Sutapa Sinha, PhD¹, Wei Ding, MD, PhD¹, Tammy Price-Troska, BS^1*, Reona Sakemura, MD, PhD¹, Shulan Tian, MS, PhD^2*, Charla R. Secreto^1*, Xiaosheng Wu, MD^1*, Timothy G. Call, MD¹, Rong He, MD³, Sameer A. Parikh, MD¹, Yucai Wang, MD, PhD⁴, Jose F. Leis, MD, PhD⁵, Huihuang Yan, PhD^2*, Karen Rech, MD^6*, Amber B. Koehler, PA-C, MS^1*, Daniel L. Van Dyke, PhD³, Minetta C. Liu, MD^7*, Susan L. Slager, PhD^2*, Esteban Braggio, PhD⁸, Stephen M. Ansell, MD, PhD⁹, Saad S. Kenderian, MD¹ and Neil E. Kay, MD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Department of Health Sciences Research, Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Rutgers New Jersey Medical School, Rochester, MN
⁵Division of Hematology and Medical Oncology, Mayo Clinic Health System, Phoenix, AZ
⁶Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁷Department of Oncology / Laboratory Medicine & Pathology, Mayo Clinic, Rochester
⁸Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁹Mayo Clinic, Rochester, MN

Yiming Wu, PhD^1*, Meiling Jin, PhD^1*, Kevyn Hart, BS^1*, Aijun Liao, MD, PhD^1*, Stacey M. Fernandes, BS^2*, Tinisha McDonald, BS^3*, Lucy Brown, PhD^4*, Daniel Roeth, PhD^5*, Markus Kalkum, PhD^5*, Raju Pillai, MD^6*, Jianjun Chen, PhD¹, Jennifer R Brown, MD, PhD⁷, Steven T. Rosen, MD⁸, Tanya Siddiqi, MD⁹ and Lili Wang, MD, PhD^1,2

¹Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Hematogic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA
⁴Analytical Cytometry Core, City of Hope, Duarte, CA
⁵Department of Molecular Imaging & Therapy, City of Hope, Duarte, CA
⁶Department of Pathology, City of Hope, Duarte, CA
⁷CLL Center, Dana-Farber Cancer Institute, Boston, MA
⁸Beckman Research Institute, City of Hope, Duarte, CA
⁹Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA

Johannes Bloehdorn, MD^1*, Andrejs Braun, PhD^2*, Billy Michael Chelliah Jebaraj, PhD^1*, Amaro Taylor-Weiner, PhD^3*, Sandra Robrecht, PhD^4*, Julia Krzykalla, PhD^5*, Karlheinz Holzmann, PhD^6*, Harvey Johnston, PhD^7*, Tetyana Klymenko, PhD^8*, Barbara Eichhorst, MD⁴, Ru-Fang Yeh, PhD^9*, Martin Weisser, MD^10*, Jennifer Edelmann, MD, PhD¹, Kirsten Fischer, MD^4*, John G. Gribben, MD, DSc, FRCP, FMedSci, FRCPath², Dan A. Landau, MD, PhD^11,12, Donna S. Neuberg, ScD¹³, Mark S Cragg, PhD^7,14*, Axel Benner^5*, Michael Hallek, MD^4*, Catherine J. Wu, MD^3,15,16,17, Hartmut Döhner¹, Stephan Stilgenbauer, MD¹ and Daniel Mertens, PhD^1,18*

¹Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
²Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf, University of Cologne, Cologne, Germany
⁵Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁶Genomics Core Facility, Ulm University, Ulm, Germany
⁷Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, United Kingdom
⁸Sheffield Hallam University, Sheffield, United Kingdom
⁹Biostatistics, Genentech Inc., South San Francisco, CA
¹⁰Roche Innovation Center Munich, Roche Pharma Research and Early Development, Penzberg, Germany
¹¹Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY
¹²New York Genome Center, New York, NY
¹³Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
¹⁴Centre for Cancer Immunology, University of Southampton, Southampton, United Kingdom
¹⁵Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁶Department of Internal Medicine, Brigham and Women’s Hospital, Boston, MA
¹⁷Harvard Medical School, Boston, MA
¹⁸German Cancer Research Center (DKFZ), Heidelberg, Germany

Salma Parvin, PhD^1*, Aditi Aryal, BA^2*, Matthew S. Davids, MD³ and Anthony G. Letai, MD, PhD⁴

¹Department of Medical Oncology, Dana Farber Cancer Institute, Brighton, MA
²Dana Farber Cancer Institute, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Medical Oncology, Dana-Farber Cancer Institute & HMS, Boston, MA

Ya Zhang, MD^1,2*, Xinting Hu, MM^1,2*, Yang Han, MM^1,2*, Xiangxiang Zhou, MD^1,2*, Na Chen, MD^2*, Peipei Li, PhD^1,2*, Kang Lu, PhD^1,2* and Xin Wang, MD, PhD^1,2

¹Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
²Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

