Yan Song, PhD^1*, Ting DU, PhD^2*, Arghya Ray, PhD², Krishan Chauhan^3*, Mehmet K. Samur, PhD⁴, Dharminder Chauhan, PhD² and Kenneth Anderson, MD⁵

¹Dana-Farber Cancer Institute, Harvard Medical School, Brookline, MA
²Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³Department of Biomedical Engineering, Wentworth Institute of Technology, Boston, MA
⁴The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁵Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Ryosuke Shirasaki, MD, PhD^1,2*, Sondra L. Downey-Kopyscinski, PhD^1,2*, Ricardo De Matos Simoes, PhD^1,2*, Olga Dashevsky^1,2*, Sara Gandolfi, MD^1,2*, Megan Bariteau, BSc^1,2*, Aviad Tsherniak, PhD^2*, Francisca Vazquez, Phd^2*, Maria Themeli, MD, PhD^3*, Jonathan D. Licht, MD⁴, Larry H. Boise, PhD⁵, Richard W.J. Groen, PhD³ and Constantine S. Mitsiades, MD, PhD^2,6

¹Dept. of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³University Medical Center Utrecht, Amsterdam, Netherlands
⁴Department of Medicine, University of Florida, Gainesville, FL
⁵Emory University, Atlanta, GA
⁶Dept. of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Brookline, MA

Linda B Baughn, PhD¹, Erik Jessen, PhD^2*, Matthew Smith^3*, Neeraj Sharma, PhD^4*, Joselle Cook, MBBS⁴, Surendra Dasari, PhD^2*, Kathryn E. Pearce, MS^5*, Nathalie Meurice, PhD^6*, Michael A. Linden, MD, PhD⁷, A. Keith Stewart, MB, ChB^6,8,9, P. Leif Bergsagel, MD⁹, Brian G. Van Ness, PhD¹⁰ and Shaji K. Kumar, MD¹¹

¹Division of Laboratory Genetics, Mayo Clinic, Rochester, MN
²Department of Health Sciences Research, Mayo Clinic, Rochester, MN
³Mayo Clinic, Rochester
⁴Mayo Clinic, Rochester, MN
⁵Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁶Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁷Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
⁸Center for Individualized Medicine, Mayo Clinic, Rochester, MN
⁹Division of Hematology, Mayo Clinic, Scottsdale, AZ
¹⁰Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN
¹¹Mayo Clinic Rochester, Division of Hematology, Rochester, MN

Cristina Panaroni, PhD¹, Keertik Fulzele, PhD^2*, Tomoaki Mori^3*, Chukwuamaka Onyewadume^3* and Noopur S. Raje, MD^3*

¹Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center, Cambridge, MA
²Forma Therapeutics, Inc., Watertown, MA
³Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center, Boston, MA

Joaquin Martinez Lopez^1*, Rafael Alonso Fernández^2*, Sandy W. Wong, MD³, Rafael Rios, MD, PhD^4*, Nina Shah, MD⁵, Maria Teresa Cedena Romero, MD, PhD^6,7*, Yanira Ruiz-Heredia^8*, Jose M. Sanchez, MD^9*, Santiago Barrio Garcia, PhD^10*, Thomas Martin III, MD¹¹ and Jeffrey L. Wolf, MD¹¹

¹Department of Medicine, Division of Hematology-Oncology, University of Califarnia San Francisco, San Francisco
²Translational Hematology Group, Hospital 12 de Octubre-CNIO, Madrid, Spain
³Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA
⁴Servicio de Hematología y Hemoterapia, Hospital Universitario Virgen de las Nieves, Granada, Spain
⁵Associate Professor of Medicine, University of California San Francisco, San Francisco, CA
⁶Hospital 12 de Octubre, Madrid, Spain
⁷Department of Hematology, Hospital Universitario 12 de Octubre, CNIO, Madrid, Spain
⁸Hematology, Hospital Universitario 12 de Octubre, CNIO, Complutense, Madrid, Spain
⁹Hospital 12 de Octubre, Madrid, ESP
¹⁰Hematology, Hospital 12 de Octubre. CNIO, Madrid, Spain
¹¹University of California, San Francisco, San Francisco, CA

Arghya Ray, PhD¹, Ting DU, PhD^1*, Yan Song, PhD^2*, Sara J Buhrlage, PhD^3*, Dharminder Chauhan, PhD¹ and Kenneth Anderson, MD⁴

¹Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Dana-Farber Cancer Institute, Harvard Medical School, Brookline, MA
³Biological Chemistry & Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁴The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Yuting Yan^1*, Xiaoqi Qin^2,3*, Lanting Liu^4*, Shuhui Deng, MD^1*, Jiahui Liu^1*, Huishou Fan^1*, Weiwei Sui, MD^5*, Fu Mingwei, MD^5*, Xue-Han Mao, MD^6*, Zhen Yu, MD^7*, Dehui Zou, MD^1*, Lugui Qiu, MD¹ and Gang An, MD, PhD^1*

¹National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, China
³State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science, Tianjin, China
⁴Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical S, Tianjin, China
⁵State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin City, China
⁶Institute of Hematology & Blood Diseases Hospital, TIANJIN, China
⁷State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Urvi A Shah, MD¹, Sæmundur Rögnvaldsson, BS^2*, Andriy Derkach, PhD^3*, Magnus Björkholm, MD, PhD⁴, Ingemar Turesson, MD, PhD⁵, Yael David, PhD^6*, Malin Hultcrantz, MD, PhD¹, Carlyn Tan, MD¹, Hani Hassoun, MD¹, Neha Korde, MD¹, Alexander M. Lesokhin, MD¹, Sham Mailankody, MBBS⁷, Sigurður Yngvi Kristinsson, MD, PhD^8,9 and Ola Landgren, MD, PhD¹

¹Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²Faculty of Medicine, University of Iceland, Reykjavík, Iceland
³Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Medicine, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
⁵Department of Hematology, Skane University Hospital, Malmö, Sweden
⁶Memorial Sloan Kettering Cancer Center, New York, NY
⁷Cellular Therapeutics Center, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden
⁹Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Christopher T Su, MD¹, Liying Chen, MS^2*, Jason Chen, MD¹, Brian Parkin, MD³, Avery Polk^1*, Malathi Kandarpa, PhD^1*, Craig E. Cole, MD⁴, Erica Campagnaro, MD^1*, Josh Vo, PhD^5*, Dan Robinson, PhD^6*, Yi-Mi Wu, PhD^6*, Moshe Talpaz, MD¹, Jennifer Yesil, MSc^7*, Daniel Auclair⁷, P. Leif Bergsagel, MD⁸, Arul Chinnaiyan, MD PhD^6*, Veerabhadran Baladandayuthapani, PhD^2* and J Christine Ye, MD, MSc¹

¹University of Michigan Medical Center, Ann Arbor, MI
²Department of Biostatistics, University of Michigan, Ann Arbor, MI
³VA Ann Arbor Healthcare System, Ann Arbor, MI
⁴Division of Hematology Oncology, Michigan State University, Lansing, MI
⁵Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI
⁶Department of Pathology, University of Michigan, Ann Arbor, MI
⁷Multiple Myeloma Research Foundation (MMRF), Norwalk, CT
⁸Division of Hematology, Mayo Clinic, Scottsdale, AZ

Yan Xie^1*, Chengcheng FU, MD, PhD^1*, Lingzhi Yan, MD, PhD^1*, Song Jin, MD^1*, Jingjing Shang, MD^1*, Xiaolan Shi, MD, PhD^1*, Jinlan Pan, MD^1*, Yan Yin, MS^2*, Tingting Mao, MS^2*, Jing Deng, PhD², Douglas D. Fang, MD, PhD^2*, Dajun Yang, MD, PhD^2*, Yifan Zhai, MD, PhD^2*, Shuang Yan, MD^1*, Yingying Zhai, MD^1*, Ying Yao, MD^1*, Panfeng Wang, MD^1*, Jing Wang, MD^1* and Depei Wu, MD, PhD¹

¹The First Affiliated Hospital of Soochow University, National Clinical Research Center for Hematologic Diseases (Suzhou), Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China
²Ascentage Pharma (SuZhou) Co., Ltd, Suzhou, China

Chenxing Du, MD^1*, Xue-Han Mao, MD^2*, Jiahui Liu^3*, Huishou Fan^3*, Weiwei Sui, MD^2*, Shuhui Deng, MD^3*, Shuhua Yi, MD^4*, Wenyang Huang^3*, Yan Xu^2*, Chengwen Li^4*, Jiawei Zhao^4*, Dehui Zou, MD^4*, Yaozhong Zhao^4*, Jianxiang Wang, MD⁵, Lugui Qiu, MD³ and Gang An, MD, PhD^2*

