Prithviraj Bose, MD¹, Naveen Pemmaraju, MD², Lucia Masarova, MD^2*, Sharon D. Bledsoe^3*, Naval Daver, MD⁴, Elias Jabbour, MD², Tapan M. Kadia, MD², Zeev E. Estrov, MD², Steven M. Kornblau, MD⁵, Michael Andreeff, MD, PhD¹, Jorge E. Cortes, MD⁶, Nitin Jain, MD², Gautam Borthakur, MD², Yesid Alvarado, MD², Julie Huynh-Lu, Physician Assistant^2*, Madeleine Nguyen-Cao, Physician Assistant^3*, Mary Ann Richie^3*, Mackenzie H. Dobbins^3*, Lingsha Zhou^2*, Sherry A. Pierce, BSN, BA^2*, Xuemei Wang, MS^7*, Allison M. Pike, RN^8*, Guillermo Garcia-Manero, MD², Hagop M. Kantarjian, MD² and Srdan Verstovsek, MD, PhD²

¹Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁵Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Georgia Cancer Center Augusta University, Augusta, GA
⁷Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸The University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX

Srdan Verstovsek, MD, PhD¹, Jingbo Yu, MD, PhD², Robyn M. Scherber, MD², Shivani Pandya, MS^3*, Christopher Dieyi, MPH^3*, Chien-Cheng Chen, MS^3* and Shreekant Parasuraman, BPharm, PhD^2*

¹The University of Texas MD Anderson Cancer Center, Leukemia Department, Houston, TX
²Incyte Corporation, Wilmington, DE
³STATinMED Research, Plano, TX

Marcio M Andrade-Campos, MD, PhD^1,2*, Lierni Fernández-Ibarrondo^3,4*, Joan Gibert, PhD^4*, Concepción Fernández^4,5*, Brayan Merchan, MD^2,6*, Nieves García Gisbert, BSc^7*, Laura Camacho^4,8*, Leonor Arenillas, MD, PhD^9*, Sara García Ávila, MD^10*, Raquel Longarón^4,11*, Antonio Salar, MD, PhD^4,12*, Carles Besses, MD, PhD^4,13* and Beatriz Bellosillo, PhD^14*

¹Department of Hematology, Hospital del Mar, Barcelona, Spain
²Grup de Recerca Clínica Aplicada en Neoplàsies Hematològiques-Hospital del Mar-IMIM, Barcelona, Spain
³Pompeu Fabray University, Barcelona, Spain
⁴Group of Applied Clinical Research in Hematology. Cancer research program-IMIM, Barcelona, Spain
⁵Department of Pathology, Hospital del Mar, Barcelona, Spain
⁶Hematology Department, Hospital del Mar, Barcelona, Catalonia, Spain
⁷Grup de Recerca Clínica, Aplicada en Neoplàsies Hematològiques-Hospital del Mar-IMIM. Pompeu Fabra University, Barcelona, Spain
⁸Pathology Department-IMIM, Universidad Pompeu Fabra, Hospital del Mar, Barcelona, Barcelona, Spain
⁹Seccion of Cytology, Pathology Department, Hospital del Mar, Barcelona, Spain
¹⁰Grup de Recerca Clínica, Aplicada en Neoplàsies Hematològiques-Hospital del Mar-IMIM. Department of Hematology, Hospital del Mar., Barcelona, Spain
¹¹Pathology Department, Hospital del Mar, Barcelona, Spain
¹²Department of Haematology, Hospital del Mar, Barcelona, Spain
¹³Hematology Department, Hospital del Mar, Barcelona, Ba, Spain
¹⁴Pathology Department-IMIM, Universidad Pompeu Fabra, Hospital del Mar, Barcelona, Barcelona, ESP Group of Applied Clinical Research in Hematology. Cancer research program-IMIM, Barcelona, Spain

Gabriela S. Hobbs, MD¹, Cansu Cimen Bozkus^2*, Martha Wadleigh, MD³, Lonette Sandy^4*, Mikaela Doughtery^5*, Kathryn Johnson^5*, Gillian Sanchez^5*, Julia E. Foster, NP^1*, Molly Macrae^1*, Tina T. Som, RN^1*, Michal Bar-Natan, MD^6*, Richard M. Stone, MD⁷, Erin Moshier, MS^8*, Camelia Iancu-Rubin, PhD⁹ and John Mascarenhas, MD¹⁰

¹Leukemia Center, Massachusetts General Hospital, Boston, MA
²Division of Hematology/Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine At Mount Sinai, New York, NY
³Dana-Farber Cancer Institute, Boston, MA
⁴Ichan School of Medicine At Mount Sinai, New York City, NY
⁵MSSM, New York, NY
⁶Division of Hematology/Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁷Department of Medical Oncology, Dana-Farber Cancer Institute, Boston
⁸Department of Population Health Science and Policy, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁹Tisch Cancer Institute, Division of Hematology and Medical Oncology, Mount Sinai School of Medicine Division of Hematology, New York, NY
¹⁰Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY

Moshe Talpaz, MD¹, Raajit K. Rampal, MD, PhD², Srdan Verstovsek, MD, PhD³, Claire Harrison, DM, FRCPath⁴, Mark W. Drummond, PhD, FRCPath^5*, Jean-Jacques Kiladjian, MD, PhD⁶, Alessandro Vannucchi, MD⁷, Marina Kremyanskaya⁸, Gary J. Schiller, MD⁹, Andrea Patriarca, MD^10*, Gwendolyn Van Gorkom^11*, Prithviraj Bose, MD¹², Ronald Hoffman, MD¹³, Katarina Luptakova, MD^14*, Jessica Christo, MA^14*, Jing Wang, PhD^14*, Jennifer A Mertz, PhD^14*, Gozde Colak, PhD^15*, James Shao, MS^14*, Suresh Bobba, MD^14*, Patrick Trojer, PhD^14*, Adrian Senderowicz, MD^14* and John Mascarenhas, MD⁸

¹Rogel Cancer Center, The University of Michigan, Ann Arbor, MI
²Leukemia Service, Department of Medicine, Clinical Director, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Guy's and St Thomas' Hospital, London, United Kingdom
⁵Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
⁶Clinical Investigations Center, Saint-Louis hospital, Université de Paris, Paris, France
⁷Azienda Ospedaliero Universitaria Careggi, Firenze, Italy
⁸Division of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY
⁹David Geffen School of Medicine at UCLA, Los Angeles, CA
¹⁰Azienda Ospedaliero Universitaria Maggiore della Carità di Novara SCDU Ematologia, Novara, Italy
¹¹University Hospital Maastricht, Maastricht, NLD
¹²Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX
¹³Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
¹⁴Constellation Pharmaceuticals, Cambridge, MA
¹⁵Constellation Pharmaceuticals, CAMBRIDGE, MA

Naveen Pemmaraju, MD¹, Boyd Mudenda, MD, MSc, MBBChir^2*, Cunlin Wang, MD^2*, Jiao JI, PhD, MD^3*, Ming Lu, PhD^2*, Tommy Fu, PhD^2*, Eric Liang, PhD^2*, Sasha McClain, PharmD^2*, Piyush Sheladia, MS^2*, Srdan Verstovsek, MD, PhD¹, Dajun Yang, MD, PhD^4* and Yifan Zhai, MD, PhD^2*

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Ascentage Pharma Group Inc., Rockville, MD
³Ascentage Pharma (Suzhou) Co. Ltd., Shanghai, China
⁴Ascentage Pharma (Suzhou) Co. Ltd., Suzhou, China

Daniel O'Leary, MD and Amrita Goyal, MD^*

University of Minnesota, Minneapolis, MN

Christine Lihou, BS^*, Gongfu Zhou, PhD^* and Fred Zheng, MD^*

Incyte Corporation, Wilmington, DE

Francesca Palandri, MD, PhD^1*, Daniela Bartoletti, MSc^1*, Giulia Benevolo^2*, Massimo Breccia, MD^3*, Elena M Elli, MD^4*, Francesco Cavazzini, MD^5*, Gianni Binotto, MD^6*, Alessia Tieghi, MD^7*, Mario Tiribelli, MD^8*, Florian H. Heidel, MD^9*, Massimiliano Bonifacio, MD^10*, Novella Pugliese, MD^11,12*, Giovanni Caocci, MD¹³, Monica Crugnola, MD^14*, Francesco Mendicino, MD^15*, Enrica A Martino, MD^15*, Alessandra D'Addio, MD^16*, Simona Tomassetti, MD^17*, Bruno Martino, MD^18*, Giuseppe Auteri, MD^1*, Lucia Catani, PhD^1*, Rossella Stella, MD^8*, Fabio D'Amore, MD^6*, Luigi Scaffidi, MD^10*, Nicola Polverelli, MD^19*, Fabrizio Pane, MD¹¹, Antonio Cuneo, MD^20*, Mauro Krampera, MD, PhD¹⁰, Gianpietro Semenzato, MD^6*, Roberto M. Lemoli²¹, Nicola Vianelli, MD^1*, Michele Cavo^1*, Giuseppe A. Palumbo, MD, PhD^22* and Roberto Latagliata^23*

