Luca Malcovati, MD^1,2, Simon Crouch, PhD, BA, MA, MSc^3*, Aniek O. De Graaf, PhD^4*, Sarah Sandmann^5*, Magnus Tobiasson, MD^6*, Olivier Kosmider, PharmD, PhD^7*, Bert A. van der Reijden, PhD⁸, Daniel Painter, BSc^9*, Arjan A. Van de Loosdrecht, MD, PhD¹⁰, Argiris Symeonidis, MD, PhD¹¹, Jaroslav Cermak, MD, PhD^12*, Emmanuelle Clappier, PharmD, PhD^13*, Claude Preudhomme, MD, PhD¹⁴, Reinhard Stauder, MD, MSc¹⁵, Moshe Mittelman, MD^16*, Ulrich Germing^17*, David Bowen, MD¹⁸, Pierre Fenaux, MD, PhD¹⁹, Corine Van Marrewijk, PhD^20*, Alexandra Smith, PhD^21*, Martin Dugas^22*, Eva Hellstrom Lindberg, MD, PhD²³, Theo M de Witte, MD²⁴, Michaela Fontenay^25* and Joop Jansen, PhD²⁶

¹Department of Hematology Oncology & Molecular Medicine, University of Pavia Medical School, Piazzale Golgi, Italy
²Department of Molecular Medicine & Hematology Oncology, University of Pavia & IRCCS Policlinico S. Matteo Foundation, Pavia, Italy
³Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, United Kingdom
⁴Laboratory of Hematology, Radboud University Medical Centre, Nijmegen, The Netherlands., Nijmegen, Netherlands
⁵Muenster University, Muenster, DEU
⁶Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institute, Stockholm, Sweden
⁷Assistance Publique Hôpitaux de Paris, Laboratoire d'hématologie, Hôpital Cochin, APHP Laboratoire d'Hématologie, Hôpital Cochin, Paris, France
⁸Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Centre, Nijmegen, GL, Netherlands
⁹Epidemiology and Cancer Statistics Group, University of York, York, United Kingdom
¹⁰Department of Hematology, VUMC, Kamerik, Netherlands
¹¹Hematology Division, Department of Internal Medicine, University of Patras Medical School, Patras, Greece
¹²Institute of Hematology and Blood Transfusion, Prague, Czech Republic
¹³Hôpital Robert Debré, AP-HP, Paris, FRA
¹⁴Centre de Biologie-Pathologie, CHU Lille, Lille, France
¹⁵Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University, Innsbruck, Austria
¹⁶Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv Universi, Tel-Aviv, ISR
¹⁷Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Faculty of Medicine, Düsseldorf, Germany
¹⁸Department of Haematology, Leeds Teaching Hospitals, Leeds, United Kingdom
¹⁹Hôpital Saint-Louis, Paris, France
²⁰Department of Hematology, Radboud university medical center, Nijmegen, Netherlands
²¹Epidemiology and Cancer Statistics Group, Department of Heath Sciences, University of York, York, United Kingdom
²²Institute of Medical Informatics, Universitiy of Muenster, Münster, DEU
²³HERM, Dept. of Medicine, Huddinge, Karolinska Institute, and PO Hematology, Karolinska University Hospital, Stockholm, Sweden
²⁴Dep. of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, Netherlands
²⁵Laboratoire d'Hématologie, Hôpital Cochin, Paris, FRA
²⁶Radboud Institute Molecular Studies, Radboud University Medical Center, Nijmegen, Netherlands

Manja Meggendorfer, PhD, Wencke Walter, PhD^*, Niroshan Nadarajah^*, Claudia Haferlach, MD, Wolfgang Kern, MD and Torsten Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

Senthilkumar Ramamoorthy, PhD^1,2*, Dirk Lebrecht, PhD^1*, Denny Schanze, PhD^3*, Ina Schanze, MD^3*, Ilse Wieland, PhD^3*, Michael H. Albert, MD^4*, Arndt Borkhardt, MD⁵, Dorine Bresters, MD, PhD^6*, Jochen Büchner, MD, PhD^7*, Albert Catala, MD, PhD^8*, Valerie De Haas, MD, PhD^9*, Michael Dworzak, MD, PhD^10*, Miriam Erlacher, MD, PhD^11,12*, Henrik Hasle, MD¹³, Kirsi Jahnukainen, MD, PhD^14*, Franco Locatelli, MD, PhD¹⁵, Riccardo Masetti, MD, PhD^16*, Jan Stary, MD, PhD^17*, Dominik Turkiewicz, MD^18*, Luca Vinci, MD^1*, Marcin W. Wlodarski, MD, PhD¹, Ayami Yoshimi, MD, PhD^1*, Maria Hess^2*, Melanie Boerries, MD, PhD^2,12*, Charlotte M. Niemeyer, MD^1,12, Martin Zenker, MD^3* and Christian Flotho, MD^1,12*