¹National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin City, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin City, China
³National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, TIANJIN, China
⁵State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Patrick Mellors¹, Surendra Dasari, PhD^2*, Mindy Kohlhagen^3*, Bonnie Kaye Arendt^3*, Morie Gertz⁴, Shaji K. Kumar, MD⁴, Francis K. Buadi, MB, CHB^4*, Maria Alice V. Willrich, PhD^3*, John A. Lust, MD, PhD⁵, Prashant Kapoor, MD⁴, Martha Q. Lacy, MD⁴, David Dingli, MD, PhD⁴, Yi L. Hwa, NP⁵, Amie Fonder, PA-C, MS^5*, Miriam A. Hobbs, APRN, CNP, DNP^5*, Suzanne R. Hayman, MD⁵, Taxiarchis Kourelis, MD⁴, Rahma M Warsame, MD⁶, Eli Muchtar, MD^4*, Nelson Leung, MD⁵, Ronald S. Go, MD⁷, Yi Lin, MD, PhD⁵, Wilson I Gonsalves, MD⁴, Mustaqeem Siddiqui, MD^5*, Robert A. Kyle, MD⁴, S. Vincent Rajkumar, MD⁴, David L. Murray, MD, PhD^3* and Angela Dispenzieri, MD^5*

¹Department of Internal Medicine, Mayo Clinic, Rochester, MN
²Department of Health Sciences Research, Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Mayo Clinic Rochester, Division of Hematology, Rochester, MN
⁵Division of Hematology, Mayo Clinic, Rochester, MN
⁶Mayo Clinic, Rochester, MN
⁷Mayo Clinic Rochester, Division of Hematology, Onalaska, WI

Federica Costa^1*, Rosanna Vescovini, PhD^1*, Laura Notarfranchi^1*, Paola Storti, PhD^1*, Valentina Marchica, MS^1*, Anna Benedetta Dalla Palma, MD^1,2*, Cristina Manferdini, BS^3*, Denise Toscani, PhD^1*, Rosalba Eufemiese, MS^1*, Jessica Burroughs, PhD^1*, Gina Lisignoli, PhD^4* and Nicola Giuliani^1,2

¹Department of Medicine and Surgery, University of Parma, Parma, Italy
²Hematology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
³Laboratory of Immunorheumatology and Tissue Regeneration, Istituto Ortopedico Rizzoli, Bologna, Italy
⁴Laboratory Immunorheumatology and Tissue Regeneration, Istituto Ortopedico Rizzoli, Bologna, Italy

Karen Sweiss, PharmD¹, Gregory Sampang Calip, PharmD, MPH, PhD^2*, Damiano Rondelli, MD³ and Pritesh Patel, MB, ChB³

¹Department of Pharmacy Practice, University of Illinois, Hinsdale, IL
²Department of Pharmacy Systems, Outcomes and Policy, University of Illinois at Chicago, Chicago, IL
³Division of Hematology/Oncology, University of Illinois, Chicago, IL

Subodh Kumar, PhD^1,2*, Srikanth Talluri, PhD^2,3*, Jiangning Zhao, PhD, MD^3*, Chengcheng Liao, PhD, MD^2,3*, Lakshmi B. Potluri, MBBS^2,3*, Leutz Buon^1*, Shidai Mu^4*, Jialan Shi, MD, PhD^2,3, Mychell Neptune-Buon^2,4*, Chandraditya Chakraborty, Ph D^3*, Yu-Tzu Tai, PhD³, Mehmet K. Samur, PhD³, Mariateresa Fulciniti, PhD³, Rao Prabhala^2,3, Masood A. Shammas, PhD^2,3* and Nikhil C. Munshi, MD^2,3,5

¹Dana Farber Cancer Institute, Boston, MA
²VA Boston Healthcare System, Boston, MA
³Dana-Farber Cancer Institute, Boston, MA
⁴Dana-Farber cancer institute, Boston, MA
⁵Harvard Medical School, Boston, MA

Alissa Visram, MD^1*, Eli Muchtar, MD², S. Vincent Rajkumar, MD³, Celine M. Vachon, PhD⁴, Angela Dispenzieri, MD⁵, Prashant Kapoor, MD³, Martha Q. Lacy, MD³, Francis K. Buadi, MB, CHB^3*, Suzanne R. Hayman, MD¹, Morie Gertz³, Robert A. Kyle, MD³ and Shaji K. Kumar, MD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Mayo Clinic Rochester, Division of Hematology, Saint Paul, MN
³Mayo Clinic Rochester, Division of Hematology, Rochester, MN
⁴Division of Epidemiology, Mayo Clinic, Rochester, MN
⁵Mayo Clinic, Rochester, MN

Ignacio Isola, MD^1*, David Moreno, MD^1*, Esther Moga, MD, PhD^2*, Mari-Pau Mena, PhD^1*, Natalia Tovar^1*, Luis Gerardo Rodríguez-Lobato, MD, PhD^1*, M. Teresa Cibeira, MD, PhD^1*, Laura Rosinol, MD, PhD^1*, Joan Bladé, MD, PhD^1* and Carlos Fernandez de Larrea, MD, PhD¹

