65th ASH Annual Meeting & Exposition: 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Inflammation, Metabolism, and Stress

Symposia: Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, hematopoiesis, immunology, Biological Processes, molecular biology

Room 24 (San Diego Convention Center)

Moderators:

Katherine Y. King, MD, PhD, Baylor College of Medicine and Stephanie Z Xie, PhD, Princess Margaret Cancer Centre, University Health Network

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

Maternal Obesity Causes Sex Specific Long-Term Hematopoietic and Metabolic Defects

Merve Denizli, M.D.¹^*, James Ropa, BS, MSc, PhD², Lindsay Beasley, MS²^*, Kelli DeVanna, M.S.¹^*, Laura S. Haneline, M.D.³^*, Kok Lim Kua, M.D.¹^* and Maegan L Capitano, PhD²

¹Department of Pediatrics-Neonatal Medicine, Indiana University School of Medicine, Indianapolis, IN
²Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN
³Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN

9:45 AM

Lnk/Sh2b3 Deficiency Increases DNA Damage Tolerance to Promote Hematopoietic Stem Cell Fitness

Md_Akram Hossain, PhD^1,2^*, Brijendra Singh, PhD^1,2^*, Jeremie Fages, PhD^1,2^*, Carlo Salas Salinas, B.Sc^1,2^*, Xiao Hua Liang, B.Sc^1,2^* and Wei Tong, PhD^1,2

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

10:00 AM

Hematopoietic Stem Cells from Mice and Individuals with Sickle Cell Disease Display Premature Senescence and Loss of Function That Is Targetable By Senolytic Therapy

Aditya Barve, PhD¹, Mahmoud Dabbah, PhD², Emilia Kooienga¹^*, Esther A. Obeng, MD, PhD³, Jacquelyn Myers³^*, Akshay Sharma, MBBS⁴ and Shannon McKinney-Freeman, PhD¹

¹Hematology, St. Jude Children's Research Hospital, Memphis, TN
²Retro Biosciences, San Francisco, CA
³Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis

10:15 AM

Cytotoxic Stress Transiently Increases the Contribution of Platelet-Biased Hematopoietic Stem Cells to Platelet Production

Yiran Meng¹, Xiying Ren, PhD¹^*, Rong Li, PhD^1,2^*, Bowen Zhang¹^* and Claus Nerlov, PhD¹^*

¹Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
²Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, United Kingdom

10:30 AM

Megakaryocytes Direct CD4⁺ T Cell Responses Via Major Histocompatibility Complex Class II Antigen Presentation

Virginia Camacho, PhD^1,2, Karen Guo¹^*, Pavel Hanc, PhD³^*, Estelle Carminita, PhD¹^*, Isabelle C. Becker, PhD², Em Harrington, MD, PhD⁴^*, Joseph E. Italiano, PhD^1,2 and Kellie R. Machlus, PhD^1,5

¹Boston Children's Hospital, Boston, MA
²Harvard Medical School, Boston, MA
³Immunology, Harvard Medical School, Boston, MA
⁴Neurology, Wexner Medical Center, Columbus, OH
⁵Boston Children's Hospital and Harvard Medical School, Boston, MA

10:45 AM

Distinct Cellular, Transcriptional, and Mechanistic Properties Determine HSC Fate during Emergency Granulopoiesis

Karolina Vanickova^1,2^*, Mirko Milosevic³^*, Irina Ribeiro Bas^1,2^*, Monika Burocziova, Ph.D.¹^*, Asumi Yokota, PhD⁴^*, Petr Danek, Ph.D.¹^*, Srdjan Grusanovic, Ph.D.¹^*, Mateusz Chiliński^5,6^*, Dariusz Plewczynski, Ph.D.^5,6^*, Jakub Rohlena, Ph.D.³^*, Hideyo Hirai, Ph.D.⁷^*, Katerina Rohlenova, Ph.D.³^* and Meritxell Alberich Jorda, Ph.D.^1,8^*

¹Laboratory of Hemato-oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague 4, Czech Republic
²Faculty of Science, Charles University, Prague, Czech Republic
³Institute of Biotechnology of the Czech Academy of Sciences, Prague-West, Czech Republic
⁴Laboratory of Stem Cell Regulation, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
⁵Laboratory of Bioinformatics and Computational Genomics, Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland
⁶Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw, Warsaw, Poland
⁷Laboratory of Stem Cell Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
⁸Childhood Leukaemia Investigation Prague, Department of Pediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague, University Hospital Motol, Prague, Czech Republic

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^*signifies non-member of ASH

501.O1.6 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Inflammation, Metabolism, and Stress