Deena Iskander, MD^1*, Guanlin Wang, PhD^2*, Elisabeth F Heuston, PhD^3*, Chrysi Christodoulidou^1*, Bethan Psaila, MD⁴, Mark E Robinson, PhD^1*, Aristeidis Chaidos, MD, PhD^1*, Pritesh Trivedi, MSc^5*, Nikolaos Trasanidis, PhD^1*, Alexia Katsarou, MD^1*, Richard Szydlo, PhD^6*, NISC Comparative SequencingProgram^7*, Qais Al-Oqaily, MD, PhD^6*, Valentina S Caputo, PhD^1*, Kanagaraju Ponnusamy, PhD^1*, Anindita Roy, MD, PhD⁸, Leena Karnik, FRCPath, MRCP^9*, Kikkeri Naresh, MD^5*, Adam J. Mead, MD, PhD⁴, Supat Thongjuea, PhD^2*, Marjorie Brand, PhD^10*, Josu de la Fuente^6,11, David M Bodine, PhD³, Irene Roberts, MD, PhD¹² and Anastasios Karadimitris, MD, PhD^1*

¹Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
²MRC WIMM Centre for Computational Biology, University of Oxford, U.K, Oxford, United Kingdom
³NHGRI, National Institutes of Health, Bethesda, MD
⁴MRC Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
⁵Department of Histopathology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
⁶Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
⁷NHGRI, Bethesda
⁸Department of Paediatrics, University of Oxford, Oxford, United Kingdom
⁹Department of Paediatrics, St. Mary's Hospital, London, United Kingdom
¹⁰Ottawa Hospital Research Institute, Ottawa, ON, Canada
¹¹Department of Paediatrics, St. Mary's Hospital/Imperial College London, London, United Kingdom
¹²Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, United Kingdom

Marcus A Florez, BS^1,2, Katie A Matatall, PhD^1,3,4,5*, Youngjae Jeong, PhD^6*, Laura Ortinau, PhD^7*, Paul Shafer, BS^8*, Anne Lynch, BS^9*, Roman Jaksik, PhD^10*, Marek Kimmel, PhD, DSc^10*, Dongsu Park, PhD^7,11* and Katherine Y. King, MD, PhD^1,2,4,11

¹Pediatric Infectious Diseases, Baylor College of Medicine, Houston, TX
²Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX
³Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX
⁴Stem Cells and Regenerative Medicine Center/Pediatric Infectious Diseases, Baylor College of Medicine, Houston, TX
⁵Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX
⁶Human and Molecular Genetics, Baylor College of Medicine, Houston, TX
⁷Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
⁸Immunology, Baylor College of Medicine, Houston, TX
⁹Developmental Biology, Baylor College of Medicine, Houston, TX
¹⁰Department of Statistics, Rice University, Houston, TX
¹¹Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX

Fengkui Zhang^1*, Guangxin Peng^1*, Guangsheng He, MD, PhD^2*, Hong Chang^3*, Sujun Gao^4*, Xinjian Liu^5*, Tong Chen, MD, PhD⁶, Pei Li^7*, Bing Han^8*, Miao Miao^9*, Zheng Ge, MD, PhD¹⁰, Xiaoyan Ge^11*, Fei Li^12*, Yingmei Li^13*, Shunqing Wang^14*, Yi Wang, MD^15*, Yaqi Shen^16*, Yanfei Tai^16*, Tao Zhang^16*, Bo Zhu^16* and Jianjun Zou^16*

¹Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China
²Jiangsu Province Hospital, Nanjing, China
³West China Hospital of Sichuan University, Chengdu, China
⁴Jilin University, First Hospital of Bethune Medical, Changchun, China
⁵Henan Cancer Hospital, Zhengzhou, China
⁶Division of Hematology, Huashan Hospital of Fudan University, Shanghai, China
⁷Huashan Hospital Affiliated to Fudan University, Shanghai, China
⁸Peking Union Medical College Hospital, Beijing, China
⁹The First Affiliated Hospital of Suzhou University, Suzhou, China
¹⁰Zhongda Hospital Affiliated to Southeast University, Nanjing, China
¹¹The Second Hospital of Shanxi Medical University, Taiyuan, China
¹²The First Affiliated Hospital of Nanchang University, Nanchang, China
¹³The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
¹⁴Guangzhou First People's Hospital, Guangzhou, China
¹⁵Department of Hematology, Shaanxi Provincial People's Hospital, Xi'an, China
¹⁶Jiangsu Hengrui Medicine Co., Ltd, Shanghai, China

