Elisabetta Abruzzese, MD ¹, Rossana Gloria, MD^2*, Andrea Siani, MD^3*, Carla Mazzone, MD^1*, Matteo Molica, MD^1*, Teresa Dentamaro, MD^1*, Luca Cupelli, MD^1*, Malgorzata Monika Trawinska, MD^1* and Paolo De Fabritiis, MD^1*

¹Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma2, Rome, Italy
²Angiology, S. Eugenio Hospital, ASL Roma2, Rome, Italy
³Vascular Surgery, S. Eugenio Hospital, ASL Roma2, Rome, Italy

Guillermo Montalban Bravo, MD¹, Rashmi Kanagal-Shamanna, MD², Koji Sasaki, MD³, Lucia Masarova, MD^3*, Kiran Naqvi, MD, MPH³, Elias Jabbour, MD¹, Courtney D. DiNardo, MD, MSc³, Koichi Takahashi, MD, PhD³, Marina Konopleva, MD, PhD⁴, Naveen Pemmaraju, MD⁵, Nicholas J. Short, MD³, Ghayas C. Issa, MD³, Tapan M. Kadia, MD³, Farhad Ravandi, MBBS³, Naval Daver, MD⁶, Gautam Borthakur, MD¹, Zeev E. Estrov, MD¹, Joseph D. Khoury, MD², Sanam Loghavi, MD², Sherry A. Pierce, BSN, BA^3*, Carlos E. Bueso-Ramos, MD, PhD², Keyur Patel, MD, PhD^7*, Srdan Verstovsek, MD, PhD³, Hagop M. Kantarjian, MD¹, Prithviraj Bose, MD³ and Guillermo Garcia-Manero, MD³

¹Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX
⁵University of Texas, MD Anderson Cancer Center, Houston, TX
⁶The University of Texas MD Anderson Cancer Center, Houston, TX
⁷University of Texas MD Anderson Cancer Center, Houston, TX

Amer M. Zeidan, MBBS, MHS^1,2, Victoria Wang^3*, Jerald P. Radich, MD^4,5, Jan Philipp Bewersdorf, MD⁶, Vijaya R. Bhatt, MD⁷, Elad Sharon, MD, MPH^8*, Steven D. Gore, MD⁹, Selina M. Luger, MD, FRCPC¹⁰ and Mark Litzow, MD¹¹

¹Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center,, Yale University, New Haven, CT
²Yale University School of Medicine and Yale Cancer Center, New Haven, CT
³Harvard University, Boston, MA
⁴Departments of Oncology and Hematology, University of Washington, Seattle, WA
⁵Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁶Department of Internal Medicine, Yale University, New Haven, CT
⁷Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE
⁸Division of Cancer Treatment and Diagnosis, National Cancer Institute, Cancer Therapy Evaluation Program, Bethesda, MD
⁹NIH/NCI Cancer Therapy Evaluation Program, Rockville, MD
¹⁰Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
¹¹Division of Hematology, Mayo Clinic, Rochester, MN

Kelly L. Schoenbeck, MD¹, Sirisha Tummala, MD^2*, Neha G. Goyal, PhD^3*, Catherine C. Smith, MD³ and Neil P. Shah, MD, PhD⁴

¹Division of Hematology and Oncology, UCSF, San Francisco, CA
²Department of Medicine, University of California San Francisco, San Francisco, CA
³Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
⁴Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA

Koji Sasaki, MD¹, Elias Jabbour, MD¹, Kiran Naqvi, MD, MPH¹, Jeffrey Skinner, MHA^1*, Kristin Anderson^1*, Sara E Dellasala, BS^2*, Musa Yilmaz, MD¹, Alessandra Ferrajoli, MD¹, Prithviraj Bose, MD³, Philip A. Thompson, MB, MS³, Yesid Alvarado, MD¹, Nitin Jain, MD¹, Guillermo Garcia-Manero, MD¹, Koichi Takahashi, MD, PhD¹, Jan A. Burger, MD, PhD¹, Gautam Borthakur, MD¹, Naveen Pemmaraju, MD¹, Rita Khouri^1*, Shilpa Paul, PharmD^4*, Sherry A. Pierce, BSN, BA^1*, Jorge E. Cortes, MD⁵ and Hagop M. Kantarjian, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston
³Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX
⁴Department of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Georgia Cancer Center Augusta University, Augusta, GA