¹Amyloidosis and Myeloma Unit. Department of Hematology. Hospital Clínic de Barcelona. IDIBAPS., Barcelona, Spain
²Department of Immunology. Hospital de la Santa Creu I Sant Pau, Barcelona, Spain

Ryosuke Shirasaki, MD, PhD^1*, Ricardo De Matos Simoes, PhD^1,2*, Shizuka Yamano^1,2*, Sondra L. Downey-Kopyscinski, PhD^1,2*, Brian Glassner, PhD^1,2*, Huihui Tang, PhD^1,2*, Vikas Gupta, MD, PhD^3*, Aviad Tsherniak, PhD^2*, Francisca Vazquez, Phd^2*, Jonathan D. Licht, MD⁴, Larry H. Boise, PhD³ and Constantine S. Mitsiades, MD, PhD^2,5

¹Dept. of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³Emory University, Atlanta, GA
⁴Department of Medicine, University of Florida, Gainesville, FL
⁵Dept. of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Brookline, MA

Luciano J. Costa, MD, PhD¹, Nicholas Burwick, MD², Andrzej Jakubowiak, MD, PhD³, Jonathan L. Kaufman, MD⁴, Fernando Cabanillas, MD⁵, Monique Dail, PhD^6*, Sudeep Karve^7*, Abdullah A. Masud, PhD^8*, Xiaoqing Yang, PhD^7*, Orlando F. Bueno⁷, Sarah Mudd, PhD^8*, Jeremy A. Ross^7* and Faith E. Davies⁹

¹Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL
²Department of Hospital and Specialty Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA
³University of Chicago Medicine, Chicago, IL
⁴Winship Cancer Institute of Emory University, Atlanta, GA
⁵Auxilio Mutuo Cancer Center, San Juan, PR
⁶Genentech Inc., South San Francisco, CA
⁷AbbVie, Inc., North Chicago, IL
⁸AbbVie Inc., North Chicago, IL
⁹Perlmutter Cancer Center, NYU Langone Health, New York, NY

Ana Jimenez-Ubieto^1*, Bruno Paiva, PhD^2*, Joaquin Martinez Lopez^3,4*, María Teresa Cedena, MD^5*, Noemi Puig, MD, PhD^6*, Albert Oriol, MD^7*, Maria Jesús Blanchard, MD^8*, Rafael Rios, MD, PhD^9*, Lucia Lopez-Anglada, PhD^10*, Jesús Martín^11*, Rafael Martínez^12*, Anna Sureda Balari, MD, PhD^13*, Miguel Hernández^14*, Javier de la Rubia^15,16*, Isabel Krsnik, MD, PhD^17*, Valentin Cabañas, MD^18*, Luis Palomera, MD, PhD^19*, Joan Bargay, MD^20*, Jose Maria Moraleda, MD, PhD^21*, Laura Rosinol, MD, PhD^22*, María-Victoria Mateos, MD, PhD²³, Jesus F. San-Miguel, MD, PhD²⁴, Joan Bladé, MD, PhD²⁵ and Juan-José Lahuerta, MD, PhD^26*

¹Hematology, Hospital 12 de Octubre. Madrid, Madrid, Spain
²Clinica Universidad De Navarra, Pamplona, Navarra, Spain
³Hospital Universitario 12 de Octubre, Madrid, Spain
⁴Hematology Department Hospital 12 de Octubre, Complutense University, H12O-CNIO Clinical research unit, CIBERONC, Madrid, Spain
⁵Hematology Department, Hospital Universitario 12 de Octubre,, Madrid, Spain
⁶Hospital Universitario de Salamanca Hematología. Instituto de investigación biomédica de Salamanca (IBSAL), Salamanca, Spain
⁷Institut Català d’Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Barcelona, Spain
⁸Hematology and Hemotherapy Department, Hospital Universitario Ramón y Cajal, Madrid, Spain
⁹Hospital Universitario Virgen de las Nieves de Granada, Granada, Spain
¹⁰Hospital 12 de Octubre, Madrid, Spain
¹¹Hospital Virgen del Rocío, Sevilla, Spain
¹²Hospital Clínico San Carlos, Madrid, Spain
¹³Hematology Department, Institut Català d'Oncologia Hospitalet, Barcelona, Spain
¹⁴Hospital Universitario De Canaria, La Laguna, ESP
¹⁵Hematology Department, Universidad Católica de Valencia Hospital Dr. Peset, Valencia, Spain
¹⁶Hematology Department, Internal Medicine, School of Medicine and Dentistry, Catholic University of Valencia, Valencia, Spain
¹⁷Hospital Universitario Puerta de Hierro, Madrid, Spain
¹⁸Hospital Virgen de la Arrixaca de Murcia, Murcia, Spain
¹⁹Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
²⁰Department of Hematology, Son Llatzer University Hospital/ IdISBa, Palma de Mallorca, Spain
²¹Hematopoietic Transplant and Cellular Therapy Unit, Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Virgen de la Arrixaca University Hospital, University of Murcia, Murcia, Spain, Murcia, Spain
²²Servicio de Onco-Hematología, Hospital Clínica de Barcelona, Barcelona, Spain
²³Institute of Cancer Molecular and Cellular Biology, University Hospital of Salamanca, Salamanca, Spain
²⁴Clinica Universidad de Navarra, Pamplona, Spain
²⁵Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain
²⁶Hospital 12 de Octubre, CIBERONC, Madrid, Spain