Shulan Tian, MS, PhD^1*, Hanyin Wang, MD^2*, Timothy G. Call, MD³, Eric W. Klee, PhD^4*, Minetta C. Liu, MD^5*, Erik Jessen, PhD^1*, Sameer A. Parikh, MD³, Yucai Wang, MD, PhD⁶, Saad S. Kenderian, MD³, Jose F. Leis, MD, PhD⁷, Min Shi, MD, PhD⁸, Eli Muchtar, MD^3*, Daniel L. Van Dyke, PhD⁸, Amber B. Koehler, PA-C, MS^3*, Neil E. Kay, MD³, Susan L. Slager, PhD^1*, Esteban Braggio, PhD⁹, Huihuang Yan, PhD^1* and Wei Ding, MD, PhD³

¹Department of Health Sciences Research, Mayo Clinic, Rochester, MN
²Department of Hospital Medicine, Mayo Clinic Health System, Mankato, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Center for Individualized Medicine, Department of Health Sciences Research, Mayo Clinic, Rochester, MN
⁵Department of Oncology / Laboratory Medicine & Pathology, Mayo Clinic, Rochester
⁶Division of Hematology, Rutgers New Jersey Medical School, Rochester, MN
⁷Division of Hematology and Medical Oncology, Mayo Clinic Health System, Phoenix, AZ
⁸Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁹Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ

Jonathan S. Wall, PhD^1*, R. Eric Heidel, PhD^2*, Alan Stuckey^3*, Emily B. Martin, PhD^1*, Tina Richey, MS^3*, Angela Williams, MS^1*, James S. Foster, MS^3*, Bryan Whittle^4*, Yitong Fu, MD^4*, Dustin Powell, MD^4*, Ronald H. Lands, MD¹, Spencer Guthrie^5* and Stephen J. Kennel, PhD^1*

¹Department of Medicine, University of Tennessee Medical Center, Knoxville, TN
²Surgery, University of Tennessee Medical Center, Knoxville, TN
³Medicine, University of Tennessee Medical Center, Knoxville, TN
⁴Radiology, University of Tennessee Medical Center, Knoxville, TN
⁵Attralus Bio, South San Francisco, CA

Akiva Diamond, MD¹, Wyatt P. Bensken, BS^2*, Weichuan Dong, Ph.D.^2*, Sarah C. Markt, ScD, MPH^2*, Siran M. Koroukian, Ph.D.^2* and Paolo Caimi, MD³

¹Dan L Duncan Comprehensive Cancer Center at Baylor St. Luke's Medical Center, Houston, TX
²Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH
³University Hospitals Seidman Cancer Center, Cleveland, OH

Claudio Giacinto Atene^1*, Rossana Maffei², Stefania Fiorcari^3*, Silvia Martinelli^3*, Patrizia Zucchini^3*, Monica Maccaferri^2*, Giulia Debbia^4*, Leonardo Potenza^4*, Mario Luppi^4* and Roberto Marasca⁴

¹Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
²Hematology Unit, A.O.U of Modena-Policlinico Department of Oncology and Hematology, Italy, Modena, Italy
³Department of Medical and Surgical Sciences, Hematology Unit, University of Modena and Reggio Emilia, Modena, Italy
⁴Department of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Modena, Italy

Maria Teresa Voso, MD¹, Tatjana Pandzic, PhD^2,3*, Michail Iskas, MD, MSc^4*, Marija Denčić-Fekete^5*, Eleonora De Bellis^6*, Lydia Scarfo^7,8*, Viktor Ljungström^3,9*, Giovanni Del Poeta, MD¹⁰, Pamela Ranghetti^7,8*, Stamatia Laidou^11*, Giulia Falconi, PhD^12*, Silvia Imbergamo, MD^13*, Chiara Salvetti, MD^14*, Antonella Zucchetto, PhD^15*, Niki Stavroyianni^16*, Lucia Cavelier, PhD^9,17*, Paolo Ghia, MD, PhD^7,8, Kostas Stamatopoulos, MD¹⁸, Emiliano Fabiani, PhD^19* and Panagiotis Baliakas, MD^3,20*

¹University of Rome Tor Vergata, Rome, Italy
²Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, SWE
³Department of Clinical Genetics, Uppsala University Hospital, Uppsala, Sweden
⁴Hematology Department & HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
⁵Institute for pathology, Medical Faculty, Belgrade, Serbia
⁶Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁷Strategic Research Program in CLL, Division of Experimental Oncology, IRCCS, Milan, Italy
⁸San Raffaele Hospital and Università Vita-Salute San Raffaele, Milan, Italy
⁹Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
¹⁰Hematology, Department of Biomedicine and Prevention, University Tor Vergata, Roma, Italy
¹¹Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
¹²Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Rome, Italy
¹³Hematology and Clinical Immunology unit, Department of Medicine, University of Padua, Padua, Italy
¹⁴Division of Hematology, University of Turin, Torino, Italy
¹⁵Clinical and Experimental Onco-Hematology Unit, IRCCS Centro Di Riferimento Oncologico, Aviano, Italy
¹⁶Hematology Department - HCT Unit, George Papanikolaou Hospital, Thessaloniki, Greece
¹⁷Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
¹⁸Institute of Applied Biosciences, Centre for Research and Technology Hellas, Asvestohori, Greece
¹⁹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, rome, Italy
²⁰Immunology, Genetics and pathology, Uppsala University, Uppsala, Uppsala, Sweden