Lindsay A.M. Rein, MD and David A Rizzieri, MD

Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, Durham, NC

Tim H Brümmendorf, MD¹, Jorge E. Cortes, MD², Yeow Tee Goh, MBBS³, Musa Yilmaz, MD⁴, Rebecca B. Klisovic, MD^5*, Simon Purcell^6*, Andrea Viqueira^7*, Eric Leip^8* and Carlo Gambacorti-Passerini, MD⁹

¹Universitätsklinikum RWTH Aachen, Aachen, Germany
²Georgia Cancer Center Augusta University, Augusta, GA
³Department of Hematology, Singapore General Hospital, Singapore, Singapore
⁴Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁵Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA
⁶Pfizer Ltd, London, GBR
⁷Pfizer SLU, Madrid, Spain
⁸Pfizer Inc., Cambridge, MA
⁹Dept of Medicine and Surgery, University of Milano Bicocca, Monza, MB, Italy

Ming Lu, PhD^1*, Chenhui Deng, PhD^2*, Yifeng Xiong, PhD^2*, Hengbang Wang^3*, Ping Xu, PhD^3*, Lichuang Men^3*, Tanhong Xie^3*, Qian Jiang, MD⁴, Zi Chen, MD^3*, Qian Niu, MD^3*, Ping Liu, PhD^2*, Dajun Yang, MD, PhD^1,5* and Yifan Zhai, MD, PhD^1,3*

¹Ascentage Pharma Group Inc., Rockville, MD
²Linking Truth Technology Co., Ltd., Beijing, China
³Guangzhou Healthquest Pharma Co. Ltd., Guangzhou, China
⁴Peking University Institute of Hematology, Peking University People's Hospital, Beijing, China
⁵Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangzhou, China

Hyejin Shin^1,2*, Jung-Eun Ha^1,2*, Dae Young Zang, MD, PhD^3*, Sung-Hyun Kim, MD, PhD⁴, Young Rok Do, PhD, MD⁵, Won Sik Lee, MD, PhD⁶, Soo-Hyun Kim^7*, Kyung-Mi Kee^7*, Seon-Young Yang^7*, So-Yoon Hwang^7*, Eun-Jung Jang^7*, Jangik Lee, PharmD^2,8* and Dong-Wook Kim, MD^7,9

¹Seoul National University, Seoul, Korea, Republic of (South)
²Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea, Republic of (South)
³Department of Internal Medicine, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Anyang-Si, Korea, Republic of (South)
⁴Department of Internal Medicine, Dong-A University College of Medicine, Dong-A University Hospital, Busan, Korea, Republic of (South)
⁵Department of Medicine, Dongsan Medical Center Keimyung University, Daegu, Korea, Republic of (South)
⁶Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea, Republic of (South)
⁷Leukemia Research Institute, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁸Seoul National University, Seoul, South Korea
⁹Department of Hematology, Catholic Hematology Hospital and Leukemia Research Institute, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Seoul, Korea, Republic of (South)

Jose Valentín García Gutiérrez, MD, PhD¹, Jerald P. Radich, MD², Andreas Hochhaus, MD³, Giuseppe Saglio, MD, PhD⁴, Tamas Masszi, MD, PhD, Prof.⁵, Andrzej Hellmann, MD, PhD^6*, Jesper Stentoft, MD, PhD^7*, María Teresa Gomez Casares, MD, PhD^8*, Eibhlin Conneally, MB, PhD, MRCP, MRCPath⁹, Philipp D le Coutre, MD¹⁰, Norbert Gattermann, MD¹¹, Bruno Martino, MD^12*, Susanne Saussele, MD¹³, Francis J. Giles, MD, FRCPI, FRCPath¹⁴, Paola Aimone, MD^15*, Sai Li, MD, PhD^15*, Ksenia Titorenko, MS^16* and David M. Ross, MD, MBBS, PhD, FRACP, FRCPA^17*