¹Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
²Institute of Medical Bioinformatics and Systems Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
³Human Genetics, University of Magdeburg, Magdeburg, Germany
⁴Department of Pediatric Hematology and Oncology, Dr. v. Hauner Children’s Hospital, University Hospital, LMU, Munich, Germany
⁵Department of Pediatric Oncology, Hematology and Immunology, University of Dusseldorf, Dusseldorf, Germany
⁶Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands
⁷Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway
⁸Department of Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain
⁹Princess Maxima Center for Pediatric Oncology, Diagnostic Laboratory / DCOG Laboratory, Utrecht, Netherlands
¹⁰St. Anna Children's Hospital and Cancer Research Institute, Medical University of Vienna, Vienna, Austria
¹¹Medical Center, University of Freiburg, Freiburg, Germany
¹²German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Freiburg, Freiburg, Germany
¹³Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark
¹⁴Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, Helsinki University Hospital, Helsinki, Finland
¹⁵Department of Pediatric Hematology and Oncology, Bambino Gesu Children's Hospital, Sapienza, University of Rome, Rome, Italy
¹⁶Department of Pediatric Oncology and Hematology, University of Bologna, Bologna, Italy
¹⁷Department of Pediatric Hematology/ Oncology, Charles University and Univ Hospital Motol, Prague, Czech Republic
¹⁸Department of Pediatric Oncology/Hematology, Skåne University Hospital, Lund, Sweden

Moritz Binder, MD, MPH¹, Ryan M. Carr, MD, PhD¹, Terra Lasho, PhD¹, Christy Finke, BS^1*, Abhishek A. Mangaonkar, MBBS¹, Christopher Pin, PhD^2*, Kurt Berger^2*, Tamas Ordog, MD^3*, Bonnie Alver, PhD^4*, Keith Robertson, PhD^4*, David Marks, PhD^5*, Martin Fernandez-Zapico, MD^6*, Alexandre Gaspar Maia, PhD^4* and Mrinal M. Patnaik, MD, MBBS¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²London Regional Transgenic and Gene Targeting Facility, Lawson Health Research Institute University of Western Ontario, London, ON, Canada
³Center for Individualized Medicine, Mayo Clinic, Rochester, MN
⁴Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Division of Oncology Research, Mayo Clinic, Rochester, MN
⁶Mayo Clinic, Rochester, MN

Kazutoshi Ebisawa, MD^1*, Yosuke Masamoto, MD, PhD² and Mineo Kurokawa, MD, PhD^2,3

¹University of Tokyo, Bunkyo-Ku, TKY, Japan
²Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
³Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan

Vera Adema, PhD^1*, Cassandra M Kerr, MS^1*, Hassan Awada, MD¹, Sunisa Kongkiatkamon, MD^2*, Bhumika J. Patel, MD^1,3, Mikkael A. Sekeres, MD, MS⁴, Valeria Visconte, PhD¹, John Barnard^5*, Jaroslaw P. Maciejewski, MD, PhD^1,6 and Torsten Haferlach, MD⁷

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
³Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH
⁴Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁵Department of Quantitative Health Sciences, Cleveland Clinic., Cleveland Clinic, Cleveland, OH
⁶Leukemia Program, Department of Hematology and Medical Oncology, Clevceland Clinic, Taussig Cancer Institute, Cleveland
⁷MLL Munich Leukemia Laboratory, Munich, Germany

Vera Adema, PhD^1*, Hassan Awada, MD^2*, Laila Terkawi^1*, Sunisa Kongkiatkamon, MD^1*, Cassandra M Kerr, MS^1* and Valeria Visconte, PhD¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Hiro Tatetsu, MD¹, Miho Watanabe, MD^1*, Emily F Mason, MD, PhD^2*, Scott B Lovitch, MD, PhD³, Kenji Tokunaga, MD^1*, Eisaku Iwanaga, MD^1*, Masao Matsuoka, MD, PhD¹, Daniel G. Tenen, MD^4,5 and Li Chai, MD⁶

¹Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University Hospital, Kumamoto, Japan
²Vanderbilt University Medical Center, Nashville
³Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
⁴Harvard Medical School, Boston, MA
⁵Cancer Science Institute of Singapore, Singapore, Singapore
⁶Brigham and Women's Hospital, Boston, MA

Sunisa Kongkiatkamon, MD^1,2*, Yasunobu Nagata, MD, PhD^3*, Vera Adema, PhD^4*, Hassan Awada, MD², Misam Zawit, MD^5*, Laila Terkawi^2*, Simona Pagliuca, MD², Carmelo Gurnari, MD^6*, Cassandra M Kerr, MS^2*, Mikkael A. Sekeres, MD, MS⁷, Hetty E. Carraway, MD, MBA⁸, Yogenthiran Saunthararajah, MD², Bhumika J. Patel, MD⁹, Jaroslaw P. Maciejewski, MD, PhD³ and Valeria Visconte, PhD²

¹Department of hematology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
³Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Houston, TX
⁵Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland clinic, Cleveland, OH
⁶Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland
⁷Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁸Department of Hematology and Medical Oncology, Leukemia Program, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁹Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH