Scott R. Daigle, MS^1*, Sung Choe, PhD^1*, Courtney D. DiNardo, MD, MSc², Anthony S. Stein, MD³, Eytan M. Stein, MD⁴, Amir T. Fathi, M.D.⁵, Olga Frankfurt, MD^6*, Andre C. Schuh⁷, Hartmut Döhner, MD^8*, Giovanni Martinelli, MD⁹, Prapti Patel, MD¹⁰, Emmanuel Raffoux, MD^11*, Peter Tan, MBBS^12*, Amer M. Zeidan, MBBS, MHS¹³, Stephane De Botton, MD, PhD^14*, Richard M. Stone, MD¹⁵, Mark Frattini, MD^16*, Aleksandra Franovic, PhD^16*, Emily Xu, PhD^1*, Thomas Winkler, MD^17*, Bin Wu, PhD^17* and Paresh Vyas, MRCP, FRCP, FRCPath¹⁸

¹Agios Pharmaceuticals, Inc, Cambridge, MA
²Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
³City of Hope National Medical Center, Duarte, CA
⁴Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Massachusetts General Hospital, Harvard Medical School, Boston, MA
⁶Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
⁷Princess Margaret Cancer Centre, Toronto, ON, Canada
⁸Ulm University Hospital, Ulm, Germany
⁹Istituto Scientifico Romagnolo per lo Studio e Cura dei Tumori (IRST) IRCCS, Meldola, Italy
¹⁰University of Texas Southwestern Medical Center, Dallas, TX
¹¹Division of Hematology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France, France
¹²Department of Haematology Cell and Tissue Therapies, Royal Perth Hospital, Perth, Australia
¹³Yale University and Yale Cancer Center, New Haven, CT
¹⁴Institut Gustave Roussy, Villejuif, France
¹⁵Dana-Farber/Partners CancerCare, Boston, MA
¹⁶Bristol-Myers Squibb, New York, NY
¹⁷Agios Pharmaceuticals, Inc., Cambridge, MA
¹⁸University of Oxford, Oxford, United Kingdom

Keith W. Pratz, MD¹, Courtney D. DiNardo, MD, MSc², Dominik Selleslag, MD³, Junmin Li^4*, Kazuhito Yamamoto, MD, PhD⁵, Marina Konopleva, MD, PhD², Andrew McDonald^6*, Sunil Babu^7*, Don A. Stevens, MD⁸, Hagop M. Kantarjian, MD⁹, Fabiola Traina, MD, PhD¹⁰, Adriano Venditti, MD ¹¹, Jiri Mayer, MD¹², Melissa Montez^13*, Giridharan Ramsingh, MD^13*, Huan Jin^13*, William Ainsworth¹⁴, Yinghui Duan, PhD^15*, Anders Erik Svensson, MD^14*, Michael Werner^14*, Jalaja Potluri, MD¹⁵ and Brian A Jonas, MD, PhD, FACP¹⁶

¹Division of Hematology and Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium
⁴Ruijin Hospital, Shanghai, China
⁵Aichi Cancer Center Hospital, Nagoya, Japan
⁶Netcare Pretoria East Hospital, Pretoria, South Africa
⁷Fort Wayne Medical Oncology and Hematology, Fort Wayne, IN
⁸Norton Cancer Institute - St Matthews Campus, Louisville, KY
⁹Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX
¹⁰University of São Paulo at Ribeirão Preto Medical School, Sao Paulo, Brazil
¹¹Hematology, University Tor Vergata, Rome, Italy
¹²Department of Internal Medicine, Hematology and Oncology, Masaryk University Hospital, Brno, Czech Republic
¹³Genentech, Inc., South San Francisco, CA
¹⁴AbbVie, Inc., North Chicago, IL
¹⁵AbbVie Inc., North Chicago, IL
¹⁶Department of Internal Medicine, Division of Hematology and Oncology, University of California, Davis, Sacramento, CA