Burak Altintas, MD¹, Neelam Giri, MD², Lisa J. McReynolds, MD, PhD³ and Blanche P. Alter, MD, MPH¹

¹Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD
²Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
³NCI, National Institutes of Health, Bethesda, MD

Georgina L Ryland, PhD^1,2, Lucy C Fox, MBBS^1,2,3, Xiangting Chen, PhD^1*, Satwica Yerneni, MS^1*, Jeffrey Szer, MBBS⁴, Ashish Bajel, FRACP¹, Robin J Filshie, MBChB, PhD, FRACP, FRCPA⁵, Sue Morgan, FRACP, FRCPA, MBBS^6*, Sarah-Jane Dawson, MD, PhD^1,2* and Piers Blombery, MBBS^1,2,7*

¹Peter MacCallum Cancer Centre, Melbourne, Australia
²University of Melbourne, Melbourne, Australia
³Monash University, Melbourne, Australia
⁴Department of Clinical Haematology, Royal Melbourne Hospital, Melbourne, VIC, Australia
⁵St. Vincent's Hospital Melbourne, Melbourne, Australia
⁶Alfred Hospital, Melbourne, Australia
⁷Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia

Hind Alotaibi, MBBS¹, Mahmoud Aljurf², Regis Peffault De Latour, MD, PhD^3*, Shahid Iqbal^4*, Andrea Bacigalupo⁵, Judith Marsh⁶, Hubert Schrezenmeier⁷, Eliane Gluckman^8,9*, Mansour Alfayez^1*, Britta Hoechsmann^7*, Constantijn Halkes¹⁰, Josu de la Fuente¹¹, Nawal AlShehry^1*, Simone Cesaro^12*, Jakob Passweg^13*, Carlo Dufour¹⁴, Antonio Risitano, MD, PhD¹⁵, John F. DiPersio, MD¹⁶ and Ibraheem Motabi^1*

¹King Fahad Medical City, Riyadh, Saudi Arabia
²King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
³Saint-Louis Hospital, Paris, France
⁴Manchester Royal Infirmary, Manchester, United Kingdom
⁵Universita’ Cattolica del Sacro Cuore, Roma, Italy
⁶King’s College Hospital/King’s College London, London, United Kingdom
⁷University Hospital Ulm, Ulm, Germany
⁸Eurocord, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris, Université de Paris, Paris, France
⁹Monacord, Centre Scientifique de Monaco, Principauté de Monaco, Monaco, France
¹⁰Leiden University Medical Centre, Leiden, Netherlands
¹¹Imperial College Healthcare/Imperial College London, London, United Kingdom
¹²Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
¹³University Hospital Basel, Basel, Switzerland
¹⁴Hematology Unit, G Gaslini Children Research Hospital, Genova, Italy
¹⁵Hematology and BMT Unit, Moscati Hospital, Avellino, Italy
¹⁶Washington University School of Medicine, St. Louis, Missouri

Mark C Wilkes, PhD¹, Kavitha Siva, PhD^2*, Jacqueline D Mercado³, Ethan Patrick Wentworth^1*, Mallika Saxena^1*, Jun Chen, MD, PhD^2*, Anupama Narla, MD¹, Bertil Glader, MD, PhD¹, Shuo Lin, PhD^4*, Manuel Serrano, PhD^5*, Johan Flygare, MD, PhD² and Kathleen M. Sakamoto, MD, PhD¹

¹Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
²Molecular Medicine and Gene Therapy, Lund Strategic Center for Stem Cell Biology, Lund University, Lund, Sweden
³Michigan State University College of Human Medicine, East Lansing
⁴Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, Los Angeles, CA
⁵Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain

Adam Wahida^1*, Stephan Hutter, PhD^2*, Manja Meggendorfer, PhD², Cassandra M. Kerr, MS^3*, Carmelo Gurnari, MD^3*, Elisabeth Weiss, PhD^2*, Claudia Haferlach, MD², Wolfgang Kern, MD², Jaroslaw P. Maciejewski, MD, PhD⁴ and Torsten Haferlach, MD²

¹Torsten Haferlach Leukaemiediagnostik Stiftung, Munich, Germany
²MLL Munich Leukemia Laboratory, Munich, Germany
³Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Motoharu Hamada^1*, Hideki Muramatsu, MD, PhD², Yusuke Okuno, MD, PhD³, Ayako Yamamori, MD^4*, Taro Yoshida, MD^4*, Masayuki Imaya, MD^4*, Manabu Wakamatsu, MD^1*, Shunsuke Miwata, MD^1*, Kotaro Narita, MD, PhD^1*, Daisuke Ichikawa, MD^1*, Rieko Taniguchi, MD, PhD^1*, Atsushi Narita, MD, PhD^5*, Nozomu Kawashima, MD, PhD^1*, Eri Nishikawa, MD, PhD^1*, Nobuhiro Nishio, MD, PhD^1,6*, Asahito Hama, MD, PhD^7*, Masafumi Ito, MD, PhD^8*, Tomoo Ogi, Ph.D.^9*, Seiji Kojima, MD, PhD^1* and Yoshiyuki Takahashi, MD, PhD^1*

¹Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
²Nagoya University Graduate School of Medicine, Nagoya, Japan
³Medical Genomics Center, Nagoya University Hospital, Nagoya, Japan
⁴Pediatrics, Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁵Department of Pediatrics, Graduate School of Medicine, Nagoya University, Nagoya, Japan
⁶Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan
⁷Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
⁸Department of Pathology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
⁹Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan

Wei Zuo^1*, Bo Zhang^2*, Jing Ruan^3*, Miao Chen^4*, Jian Li, MD⁵ and Bing Han, MD/PhD^6*

¹Department of pharmacy, Perking Union Medical College Hospital, Beijing, China
²Department of pharmayc, Perking Union Medical College Hospital, Beijing, China
³Department of Hematology, Perking Union Medical College Hospital, Beijing, China
⁴Department of Hematology, Peking Union Medical Colleague Hospital, Beijing, CHN
⁵Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
⁶Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Irina N. Shipounova, PhD^1*, Alyona I. Dorofeeva^2*, Nikolay M. Kapranov^3*, Anton V. Luchkin, MD^3*, Zalina T. Fidarova, MD PhD^3*, Elena A Mikhailova, PhD, MD^4* and Valeriy G. Savchenko, MD, PhD⁵

¹Physiology of Hematopoiesis Lab, National Research Center for Hematology, Moscow, Russia
²Physiology of Hematopoiesis Lab, National Research Center for Hematology, Moscow, Russian Federation
³National Research Center for Hematology, Moscow, Russian Federation
⁴National Scientific Center for Hematology, Moscow, RUS
⁵National Research Center for Hematology, Moscow, Russian Federation, Moscow, Russian Federation

Amye M. Harrigan, BSc, MD^1*, Shelley MacDonald, MSc, CGC, CCGC^2*, Bruce N. Crooks, ChB, BSc, MRCPCH, MRCP(UK)^3*, Sarah Dyack, MD, FRCPC, FCCMG^2,4* and Amy M. Trottier, MSc, MD, FRCPC⁵

¹Department of Medicine, Dalhousie University, Saint John, NB, Canada
²Maritime Medical Genetics, IWK Health Centre, Halifax, NS, Canada
³Department of Pediatric Hematology/Oncology, IWK Health Centre, Halifax, NS, CAN
⁴Department of Pediatric Medical Genetics, IWK Health Centre, Halifax, NS, Canada
⁵Department of Hematology, QEII Health Science Centre, Halifax, NS, Canada

Daphna Nachmani^1*, Lourdes M. Mendez, MD, PhD² and Pier Paolo Pandolfi, MD, PhD³

¹Silberman Institute for Life Science, The Hebrew University, Jerusalem, Israel
²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
³Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA, Boston, MA