65th ASH Annual Meeting & Exposition: 322. Disorders of Coagulation or Fibrinolysis: Clinical and Epidemiological: Out of the Box: Acquired, Vascular and Other Neglected Bleeding Disorders

Symposia: Disorders of Coagulation or Fibrinolysis: Clinical and Epidemiological Oral and Poster Abstracts
Oral

Research, clinical trials, Bleeding and Clotting, bleeding disorders, autoimmune disorders, Antibody Therapy, Biological therapies, adult, epidemiology, Clinical Practice (Health Services and Quality), hemophilia, Non-Biological therapies, elderly, Clinical Research, health outcomes research, Chemotherapy, Combination therapy, Diseases, Immune Disorders, Therapies, Infusion, young adult , Study Population, Human

Room 30 (San Diego Convention Center)

Moderators:

Lauren Amos, MD, Children's Mercy Kansas City and Bethany T. Samuelson Bannow, MD, MCR, Oregon Health and Science University

Disclosures:

Amos: Midwest Hemophilia Association: Honoraria; Sanofi: Honoraria, Speakers Bureau; HEMA Biologics: Honoraria; Genentech: Honoraria. Samuelson Bannow: HemaBiologics: Membership on an entity's Board of Directors or advisory committees.

9:30 AM

Reduced Vitamin C Levels in Patients with Bleeding of Unknown Cause and Generalized Joint Hypermobility

Halla Fridriksdottir, Medical student¹^*, Andreas Ørslev Rasmussen, Computational biologist M. Sc.²^*, Jens Lykkesfeldt, Professor PhD, DMSc³^*, Maria Rossing, MD Phd²^* and Eva Birgitte Leinoe, MD Phd^1,2^*

¹Dept. of Hematology, Rigshospitalet, Copenhagen, Denmark
²Genomic Medicine, Rigshospitalet, Copenhagen, Denmark
³LIFEPHARM Center, Copenhagen University, Faculty of Health Sciences, Copenhagen, Denmark

9:45 AM

Epidemiology, Outcomes, and 30-Day Readmissions in Acquired Hemophilia

Aditi Sharma¹, Aditya Sharma²^* and Vijendra Singh³

¹Department of Hematology and Oncology, Karmanos Cancer Institute / Wayne State University, Detroit, MI
²Wayne State University School of Medicine, Detroit, MI
³Karmanos Cancer Institute/Wayne State University/Department of Hematology-Oncology, Detroit, MI

10:00 AM

Comprehensive Characterization of Coagulation Parameters in Venous Malformations

Valentina Restrepo, MD¹^*, Alexander B Pine, MD, PhD², Ayesha Butt, MD³, Eric Y Chang, MD^4,5, Noffar Bar, MD⁶, Audrey Baluha, RN⁷^*, Andrea Brooks, RN⁷^*, Giavanna Chirico, MMSc³^*, Jeffrey Curran, APRN⁸^*, Anne Dumont, RN⁹^*, Pauline Obura-Wilkes, RN⁷^*, Henry M Rinder, MD¹⁰, Christopher Tormey, MD⁵^*, Naiem Nassiri, MD^11,12,13,14^*, Alfred I Lee, MD, PhD¹⁵ and Stephanie Prozora, MD^16,17

¹Section of Hematology, Yale University School of Medicine, New Haven, CT
²Department of Hematology, Yale University School of Medicine/Connecticut VA, West Haven, CT
³Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT
⁴Classical Hematology, Section of Hematology, Yale University School of Medicine, New Haven, CT
⁵Yale University School of Medicine, New Haven, CT
⁶Department of Internal Medicine, Section of Hematology, Yale University School of Medicine and Yale Cancer Center, Cheshire, CT
⁷Department of Hematology, Yale New Haven Hospital, New Haven, CT
⁸Department of Vascular Surgery, Yale New Haven Hospital, New Haven, CT
⁹Yale New Haven Hospital, New Haven, CT
¹⁰Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT
¹¹Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT
¹²The Aortic Institute at Yale New Haven Hospital, Yale New Haven Hospital, New Haven, CT
¹³Director, Vascular Malformations Program (VaMP), Yale New Haven Hospital, New Haven, CT
¹⁴Vascular & Endovascular Surgery Department, Veteran's Affairs Connecticut Healthcare System, West Haven, CT
¹⁵Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT
¹⁶Department of Pediatric Hematology & Oncology, Yale University School of Medicine, New Haven, CT
¹⁷Yale University, New Haven, CT

10:15 AM

Hereditary Hemorrhagic Telangiectasia May be the Most Clinically Significant and Morbid Inherited Bleeding Disorder of Women

Ellen Zhang, MD¹^*, Zain Virk, MD²^*, Josanna Rodriguez-Lopez, MD³^* and Hanny Al-Samkari, MD⁴

¹Department of Medicine, Stanford University Medical Center, Palo Alto, CA
²Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
³Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA
⁴Division of Hematology Oncology, Massachusetts General Hospital, Boston, MA

10:30 AM

Characterization of Joint Disease in Women with Hemophilia: The Carriers Ultrasound Project (CUP) Study

Rachel S. Kronenfeld, MD¹, Kelli Fraga, DPT²^*, Maria D'Almeida Bastos, MD³^*, Amina Rafique, MD⁴^*, Christine Kempton, MD⁵, Joanna Davis, MD⁶ and Fernando F Corrales-Medina, MD^7,8

¹Division of Pediatric Hematology/Oncology, University of Miami/Jackson Memorial Hospital, Miami, FL
²Hemophilia Treatment Center, University of Miami, Miami, FL
³Department of Radiology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, FL
⁴Division of Pediatric Hematology/Oncology, Tulane University School of Medicine, New Orleans, LA
⁵Emory University, Atlanta, GA
⁶Pediatric Hemophilia Treatment Center, University of Miami, Miami, FL
⁷University of Miami-Hemophilia Treatment Center, Miami, FL
⁸Division of Pediatric Hematology-Oncology, University of Miami-Miller School of Medicine-Sylvester Cancer Center, Miami, FL

10:45 AM

Surgical Procedures and Hemostatic Outcome in Patients with Hemophilia Receiving Concizumab Prophylaxis during the Phase 3 explorer7 and explorer8 Trials

Anthony KC Chan, MBBS¹, Chris Barnes²^*, Mary Mathias³^*, Silvia Linari⁴^*, Francisco Jose Lopez Jaime, MD⁵^*, Lone Hvitfeldt Poulsen⁶^*, Julien Bovet⁷^*, Jan Odgaard-Jensen⁷^* and Tadashi Matsushita⁸

¹Mc Master Children’s Hospital, McMaster University, Hamilton, ON, Canada
²The Royal Children's Hospital, Parkville, VIC, Australia
³Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
⁴Center for Bleeding Disorders and Coagulation, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
⁵Thrombosis and Hemostasis Unit, Hospital Universitario Regional de Málaga-IBIMA, Malaga, Spain
⁶The Haemophilia Center, Department of Haematology, Aarhus University, Aarhus, Denmark
⁷Novo Nordisk, Søborg, Denmark
⁸Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan

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^*signifies non-member of ASH

322.O2.6 322. Disorders of Coagulation or Fibrinolysis: Clinical and Epidemiological: Out of the Box: Acquired, Vascular and Other Neglected Bleeding Disorders