65th ASH Annual Meeting & Exposition: 603. Lymphoid Oncogenesis: Basic: Mechanisms of Acute Lymphoblastic Leukemia Development and Progression

Symposia: Lymphoid Oncogenesis: Basic Oral and Poster Abstracts
Oral

Research, Fundamental Science, Lymphoid Leukemias, ALL, Translational Research, Diseases, Lymphoid Malignancies

Marriott Grand Ballroom 11-13 (Marriott Marquis San Diego Marina)

Moderators:

Joao T Barata, PhD, Instituto de Medicina Molecular João Lobo Antunes and Valentina Serafin, PhD, University of Padova

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

CXCR3/CXCL10 Signaling Pathway Drives T-ALL into the CNS/Meningeal Microenvironment

Nitesh D. Sharma, PhD¹^*, Esra'a Keewan²^*, Wojciech Ornatowski¹^*, Monique Nysus²^*, Silpita Paul¹^*, Quiteria Jacquez²^*, Bianca L. Myers²^*, Huining Kang²^*, Katherine E. Zychowski²^*, Stuart S Winter³^*, Stephen P. Hunger, MD⁴, Mignon L. Loh, MD⁵, Eliseo Castillo⁶^*, Tou Vue⁶^*, Nicholas Jones, PhD, BSc⁷^*, Panagiotis Ntziachristos, PhD⁸ and Ksenia Matlawska-Wasowska, PhD¹

¹University of Alabama at Birmingham, Birmingham, AL
²University of New Mexico Health Sciences Center, Albuquerque, NM
³Children's Minnesota, Minneapolis, MN
⁴Childrens Hospital of Philadelphia, Philadelphia
⁵Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Seattle, WA
⁶University of New Mexico Health Sciences Center, Albuquerque
⁷Swansea University Medical School, Swansea, GBR
⁸Ghent University, Corneel Heymanslaan 10, Ghent, Belgium

9:45 AM

Dependence of IL-7R-Mediated Signaling on Sphingosine Kinase Activity in Acute Lymphoblastic Leukemia, but Not Healthy Lymphoid Cells, Is an Exploitable Therapeutic Vulnerability

Marta B Fernandes, MSc¹^*, Alice Melão, PhD²^*, Tatiana Araújo, MSc²^*, Ana Cachucho, MSc²^*, David R Adams, PhD³^*, Jeongah Oh, PhD⁴^*, Afonso R M Almeida, PhD²^*, Federico Torta, PhD⁴^*, Vasco Barreto, PhD⁵^*, Susan Pyne, PhD³^*, Timothy Hla, PhD⁶^*, Nigel J Pyne, PhD³^* and Joao T Barata, PhD⁷^*

¹Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, American Samoa
²Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
³Strathclyde Institute For Biomedical Sciences, Glasgow, United Kingdom
⁴National University of Singapore, Singapore, Singapore
⁵Chronic Diseases Research Center, Lisbon, Portugal
⁶Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA
⁷Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Lisbon, Portugal

10:00 AM

Regulation of Alternative Splicing in B-Cell ALL By DYRK1A

Qi Jin, PhD¹, Ethan Harris, MD²^*, Jacquelyn A. Myers³^*, Anitria Cotton, MBA, BS⁴^*, Jeremy Wen⁵, Johanna Melo-Cardenas, PhD²^*, Akihide Yoshimi, MD, PhD⁶^*, Omar Abdel-Wahab, MD⁷, Esther A. Obeng, MD, PhD³ and John D. Crispino, PhD, MBA⁵

¹St. Jude Children’s Research Hospital, Memphis, TN
²St. Jude Children's Research Hospital, Memphis, TN
³Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁴Division of Experimental Hematology, St Jude Children's Research Hospital, Memphis, TN
⁵Division of Experimental Haematology, St Jude Children's Research Hospital, Memphis, TN
⁶National Cancer Center Research Institute, Tokyo, Japan
⁷Memorial Sloan Kettering Cancer Center, New York, NY

10:15 AM

Sustained MYB Activity Is Necessary for Oncogenic Transcription in KMT2A-Rearranged Acute Lymphoblastic Leukemia through Enhancer-Promoter Interactions and Epigenetic Modifications at Enhancers

I-Jun Lau, DPhil, BMBCh¹^*, Joe R Harman, PhD²^*, Nicole E Jackson²^*, Nicholas Denny, BA, BMBS, MRCP²^*, Alastair L Smith²^*, Paresh Vyas, FMedSci, DPhil, FRCPath^2,3^*, James Oliver Davies, FRCPath, MRCP²^*, Jim Hughes, BSc, PhD⁴^*, Nicholas Crump, PhD⁵^* and Thomas Arthur Milne²

¹MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Abingdon, United Kingdom
²MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
³Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁴Centre for Computational Biology, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁵Hugh & Josseline Langmuir Centre for Myeloma Research Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom

10:30 AM

SIRT5 Regulates Energy Metabolism and Survival in Acute Lymphoblastic Leukemia Cells

Nataly Cruz-Rodriguez, PhD¹, Dongqing Yan, PhD²^*, Briana Bates, MS¹^*, Daniela Uribe-Cano¹^*, Tony Pomicter, MS³^* and Michael Deininger, MD, PhD¹

¹Versiti Blood Research Institute, Milwaukee, WI
²InCyte, Wilmington, DE
³The University of Utah, Salt Lake City, UT

10:45 AM

Transient Differentiation-State Plasticity during Initiation of Pediatric Acute Lymphoblastic Leukemia

Vera M Poort, MSc^1,2^*, Rico Hagelaar, MSc^1,2^*, Mark van Roosmalen^1,2^*, Laurianne Trabut, MSc^1,2^*, Jessica G.C.A.M. Buijs-Gladdines²^*, Diego Montiel González, MSc^1,2^*, Bram van Wijk, MD, PhD³^*, Jules P.P. Meijerink, PhD^2,4 and Ruben Van Boxtel, PhD^1,2^*

¹Oncode Institute, Utrecht, Netherlands
²Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
³Department of Pediatric Cardiothoracic Surgery, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, Netherlands
⁴Acerta-Pharma B.V., Oss, Netherlands

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^*signifies non-member of ASH

603.O2.6 603. Lymphoid Oncogenesis: Basic: Mechanisms of Acute Lymphoblastic Leukemia Development and Progression