Maria Gavriatopoulou^1*, Andriani Boultadaki^2*, Vassilis Koutoulidis, MD^2*, Ioannis Ntanasis-Stathopoulos, MD^1*, Charis Bourgioti^2*, Panagiotis Malandrakis, MD^1*, Despina Fotiou, BMBS, MA^1*, Magdalini Migkou^3*, Nikolaos Kanellias, MD^1*, Evangelos Eleutherakis-Papaiakovou, MD^1*, Efstathios Kastritis, MD^4*, Evangelos Terpos, MD, PhD¹, Meletios A. Dimopoulos, MD¹ and Lia A. Moulopoulos, MD^2*

¹Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
²First Department of Radiology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
³National and Kapodistrian University of Athens, Athens, Greece
⁴National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

Carlotta Welters^1*, Meng-Tung Hsu^2*, Christian Alexander Stein^1*, Livius Penter^1,3*, María Fernanda Lammoglia Cobo^1*, Kerstin Dietze^1*, Eric Blanc^4*, Dieter Beule^4*, Lars Bullinger, MD¹, Julian Strobel^5*, Holger Hackstein^5*, Armin Gerbitz, MD PhD^6*, Klaus Dornmair^7*, Thomas Blankenstein^2,8,9,10* and Leo Hansmann^1,9,10*

¹Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
²Molecular Immunology and Gene Therapy, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston
⁴Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany
⁵Transfusion Medicine and Haemostaseology, Friedrich-Alexander-University Erlangen, Erlangen, Germany
⁶Hans Messner Allogeneic Transplant Program, Division of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada
⁷Institute of Clinical Neuroimmunology, Biomedical Center and Hospital of the LMU, Munich, Germany
⁸Institute of Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
⁹Berlin Institute of Health, Berlin, Germany
¹⁰Partner Site Berlin, German Cancer Consortium (DKTK), Berlin, Germany

Adam S Sperling, MD, PhD^1*, Rebecca Georgakopoulou, MSc^2*, Mehmet Kemal Samur, PhD^1*, Christine Ivy Liacos, MSc^2*, Brittany E Sandoval, MSc^1*, Flora Zagouri, MD^2*, Maria Gavriatopoulou^2*, Evangelos Eleutherakis-Papaiakovou, MD^2*, Magdalini Migkou^3*, Nikolaos Kanellias, MD^2*, Despina Fotiou, BMBS, MA^2*, Ioannis Ntanasis-Stathopoulos, MD^2*, Evangelos Terpos, MD, PhD², Efstathios Kastritis, MD^2*, Nikhil C. Munshi, MD¹ and Meletios A Dimopoulos⁴

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
³National and Kapodistrian University of Athens, Athens, Greece
⁴Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Alexandra General Hospital, Athens, Greece

Eileen M Boyle, MD, MSc^1,2, Louis Williams, MD, MBA², Patrick Blaney^3*, Cody Ashby, PhD^4*, Michael A Bauer, PhD⁵, Brian A Walker, PhD^6,7, Jinyoung Choi, PhD^8*, Jessica Caro, MD⁹, Beatrice Razzo, MD¹⁰, Arnaldo A. Arbini, MD^11*, David Kaminetzky, MD^12*, Marc Braunstein, MD, PhD¹³, Francesco Maura, MD¹⁴, Yubao Wang, PhD^15*, Ola Landgren, MD, PhD¹⁴, James Stoeckle, MD^16*, Kylee H Maclachlan, MBChB, PhD^14*, Rachel Litke^17*, Faith E. Davies² and Gareth Morgan, MD, PhD⁹

