65th ASH Annual Meeting & Exposition: 321. Coagulation and Fibrinolysis: Basic and Translational: Coagulation Protein: Molecular Insights and Molecular Therapies

Symposia: Coagulation and Fibrinolysis: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Bleeding and Clotting, bleeding disorders, Biological therapies, Antibody Therapy, Translational Research, hemophilia, drug development, Diseases, thrombotic disorders, Therapies, VWD

Room 33 (San Diego Convention Center)

Moderators:

Nicola Pozzi, PhD, Saint Louis University and David Gailani, MD, Vanderbilt University

Disclosures:

Gailani: Anthos Therapetuics: Consultancy, Honoraria; Aronora: Consultancy, Membership on an entity's Board of Directors or advisory committees, Patents & Royalties: Factor XI and factor XII inhibitors; Bristol-Myers Squibb: Consultancy, Honoraria; Ionis: Consultancy, Honoraria; Janssen: Consultancy, Honoraria.

We have designed an exciting session with the highest scoring abstracts submitted under "Coagulation and Fibrinolysis: Basic and Translational". Presentations will cover a wide range of techniques and proteins that should excite most scientists and clinicians working in the coagulation field.

9:30 AM

Tissue Factor Pathway Inhibitor (TFPI) Beta and Gamma Isoforms Contribute to Bleeding in Hemophilia Mice

Thomas J. Girard, PhD^*, Irem Eldem, MD, Lilian Antunes Heck, PhD^*, Renumathi Subramanian^*, Nina M. Lasky^*, Katrina Ashworth^* and Jorge Di Paola, MD

Department of Pediatrics, Washington University School of Medicine, St Louis, MO

9:45 AM

1228

Incorporation of O-Glycopeptides into FVIII Decreases Its Immunogenicity

Meng-Ni Fan, PhD¹^*, Matthew Chrzanowski, PhD²^*, Amber Vander Kooi¹^*, Tangliang Shen³^*, Rodney M. Camire, PhD⁴, Xiaohe Cai¹^*, Ting-Yen Chao¹^*, Junping Zhang, PhD²^*, Barbara A. Konkle, MD^5,6, Carol H. Miao, PhD^1,5, Lei Li, PhD³^* and Weidong Xiao, PhD²^*

¹Seattle Children's Research Institute, Seattle, WA
²Indiana University, Bloomington, IN
³Georgia State University, Atlanta, GA
⁴The Children's Hospital of Philadelphia, Philadelphia, PA
⁵University of Washington, Seattle, WA
⁶Washington Center For Bleeding Disorders, Seattle, WA

10:00 AM

Evolution Directed Gene Engineering (EDGE) Identifies Single Amino Acid Substitutions in FVIII with Six-Fold Increased in Vitro and In Vivo Activity

Lucas Van Gorder¹^*, Reilly Peng¹^*, Julia Chau¹^* and Ben J Samelson-Jones, MD, PhD²

¹The Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Hematology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA

10:15 AM

Design of a Superior Factor VIIIa Mimetic By Coupling a Membrane Binding Domain to a Factor IXa Binding Antibody Fragment

Shekhar Kumar, PhD^1,2 and Sriram Krishnaswamy, PhD^1,2

¹Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA
²Pediatrics, University of Pennsylvania, Philadelphia, PA

10:30 AM

First Validated Model of Zymogen Factor XII Provides Insights into Protein Assembly and Activation

Aleksandr Shamanaev, PhD¹, Mao-Fu Sun, BSc¹^*, Michal Ponczek, PhD²^*, Jonas Emsley, PhD³^* and David Gailani, MD⁴

¹Vanderbilt University Medical Center, Nashville, TN
²University of Lodz, Lodz, Poland
³University of Nottingham, Nottingham, United Kingdom
⁴Department of Pathology, Immunology and Microbiology, Vanderbilt University Medical Center, Nashville, TN

10:45 AM

A Mutation in Complement Factor H (W1183R) Enhances VWF Proteolysis By ADAMTS13 Under Shear

Wenjing Cao, MD, PhD¹, Yi Liu, Ph.D.²^*, X. Frank Zhang, Ph.D.²^* and X. Long Zheng, MD, PhD^1,3

¹Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS
²Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA
³Institute for Reproductive Medicine and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS

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^*signifies non-member of ASH

321.O1.6 321. Coagulation and Fibrinolysis: Basic and Translational: Coagulation Protein: Molecular Insights and Molecular Therapies