Amelia K Haj, MD, PhD^1,2,3, Justine Ryu, MD^2,4, Satoshi Koyama, MD^2*, Sean J. Jurgens, MD MSc^2,5,6*, Xin Wang, MBBS^2,3*, Seung Hoan Choi, PhD^7*, Sharjeel Chaudhry, MD^3,8*, Simone Sanna-Cherchi, MD^9*, Steven P Grover, PhD¹⁰, Patrick Ellinor, MD, PhD^2,3,5* and Pavan K Bendapudi, MD^2,3,11,12

¹Department of Pathology, Massachusetts General Hospital, Cambridge, MA
²The Broad Institute of MIT and Harvard, Cambridge, MA
³Harvard Medical School, Boston, MA
⁴Section of Hematology, Yale University School of Medicine, New Haven, CT
⁵Massachusetts General Hospital, Boston, MA
⁶Department of Experimental Cardiology, University of Amsterdam, Amsterdam, Netherlands
⁷Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA
⁸Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA
⁹Division of Nephrology, Columbia University Irving Medical School, New York, NY
¹⁰UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
¹¹Division of Thrombosis and Hemostasis, Beth Israel Deaconess Medical Center, Boston, MA
¹²Division of Hematology, Department of Medicine, Massachusetts General Hospital, Cambridge, MA

Justine Ryu, MD^1,2, Joel Rämö, MD, PhD^2,3,4*, Sean J. Jurgens, MD MSc^2,4,5*, Teemu Niiranen, MD, PhD^6,7*, Aarno Palotie, MD, PhD^2,3,4*, Mark Daly, PhD^2,3,4*, Simone Sanna-Cherchi, MD^8*, Patrick Ellinor, MD, PhD^2,4,9*, Kenneth A Bauer, MD^10,11 and Pavan K Bendapudi, MD^9,12,13,14

¹Section of Hematology, Yale University School of Medicine, New Haven, CT
²The Broad Institute of MIT and Harvard, Cambridge, MA
³Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), Helsinki, Finland
⁴Massachusetts General Hospital, Boston, MA
⁵Department of Experimental Cardiology, University of Amsterdam, Amsterdam, Netherlands
⁶Department of Internal Medicine, University of Turku, Turku, Finland
⁷Division of Medicine, Turku University Hospital, Turku, Finland
⁸Division of Nephrology, Columbia University Irving Medical School, New York, NY
⁹Harvard Medical School, Boston, MA
¹⁰Beth Israel Deaconess Medical Center, Boston, MA
¹¹Division of Hematology and Hematologic Malignancies, Beth Israel Deaconess Medical Center, Boston, MA
¹²Division of Thrombosis and Hemostasis, Beth Israel Deaconess Medical Center, Boston, MA
¹³Blood Transfusion Service, Department of Pathology, Massachusetts General Hospital, Boston, MA
¹⁴Center for the Development of Therapeutics, The Broad Institute of MIT and Harvard, Cambridge, MA

Sacha Belinda Mapombo Choupa¹, Amy Luo^2*, Clare Zarka^3*, A. Kinga Malinowski, MD⁴, Kevin H.M. Kuo, MD, FRCPC, MSc⁵, Nadine Shehata, MD, FRCPC, MSc⁶, Sophie M. Lanzkron, MD⁷ and Lydia H Pecker, MD^7,8

¹Meharry Medical College, Nashville, TN
²Johns Hopkins Bloomberg School of Public Health, Baltimore
³Johns Hopkins University School of Medicine, Baltimore, MD
⁴Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Lunenfeld-Tanenbaum Research Institute, Sinai Health, University of Toronto, Toronto, ON, CAN
⁵Department of Hematology, University of Toronto, Toronto, ON, Canada
⁶Mount Sinai Hospital, Toronto, Canada
⁷Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
⁸Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD

Gary Woods, MD¹, Alexandra Miller, MPH, CPH^2*, Maua Mosha, MPH^2*, Christoph Male^3*, Anupam Verma, MD^4*, Nicole Kucine, MD, MS⁵, Christine Sabapathy, MD, FRCPC, MSc^6*, Kisha A Beg, MBBS⁷, Sanjay Ahuja, MD⁸, Deepti A. Raybagkar, MD, MS⁹, Kerry Hege, MD¹⁰, Clara Lo, MD^11*, Rukhmi Bhat, MD, MS¹², Thomas C. Abshire, MD¹³ and Neil Goldenberg, MD, PhD¹⁴

¹Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Children's Healthcare of Atlanta, Atlanta, GA
²Data Coordinating Center for Pediatric Multicenter Studies, Johns Hopkins All Children’s Hospital Institute for Clinical and Translational Research, St. Petersburg, FL
³Medical University of Vienna, Vienna, AUT
⁴Department of Pediatrics, University of Utah and Primary Children’s Hospital, Salt Lake City, UT
⁵Weill Cornell Medical College, New York, NY
⁶Department of Pediatrics, McGill University Health Centre and The Montreal Children's Hospital, montreal, QC, Canada
⁷OUHSC, Oklahoma City, OK
⁸Case Western Reserve University, Cleveland, OH
⁹St Christopher's Hospital for Children, Philadelphia, PA
¹⁰Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN
¹¹Stanford University, Palo Alto, CA
¹²Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
¹³Department of Pediatrics Medical College of Wisconsin and Versiti Blood Research Institute, Milwaukee, WI
¹⁴All Children's Hospital Johns Hopkins Medicine, Saint Petersburg, FL

Julie Jaffray, MD, MS¹, Maua Mosha, MPH^2*, Brian R. Branchford, MD³, Ernest K Amankwah, PhD^4*, E. Vincent Faustino^5*, Emily Krava, MPH^6*, Amy Stillings^6*, Guy Young, MD^7,8 and Neil Goldenberg, MD, PhD^9,10

¹Rady Children's Hospital, University of California San Diego, San Diego, CA
²Data Coordinating Center for Pediatric Multicenter Studies, Johns Hopkins All Children’s Hospital Institute for Clinical and Translational Research, St. Petersburg, FL
³Versiti Medical Sciences Institute, Wauwatosa, WI
⁴Data Coordinating Center, Johns Hopkins All Children’s Institute for Clinical and Translational Research, St Petersburg, FL
⁵Yale School of Medicine, New Haven, CT
⁶University of California, San Diego, San Diego, CA
⁷Children's Hospital Los Angeles, Los Angeles, CA
⁸Keck School of Medicine, University of Southern California, Los Angeles, CA
⁹Johns Hopkins All Children's Hospital, Saint Petersburg, FL
¹⁰All Children's Hospital Johns Hopkins Medicine, Saint Petersburg, FL

Vilmarie Rodriguez, MD¹, Sarah O'Brien, MD, MSc², Glen Lew³, Etan Orgel, MD^4,5, Kimberly Derr^6*, Mark A. Ranalli, MD^7*, Corinna L. Schultz, MD⁸, Adam J. Esbenshade, MD, MSc^9*, Arteid Memaj, MSc, MBA^10*, Joshua Dyme^11*, Nicholas Favatella^11* and Lesley Mitchell^12*

¹Division of Pediatric Hematology/Oncology/Blood and Bone Marrow Transplant, Nationwide Children's Hospital/The Ohio State University, Columbus, OH
²Nationwide Children's Hospital, Columbus, OH
³Bristol Myers Squibb, Princeton, NJ
⁴Keck School of Medicine of USC, Los Angeles, CA
⁵Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA
⁶Geisinger Health System, Danville, PA
⁷Nationwide Children's Hospital/The Ohio State University, Columbus, OH
⁸Center for Cancer and Blood Disorders, Nemours Children's Health, Wilmington, DE
⁹Vanderbilt University, Nashville, TN
¹⁰Bristol Myers Squibb, Inc., Lawrenceville,, NJ
¹¹Bristol Myers Squibb, Inc., Lawrenceville, NJ
¹²Department of Pediatrics, University of Alberta, Edmonton, AB, Canada