¹Myeloma Research Program, Perlmutter Cancer Center, NYU Langone Health, New York, NY
²Laura & Isaac Perlmutter Cancer Center, NEW YORK UNIVERSITY SCHOOL OF MEDICINE, New York, NY
³Perlmutter Cancer Center, NEW YORK UNIVERISITY, New York, NY
⁴Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR
⁵Department of Biomedical Informatics, University of Arkansas For Medical Sciences, Little Rock, AR
⁶Division of Hematology Oncology, Indiana University, Indianapolis, IN
⁷Indiana University, Division of Hematology Oncology, Indianapolis, IN
⁸Myeloma Research Program, Laura and Isaar Perlmutter Cancer Center, NEW YORK UNIVERSITY, New-York, NY
⁹Perlmutter Cancer Center, New York University Langone Health, New York, NY
¹⁰Myeloma Research Program, Laura and Isaac Perlmutter Cancer Center, NEW YORK UNIVERSITY, New-York, NY
¹¹NYU Langone Medical Center, New York, NY
¹²NYU Langone Health, New York, NY
¹³Division of Oncology-Hematology, NYU Long Island School of Medicine, NYU Winthrop Hospital, NYU Langone Health, Great Neck, NY
¹⁴Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁵Perlmutter Cancer Center,, Myeloma Research Program, New York, NY
¹⁶Perlmutter Cancer Center, NYU Langone Medical Center, Myeloma Research Program, New York, NY
¹⁷Icahn School of Medicine at Mount Sinai, New York, NY

Hadiyah Y. Audil, MD^1*, Joselle Cook, MBBS², Patricia Greipp, DO³, Prashant Kapoor, MD⁴, Linda B Baughn, PhD³, Angela Dispenzieri, MD², Morie A Gertz, MD², Francis K. Buadi, MB, CHB^2*, Martha Q. Lacy, MD², David Dingli, MD, PhD⁴, Amie Fonder, PA-C, MS^2*, Suzanne R. Hayman, MD², Miriam A. Hobbs, APRN, CNP, DNP^2*, Eli Muchtar, MD^2*, Mustaqeem A. Siddiqui, MD, MBA², Wilson I Gonsalves, MD⁴, Yi L. Hwa, NP², Nelson Leung, MD², Ronald S. Go, MD², Yi Lin, MD, PhD², Taxiarchis Kourelis, MD⁴, Rahma M Warsame, MD^2,4, John A. Lust, MD, PhD², Robert A. Kyle, MD⁵, Rhett P. Ketterling, MD^3*, S. Vincent Rajkumar, MD² and Shaji K. Kumar, MD²

¹Division of Internal Medicine, Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Mayo Clinic, Rochester, MN
⁵Mayo Clinic Rochester, Division of Hematology, Rochester, MN

Laura Notarfranchi^1*, Rosanna Vescovini, PhD^1*, Roberta Segreto, MS^2*, Sabrina Bonomini, MS^2*, Paola Storti, PhD^1*, Valentina Marchica, MS^1*, Federica Costa^1*, Gabriella Sammarelli, PhD^2*, Giannalisa Todaro, PhD^2*, Maria Teresa Catarozzo, MS^1*, Dario De Giovanni, MD^1*, Vincenza Fabiano, MD^1*, Anna Benedetta Dalla Palma, MD^1,2* and Nicola Giuliani^1,2

¹Department of Medicine and Surgery, University of Parma, Parma, Italy
²Hematology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

Meera Mohan, MD¹, Samantha Kendrick, PhD^2*, Yadav Pandey, MD^3*, Richa Parikh, MD^4*, Phil Farmer^4*, Mathew Kottarathara, MD^4*, Shadiqul Hoque, MD^4*, Angel Mitma, MD^4*, Sharmilan Thanendrarajan, MD⁴, Carolina D. Schinke, MD⁴, Guido Tricot, MD, PhD^4*, Maurizio Zangari, MD, FACP⁴ and Frits van Rhee, MD⁴

¹Clinical Cancer Center, Division of Hematology Oncology, Medical College of Wisconsin, Milwaukee, WI
²Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR
³Department of Hematology Oncology, University of Arkansas for Medical Sciences, Little Rock, AR
⁴Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR

Xue-Han Mao, MD^1*, Yan Xu, MD^2,3*, Yuting Yan^4*, Junling Zhuang, MD, PhD^5*, Huishou Fan^4*, Weiwei Sui^4*, Jiahui Liu^4*, Shuhui Deng, MD^4*, Shuhua Yi, MD^6*, Lugui Qiu, MD⁴ and Gang An^7*

