Jelena D. Milosevic Feenstra^1*, Fiorella Schischlik, PhD^2*, Roland Jäger, PhD^3*, Daniel Ivanov, MSc^1,4*, Gregor Eisenwort, MD, PhD^1,4*, Alexandra Keller, PhD^4*, Michael Schuster, PhD^2*, Emir Hadzijusufovic, DVM^1,4,5*, Maria-Theresa Krauth, MD^1,4*, Robert Spörk, MSc^1,6*, Bettina Gisslinger, MSc^4*, Elisabeth Koller, MD^6*, Michael Fillitz, MD^6*, Michael Pfeilstocker, MD^1,6, Thamer Sliwa, MD^6*, Felix Keil, MD^1,6*, Christoph Bock, PhD^2*, Heinz Gisslinger, MD^4*, Robert Kralovics, PhD^2,3 and Peter Valent, MD^1,4

¹Ludwig Boltzmann Institute for Hematology and Oncology, Vienna, Austria
²CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
³Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
⁴Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
⁵Department for Companion Animals and Horses, University Clinic for Small Animals, Internal Medicine Small Animals, University of Veterinary Medicine Vienna, Vienna, Austria
⁶3rd Medical Department, Hematology & Oncology, Hanuschkrankenhaus, Vienna, Austria

Helene Duparc^1*, Delphine Muller^2*, Ileana Antony-Debre, PhD, PharmD^2*, Caroline Marty, PhD^2*, Najet Debili^3*, Jean-Luc Villeval, PhD^2*, Isabelle Plo^3*, William Vainchenker^4*, Laure Gilles, PhD^5* and Hana Raslova^3*

¹INSERM, UMR1287, Gustave Roussy, Université Paris-Saclay, Equipe labellisée Ligue Nationale Contre le Cancer, Université Sorbonne Paris Cité, Université Paris Diderot., Villejuif, France
²INSERM, UMR1287, Gustave Roussy, Université Paris-Saclay, Equipe labellisée Ligue Nationale Contre le Cancer., Villejuif, France
³INSERM, UMR1287, Gustave Roussy, Université Paris-Saclay, Equipe labellisée Ligue Nationale Contre le Cancer, Equipe GRex, Villejuif, France
⁴Gustave Roussy, Villejuif, France
⁵INSERM, UMR1287, Gustave Roussy, Université Paris-Saclay, Equipe labellisée Ligue Nationale Contre le Cancer, Institut National de la Transfusion Sanguine, Villejuif, IL, France

Cesarina Giallongo, PhD^1*, Mariarita Spampinato, Ph.D student^2*, Enrico La Spina^3*, Nunziatina Laura Parrinello, PhD^4*, Lucia Longhitano, Ph.D student^5*, Rosario Caltabiano, MD^6*, Lucia Salvatorelli, MD^6*, Alessandra Romano, MD, PhD⁷, Alessandro Barbato^4*, Michelino Di Rosa, PhD^8*, Giacomo Lazzarino, Ph.D.^9*, Giovanni Li Volti, MD, PhD^10*, Francesco Di Raimondo, MD¹¹, Daniele Tibullo, PhD^12* and Giuseppe A. Palumbo, MD, PhD^13*

¹Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, CT, Italy
²Section of Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania,, University of Catania, Catania, Italy
³Division of Hematology, University of Catania, Catania, Italy
⁴Division of Hematology, Azienda Policlinico - OVE, University of Catania, Catania, Italy
⁵Section of Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
⁶Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, Italy
⁷CHIRMED - Department of General Surgery and Medical-Surgical Specialties - Hematology Section, University of Catania, Tremestieri Etneo, Cantania, Italy
⁸Section of Human Anatomy, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
⁹UniCamillus-Saint Camillus International University of Health Sciences, Rome, Italy
¹⁰Department of Biomedical and Biotechnological Sciences, Univeristy of Catania, Catania, Italy
¹¹Division of Hematology, A.O.U. "Policlinico-Vittorio Emanuele", University of Catania, Catania, Italy
¹²Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
¹³Department of Medical, Surgical and Advanced Technology "G.F. Ingrassia", University of Catania, Catania, Italy

Paola Verachi^1*, Fabrizio Martelli, PhD^2*, Maria Zingariello, PhD^3*, Shalini Chaturvedi^4*, Celine Wilke, MD^5*, Valerie Campello-Iddison, MD^6* and Anna Rita Migliaccio, PhD^1,7

¹Biomedical and Neuromotorial Sciences, Alma Mater Studiorum University, Bologna, Italy
²Istituto Superiore di Sanità, Rome, Italy
³Unit of Microscopic and Ultrastructural Anatomy, Dept of Medicine, University Campus Bio-Medico, Rome, Italy
⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁵Novartis Pharma AG, Basel, Switzerland
⁶Novartis, East Hanover, NJ
⁷Myeloproliferative Neoplasm-Research Consortium, New York, NY

Tadaaki Inano, MD, PhD^1*, Marito Araki, PhD^2*, Soji Morishita, PhD^2*, Misa Imai, PhD^1,3*, Yoshihiko Kihara^1,3*, Maho Okuda, PhD^1,4*, Masafumi Ito, MD, PhD^5*, Satoshi Osaga^6*, Yinjie Yang, PhD^1*, Yoko Edahiro, MD, PhD^1*, Tomonori Ochiai, MD, PhD^1*, Kyohei Misawa, MD, PhD^1*, Yasutaka Fukuda, MD, PhD^1*, Akimichi Ohsaka, MD, PhD^2* and Norio Komatsu, MD, PhD¹

¹Department of Hematology, Juntendo University Graduate School of Medicine, Tokyo, Japan
²Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University Graduate School of Medicine, Tokyo, Japan
³Leading Center for the Development and Research of Cancer Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
⁴Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
⁵Department of Pathology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
⁶Clinical Research Management Center, Nagoya City University Hospital, Nagoya, Japan

Antonella Zagaria^1*, Francesco Tarantini, MD^2*, Luisa Anelli^3*, Paola Orsini^3*, Angela Minervini^1*, Nicoletta Coccaro^3*, Elisa Parciante^3*, Crescenzio Francesco Minervini^3*, Cosimo Cumbo^3*, Giuseppina Tota^3*, Luciana Impera^3*, Maria Rosa Conserva^4*, Immacolata Redavid^4*, Alessandra Ricco, MD^3*, Immacolata Attolico, MD^4*, Giorgina Specchia, MD⁵, Pellegrino Musto, MD⁶ and Francesco Albano^4*

¹Hematology and Stem cell Transplantation Unit - Dept. of Emergency and Organ Transplantation - University of Bari, Bari, Italy
²Hematology and Stem cell Transplantation Unit - Department of Emergency and Organ Transplantation (D.E.T.O.) - University of Bari, Bari, Italy
³Hematology and Stem cell Transplantation Unit - Dept. of Emergency and Organ Transplantation - University of Bari, Bari, Italy
⁴Hematology and Stem cell Transplantation Unit - Department of Emergency and Organ Transplantation (D.E.T.O.) - University of Bari, Bari, Italy
⁵University Policlinico, Bari, Ba, Italy
⁶Hematology and Stem cell Transplantation Unit - Department of Emergency and Organ Transplantation (D.E.T.O.) - University of Bari, Bari, Italy