Abhishek Maiti, MBBS¹, Courtney D. DiNardo, MD, MSc², Farhad Ravandi, MBBS³, Naveen Pemmaraju, MD¹, Gautam Borthakur, MD¹, Prithviraj Bose, MD⁴, Ghayas C. Issa, MD¹, Tapan M. Kadia, MD⁵, Nicholas J. Short, MD¹, Musa Yilmaz, MD⁴, Guillermo Montalban-Bravo, MD^1*, Alessandra Ferrajoli, MD⁶, Elias Jabbour, MD¹, Nitin Jain, MD⁷, Maro Ohanian, DO^1*, Koichi Takahashi, MD, PhD⁸, Philip A. Thompson, MB, MS⁹, Caitlin R. Rausch, PharmD^10*, Kathryn S Montalbano, RN^1*, Sherry A. Pierce, BSN, BA^1*, Hagop M. Kantarjian, MD¹¹, Naval Daver, MD¹² and Marina Konopleva, MD, PhD¹³

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁷Associate Professor of Medicine Department of Leukemia The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰Pharmacy, MD Anderson Cancer Center, Houston, TX
¹¹University of Texas MD Anderson Cancer Center, Houston, TX
¹²Department of Leukemia, The University of Texas, M.D. Anderson Cancer Center, Houston, TX
¹³Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX

Jorge E. Cortes, MD¹, Tara Lin, MD², Geoffrey L Uy, MD³, Robert J. Ryan^4*, Stefan Faderl⁵ and Jeffrey E. Lancet, MD⁶

¹Georgia Cancer Center, Augusta University, Augusta, GA
²University of Kansas Medical Center, Kansas City, KS
³Washington University School of Medicine, Saint Louis, MO
⁴Jazz Pharmaceuticals, Philadelphia, PA
⁵Jazz Pharmaceuticals, Palo Alto, CA
⁶H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Frank Cichocki, PhD^1*, Ryan Bjordahl, PhD^2*, Karrune Woan, MD, PhD³, Zachary Davis, PhD, BS^4*, Greg Bonello^2*, Sajid Mahmood, PhD^2*, Paul Rogers, PhD^2*, Moyar Q. Ge, PhD^2*, Tom Lee, PhD^5*, Martin Felices, PhD^3*, Bruce Walcheck, PhD^6*, Bruce R. Blazar, MD⁷, Bahram Valamehr, PhD⁵ and Jeffrey S. Miller, MD³

¹Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
²Fate Therapeutics Inc., San Diego, CA
³Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
⁴Masonic Cancer Center, University of Minnesota, Minneapolis, MN
⁵Fate Therapeutics, Inc., San Diego, CA
⁶Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN
⁷Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN

Amina Cherait^1,2*, Thorsten Braun, MD, PhD^3,4,5,6,7, Krimo Bouabdallah, MD^8*, Denis Caillot^9*, Agnès Guerci, MD, PhD^10*, Emmanuel Raffoux, MD^11*, Jean Pierre Marolleau¹², Cecile Pautas, MD^13*, Anne Banos, MD^14*, Chantal Himberlin, MD^15*, Anne Laure Taksin^16*, Arnaud Pigneux, MD, PhD^17*, Xavier Thomas, MD, PhD¹⁸, Norbert Vey, MD^19,20,21, Sylvie Chevret, MD, PhD^22*, Herve Dombret, MD, PhD^{23,24,25,26,27,28,29,30,31,32*}, Fatiha Chermat^1*, Lionel Ades, MD, PhD^{29,33,34,35,36,37}, Claude Gardin^38,39,40,41* and Pierre Fenaux, MD, PhD^{26,42,43,44,45,46,47,48,49,50,51,52,53}

