada, MS²^*, Anitria Cotton, MBA, BS³^*, Lance Palmer, PhD¹^*, Trent Hall, PhD¹^*, Michael Schieber, MD, PhD⁴, Peng Xu, PhD⁵, Mitchell Weiss, MD, PhD¹, Raajit K. Rampal, MD, PhD⁶ and John D. Crispino, PhD, MBA³

¹St. Jude Children's Research Hospital, Memphis, TN
²Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN
³Division of Experimental Hematology, St Jude Children's Research Hospital, Memphis, TN
⁴Northwestern Medical Group, Lake Forest, IL
⁵Hematology Center, Cyrus Tang Medical Institute, Soochow University, Suzhou, Jiang Su, China
⁶Memorial Sloan Kettering Cancer Center, New York, NY

11:30 AM

713

SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML

Yu-Hsuan Chang¹^*, Keita Yamamoto, MD, PhD²^*, Takeshi Fujino, MD, PhD²^*, Teh-Wei Wang, PhD³^*, Emi Sugimoto, PhD¹^*, Wenyu Zhang¹^*, Tomohiro Yabushita, MD PhD⁴^*, E. Christine Pietsch, PhD⁵, Barbara A. Weir⁶^*, Ramona Crescenzo, PhD⁷^*, Glenn S. Cowley⁸^*, Ricardo M. Attar, PhD⁸^*, Ulrike Philippar, PhD⁹, Yutaka Enomoto, PhD⁴^*, Yoichi Imai, MD PhD¹⁰^*, Toshio Kitamura, MD, PhD¹¹^* and Susumu Goyama, MD PhD¹^*

¹Division of Molecular Oncology, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
²Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
³Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁴Division of Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
⁵Janssen Research and Development, Springhouse, PA
⁶Janssen Research and Development, Cambridge, MA
⁷Janssen Research and Development, Beerse, Belgium
⁸Janssen Research and Development, Spring House, PA
⁹Janssen Research & Development, LLC, Beerse, Belgium
¹⁰Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan
¹¹Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan

11:45 AM

714

Impaired Early Spliceosome Complex Assembly Underlies Gene Body Elongation Transcription Defect in SF3B1K700E

Prajwal Boddu, MD¹^*, Abhishek Gupta²^*, Rahul Roy²^*, barbara De La Pena Avalos³^*, Anne Olazabal Herrero⁴^*, Joshua Zimmer²^*, Matthew Simon²^*, Namrata Sonia Chandhok, MD⁵, Darren King⁶^*, Nils Neuenkirchen⁷^*, Elois Dray⁸^*, Haifan Lin²^*, Gary Kupfer, MD⁹, Amit Verma, MD¹⁰, Karla Neugebauer, PhD¹¹^* and Manoj Pillai, MD¹²

¹YALE UNIVERSITY, New Haven, CT
²yale university, new haven
³UTHSCSA, san antonio
⁴Georgetown university, Washington D.C, DC
⁵University of Miami, Miami, FL
⁶University of Chicago, Chicago, IL
⁷yale university, chicago
⁸uthscsa, san antonio
⁹Georgetown University Medical Center, Washington, DC
¹⁰Department of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
¹¹Yale University, New Haven, CT
¹²yale university, New Haven, CT

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^*signifies non-member of ASH

602A.O1.6 602. Myeloid Oncogenesis: Basic: RNA Splicing, Transcription, and Chromatin Dynamics