¹Institute of Hematology "L. & A. Seragnoli", Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy
²Hematology Division , Città della Salute e della Scienza Hospital, Turin, Italy
³Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
⁴Hematology, San Gerardo Hospital, MONZA, Italy
⁵Division of Hematology, Department of Medical Sciences, University of Ferrara, Azienda Ospedaliera-Universitaria, Arcispedale S. Anna, Ferrara, Italy
⁶Department of Medicine, Hematology and Clinical Immunology, Padua School of Medicine, Padua, Italy
⁷Hematology Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Reggio Emilia, Italy
⁸Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
⁹Internal Medicine II, Hematology and Oncology, Friedrich-Schiller-University Medical Center, Jena, Germany, Jena, Germany
¹⁰Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
¹¹Hematology - Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy
¹²Hematology Unit, University Federico II, Naples, Italy
¹³Hematology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, ITA
¹⁴Hematology and BMT Center, Department of Medicine and Surgery, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
¹⁵Hematology Unit, Department of Hemato-Oncology, Ospedale Annunziata, Cosenza, Italy
¹⁶Division of Hematology, Onco-hematologic Department, AUSL della Romagna, Ravenna, Ravenna, ITA
¹⁷Hematology Unit, Infermi Hospital Rimini, Rimini, ITA
¹⁸Hematology Unit, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy
¹⁹Unit of Blood Diseases and Stem Cell Transplantation, Dpt of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili di Brescia, Brescia, Italy
²⁰Hematology section, Department of Medical Sciences, University of Ferrara - Azienda Ospedaliera-Universitaria di Ferrara, University of Ferrara, Ferrara, Italy
²¹Clinic of Hematology, Department of Internal Medicine (DiMI), IRCCS AOU San Martino-IST, Genova, Genova, Italy
²²Dipartimento di Scienze Mediche Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Università degli Studi di Catania, Catania, Italy
²³Hematology Unit, Ospedale Belcolle, Viterbo, Italy

John Mascarenhas, MD¹, Rabih Saab, PhD^2*, Deanna Brackman, PhD^2*, Dimple A. Modi, PhD^2*, Linu Abraham, PhD^2*, James E. Ward, MD^2* and Srdan Verstovsek, MD, PhD³

¹Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
²AbbVie Inc., North Chicago, IL
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Gina L. Mazza, PhD^1*, Carolyn Mead-Harvey, MS^1*, John Mascarenhas, MD², Abdulraheem Yacoub, MD³, Ronald Hoffman, MD², Heidi E. Kosiorek, MS^1*, Josef T. Prchal, MD⁴, Richard T. Silver, MD⁵, Tiziano Barbui, MD^6*, Amylou C. Dueck, PhD¹ and Ruben Mesa, MD⁷

¹Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ
²Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
³The University of Kansas Cancer Center, Leawood, KS
⁴Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁵Weill Cornell Medical College, New York, NY
⁶Ospedali Riuniti, Bergamo, Italy
⁷Mays Cancer Center at UT Health San Antonio MD Anderson, San Antonio, TX

Erika Morsia, MD^1*, Naseema Gangat, MBBS¹, James M. Foran, MD², Jeanne M. Palmer, Md³, Michelle A Elliott, MD¹ and Ayalew Tefferi, MD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL
³Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ

Radovan Vasic, MD, MHS¹, Yuliang Shi^2*, Andrea Arruda, MSc^3*, Sarah Malik^2*, Jaime Claudio, PhD^4*, Jose-Mario Capo-Chichi, PhD^5*, Aniket Bankar, MBBS, MD, DM², Hassan Sibai, MBBS^6*, Dawn Maze, MD, FRCPC, MSc⁷, James A. Kennedy, MD PhD⁴, Wei Xu, PhD^8* and Vikas Gupta, MD, FRCP, FRCPath^2,6

¹Department of General Internal Medicine, University of Toronto, Toronto, ON, Canada
²Princess Margaret Cancer Centre, Toronto, ON, Canada
³Princess Margaret Cancer Centre, Division of Medical Oncology and Hematology, University Health Network, University of Toronto, Toronto, ON, Canada
⁴Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁵University of Health Network, Toronto, ON, CAN
⁶Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁷Leukemia Program, Division of Medical Oncology and Hematology, The Ottawa Hospital, Toronto, ON, Canada
⁸University Health Network, Toronto, ON, Canada

Jeanne M. Palmer, Md¹, Heidi E. Kosiorek, MS^2,3*, Amylou C. Dueck, PhD², John Camoriano, MD^4*, Craig Zimmerman, PhD^5* and Ruben Mesa, MD⁶

¹Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ
²Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ
³Department of Biostatistics, Mayo Clinic, Phoenix, AZ
⁴Mayo Clinic Scottsdale, Phoenix, AZ
⁵Pharmaessentia, Taipei, Taiwan
⁶UT Health San Antonio Cancer Center, San Antonio, TX