¹Institute of Hematology & Blood Diseases Hospital, TIANJIN, China
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Institute of Hematology & Blood Diseases Hospital, Chinese Academic Medical Science & Peking Union Medical College, Tianjin, China
⁴National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁵Peking Union Medical Colleague Hospital, Nashville, TN
⁶National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Duarte, CA
⁷lymphoma and myeloma center, National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Isabel Cuenca, MSc^1*, Alejandro Medina, MD^2*, Laura Rosinol, MD, PhD^3*, Iria Vazquez, PhD, BSc^4,5*, Ricardo Sanchez^6*, Norma C. Gutierrez, MD, PhD^7,8*, Yanira Ruiz-Heredia^9*, Santiago Barrio^6*, Albert Oriol, MD^10*, Maria Luisa Martin-Ramos^11*, Manuela Fernández-Guijarro^11*, María Jesús Blanchard^12*, Rafael Rios, MD, PhD^13,14*, Anna Sureda Balari, MD, PhD^15*, Miguel T Hernández^16*, Javier de la Rubia^17*, Gorka Alkorta^18*, Xabier Agirre, PhD^19*, Gonzalo R Ordóñez^20*, Rafael Valdés-Mas^21*, Maria-Victoria Mateos, MD, PhD²², Joan Blade Creixenti²³, Juan Jose Lahuerta, MD, PhD^24*, Jesus F. San-Miguel, MD, PhD^25,26, Maria Jose Calasanz, PhD, BSc^27*, Ramon Garcia-Sanz²⁸ and Joaquin Martinez-Lopez, MD, PhD^6*

¹Hematology Department Hospital 12 de Octubre, Complutense University, H12O-CNIO Clinical research unit, Madrid, Spain
²Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC), CIBERONC, Salamanca, Spain., Salamanca, Spain
³Hematology, Hospital Clinic i Provincial, Barcelona, Spain
⁴Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; Hematological Diseases Laboratory, CIMA LAB Diagnostics, University of Navarra, CIMA LAB Diagnostics, University of Navarra, Hematological Diseases Laboratory, Pamplona, Spain
⁵Hematological Diseases Laboratory, CIMA LAB Diagnostics, University of Navarra, Pamplona, Spain
⁶Hematology Department Hospital 12 de Octubre, Complutense University, H12O-CNIO Clinical research unit, CIBERONC, Madrid, Spain
⁷Servicio de Hematología, Hospital Universitario de Salamanca (HUSAL/IBSAL), and IBMCC (USAL-CSIC), Salamanca, Spain
⁸Departamento de Hematología, Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC), CIBERONC, Salamanca, Spain
⁹Department of Translational Hematology, Research Institute Hospital 12 de Octubre (i+12) Hematological Tumors Clinical Research Unit H12O-CNIO, Madrid, Spain, Madrid, Spain
¹⁰Institut Català d’Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Barcelona, Spain
¹¹Hospital Universitario 12 de Octubre, Madrid, Spain
¹²Hospital Ramón y Cajal, Madrid, Spain
¹³Hospital Universitario Virgen de las Nieves de Granada, Granada, Spain
¹⁴Servicio de Hematología y Hemoterapia, Hospital Universitario Virgen de las Nieves, Granada, Spain
¹⁵ICO-Hospital Duran i Reynals, Hospitalet del Llobregat, Spain
¹⁶Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
¹⁷Hematology Service, University Hospital Doctor Preset, Valencia, Spain
¹⁸Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IDISNA), Centro de Investigación Biomédica en Red de Cáncer (CIBER-ONC)., Pamplona, Spain
¹⁹Hematology-Oncology Program, Centro de Investigación Médica Aplicada (CIMA), IDISNA, Universidad de Navarra, Pamplona, Spain
²⁰Disease Research And Medicine (DREAMgenics) S. L., Oviedo, Spain
²¹Dreamgenics, Oviedo, ESP
²²University Hospital of Salamanca/IBSAL/Cancer Research Center- IBMCC (USAL-CSIC), Salamanca, Spain
²³Hematology Department, IDIBAPS, Hospital Clinic, Barcelona, Spain
²⁴Hospital Doce de Octubre, CIBERONC, Madrid, Spain
²⁵Hematology Department, Clínica Universidad De Navarra, Pamplona, Spain
²⁶Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain
²⁷Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBERONC, Clínica Universidad de Navarra, Pamplona, Spain
²⁸Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC), CIBERONC, Salamanca, Spain

Yang Liang, MD¹, Han-ying Huang^2*, Yun Wang, MD, PhD^2*, Weida Wang, MD, PhD^2*, Jin-Yuan Li^2* and Ling-ling Shu^2*

¹Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China
²State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China

Jishi Wang, PhD¹ and Jie Xiong, M.D.^2*

¹Department of Hematology, Affiliated Hospital, Guizhou Medical University, Guiyang, China., Chongqing, China
²Affiliated Hospital of Guizhou Medical University, Guiyang, China

Annita Ioanna Gkioka, MD^1*, Aspasia Koudouna, MD^1*, Vasiliki Bartzi, MD^1*, Maria Dimou, MD, PhD¹, Theodoros Iliakis, MD^2*, Aikaterini Bitsani, MD^1*, Vasileios Pardalis, MD^2*, Panayiotis Panayiotidis, MD¹ and Marie-Christine Kyrtsonis, MD¹

¹First Department of Propedeutic Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
²1st Department of Propedeutic Medicine, Hematology Clinical trials Unit, Laikon General Hospital, Medical School , National and Kapodistrian University of Athens, Athens, Greece

David Zihala^1,2*, Tereza Sevcikova^1,2,3*, Michal Simicek^1,2,3*, Tereza Popkova^2*, Hana Plonkova^2*, Lucie Broskevicova^2*, Jan Vrana^1,2*, Juli R. Bago^1,2*, Roman Hajek^1,2, Giovanni Stracquadanio^4* and Tomas Jelinek^1,2*

¹Department of Clinical Studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
²Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic
³Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic
⁴Institute of Quantitative Biology, Biochemistry, and Biotechnology, SynthSys, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

Shaadi Mehr, PhD^1*, Daniel Auclair¹, Mark Hamilton, PhD^1*, Leon Rozenblit^2*, Hearn Jay Cho, MD, PhD^3,4, Lijun Yao^5*, Reyka G Jayasinghe, PhD^5*, Manoj Bhasin, PhD^6*, Steven E. Labkoff, MD^1*, Taxiarchis Kourelis, MD⁷, Madhav V. Dhodapkar, MD⁸, Deon Doxie^9*, Sacha Gnjatic^10*, Cassandra Dewitt^2* and Sergey Miron^2*

¹Multiple Myeloma Research Foundation, Norwalk, CT
²Prometheus, New Haven, CT
³The Multiple Myeloma Research Foundation, Mount Sinai School of Medicine, New York, NY
⁴MMRF; Icahn School of Medicine at Mount Sinai, Norwalk, CT
⁵Department of Medicine, Washington University School of Medicine, Saint Louis, MO
⁶Emory School of Medicine, Aflac Cancer and Blood Disorders Center, Atlanta, GA
⁷Mayo Clinic Rochester, Division of Hematology, Rochester, MN
⁸Emory University School of Medicine, Atlanta, GA
⁹Emory University, Atlanta, GA
¹⁰Mount Sinai School of Medicine, New York, NY

Misaki Sugai, BS^1*, Naohiro Tsuyama, PhD^1*, Yu Abe, PhD^1*, Yusuke Azami, MD^2*, Kenichi Kudo, PhD^3*, Akinobu Ota, PhD^4*, Sivasundaram Karnan, PhD^5*, Moe Muramatsu, BS^6*, Tomonari Shigemura, MD, PhD^7*, Megumi Sasatani, PhD^8*, Yuko Hashimoto, MD, PhD^6*, Kenji Kamiya, MD, PhD^8*, Ichiro Hanamura, MD, PhD^9*, Takayuki Ikezoe, MD, PhD¹⁰, Masafumi Onodera, MD, PhD^11* and Akira Sakai, MD, PhD¹

¹Dept. of Radiation Life Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan
²Dept. of Medical Oncology, Fukushima Medical University School of Medicine, Fukushima, Japan
³Dept. of Radiation Life Sciences, Fukushima Med. Univ. School of Medicine, Fukushima, Japan
⁴Dept. of Hematology, Aichi Medical University School of Medice, Nagakute, Japan
⁵Dept. of Hematology, Aichi Med. Univ. School of Medicine, Nagakute, Japan
⁶Dept. of Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan
⁷Dept. of Pediatrics, Shinshu University, Matsumoto, Japan
⁸Dept. of Experimental Oncology, RIRBM, Hiroshima University, Hiroshima, Japan
⁹Dept. of Hematology, Aichi Medical University School of Medicine, Nagakute, Japan
¹⁰Dept of. Hematology, Fukushima Medical University School of Medicine, Fukushima, Japan
¹¹Dept. of Genetics, National Research Institute for Child Health and Development, Tokyo, Japan