¹Hematology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
³Abteilung Hämatologie/Onkologie, Universitätsklinikum Jena, Jena, Germany
⁴Division of Internal Medicine & Hematology, University of Turin, Orbassano, Italy
⁵3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
⁶Haematology and Transplantology, Medical University of Gdansk, Gdansk, Poland
⁷Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
⁸Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain
⁹St. James's Hospital, Dublin, IRL
¹⁰Charité – Universitätsmedizin Berlin, Berlin, Berlin, Germany
¹¹Universitätsklinikum Düsseldorf, Düsseldorf, Germany
¹²Azienda Ospedaliera "Bianchi Melacrino Morelli", Reggio Calabria, Italy
¹³III. Medizinische Klinik, Hämatologie und Onkologie, Universitätsmedizin Mannheim, Mannheim, Germany
¹⁴Developmental Therapeutics Consortium, Chicago, IL
¹⁵Novartis Pharma AG, Basel, Switzerland
¹⁶Novartis Pharmaceuticals Corporation, Moscow, Russian Federation
¹⁷Division of Haematology, SA Pathology, Royal Adelaide Hospital, Adelaide, Australia

Giovanni Caocci, MD¹, Olga Mulas^2*, Isabella Capodanno, MD^3*, Mario Annunziata, MD^4*, Elisabetta Abruzzese, MD ⁵, Sara Galimberti, MD, PhD^6*, Mario Tiribelli, MD^7*, Luigiana Luciano, MD⁸, Bruno Martino, MD^9*, Fausto Castagnetti, MD, PhD¹⁰, Gianni Binotto, MD^11*, Patrizia Pregno^12*, Fabio Stagno, MD, PhD¹³, Monica Bocchia^14*, Francesco Albano^15*, Debora Luzi^16*, Claudio Fozza, MD^17*, Massimiliano Bonifacio, MD^18*, Chiara Elena, MD^19*, Antonella Gozzini, MD^20*, Maria Pina Simula^21*, Malgorzata Monika Trawinska, MD^22*, Claudia Baratè, MD^6*, Rossella Stella, MD^7*, Fiorenza De Gregorio, MD^23*, Gabriele Gugliotta, MD, PhD¹⁰, Francesca Pirillo^24*, Daniele Cattaneo^25*, Anna Sicuranza, PhD^26*, Imma Attolico, MD^27*, Luigi Scaffidi, MD^18*, Emilia Scalzulli, MD^28*, Alessandra Iurlo, MD, PhD^29*, Robin Foà, MD³⁰, Massimo Breccia, MD^31* and Giorgio La Nasa, MD^32*

¹Ematologia-Centro Trapianti Midollo Osseo, Ospedale Businco, Dipartimento di Scienze mediche e Sanità Pubblica, Università di Cagliari, Cagliari, Italy
²Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
³Hematology Department, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy
⁴Hematology Unit, Cardarelli Hospital, Naples, Italy
⁵Hemoglobinopathies Unit, Hematology Department, S. Eugenio Hospital (ASL Roma 2), Tor Vergata University, Rome Italy, Rome, Italy
⁶Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa, Pisa, Italy
⁷Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
⁸Hematology Unit, Federico II University of Naples, Napoli, Italy
⁹Division of Hematology, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy
¹⁰Institute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy
¹¹Department of Medicine, Hematology and Clinical Immunology, Padua School of Medicine, Padua, Italy
¹²AZ OSP CITTA' DELLA SALUTE E SCIENZA TORINO, University of Torino, TORINO, Italy
¹³Hematology Section and BMT Unit, Rodolico Hospital, AOU Policlinico - V. Emanuele, Catania, Catania, Italy
¹⁴Hematology, University of Siena, Siena, Italy
¹⁵Hematology and Stem cell Transplantation Unit - Department of Emergency and Organ Transplantation (D.E.T.O.) - University of Bari, Bari, Italy
¹⁶Hematology, Azienda Ospedaliera - S. Mariai Terni, Terni, ITA
¹⁷Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
¹⁸Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
¹⁹Department of Hematology Oncology, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
²⁰Hematology Unit, AOU Careggi, University of Florence, Florence, ITA
²¹Hematology, Businco Hospital, Cagliari, ITA
²²ASL Roma2, Department of Hematology S. Eugenio Hospital, Rome, Italy, Rome, Italy
²³Hematology - Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy
²⁴Hematology Unit, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, Torino, Italy
²⁵FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO, MILANO, ITA
²⁶Hematology, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy
²⁷Haematology, University of Bari, Potenza, Italy
²⁸Department of Cellular Biotechnologies and Hematology, University "Sapienza", Rome, Italy
²⁹Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
³⁰Hematology, Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome, Rome, Italy
³¹Department of Translational and Precision Medicine, Sapienza University, Roma, Italy
³²Hematology, Hospital Businco, Department of Medical Sciences, University of Cagliari, Cagliari, Italy