¹Hospital, Paris, France
²Service d'Hématologie Séniors, Hôpital Saint-Louis, Paris, CO, France
³Hopital Avicenne, AP-HP, Bobigny, France
⁴IRSL, EA3518 Leukemia Translational Laboratory, Paris, France
⁵Avicenne Hospital, Bobigny, FRA
⁶Hopital Avicenne, Bobigny, France
⁷Hopital Avicenne, BOBIGNY CEDEX, France
⁸HOPITAL, BORDEAUX, France
⁹HOPITAL, DIJON, France
¹⁰HOPITAL, NANCY, France
¹¹Hématologie clinique, Hôpital Saint-Louis, Paris, France
¹²HOPITAL, AMIENS, France
¹³HOPITAL, CRETEIL, France
¹⁴HOPITAL, COTE BASQUE, France
¹⁵HOPITAL, REIMS, France
¹⁶Hospital, Versailles, France
¹⁷Hematology Clinic, Bordeaux University Hospital, Pessac, France
¹⁸Department of Hematology, Hospices Civils de Lyon, Lyon-Sud Hospital, Pierre-Bénite, Lyon, France
¹⁹Onco-Hematology Department, Paoli-Calmette Cancer Institute, Marseille, France
²⁰Institut Paoli-Calmettes, Marseille, France
²¹Paoli-Calmette Cancer Institute, Marseille, France
²²APHP, HOPITAL St LOUIS, PARIS, France
²³ALFA Group, Paris, France
²⁴Assistance Publique-Hôpitaux de Paris, Paris, France
²⁵Hematology Department, Saint-Louis Hospital, Paris, France
²⁶Hôpital Saint-Louis, Paris, France
²⁷Hôpital Saint-Louis, AP-HP, Paris, France
²⁸Hematology, University Hôpital Saint-Louis, Paris, France
²⁹Hopital Saint Louis, Paris, France
³⁰Saint-Louis University Hospital, University Paris Diderot, Paris, France
³¹Hematology, Hôpital Saint-Louis, Paris, France
³²Université Paris Diderot, Hôpital Saint-Louis AP-HP, Paris, France
³³Service d'Hématologie Séniors, Hôpital Saint-Louis, Paris, France
³⁴Institut Univeristaire d'Hematologie, Hopital Saint Louis, Paris, France
³⁵INSERM UMR-S1131, Institut Universitaire d'Hématologie, Université Paris-Diderot, Assistance Publique-Hôpitaux de Paris Hôpital Saint-Louis, Paris, France
³⁶INSERM UMR-S1131, Insitut Univeristaire d'Hématologie, Université de Paris-Diderot, Assistance Publique Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France
³⁷Hopital Saint-Louis, Paris, France
³⁸Hopital Avicenne, AP-HP, University Paris 13, Bobigny, France
³⁹Hematology, Avicenne Hospital, APHP, University Paris XIII, Bobigny, France, Bobigny, France
⁴⁰IUH, EA3518 Leukemia Translational Laboratory, Paris, France
⁴¹Hematology, Avicenne Hospital, APHP, University Paris XIII, Bobigny, France
⁴²Service d'Hématologie,Assistance Publique des Hôpitaux de Paris (AP-HP) and Université Paris 7, Hôpital Saint-Louis / Université Paris 7, Paris, France
⁴³Service d’Hématologie Séniors, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
⁴⁴Hôpital Saint-Louis, Université Paris Diderot, Paris, France
⁴⁵Université Paris 7, Paris, France
⁴⁶Hôpital St Louis/ Paris 7 University, PARIS, FRA
⁴⁷Service d'Hématologie clinique, Hôpital Saint-Louis, Paris, France
⁴⁸Service d'Hématologie Clinique, Hopital Avicenne Université Paris XIII, Bobigny, France
⁴⁹Hopital Avicenne, Bobigny Cedex, FRA
⁵⁰Service d’Hématologie Séniors, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris and Université Paris 7, Paris, France
⁵¹Clinical Hematology, CHU Saint-Louis, Paris, France
⁵²Groupe Francophone des Myélodysplasies (GFM), Paris, France
⁵³Hôpital St Louis/Paris 7 University, PARIS, FRA

Gina Keiffer, MD¹, Kelly Hughes^2*, Tingting Zhan, PhD^3*, Lindsay Wilde, MD¹, Neil Palmisiano, MD, MS¹ and Margaret Kasner, MD, MSc¹

