Jie Liu, MBBS, MPH¹, Duc Tran^1*, Irenaeus C.C. Chan, MSc^1*, Brian Wiley^1*, Caroline Watson^2*, Armel L. Batchi-Bouyou, MD^1*, Xiaoyu Zong, MPH^3*, Konrad H. Stopsack, MD, MPH^4*, Paul Pharoah, PhD^5*, Li Ding, PhD^6*, Jamie R Blundell, PhD^7*, Yin Cao, ScD, MPH^8*, Matthew J. Walter, MD¹, Nilanjan Chatterjee^9*, Kenneth Offit, MD^10*, Lucy Godley, MD, PhD¹¹, Daniel C. Link, MD¹, Zsofia Stadler^12* and Kelly L. Bolton, MD¹³

¹Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
²University of Cambridge, Cambridge, United Kingdom
³Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO
⁴School of Public Health, Harvard University, Boston, MA
⁵Cedars-Sinai Hospital, Los Angeles, CA
⁶WUSTL, St Louis
⁷University of Cambridge, Cambridge, GBR
⁸Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis
⁹Johns Hopkins Bloomberg School of Public Health, Baltimore
¹⁰Memorial Sloan-Kettering Cancer Ctr., New York, NY
¹¹Northwestern University, Chicago, IL
¹²Memorial Sloan-Kettering Cancer Center, New York
¹³Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, Saint Louis, MO, Washington University In St Louis, St Louis, MO

Xuesen Zheng, PhD^1*, Amandine Tan^2*, Maria del Pilar Casares Alaez^2*, Garry Mallett^2*, Deniz Ece Kaya, PhD^3*, Nogayhan Seymen, MSc^3*, Marta Rzepkowska^2*, Sarah Mackie^2*, Prodromos Chatzikyriakou^4*, Laarni Bogaanay^5*, Jen Lewis^5*, Maroof Hasan^6*, Rajasekhar N.V.S. Suragani, PhD⁶, James Carmichael^7*, Ghulam Mufti, DM, FRCPath^5,8*, Anita K. Gandhi, PhD⁹, Giorgio Napolitani, PhD^8* and Lynn Quek, MD, PhD^4,5*

¹Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, ENG, United Kingdom
²Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
³Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom, London, United Kingdom
⁴Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
⁵King's College Hospital, London, United Kingdom
⁶Hematology, Translational Medicine and Disease Team, Bristol Myers Squibb, Summit, NJ
⁷Bristol Myers Squibb, San Diego, CA
⁸King’s College London, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, London, United Kingdom
⁹Translational Development and Diagnostics, Bristol Myers Squibb, Summit, NJ

Saravanan Ganesan, PhD^1,2,3, Rebecca Murray, BS^1,3,4*, Jesus Sotelo, BS^1,3,4*, Theo Botella, MS^1,3,4*, Elliot Eton, BS^1,3,4*, Nada Chraiki, BS^1,3,4*, Carolyne Croizier, MD^1,3,4*, Franco Izzo, PhD^1,3,4, Catherine Potenski, PhD^1,3,4*, Benjamin Terrier, MD, PhD^5*, Mael Heiblig^6*, Pierre Sujobert, MD, PhD^6*, Olivier Kosmider, PharmD, PhD^7*, David B Beck, MD, PhD^8,9* and Dan A. Landau, MD, PhD^1,3,4*

¹New York Genome Center, New York
²Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY
³Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York
⁴Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York
⁵Department of Internal Medicine, National Referral Center for Rare and Systemic Autoimmune Diseases, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
⁶Service d'hématologie clinique, Hospices Civils de Lyon, Hôpital Lyon Sud, Pierre-Bénite, France
⁷Laboratory of Hematology, Université Paris Cité and Assistance Publique-Hôpitaux de Paris. Centre, Hôpital Cochin, Paris, France
⁸Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York
⁹Center for Human Genetics and Genomics, New York University School of Medicine, New York

Nikolaos Sousos, MD, MSc, DPhil^1,2*, Lauren Murphy, BSc^2*, Sean Wen, BSc, MSc, PhD^2*, Angela Hamblin, MD, PhD^1*, Sally-Ann Clark, BSc, PhD^2*, Christina Simoglou Karali^2*, Jessica Whittle, BSc, MSc^2*, Zemin Ren, BSc, PhD^2*, Haseeb Rahman, BSc^2*, Nawshad Hayder, BSc, MSc^2*, Akriti Rastogi, BTech, MEng, PGDip, PhD^2*, Michael Jacobs^3*, Susan Shapiro, MA, BM, BCh, FRCP, FRCPath, PhD^2,4*, Bethan Psaila, MD, PhD^1,5 and Adam J Mead, MRCP, FRCPath, PhD^1,2

¹Cancer and Haematology Centre, The Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
²Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
³National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
⁴Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁵Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, ENG, United Kingdom

Alexander J Silver, BA¹, Donovan J Brown, BS^1*, Caitlyn Vlasschaert, MD, PhD^2*, Pawan Bhat, BS¹, Fabio Puddu, PhD^3*, Joseph C Van Amburg, MS^1*, Matthew T Villaume, MD, PhD^1*, Melissa A Fischer, PhD¹, Maria P Arrate, BS^1*, Yu Wang, PhD^4*, Jamie Scotcher, MS^3*, Kristy Stengel, PhD^1*, Brianna Nicole Smith, MD, MS⁵, Brian Sharber, BS^1*, Chad R Potts, BS^1*, Mark Consugar, MS^3*, Jonathan Brett Heimlich, MD, PhD^1*, Yaomin Xu, PhD^4,6*, P. Brent Ferrell Jr., MD^1,7, Alexander G. Bick, MD, PhD^1* and Michael R. Savona, MD^1,7

¹Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
²Department of Medicine, Queen's University, Kingston, ON, CAN
³Biomodal, Cambridge, United Kingdom
⁴Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
⁵Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
⁶Department of Bioinformatics, Vanderbilt University Medical Center, Nashville, TN
⁷Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN

Sean Wen^1*, Fengyuan Hu^1*, Abhishek Nag^1*, Ioanna Tachmazidou^1*, Sri Vishnu Vardhan Deevi^1*, Haeyam Taiy^1*, Katherine Smith^1*, Keren Carss^1*, Sebastian Wasilewski^1*, Jesus Alegre-Díaz^2*, Pablo Kuri-Morales^2*, Jaime Berumen^2*, Roberto Tapia-Conyer^2*, Jonathan Emberson^3*, Jason M. Torres^3*, Rory Collins^3*, Quanli Wang^4*, Slavé Petrovski^1*, Margarete Fabre^1,5*, Andrew Harper^1,6*, George Vassiliou, FRCPath, MRCP, PhD, MBBS^7,8,9 and Jonathan Mitchell^1*

¹Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
²Faculty of Medicine, National Autonomous University of Mexico, Coyoacán, Mexico
³Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
⁴Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham
⁵Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
⁶Early Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
⁷Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom
⁸Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⁹Department of Haematology, University of Cambridge, Cambridge, United Kingdom