Sara Di Giusto, PhD^1*, Eleonora Toffoletti, MD^2*, Massimiliano Bonifacio, MD^3*, Gianni Binotto, MD^4*, Maria Cristina Miggiano, MD^5*, Elisabetta Calistri, MD^6*, Manuela Stulle, MD^7*, Anna Ermacora, MD^8*, Rossella Stella, MD^2*, Luigi Scaffidi, MD^3*, Fabio D'Amore, MD^4*, Giorgia Scotton, MD^4*, Giovanna De Matteis, PhD^9*, Roberta Bertorelle, PhD^10*, Renato Fanin, MD^2*, Mauro Krampera, MD, PhD³, Gianpietro Semenzato, MD^4*, Daniela Damiani, MD^2* and Mario Tiribelli, MD^2*

¹Division of Hematology and BMT, Azienda Sanitaria Universitaria Friuli Centrale - Ospedale di Udine, Udine, Italy
²Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
³Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
⁴Department of Medicine, Hematology and Clinical Immunology, Padua School of Medicine, Padua, Italy
⁵Hematology Department, San Bortolo Hospital, Azienda ULSS8 "Berica" di Vicenza, Vicenza, Italy
⁶Hematology Unit, Ospedale Ca’ Foncello, Treviso, Italy
⁷Division of Hematology, Azienda Sanitaria Universitaria Giuliano-Isontina, Trieste, Italy
⁸Division of Internal Medicine, Azienda Ospedaliera S. Maria Angeli, Pordenone, Italy
⁹Department of Neurociences, Biomedicine and Movement Sciences - Section of Clinical Biochemistry, University of Verona, Verona, Italy
¹⁰Immunology and Molecular Oncology, Istituto Oncologico Veneto, Padua, Italy

Gianantonio Rosti, MD^1*, Tim H Brümmendorf, MD², Bjorn T. Gjertsen, MD, PhD³, Pilar Giraldo, PhD⁴, Ulla Olsson-Strömberg, MD, PhD^5*, Fausto Castagnetti, MD, PhD⁶, Carlo Gambacorti-Passerini, MD⁷, Andrea Viqueira^8*, Eric Leip^9*, Simon Purcell^10*, Francis J. Giles, MD, FRCPI, FRCPath¹¹ and Andreas Hochhaus, MD¹²

¹University of Bologna, Bologna, Italy
²Universitätsklinikum RWTH Aachen, Aachen, Germany
³Haukeland University Hospital, Bergen, Norway
⁴CIBER Enfermedades Raras (CIBERER), Miguel Servet University Hospital, Zaragoza, Spain
⁵Department of Hematology, University Hospital Uppsala, Uppsala, Sweden
⁶University Hospital, University of Bologna, Bologna, Italy
⁷Dept of Medicine and Surgery, University of Milano Bicocca, Monza, MB, Italy
⁸Pfizer SLU, Madrid, Spain
⁹Pfizer Inc., Cambridge, MA
¹⁰Pfizer Ltd, London, GBR
¹¹Developmental Therapeutics Consortium, Chicago, IL
¹²Klinik für Innere Medizin II, Jena, Germany