¹Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA
²Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA
³Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University Hospital, Philadelphia, PA

Qi Wang^1*, Nathalie H. Gosselin^2*, Michael J. Absalon³, E. Anders Kolb, MD⁴, J.F. Marier^2*, Todd A. Alonzo, PhD^5*, Stefan Faderl¹ and Todd M. Cooper, DO⁶

¹Jazz Pharmaceuticals, Palo Alto, CA
²Certara, Princeton, NJ
³Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁴Center for Cancer and Blood Disorders, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE
⁵University of Southern California, Los Angeles, CA
⁶Seattle Children’s Hospital, Cancer and Blood Disorders Center, Seattle, WA

Jenn Miller^1*, Lindsey Shannon, PharmD^1*, Amanda Finch, PharmD², Jessica K Altman, MD³ and Daniel Wojenski, PharmD^4*

¹Northwestern Memorial Hospital, Chicago, IL
²Northwestern Memorial Hospital, Chicago
³Robert H. Lurie Comprehensive Cancer Center, Chicago, IL
⁴Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL

Chi-Joan How, MD¹, Siyang Ren^2*, Jennifer Lombardi Story^3*, Meghan Bergeron, NP^3*, Julia E. Foster, NP^3*, Philip C. Amrein, MD⁴, Andrew M. Brunner^5*, Amir T. Fathi⁶, Hanno R. Hock, MD, PhD^7*, Jenna A. Moran, NP^3*, Rupa Narayan^8*, Donna S. Neuberg, ScD⁹, Aura Y. Ramos, RN^3*, Tina T. Som, RN^3*, Megan Vartanian, RN^10*, Yi-Bin Chen, MD¹¹ and Gabriela S. Hobbs, MD³

¹Dana Farber Cancer Institute / Massachusetts General Hospital, Boston, MA
²Department of Data Science, Boston, MA
³Leukemia Center, Massachusetts General Hospital, Boston, MA
⁴Leukemia Center/MGH Cancer Center, Massachusetts General Hospital, Belmont, MA
⁵Hematology/Oncology, Massachusetts General Hospital, Boston, MA
⁶Leukemia Center, Massachusetts General Hospital, Center for Leukemia, Cambridge, MA
⁷Leukemia Center, Massachusetts General Hospital / Harvard Medical School, Boston, MA
⁸Massachusetts General Hospital, Boston, MA
⁹Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
¹⁰MGH, Boston, MA
¹¹MGH, Boston

Claire Andrews^1*, Taylor Young^1*, Eshetu G Atenafu, M.Sc., P.Stat^2*, Sarit E Assouline, MD, MSc³, Joseph M Brandwein, MD⁴, Steven M Chan, MD, PhD¹, Signy Chow, MD, FRCP(C)⁵, Dina Khalaf, BSc, MSc, MD⁶, Vikas Gupta, MD, FRCP, FRCPath¹, Dennis Dong Hwan Kim, MD⁷, Dawn Maze, MD, FRCPC, MSc⁸, Mark D. Minden¹, Caroline J McNamara, MBBS¹, Tracy Murphy, MD, FRCP, FRCPath¹, David Sanford, MD⁹, Aaron D Schimmer, MD, PhD¹, Andre C. Schuh¹, Karen W.L. Yee, MD¹ and Hassan Sibai, MBBS^1*

¹Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
³Division of Hematology, Sir Mortimer B. Davis-Jewish General Hospital, Department of Oncology, McGill University, Montreal, QC, Canada
⁴Division of Hematology, University of Alberta, Edmonton, AB, Canada
⁵Odette Cancer Centre, Sunnybrook Health Science Centre, Toronto, ON, Canada
⁶Division of Hematology, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada
⁷Hans Messner Allogeneic Blood and Marrow Transplant Program, Division of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
⁸Leukemia Program, Division of Medical Oncology and Hematology, The Ottawa Hospital, Toronto, ON, Canada
⁹Leukemia/Bone Marrow Transplant Program of British Columbia, University of British Columbia, Vancouver, BC, Canada